Article
Microbiology
Wenya Weng, Shicui Jiang, Chuchu Sun, Xiaofu Pan, Li Xian, Xuemian Lu, Chi Zhang
Summary: In this study, eight structurally diverse secondary metabolites were isolated and identified from the endophytic fungus Penicillium sp. YT2019-3321 derived from traditional Chinese medicine Lonicera japonica. Among them, a new compound exhibited dose-dependent cytotoxicity against human pancreatic tumor cells and induced apoptosis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Si -Si Liu, Rong Huang, Shou-Peng Zhang, Tang-Chang Xu, Kun Hu, Shao-Hua Wu
Summary: Two new nucleoside derivatives, kipukasins O (1) and P (2), one new cyclohexenone derivative, arthropsadiol D (5), and one new natural product, (+)-2,5-dimethyl-3(2H)-benzofuranone (6), were isolated from the culture broth of the endophytic fungus Aspergillus polyporicola R2. The absolute configuration of compound 5 was determined and the antimicrobial activities of these compounds were evaluated.
Article
Plant Sciences
Yan Chen, Huan Wang, Xin Ke, Zihuan Sang, Min Kuang, Weiwei Peng, Jianbing Tan, Yuting Zheng, Zhenxing Zou, Haibo Tan
Summary: Two previously undescribed lactones and three new sesquiterpenoids were isolated from the fungus Phomopsis sp. SZSJ-7B. Their chemical structures were determined by various analytical techniques, and one of the lactones showed significant antibacterial activity against methicillin-resistant Staphylococcus aureus.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Applied
Usama W. Hawas, Lamia T. Abou El-Kassem, Eman F. Ahmed, Rana A. Alghamdi
Summary: Two new sulfonyl metabolites, pensulfonoxy and pensulfonamide, along with four known metabolites were isolated from the endophytic fungus Penicillium aculeatum, showing potent antibacterial and antifungal activities against Escherichia coli and Candida albicans, respectively. Additionally, compound 2 exhibited significant preferential cytotoxicity against MCF-7 cells compared to compound 1 and the drug control, paclitaxel.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
Chen Chen, Geting Ye, Jing Tang, Jialin Li, Wenbin Liu, Li Wu, Yuhua Long
Summary: Four new polyketide compounds and two new citreoviridin derivatives were isolated from the mangrove endophytic fungus Penicillium sp. BJR-P2. Compound 2 exhibited stronger anti-inflammatory activity by inhibiting NO production induced by LPS.
Article
Chemistry, Medicinal
Yan Chen, Ge Zou, Wencong Yang, Yingying Zhao, Qi Tan, Lin Chen, Jinmei Wang, Changyang Ma, Wenyi Kang, Zhigang She
Summary: New compounds were isolated from the endophytic fungus, with two showing potent anti-inflammatory activities. The structures were determined through extensive analysis, and the absolute configurations were established by ECD calculations and specific rotation comparison.
Article
Chemistry, Applied
Eveline Christelle Siebatcheu, Duplex Wetadieu, Olivier Youassi Youassi, Marie Ampere Bedine Boat, Kibrom Gebreheiwot Bedane, Nguemezi Severin Tchameni, Modeste Lambert Sameza
Summary: Chemical investigation of the endophytic fungus Trichoderma erinaceum isolated from healthy and asymptomatic common bean field crop resulted in the discovery of a new compound that showed significant inhibition of Pythium ultimum mycelial growth.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Chang-Yan Li, Hong-Tao Li, Ya-Ting Shao, Xing-Yi Guo, Wei Li, Tian-Peng Yin
Summary: The chemical epigenetic modifier 5-azacitidine was used to manipulate the endophytic fungus Penicillium sp. KMU18029. A new polyketone compound, along with 13 known compounds, was isolated from its rice fermentation extract. The new compound was identified by spectroscopic techniques. Only compounds 1, 2 and 11 showed weak antimicrobial activities against S. aureus.
NATURAL PRODUCT RESEARCH
(2023)
Article
Microbiology
Shikai Zhang, Qing Xu, Changbo Ji, Xiaoyu Han, Yang Zhou, Chao Liang, Linran Ma, Weijian Sun, Yanling Li, Zhengyou Yang, Fengchun Zhao, Yuan Tian
Summary: This study investigates the effects of small molecule-induced secondary metabolites of the endophytic fungus Diaporthe sp. AC1 on antibacterial activity and tumor cytotoxicity. The results show that the compound induced by 1-MT exhibits optimal antibacterial activity and tumor cytotoxicity, while other compounds show varying levels of biological activity.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Changrong Lai, Danmei Tian, Mingxin Zheng, Binglei Li, Jia Jia, Jihua Wei, Bin Wu, Hongkai Bi, Jinshan Tang
Summary: This study obtained six new citrinin derivatives from a marine-derived fungus, and four of them exhibited potent antimicrobial activities, suggesting their potential as lead compounds for the development of novel antimicrobial drugs.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Microbiology
Viridiana Morales-Sanchez, Carmen E. Diaz, Elena Trujillo, Sonia A. Olmeda, Felix Valcarcel, Ruben Munoz, Maria Fe Andres, Azucena Gonzalez-Coloma
Summary: The ethyl acetate extract from the endophytic fungus Aspergillus sp. SPH2 showed potential biocontrol properties against various plant pathogens, insect pests, and plant parasites. Compound 1, mellein, demonstrated strong ixodicidal effects, while compound 2, neoaspergillic acid, exhibited potent antifungal effects. The study also suggested that compound 2 may be the biosynthetic precursor of compound 3, neohydroxyaspergillic acid.
Article
Biochemistry & Molecular Biology
Di Zhang, Jinyang Zheng, Mingyi Chu, Yao Feng, Huifang Li
Summary: Eight compounds were isolated from the fermentation of an endophytic fungus Cladosporium sp. ZLM-6 derived from Suaeda salsa (Linn.) Pall. Compound 4 showed good inhibitory activity against Pseudomonas aeruginosa, Escherichia coli, and four different vibrios. This study further expanded the chemical diversity of the genus Cladosporium.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Chemistry, Medicinal
Xuan Lu, Jun-kai Qi, Xiao-yuan Tang, Xu-de Wang, Chong-tao Ye, Jing Bai, Chuan Tang, Yu-fei Xi, Bin Wu, Xue Wan, Bao-min Feng
Summary: Seven undescribed polyketide compounds (1-4, 9-11) and six known polyketide compounds (5-8,12, 13) were isolated from Rhodiola tibetica endophytic Penicillium sp. HJT-A-10. The structures of the seven undescribed polyketide metabolites were determined using spectroscopic methods. The results of the anti-inflammatory activity assay demonstrated that compounds 1-8, 10-13 exhibited significant inhibitory effects on LPS-induced NO production in RAW 264.7 cells.
Article
Plant Sciences
Xu Pang, Guo-Wei Cai, Meng-Yan Wang, Xiu-Fei Chen, Wen-Ni He, Wu-Li Zhao, Tao Zhang, Li-Yan Yu
Summary: Twenty-two metabolites were isolated from Penicillium sp. CPCC 401423 cultured on rice and their structures were identified. Among them, nine compounds were identified as new. These compounds were tested for their cytotoxic activity against pancreatic carcinoma cells.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Plant Sciences
Guowei Cai, Xinxin Hu, Ran Zhang, JuXian Wang, Xiaomei Fang, Xu Pang, Jinglin Bai, Tao Zhang, Tao Zhang, Hui Lv, Xuefu You, Wenni He, Liyan Yu
Summary: Ten new xanthone dimers, named Subplenones A-J, have been isolated from the endophytic fungus Subplenodomus sp. CPCC 401465, which resides within the Chinese medicinal plant Gentiana straminea. These compounds exhibited significant inhibitory activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.
JOURNAL OF NATURAL PRODUCTS
(2023)
