Article
Plant Sciences
Kang Ren, Wenbo Xu, Bailing Ren, Jinqiu Fu, Chunmei Jiang, Jiang Zhang
Summary: Multiple linear DNA fragments with homologous sequences were used for plastid transformation without the need for vector construction. This technology simplifies the plastid transformation procedure and provides a novel solution for expressing toxic proteins or large operons in plastids.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Biotechnology & Applied Microbiology
Megumu Takahashi, Koji Mikami
Summary: Phycobilisomes in cyanobacteria, red algae and glaucophyte algae can absorb various light wavelengths to optimize photosynthesis. Research on the red alga Pyropia yezoensis showed that changes in light wavelength, specifically blue and red light, can modify the composition of phycobilisomes, resulting in reversible color changes in the algae. This blue-red chromatic acclimation in Pyropia yezoensis provides new insights into regulatory mechanisms for adjusting photosynthetic pigment contents in phycobilisomes of photosynthetic organisms.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Plant Sciences
Xinzi Yu, Lei Tang, Xianghai Tang, Yunxiang Mao
Summary: This study conducted a comprehensive analysis of the MYB gene family in Pyropia yezoensis, a type of red algae. The research identified several MYB gene members in Py. yezoensis and investigated their structural features and expression profiles. The study provides valuable insights into the functional divergence of MYB genes.
Article
Biochemistry & Molecular Biology
Hae-Bin Park, So-Jung Kim, Dhananjay Yadav, Eun-Koung An, Wei Zhang, Hee-Yun Eom, Minseok Kwak, Tatsuya Oda, Peter Chang-Whan Lee, Jun-O Jin
Summary: This study found that porphyran derived from Pyropia yezoensis has an inhibitory effect on dextran sodium sulfate (DSS)-induced colitis in mice. Oral or intraperitoneal administration of porphyran can inhibit the progression of colitis and prevent immune cell infiltration in the colon. Porphyran inhibits T cell activation by suppressing dendritic cells and macrophages and attenuates chronic colitis caused by long-term DSS administration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Plant Sciences
Yuan Zhang, Gennady Ananyev, Aki Matsuoka, G. Charles Dismukes, Pal Maliga
Summary: The D1 polypeptide mutations (LL-E130Q and HL-A152S) from Synechococcus cyanobacteria can confer specific photosystem II photochemical phenotypes to tobacco plants, resulting in increased biomass under low light condition and improved photoprotection under high light condition.
Article
Chemistry, Applied
Lihua Geng, Quanbin Zhang, Qishan Suo, Jing Wang, Yingxia Wang, Cong Wang, Ning Wu
Summary: The oligo-porphyran OP145, isolated from Pyropia yezoensis, shows potential in inhibiting SARS-CoV-2. Through experiments and simulations, it is found that OP145 can bind to Spike glycoprotein and prevent viral infection.
CARBOHYDRATE POLYMERS
(2023)
Article
Biotechnology & Applied Microbiology
Jihae Park, Hojun Lee, Soyeon Choi, Lalit K. Pandey, Stephen Depuydt, Jonas De Saeger, Joon-Tae Park, Taejun Han
Summary: This study investigated the depigmentation and anti-ageing properties of red seaweed extracts for skin care. The results showed that the extracts did not have cytotoxic effects and had inhibitory effects on melanogenesis and tyrosinase activity, as well as promoting collagen production.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yingchao Ma, Bangxiang He, Xulei Wang, Linwen He, Jianfeng Niu, Li Huan, Xiaoping Lu, Xiujun Xie, Guangce Wang
Summary: This study analyzed the proteome changes in the mutant strain E and initial strain NA of Pyropia yezoensis, showing that the mutant strain E had enhanced proteins related to photosynthesis, protein biosynthesis, and glycolysis, promoting its growth. It also exhibited increased stress resistance, while proteins related to methylation were decreased in mutant strain E. This research provides a theoretical foundation for molecular breeding of Py. yezoensis.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Fisheries
Xiaoqing Wang, Jing Liu, Lihua Geng, Yue Yang, Ning Wu, Quanbin Zhang, Jing Wang
Summary: This study evaluated the supplemental effect of Pyropia yezoensis enzymatic hydrolysate (PYE) in fish diet using zebrafish as a model. The results showed that adding 1% PYE to the diet significantly improved the growth performance of zebrafish and increased the crude protein content of their bodies. Moreover, PYE supplementation enhanced the innate immune responses and activity of digestive enzymes in zebrafish, as well as regulating the intestinal flora. These findings suggest that PYE could potentially be used as an aquatic additive.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Editorial Material
Medicine, Research & Experimental
Jonas Schwickert, Franziska M. Zickgraf, Martin R. Sprick
Summary: Ovarian cancer, especially high-grade serous ovarian cancer (HGSOC), has the worst prognosis among all gynecological cancers. RAD51 expression is proposed as a biomarker of platinum resistance in HGSOC patients, which can help in selecting effective therapies for therapy-resistant patients.
EMBO MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Calum H. G. Johnston, Rachel Hope, Soulet Anne-Lise, Marie Dewailly, David De Lemos, Patrice Polard
Summary: Homologous recombination is a crucial mechanism that promotes genetic repair and diversity. In bacteria, natural transformation is a horizontal gene transfer mechanism dependent on RecA and the conserved DprA. The interaction between DprA-mediated RecA filaments and replication machinery highlights the role of replisomes in chromosomal integration of transforming DNA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Agriculture, Multidisciplinary
Dan He, Qifang Wu, Chenying Lu, Jinlan Wu, Peichao Chen, Mingjiang Wu, Jong-Il Choi, Haibin Tong
Summary: The study found that PYP can improve metabolic abnormalities caused by high sucrose by modulating gut microbiota. PYP reduced the relative abundance of bacteria causing metabolic abnormalities and increased the relative abundance of beneficial bacteria. However, PYP had no effect on triglyceride and circulating sugar contents in larvae fed with high sucrose after gut microbiota removal by antibiotics.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Thomas Bachelot, Thomas Filleron, Ivan Bieche, Monica Arnedos, Mario Campone, Florence Dalenc, Florence Coussy, Marie-Paule Sablin, Marc Debled, Claudia Lefeuvre-Plesse, Anthony Goncalves, Marie-Ange Mouret Reynier, William Jacot, Benoit You, Philippe Barthelemy, Benjamin Verret, Nicolas Isambert, Xavier Tchiknavorian, Christelle Levy, Jean-Christophe Thery, Tifenn L'Haridon, Jean-Marc Ferrero, Alice Mege, Francesco Del Piano, Etienne Rouleau, Alicia Tran-Dien, Julien Adam, Amelie Lusque, Marta Jimenez, Alexandra Jacquet, Ingrid Garberis, Fabrice Andre
Summary: The study found that single-agent antibodies against PD-L1 as maintenance therapy did not significantly benefit the overall population with metastatic breast cancer, but showed improved overall survival in patients with triple-negative breast cancer. Durvalumab may have better sensitivity in patients with CD274 amplification. Analysis of lymphocyte infiltration and homologous recombination deficiency did not predict sensitivity to durvalumab, warranting further research. Maintenance chemotherapy was more effective than durvalumab in patients with hormone receptor-positive and Her2-negative disease.
Article
Chemistry, Medicinal
Dan He, Liping Yan, Yingxia Hu, Qifang Wu, Mingjiang Wu, Jong-il Choi, Haibin Tong
Summary: Macroalgae polysaccharides, such as Pyropia yezoensis porphyran (PYP), have been optimized for extraction in this study. The extracted PPYP has lipid-lowering effects in both HepG2 cells and Drosophila melanogaster larvae, indicating its potential as a marine lipid-lowering drug.
Article
Biotechnology & Applied Microbiology
Chao-Feng Teng, Da -Hai Gao, Hong -Chang Ding, Xing -Hong Yan
Summary: In this study, the regulation of reactive oxygen species (ROS) on the processes of formation, release, and germination of archeospores of Pyropia yezoensis was investigated using in situ ROS fluorescence detection. The results showed that ROS fluorescence was observed in the marginal cells during the release of archeospores, and intensive ROS fluorescence was present in the released archeospores. Once adhered to a glass substrate, the ROS fluorescence faded and round cell shape and cell wall formation occurred. ROS fluorescence disappeared during the first germination and division, and no ROS fluorescence was observed in germlings with two or more cells. Culturing somatic cells from the blades revealed that ROS fluorescence could be detected from single cells to cell-masses, with higher intensity in cell-masses with more cells. Addition of diphenyleneiodonium (DPI), which inhibits ROS production, affected cell division and reduced ROS fluorescent intensity. These results demonstrate the regulatory roles of ROS in the formation, release, and early germination of archeospores of Pyropia yezoensis.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)