Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 79, Issue 1, Pages 394-400Publisher
WILEY
DOI: 10.1002/mrm.26643
Keywords
background suppression (BS); arterial spin labeling (ASL); simultaneous multislice (SMS); controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA)
Funding
- National Institute of Health (NIH) [UH2-NS100614, R01-EB014922, P41-EB015894]
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PurposeTo present a constrained slice-dependent (CSD) background-suppression (BS) scheme in 2D arterial spin labeling (ASL) using simultaneous multislice acquisition with blipped-CAIPIRINHA (controlled aliasing in parallel imaging results in higher acceleration). MethodsBackground suppression for 2D acquisition is challenging because of the multiple nulling points required for sequential slice readout. Constrained slice-dependent BS exploits the simultaneous multislice technique to reduce the readout duration, and uses slice-dependent premodulation pulses to achieve BS across slice groups. The proposed scheme was evaluated by in vivo brain experiments at 3 Tesla with multiband acceleration factors up to four. The utility of CSD BS was demonstrated through comparison against standard 2D acquisitions as well as 3D-BS pseudo-continuous ASL (pCASL). ResultsAn average of 95% background signal reduction was achieved with CSD BS. As a result, the temporal signal-to-noise ratio (SNR) increased 48.2/39.9/36.9/36.0% and spatial SNR increased 132.5/80.0/63.5/54.2 in CSD-BS MB-1/2/3/4 scans, respectively. Whole-brain coverage was achievable with CSD-BS pCASL with MB-4, which yielded comparable spatial SNR as 3D BS pCASL. ConclusionsThe proposed CSD-BS scheme for 2D-SMS pCASL offers a promising approach for effective suppression of background signals across a wide range of T-1 to achieve whole-brain perfusion imaging. Magn Reson Med 79:394-400, 2018. (c) 2017 International Society for Magnetic Resonance in Medicine.
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