Journal
MACROMOLECULAR BIOSCIENCE
Volume 17, Issue 12, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201700229
Keywords
allergenicity; immunogenicity; inflammatory; sericin; silk
Funding
- National Natural Science Foundation of China Programs [81272559, 81572866]
- International Science and Technology Corporation Program of Chinese Ministry of Science and Technology [S2014ZR0340]
- Science and Technology Program of Chinese Ministry of Education [113044A]
- Frontier Exploration Program of Huazhong University of Science and Technology [2015TS153]
- Natural Science Foundation Program of Hubei Province [2015CFA049]
- Hubei Province Hundreds of Talents Program
- European Union Framework Programme for Research and Innovation Horizon [668983 - FoReCaST]
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The biosafety of sericin remains controversial. The misunderstanding regarding sericin causing adverse biological responses have been clarified by extensively reviewing relevant literatures and experimentally demonstrating that sericin exhibits mild inflammatory responses, negligible allergenicity, and low immunogenicity in vivo. This study supports that sericin is biosafe as a natural biomaterial.
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