Review
Pharmacology & Pharmacy
Xiaohan Ma, Jonathan C. Knowles, Alessandro Poma
Summary: Molecular imprinting technology has made significant advancements in the design and production of MIP nanoparticles (MIP NPs) as antibody substitutes. However, its overall sustainability and biodegradability have been questioned. This review aims to examine the production and purification strategies of MIP NPs from a sustainability and waste management perspective.
Article
Biophysics
Oluwafemi S. Obisesan, Timothy O. Ajiboye, Sabelo D. Mhlanga, Hazel T. Mufhandu
Summary: Magnetic nanoparticles (MNPs) have become a focus of attention in the past decade due to their unique properties, making them suitable for drug delivery and various biomedical applications when combined with biodegradable polymers. This review discusses the synthesis of polycaprolactones (PCL), methods of synthesizing magnetic iron oxide nanoparticles, and the synthesis of PCL-based composites. It comprehensively reviews the application of these composites in drug delivery, cancer treatment, wound healing, hyperthermia, bone tissue engineering, and other biomedical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Pharmacology & Pharmacy
Hani Z. Asfour, Nabil A. Alhakamy, Osama A. A. Ahmed, Usama A. Fahmy, Mohamed A. El-moselhy, Waleed Y. Rizg, Adel F. Alghaith, Basma G. Eid, Ashraf B. Abdel-Naim
Summary: This study developed a new nanoformula called Amitrip-based biodegradable PEG-PLGA self-assembled nanoparticles (Amitrip-NPs), which expedited wound healing in diabetic rats and exhibited anti-inflammatory, antioxidant, pro-collagen, and angiogenic activities.
Review
Biochemistry & Molecular Biology
Mingrui Li, Ying Liu, Benno Weigmann
Summary: Inflammatory bowel disease (IBD) is a chronic disorder that causes inflammation in the gastrointestinal tract. The prevalence of IBD has increased in recent years. Flavonoids, natural chemicals found in plants, have been used in the treatment of IBD, but their effectiveness is limited due to solubility and stability issues. Nanoparticles (NPs) can improve the stability and bioavailability of flavonoids, enhancing their therapeutic effects on IBD. This review aims to evaluate the therapeutic effect of flavonoid NPs on IBD and discuss potential challenges and future perspectives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Yixiu Liu, Xu Li, A. Liang
Summary: Chronic osteomyelitis is a challenging disease in orthopedic treatment. Local drug delivery systems based on biodegradable polymers provide new hope for treating this condition by reducing drug side effects and promoting bone healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maomao He, Ran Wang, Peiyuan Wan, Hexiang Wang, Yi Cheng, Pengcheng Miao, Zhiyong Wei, Xuefei Leng, Yang Li, Jianjun Du, Jiangli Fan, Wen Sun, Xiaojun Peng
Summary: A biodegradable Ru-containing polymer with high drug loading capacity has been developed for effective release of anticancer drug and inhibition of tumor growth under light stimulation. The method shows good biocompatibility and opens up opportunities for multi-therapeutic agent delivery and enhanced phototherapy.
Article
Polymer Science
Xianshuo Zhang, Peipei Wang, Yaoyu Xu, Jun Wang, Yunfeng Shi, Wenxu Niu, Wenjing Song, Ruru Liu, Cui-Yun Yu, Hua Wei
Summary: A robust yet facile strategy for the synthesis of biodegradable hyperbranched amphiphilic copolymers is reported in this study. The block-statistical structure is identified as a better polymer architecture for controlled release applications.
Review
Chemistry, Multidisciplinary
Yuvaraj Arun, Radhakanta Ghosh, Abraham J. Domb
Summary: Biodegradable, hydrophobic, and injectable liquid polymers are able to achieve sustained, local drug release, with potential applications in regenerative medicine.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Jerika A. Chiong, Helen Tran, Yangju Lin, Yu Zheng, Zhenan Bao
Summary: The field of wearable and implantable skin-inspired devices is rapidly growing interest in the consumer market, with a focus on developing environmentally-friendly electronics using recyclable, biodegradable, and biocompatible polymer technologies to mitigate the adverse impact on the environment and human health. Through advancements in molecular design, processing parameters, and fabricating techniques, there is a potential for economic growth and increased efficiency in these devices, which aim to enhance human-environment interaction levels.
Review
Polymer Science
Vincent S. D. Voet, Jarno Guit, Katja Loos
Summary: The global market for 3D printing materials has grown rapidly in the past decade, with photopolymers dominating sales. However, the lack of sustainable resins that can compete with commercial materials in vat photopolymerization remains a challenge. Developing green alternatives is crucial for reducing the environmental impact of additive manufacturing.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Layla Filiciotto, Gadi Rothenberg
Summary: Plastics are everywhere and have both improved our lives and posed threats to the environment and health. Biodegradable plastics offer a solution to reduce climate change, microplastics, and littering issues. However, they still make up a small portion of the global plastics market and require more research and commercialization efforts.
Article
Food Science & Technology
Shima Jafarzadeh, Ali Salehabadi, Abdorreza Mohammadi Nafchi, Nazila Oladzadabbasabadi, Seid Mahdi Jafari
Summary: Research shows that bionanocomposite films can effectively reduce weight loss and microbial spoilage in cheese packaging, improving the shelf life of cheese. Furthermore, there is a call to reduce the use of non-biodegradable polymers and promote the application of bio-materials in cheese packaging.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Polymer Science
Amal Patel, Bhausaheb S. Rajput, Thien An Phung Hai, Daniel Zhen, Natasha R. Gunawan, Marissa Tessman, Jaysen Reindel, Jenna Shepherd, Ryan Simkovsky, Robert S. Pomeroy, Naser Pourahmady, Stephen P. Mayfield, Michael D. Burkart
Summary: Non-biodegradable petroleum-based plastic wastes are a major environmental concern. New efforts are being made to develop biobased and biodegradable alternatives. In this study, waterborne, biodegradable adhesives with over 70% biocontent were developed, avoiding viscosity challenges and the use of volatile organic solvents. The resulting polyurethane dispersions showed good material properties and met the desired mechanical and biodegradability targets, indicating their viability as lamination adhesives.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Engineering, Chemical
Samaneh Bandehali, Hamidreza Sanaeepur, Abtin Ebadi Amooghin, Saeed Shirazian, Seeram Ramakrishna
Summary: This review emphasizes the importance of utilizing bio-based and petroleum-based biodegradable polymers in developing modern membrane separation technology, including different synthesis, preparation methods, and modifications. State-of-the-art membranes are prepared through various strategies such as blending, copolymerization, cross-linking, and composites with nanoparticles for advanced performance.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Polymer Science
Aamna Bibi, Ying-Hsuan Li, Hsi-Wei Jia, Hsien-po Kuo, Nadaraj Sathishkumar, Hsin-Tsung Chen, Karen S. Santiago, Jui-Ming Yeh
Summary: In this study, biodegradable-electroactive polymers (BEP) and its composite with gold nanoparticles (BEP-Au) were prepared and successfully applied for the detection of H2S gas. The sensors exhibited good sensitivity, rapid response and recovery rates, good repeatability, and high selectivity. The ab initio density functional theory (DFT) calculations complemented the experimental results, providing further insights into the adsorption process.
EXPRESS POLYMER LETTERS
(2022)
Article
Chemistry, Medicinal
David Vrbata, Marcela Filipova, Marina R. Tavares, Jakub Cerveny, Miluse Vlachova, Milada Sirova, Helena Pelantova, Lucie Petraskova, Ladislav Bumba, Rafal Konefal, Tomas Etrych, Vladimir Kren, Petr Chytil, Pavla Bojarova
Summary: Galectin-3 plays a role in cancer-related metabolic processes. Inhibiting overexpressed Galectin-3, such as with beta-galactoside-based inhibitors, holds promise for cancer treatment. A library of inhibitors was synthesized and displayed on a suitable biocompatible carrier to enhance affinity for Gal-3. One of the candidates exhibited strong inhibitory effects in cancer cells and shows potential for Gal-3-associated cancer therapy.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Oncology
Tomas Etrych, Alena Braunova, David Zogala, Lukas Lambert, Nicol Renesova, Pavel Klener
Summary: Targeted drug delivery (TDD) is an innovative and effective treatment approach that aims to minimize damage to healthy tissues. Current TDD modalities include radioimmunotherapy (RIT), antibody-drug conjugates (ADC), and new formulations based on the enhanced permeability and retention effect. Diagnostic and restaging procedures in aggressive lymphomas are based on nuclear imaging, and a theranostic approach that combines diagnostic imaging with targeted treatment is an appealing strategy in personalized medicine.
Article
Biochemistry & Molecular Biology
Libor Kostka, Ladislav Sivak, Vladimir Subr, Jirina Kovarova, Milada Sirova, Blanka Rihova, Radislav Sedlacek, Tomas Etrych, Marek Kovar
Summary: The derivative of protease inhibitor ritonavir (RD) was found to be a potent P-gp inhibitor and cancerostatic drug. In this study, high-molecular-weight HPMA copolymer conjugates with a PAMAM dendrimer core bearing both doxorubicin (Dox) and RD (Star-RD + Dox) were designed to increase the circulation half-life and maximize simultaneous delivery of Dox and RD into the tumor. It was found that Star-RD + Dox exhibited higher cytostatic and proapoptotic activities compared to other treatments in vitro, and also inhibited STAT3 signaling in vivo.
Article
Biochemistry & Molecular Biology
Nela Pilbauerova, Jan Schmidt, Tomas Soukup, Tomas Prat, Kristina Nesporova, Vladimir Velebny, Jakub Suchanek
Summary: This study investigated the use of high-molecular-hyaluronic acid (HMW-HA) as a cryoprotectant for human mesenchymal stem cells (hMSCs) to reduce DMSO concentration in the cryopreservation medium. The results showed that HMW-HA combined with lower DMSO concentrations improved total cell count, viability, and proliferation potential of hMSCs post-cryopreservation, without affecting their differentiation ability.
Article
Biochemistry & Molecular Biology
Niuosha Sanaeifar, Karsten Maeder, Dariush Hinderberger
Summary: We report extended ethanol-induced gelation procedures of bovine serum albumin (BSA) at 37 degrees C and investigate the release behavior of a spin-labeled naproxen derivative (SL-NPX) from these hydrogels. The alteration of initial drug loading percentage, hydrogel incubation time, BSA and alcohol concentrations affect the release rate of SL-NPX from BSA hydrogels. BSA hydrogels offer a remarkable fine-tuning capability for controlled drug delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Marina Rodrigues Tavares, Kaplan Kirakci, Nikolay Kotov, Michal Pechar, Kamil Lang, Robert Pola, Tomas Etrych
Summary: In this study, biocompatible and water-soluble copolymers were utilized as carriers to overcome the delivery obstacles of photosensitizers. The results showed that the conjugates prepared by covalent interactions exhibited good colloidal stability and high luminescence quantum yields, making them potential candidates for photodynamic applications.
Article
Chemistry, Multidisciplinary
Libor Kostka, Lenka Kotrchova, Eva Randarova, Carolina A. Ferreira, Iva Malatova, Hye Jin Lee, Aeli P. Olson, Jonathan W. Engle, Marek Kovar, Weibo Cai, Milada Sirova, Tomas Etrych
Summary: nanomedicines are being developed as an improved therapeutic option with reduced side effects, and this study introduces tailored nanosystems for the treatment of solid tumors or hematological malignancies. The relationship between the structure of the nanosystem and its distribution in the body was evaluated through independent assessments of the polymer carrier and drug pharmacokinetics. The results showed enhanced tumor accumulation of the polymer carriers in mice with solid tumors, as well as significant accumulation of doxorubicin bound to the polymer carriers in specific tumor types.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
A. Libanska, E. Randarova, S. Skoroplyas, M. Bartos, J. Lunackova, F. Lager, G. Renault, D. Scherman, T. Etrych
Summary: This study presents biocompatible and stimuli-sensitive polymer conjugates with an anti-inflammatory drug, dexamethasone, which are designed for prolonged blood circulation, enhanced inflammatory site accumulation, site-specific drug release, and subsequent elimination via urine excretion. The polymer nanomedicines demonstrated the ability to reduce joint inflammation and arthritis-induced bone damage in a mouse model of rheumatoid arthritis.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Okan Tezcan, Asmaa Said Elshafei, Karina Benderski, Elena Rama, Maike Wagner, Diana Moeckel, Robert Pola, Michal Pechar, Tomas Etrych, Saskia von Stillfried, Fabian Kiessling, Ralf Weiskirchen, Steffen Meurer, Twan Lammers
Summary: Multidrug resistance (MDR) reduces the efficacy of chemotherapy by inducing drug efflux pumps and altering the tumor microenvironment (TME) composition, limiting drug delivery. Multidrug-resistant tumors displayed a more mesenchymal phenotype, increased collagen production, enriched TME, and enhanced vascular perfusion. Drug carriers accumulated more efficiently in resistant tumors but had a limited ability to penetrate the interstitium. Microenvironmental drug resistance affected liposomal doxorubicin performance more than free doxorubicin.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nanoscience & Nanotechnology
Sarah Schraven, Stefanie Rosenhain, Ramona Brueck, Tim Marvin Wiechmann, Robert Pola, Tomas Etrych, Wiltrud Lederle, Twan Lammers, Felix Gremse, Fabian Kiessling
Summary: Biodistribution of nanocarriers with different dye tags was compared, showing that hydrophobic dyes were preferentially taken up by tumor cells. The uptake was actively mediated but not influenced by transporters. Additionally, labeling significantly impacted the tumor accumulation and biodistribution of nanocarriers, emphasizing the need for low-interference dyes and further exploration of dye tags for unbiased results.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Rayhanul Islam, Kevin Kotalik, Vladimir Subr, Shanghui Gao, Jian-Rong Zhou, Kazumi Yokomizo, Tomas Etrych, Jun Fang
Summary: In this study, a nanoformulation of 5-aminolevulinic acid (5-ALA) was developed for targeted photodynamic therapy. The nanoformulation, called P-ALA, exhibited rapid release in acidic tumor environment, increased cytotoxicity under light irradiation, and higher tumor accumulation compared to 5-ALA. The results suggest the potential application of P-ALA as a nano-designed photosensitizer for anticancer photodynamic therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Robert Pola, Matej Vicha, Jiri Trousil, Eliska Grosmanova, Michal Pechar, Anna Rumlerova, Martin Studenovsky, Emilie Kucerova, Pavel Ulbrich, Barbora Vokata, Tomas Etrych
Summary: Microbial resistance is a significant issue in modern medicine. Antimicrobial peptides have shown potential as a solution, but their limitations in stability, toxicity, and immunogenic response have hindered their clinical application. In this study, polymer-antibacterial peptide constructs were designed and synthesized. The constructs demonstrated antibacterial activity against both gram-positive and negative bacteria, with the peptide being released from the polymer carrier in response to a pH decrease.
Article
Health Care Sciences & Services
Steffen Hackbarth, Shanghui Gao, Vladimir Subr, Lisheng Lin, Jakob Pohl, Tomas Etrych, Jun Fang
Summary: Recently, we discovered induced anoxia as a limiting factor for photodynamic tumor therapy. The amount of generated singlet oxygen depends on photosensitizer accumulation, efficiency, and illumination intensity. Our experimental results provide proof for the described model and demonstrate characteristic changes in signal kinetics of singlet oxygen and photosensitizer phosphorescence in vivo, allowing for better optimization and coordination of PDT drugs and treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Engineering, Biomedical
M. Hrochova, L. Kotrchova, M. Frejkova, R. Konefal, S. Gao, J. Fang, L. Kostka, T. Etrych
Summary: Biodegradable polymer-based therapeutics have become essential drug delivery biomaterials. This study presents an adaptable polymerization platform for the synthesis of long-circulating, stimulus-sensitive and biodegradable biomaterials. The controlled polymerization allows for controlled degradation and increased antitumor efficacy.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Kaplan Kirakci, Robert Pola, Marina Rodrigues Tavares, Michal Pechar, Tomas Pribyl, Ivana Krizova, Jaroslav Zelenka, Tomas Ruml, Tomas Etrych, Kamil Lang
Summary: This study successfully conjugated octahedral molybdenum clusters with organic polymers, resulting in a highly stable nanosized conjugate. The conjugate demonstrated the ability to photosensitize the production of singlet oxygen without being toxic to cells. It also showed potential as a radiosensitizer upon X-ray irradiation. This research provides a promising therapeutic tool for photo/radiodynamic applications.
MATERIALS ADVANCES
(2023)
