Dual occurrence of ALK G1202R solvent front mutation and small cell lung cancer transformation as resistance mechanisms to second generation ALK inhibitors without prior exposure to crizotinib. Pitfall of solely relying on liquid re-biopsy?

Published 2017 View Full Article

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Title
Dual occurrence of ALK G1202R solvent front mutation and small cell lung cancer transformation as resistance mechanisms to second generation ALK inhibitors without prior exposure to crizotinib. Pitfall of solely relying on liquid re-biopsy?
Authors
Keywords
Small cell lung cancer transformation, Lorlatinib, ALK G1202R solvent front mutation, Circulating tumor DNA, Rb1 C706Y, ALK+ NSCLC
Journal
LUNG CANCER
Volume 106, Issue -, Pages 110-114
Publisher
Elsevier BV
Online
2017-02-10
DOI
10.1016/j.lungcan.2017.02.005

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