Article
Multidisciplinary Sciences
Sung Shin Ahn, Hyunjin Yeo, Euitaek Jung, Yoongho Lim, Young Han Lee, Soon Young Shin
Summary: This study identified the molecular mechanisms by which inflammatory cytokines inhibit the expression of FLG in the skin. It was found that the formation of the FRA1:c-JUN:HDAC1 complex is promoted under TNFa + IFNγ stimulation, leading to the downregulation of FLG expression. This insight into the regulatory pathways of FLG expression provides potential therapeutic strategies for restoring skin barrier function in chronic skin inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Fisheries
Xuexi Wang, Min Jin, Xin Cheng, Xiaoying Hu, Mingming Zhao, Ye Yuan, Peng Sun, Lefei Jiao, Monica B. Betancor, Douglas R. Tocher, Qicun Zhou
Summary: The optimal dietary DHA/EPA ratios for mud crab S. paramamosa were estimated to be 2.2 and 1.2 when supplied with optimal n-3 LC-PUFA at 7% and 12% lipid, respectively. The DHA/EPA ratio affected weight gain, growth rate, lipid content, fatty acid composition, and gene expression levels in the mud crabs. Differences in dietary lipid levels also influenced the crabs' response to the DHA/EPA ratio.
Article
Agricultural Engineering
Ajeet Singh Chauhan, Chiu-Wen Chen, Vaibhav Sunil Tambat, Reeta Rani Singhania, Jo-Shu Chang, Cheng-Di Dong, Anil Kumar Patel
Summary: Recent studies have shown that the thraustochytrid can be used as a sustainable alternative to fish oil or polyunsaturated fatty acid (PUFA) sources. This study aims to maximize PUFA yield by optimizing the glucose carbon and nitrogen ratio, and found that the highest biomass and lipid yields were obtained at a glucose concentration of 40 g/L. However, the highest yields of relative lipid, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA) were obtained at a glucose concentration of 30 g/L.
BIORESOURCE TECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Jiao Wu, Jun Luo, Qiuya He, Yingying Xia, Huibin Tian, Lu Zhu, Cong Li, Juan J. Loor
Summary: Goat milk is recognized for its high nutritional value and richness in PUFA such as DHA. This study investigated the effect of DHA on lipid metabolism in goat mammary epithelial cells (GMEC) and found that DHA supplementation altered lipid metabolism processes and fatty acid composition in GMEC through transcriptional programs and H3K9ac epigenetic modifications. Specifically, DHA increased H3K9ac enrichment in the promoter region of PDK4, promoting its transcription and inhibiting lipid synthesis. Moreover, DHA affected the expression of fatty acid metabolism-related genes through the PDK4-AMPK-SREBP1 signaling axis. These findings provide insights into the mechanism through which DHA affects mammary cell function and regulates milk fat metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Bjorg Kristine Hundal, Esmail Lutfi, Trygve Sigholt, Grethe Rosenlund, Nina Sylvia Liland, Brett Glencross, Nini Hedberg Sissener
Summary: This study aimed to investigate the effects of different levels of EPA and DHA on the hepatic metabolic health of Atlantic salmon reared in sea cages. The results showed that feeding low levels of EPA+DHA altered hepatic energy metabolism, resulting in reduced beta-oxidation and compensated by increased activity in alternative energy pathways. Increased acylcarnitines in the liver indicated issues with lipid metabolism. Fish fed higher levels of EPA+DHA showed improved growth compared to other groups.
Article
Environmental Sciences
Caiyun Lai, Fan Wu, Yan Wang, Wei Wang, Yueqi Li, Gaoqiang Zhang, Jianji Gao, Zhiliang Zhu, Jianhui Yuan, Jianping Yang, Wenjuan Zhang
Summary: TCE exposure can cause DNA hypomethylation and histone hyperacetylation in cells, leading to increased protein levels of tumor-related genes and inhibiting cell growth. These changes could serve as early biomarkers for TCE-associated diseases.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Fang Wu, Dan-Dan Wang, Hao-Hao Shi, Cheng-Cheng Wang, Chang-Hu Xue, Yu-Ming Wang, Tian-Tian Zhang
Summary: Early dietary n-3 PUFA deficiency exacerbates the development of Parkinson's disease in old age, while supplementation with DHA/EPA-PLs can restore brain DHA levels and exert neuroprotective effects in long-term n-3 PUFA-deficient mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Oncology
Yongxu Jia, Qian Yan, Yinli Zheng, Lei Li, Baifeng Zhang, Zhiwei Chang, Zehua Wang, Hong Tang, Yanru Qin, Xin-Yuan Guan
Summary: This study identified a key molecular mechanism that influences lymph node metastasis. RPRD1B was found to promote lymph node metastasis by regulating the c-Jun/c-Fos/SREBP1 axis, and NEAT1 enhanced the activity of this axis through a positive feedback loop. These findings provide a potential therapeutic target for the treatment of gastric cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Environmental Sciences
Chuan-Ho Tang, Shu-Han Shi, Hsing-Hui Li, Ching-Yu Lin, Wei-Hsien Wang
Summary: Copper micropollutants restrict the assimilation of carbonate by coral and affect the lipid metabolism of symbiotic algae, leading to adaptations to light stress conditions and compromising the stability of symbiosis.
Article
Food Science & Technology
Xiaodan Lu, Luyao Huang, Yanjun Chen, Ling Hu, Rongbin Zhong, Lijiao Chen, Wenjian Cheng, Baodong Zheng, Peng Liang
Summary: Lipid metabolism disorder is a significant threat to human health, and various supplements have been studied to treat it. This study focused on the effect of DHA-enriched phospholipids from large yellow croaker roe (LYCRPLs) on lipid regulation in rats, specifically analyzing the fecal metabolites using metabolomics. The results showed that LYCRPLs activated several metabolic pathways related to lipid metabolism, and L-cysteine was identified as a potential biomarker for LYCRPLs' effects on rat fecal metabolites.
Article
Cell Biology
Hideto Osada, Eriko Toda, Kohei Homma, Naymel A. Guzman, Norihiro Nagai, Mamoru Ogawa, Kazuno Negishi, Makoto Arita, Kazuo Tsubota, Yoko Ozawa
Summary: Mutations in lipid metabolism-related genes may lead to retinal degeneration, as evidenced by Adipor1 knockout mouse models showing neurodegeneration and visual dysfunction. Adipor1 deficiency is crucial for proper photoreceptor function and survival, likely through mechanisms involving Elovl2 repression and increased expression of lipogenic genes.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
James T. Leech, Andrew Brennan, Nicola A. Don, Jody M. Mason, Neil M. Kad
Summary: The AP-1 transcription factor family plays a crucial role in regulating the cell cycle and has various functions in proliferation, differentiation, and stress response. This study shows that cFos can bind to DNA independently of cJun and can interact with DNA as both monomers and dimers.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Samuel Furse, Samuel Virtue, Stuart G. Snowden, Antonio Vidal-Puig, Philip C. Stevenson, Davide Chiarugi, Albert Koulman
Summary: The study found that supplementation of individual PUFAs has system-level effects dependent on the molecular structure of the PUFA, affecting changes in lipid metabolism variety and total number of variables in phosphatidylcholine and triglycerides, as well as influencing endogenous biosynthesis of fatty acids, elongation, and desaturation of fatty acids.
MOLECULAR METABOLISM
(2022)
Article
Chemistry, Applied
Xuexi Wang, Min Jin, Xin Cheng, Xiaoying Hu, Mingming Zhao, Ye Yuan, Peng Sun, Lefei Jiao, Douglas R. Tocher, Monica B. Betancor, Qicun Zhou
Summary: The study showed that dietary DHA/EPA ratio can impact the lipid molecular species and fatty acid positional distribution in mud crab hepatopancreas. An optimal ratio can increase specific lipid contents and affect esterified site distribution.
Article
Biochemistry & Molecular Biology
Siyan Yu, Qunying Xie, Weifeng Tan, Manjiang Hu, Guiling Xu, Xiao Zhang, Guanghang Xie, Limei Mao
Summary: This study found that supplementation of fish oil with an appropriate higher ratio of DHA (1.5:1) can alleviate insulin resistance, reduce adipocyte hypertrophy and oxidative stress, improve lipid metabolism, and reduce hepatic steatosis in high-fat diet-induced insulin resistance mice.
Article
Environmental Sciences
Lei Zhang, Jiahuai Zhang, Sai Fan, Yuxin Zhong, Jingguang Li, Yunfeng Zhao, Song Ni, Jiaying Liu, Yongning Wu
Summary: This case-control study investigated the associations between urinary concentrations of bisphenols and the risk of papillary thyroid cancer (PTC). The results showed significant positive associations between bisphenol F (BPF) concentration and PTC risk, but negative associations between bisphenol A (BPA) and bisphenol S (BPS) concentrations and PTC risk in the overall population. However, the significant associations were only observed in non-smoking women after stratification by age and smoking.
Article
Engineering, Environmental
Feng Han, Jiaying Liu, Yuxin Wang, Jingguang Li, Bing Lyu, Yunfeng Zhao, Yongning Wu
Summary: The mechanism of blood to milk transfer of PFOS and Cl-PFESAs was studied using 145 paired maternal serum and human milk samples. The transfer efficiency was found to be influenced by the physicochemical properties and primary components of human milk. Results suggest that passive diffusion through the paracellular route may be the main transfer pathway for PFOS and Cl-PFESAs from blood to milk.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Yizhong Shen, Yunlong Wei, Xiang Gao, Chao Nie, Jianlong Wang, Yongning Wu
Summary: Scientists successfully synthesized a novel blue fluorescence nanozyme CeO2@TPE with high peroxidase-like activity. By embedding aggregation-induced emission (AIE) tetraphenylethene (TPE) into hollow CeO2 nanospheres and combining ethanol oxidase (AOX) and o-phenylenediamine (OPD), they developed an enzymatic cascade activation ratiometric fluorescence-colorimetric dual-mode system for detecting methyl mercaptan (CH3SH). This study provides a new insight into designing target-responsive enzymatic cascade activation systems and enables real-time point-to-point detection of environmental health.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Xuezhen Zhao, Bing Lyu, Lei Zhang, Jingguang Li, Yunfeng Zhao, Yongning Wu, Zhixiong Shi
Summary: Based on the 6th China Total Diet Study, both legacy and novel brominated flame retardants (BFRs) were found in animal-derived foods across China. The levels and estimated dietary intakes (EDIs) of most BFRs showed a significant decrease compared to previous studies conducted from 2007 to 2011. Meat consumption was identified as the primary source of dietary BFR intake. However, daily dietary intakes of BFRs were still unable to cause significant health risks to the general population in China.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Infectious Diseases
Danxia Gu, Zelin Yan, Chang Cai, Jiaping Li, Yanyan Zhang, Yuchen Wu, Jiaxing Yang, Yonglu Huang, Rong Zhang, Yongning Wu
Summary: In this study, the efficacy of three different methods for the rapid detection of carbapenemases (KPC, NDM, IMP, OXA-48, and VIM) was evaluated. The NG-test Carba 5, colloidal gold immunoassay (CGI) test, and Xpert Carba-R assay showed reliable performances in carbapenemase detection, with Xpert Carba-R being recommended for the detection of KPC variants.
Article
Chemistry, Applied
Feifei Huang, Lei Zhang, Moqin Zhou, Jianwen Li, Qing Liu, Bo Wang, Ke Deng, Pingping Zhou, Yongning Wu
Summary: Polycyclic aromatics hydrocarbons (PAHs) are commonly found in foods and the environment and have carcinogenic and mutagenic potential. A study in China determined the concentrations of 16 PAHs in commonly consumed food items. Edible vegetable oils had the highest concentration of PAHs, while fruits had the lowest. PAH4 was identified as a suitable indicator for PAH contamination, and the overall dietary exposure for PAHs in the Chinese population was estimated to be within safe limits.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
Article
Agriculture, Multidisciplinary
Chi Zhang, Heli Li, Huijing Shen, Bing Lyu, Shaohua Li, Jingguang Li, Yunfeng Zhao, Dawei Chen, Yongning Wu
Summary: This study is the first nationwide study in China on the chronic health risks of chlorothalonil and its metabolite (4-OH-chlorothalonil) for Chinese adults and breastfed infants. The study found that chlorothalonil and 4-OH-chlorothalonil were detected in dietary samples, with higher levels in Northwest China and Shandong regions. Other exposure routes besides dietary intake were also identified. The study concluded that the chronic health risks from dietary exposure to chlorothalonil and 4-OH-chlorothalonil are low for Chinese adults and breastfed infants.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Lan Ma, Huijing Shen, Xiaohong Shang, Shuang Zhou, Bing Lyu, Xin Zhao, Jingguang Li, Yunfeng Zhao, Yongning Wu
Summary: The recent total diet study comprehensively evaluated the intake of nutrient elements in the general Chinese population. Plant foods were the main source of both macro-elements and trace elements. The average intake of Na, Ca, Mg, Zn, and Se did not meet the health guidance values, while the intake of K, P, Mn, Fe, Cu, Mo, and Cr fell within a reasonable range. A dietary imbalance was identified in the Na/K ratio and Ca/P ratio. This study highlights the importance of salt reduction and dietary structure optimization for the population.
Article
Nutrition & Dietetics
Hangyu Yu, Rui Wang, Yunfeng Zhao, Yan Song, Haixia Sui, Yongning Wu, Hongjian Miao, Bing Lyu
Summary: The sixth Total Diet Study (TDS) of China conducted a nationwide study to evaluate the health effects of MSG. The study analyzed 168 samples from seven food categories of the typical Chinese daily diet to determine MSG content, consumption patterns, and associated risks. The study found that the highest MSG level in the Chinese population's daily diet was 8.63 g/kg. By combining food consumption and MSG content measurements, the estimated MSG intake for the general population of China was 17.63 mg/kg bw/d, while the apparent consumption alone resulted in an overestimated intake of 40.20 mg/kg bw/d due to the omission of MSG loss during cooking. The study also compared and analyzed MSG content, food category contributions, and ingestion levels across different nations to provide a global perspective. Furthermore, a realistic, logical, and precise risk assessment protocol for daily MSG intake was developed in this article.
Article
Allergy
Hua Feng, Jiangdong Zhou, Yuanan Lu, Qian Zhao, Zifei Yang, Xiujuan Xiong, Nan Luo, Yan Chen, Lianglu Wang, Yongning Wu
Summary: The prevalence of self-reported food allergy among adults in China is approximately 4.0%, with 3.1% in men and 4.8% in women. The most common allergic symptom is skin reaction, reported by 63.9% of participants with self-reported food allergy. Shrimp, mollusks, and mango are the most common allergenic foods, accounting for 39.8%, 20.8%, and 18.7% of cases respectively. Gender, age, and other allergic conditions are associated factors with food allergy in adults.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Food Science & Technology
Hui -Ming Chen, Quan Zhou, Li-Jun Huang, Jun Lin, Jia-Fei Liu, Zi-Yong Huang, Rong-Lin Zhang, Jing-Jing Wang, Yong Zhao, Yong-Ning Wu, Xing-Fen Yang, Wei-Liang Wu
Summary: This study aimed to evaluate the effects of curcumin-mediated photodynamic treatment (PDT) on the shelf-life quality of ready-to-eat salmon fillets. The results showed that PDT had outstanding bacterial inhibition and extended the shelf-life of salmon fillets. Additionally, PDT was able to maintain the physicochemical indicators and freshness of the salmon fillets, and improve the sensory scores.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Agriculture, Multidisciplinary
Guojian Wu, Abudoushukeer Dilinaer, Peng Nie, Xin Liu, Zhi Zheng, Pengjie Luo, Wenjuan Chen, Yongning Wu, Yizhong Shen
Summary: Developing efficient meat freshness assays is crucial for ensuring food safety. In this study, a bimetallic nanozyme Fe@CeO2 with high peroxidase-like activity was synthesized, and a self-supplying enzymatic cascade catalytic system was developed for colorimetric and photothermal detection of meat freshness. The assay showed both reliability and sensitivity, providing new insights for onsite visual monitoring of meat freshness.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jinde Liu, Qiao Rong, Chunxiao Zhang, Ali Tariq, Lin Li, Yongning Wu, Feifei Sun, Michal Tomczyk
Summary: It has been reported that Mori Folium (MF) and Eucommiae Cortex (EC) exhibit pharmacological effects in the treatment of immunosuppression. This study aimed to explore the mechanism of action of MF and EC against immunosuppression using network pharmacology, molecular docking, molecular dynamics simulations, and animal experiments. The results obtained from network pharmacology identified important components, hub targets, and signaling pathways involved in the treatment of immunosuppression. Molecular docking and dynamics simulations confirmed the stable binding of certain critical components to hub targets. Animal experiments also demonstrated the significant effect of MF and EC in treating immunosuppression. These findings suggest that MF and EC may have a multi-component, multi-target, and multi-pathway mode of action in treating immunosuppression.
Article
Biochemistry & Molecular Biology
Luyao Zhang, Jialu Liu, Bufan Xu, Di Wu, Yongning Wu, Guoliang Li
Summary: In this study, the effects of exposure to different concentrations of beta-carbolines norharman and harman on the survival rate and behaviors of C. elegans were assessed. The changes in antioxidant system, neurotransmitter levels, and acetylcholinesterase activity were evaluated. RNA-seq analysis identified potential molecular mechanisms underlying the toxic effects of norharman and harman. The results suggest that long-term exposure to low doses of beta-carbolines in food poses a risk of neurotoxicity.
Review
Chemistry, Analytical
Jin Liu, Guoliang Li, Jianghua Liu, Panxue Wang, Di Wu, Xianlong Zhang, Yongning Wu
Summary: PCBs, a class of synthetic organochlorine chemicals, had been widely used in industrial and commercial applications in the last century. However, PCBs have significant impacts on human health and the ecosystem, including neurotoxicity and carcinogenicity. This review mainly focuses on the recent progress in the toxicity and detection techniques of PCBs in the environment and food, covering classification, source, distribution, and toxicity, as well as sample preparation and analytical determination technologies.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)