Review
Food Science & Technology
Lily Jaiswal, Mulumebet Worku
Summary: Cow's milk contains potential allergens in the form of proteins, making some infants, children, and adults allergic to cow's milk. Strict exclusion of milk and other dairy products puts children with cow's milk allergy at higher nutritional risk.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Hannah G. Juncker, Eliza J. M. Ruhe, George L. Burchell, Chris H. P. van den Akker, Aniko Korosi, Johannes B. van Goudoever, Britt J. van Keulen
Summary: The antioxidant properties of human milk help reduce oxidative damage in preterm infants, but donor milk needs to be pasteurized for safety. Pasteurization can affect the antioxidant properties of the milk, with Holder pasteurization showing more reduction compared to alternative methods.
Article
Food Science & Technology
Aliah Zannierah Mohsin, Anis Asyila Marzlan, Belal J. Muhialdin, Lew Kah Wai, Nameer Khairullah Mohammed, Anis Shobirin Meor Hussin
Summary: The study found that fat content has significant effects on the viscosity and particle size of yogurt, as well as its GABA content, antioxidant capacity, and antimicrobial effects. Yogurt with 3.5% fat showed high antioxidant capacity and antimicrobial effects, making it the optimized formula for large-scale production from Murrah buffalo milk.
Article
Food Science & Technology
Ashwajit Tejram Patil, Ganga Sahay Meena, Neelam Upadhyay, Yogesh Khetra, Ashish Kumar Singh, Sanket Girdharbhai Borad
Summary: Different heat treatments were used to manufacture and characterize buffalo skim milk-based MPC60 powder, with heat treatment at 85±1°C/5min significantly improving reconstitutability, viscosity, and emulsification. The resulting MH-MPC60 powder showed improved properties and microstructure compared to LH-MPC60, with higher densities and specific surface area. Evaluations such as protein gelation temperature and FTIR analysis supported the conclusion that 85±1°C/5min heat treatment enhances the reconstitutability of buffalo MH-MPC60.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Dorota Martysiak-Zurowska, Edyta Malinowska-Panczyk, Malgorzata Orzolek, Bogumila Kielbratowska, Elena Sinkiewicz-Darol
Summary: Bioactive substances in human milk are important for premature newborns. Microwave heating compared to convection heating preserves more active proteins in human milk, but may degrade certain components like lysozyme. Controlled conditions of microwave heating are better for preserving the bioactive components of human milk.
Review
Agriculture, Dairy & Animal Science
Zitai Guo, Shengtao Gao, Jialiang Ouyang, Lu Ma, Dengpan Bu
Summary: Heat stress negatively affects milk protein synthesis in dairy cows, potentially by reducing appetite and dry matter intake, leading to oxidative stress and regulating apoptosis, reducing mammary epithelial cell numbers, and influencing endocrine function. Further research is needed to fully understand the mechanisms involved.
Article
Food Science & Technology
Shanshan Yang, Yuqiong Piao, Xinfei Li, Delun Mu, Shuaiqi Ji, Rina Wu, Junrui Wu
Summary: Thermosonication is a viable technique to replace conventional thermal processing and has been used to kill heat-resistant Bacillus and extend the shelf life of pasteurized milk. The study found that thermosonication treatment significantly reduced the number of Bacillus subtilis and improved the quality of milk. It also had an effect on cell membrane permeability and enzyme activities. The findings suggest that this new decontamination method can be implemented in the dairy industry to enhance the quality and shelf life of pasteurized milk.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Prashant Ashok Shelke, Latha Sabikhi, Yogesh Khetra, Sangita Ganguly, Davuddin Baig
Summary: The study found that using a lower proportion (90:10) of skim milk and higher temperature (95 degrees C) in the heat treatment during cow milk Ricotta cheese production results in better quality cheese. Principal component analysis can group cheeses based on the level of cheese milk and heating temperature.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
Rajan Sharma, Archana Verma, Nitin Shinde, Bimlesh Mann, Kamal Gandhi, Jan H. Wichers, Aart van Amerongen
Summary: A competitive lateral flow immunoassay using amorphous carbon nanoparticles and specific antibodies has been developed for rapid detection of cow's milk adulteration with buffalo's milk. The sensitivity of the test is detecting 5% adulteration, with applicability at milk receiving stations and for heated milk samples.
Article
Food Science & Technology
Mutamed Ayyash, Abdelmoneim Abdalla, Basim Abu-Jdayil, Thom Huppertz, Raman Bhaskaracharya, Saleha Al-Mardeai, Anusha Mairpady, Arachchige Ranasinghe, Anas Al-Nabulsi
Summary: The study found that high-pressure processing and ultra-high temperature treatment can enhance the rheological properties of fermented camel milk, with the lowest viscosity observed in fermented milk treated with low-temperature long-time and high-temperature short-time methods.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Marije Kleinjan, Martijn J. C. van Herwijnen, Sten F. W. M. Libregts, R. J. Joost van Neerven, Anouk L. Feitsma, Marca H. M. Wauben
Summary: Commercial milk subjected to pasteurization or UHT heating contains fewer or no intact EVs, respectively. Although most EVs appear resistant to pasteurization based on particle numbers, their integrity and molecular composition are altered. This may decrease or change the potential transfer of bioactive components through bovine milk EVs to human consumers in heat-treated commercial milk.
JOURNAL OF NUTRITION
(2021)
Article
Energy & Fuels
Sedat Akmese, Gokhan Omeroglu, Omer Comakli
Summary: The study explores the use of a hybrid photovoltaic-thermal heat pump system for milk pasteurization, focusing on energy efficiency. Results show that PV/T support reduced total pasteurization time and increased thermal efficiency, leading to significant energy savings compared to conventional systems.
Article
Biochemistry & Molecular Biology
Fouad M. F. Elshaghabee, Ahmed A. Abd El-Maksoud, Sulaiman Ali Alharbi, Saleh Alfarraj, Mahmoud S. M. Mohamed
Summary: The study found that adding heat-treated industrial yeasts could enhance the growth and viability of probiotics in ABT fermented milk, increase levels of organic acids and antioxidant capacity, and thus improve the nutritional value of the milk.
Article
Green & Sustainable Science & Technology
Mariem Lazaar, Hassen Boughanmi, Salwa Bouadila, Mohamed Jarraya
Summary: The study proposed a solar pasteurization system for small productions collection centers to minimize rejected milk during transportation. Both numerical and experimental studies were conducted to evaluate the heat transfer behavior of the plate heat exchanger (PHE). Results showed that the global heat transfer coefficient of PHE increased with hot fluid flow.
SUSTAINABLE ENERGY TECHNOLOGIES AND ASSESSMENTS
(2021)
Article
Chemistry, Applied
Angela Salzano, Gianluca Neglia, Nunzia D'Onofrio, Maria Luisa Balestrieri, Antonio Limone, Alessio Cotticelli, Raffaele Marrone, Aniello Anastasio, Michael J. D'Occhio, Giuseppe Campanile
Summary: The study demonstrated that adding green feed to the diet of dairy buffaloes enhances the content of health-promoting biomolecules and the antioxidant and antineoplastic properties in milk. Treated buffaloes had higher levels of L-carnitine biomolecules in their milk and showed greater antioxidant activity. Additionally, milk from the treated buffaloes exhibited stronger potency in inhibiting the viability of cancer cells.
Article
Biochemistry & Molecular Biology
Mehreen Ghufran, Ashfaq Ur Rehman, Muhammad Ayaz, Zaheer Ul-Haq, Reaz Uddin, Syed Sikander Azam, Abdul Wadood
Summary: This study used computer-aided drug designing approaches and experimental methods to find new and potential anti-cancer drugs. A pharmacophore model was developed and used for virtual screening, resulting in the identification of compounds with good interactions with the target protein. The results were further validated through molecular dynamics simulation analysis.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Mohammed A. Huneif, Mater H. Mahnashi, Muhammad Saeed Jan, Muhammad Shah, Sultan A. Almedhesh, Seham M. Alqahtani, Mohammad Jamaan Alzahrani, Muhammad Ayaz, Farhat Ullah, Umer Rashid, Abdul Sadiq
Summary: Diabetes mellitus (DM) is a metabolic disorder resulting from pancreatic dysfunction, characterized by reduced insulin production or insulin resistance. In this study, we designed and synthesized new succinimide-thiazolidinedione hybrids for the treatment of DM. We successfully synthesized five new derivatives (10a-e) with different substitution patterns on the N-atom of the succinimide ring. Compound 10d showed the most potential as an antidiabetic agent in in vitro assays. Further investigations in experimental animals confirmed its promising antidiabetic activity. Molecular docking studies also demonstrated the interaction of compound 10d with target enzymes involved in diabetes. Overall, we have identified a new class of compounds with potential as antidiabetic agents.
Article
Biotechnology & Applied Microbiology
Mehreen Ghufran, Mehran Ullah, Haider Ali Khan, Sabreen Ghufran, Muhammad Ayaz, Muhammad Siddiq, Syed Qamar Abbas, Syed Shams ul Hassan, Simona Bungau
Summary: During the SARS-CoV-2 outbreak, researchers extensively studied pharmacological strategies to decrease the viral load in severe patients. The M-pro protease, which is essential for viral replication, has been identified as a potential therapeutic target. To prevent further spread of the pandemic, scientists are actively searching for more efficient inhibitors against SARS-CoV-2.
BIOENGINEERING-BASEL
(2023)
Article
Chemistry, Applied
Hamza Elsayed Ahmad Mohamed, Ali Talha Khalil, Khaoula Hkiri, Muhammad Ayaz, Asad Usman, Abdul Sadiq, Farhat Ullah, Muhammad Arif Khan, Arshad Islam, Muhammad Ovais, Malik Maaza
Summary: Phytoextracts of Hyphaene thebaica were used to synthesize nano-scaled spherical lanthanum oxide nanoparticles (La2O3 NPs) as a bioreducing and chelating agent. XRD, HR-TEM, and infrared spectroscopy confirmed the purity and crystalline nature of the HT-La2O3 NPs. The NPs showed potential antioxidant, anticancer, antiangiogenic, and cytotoxic properties, with highest DPPH scavenging activity and median lethal concentration values on MCF-7 and 3T3 cell lines.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Muhammad Imran, Arshad Iqbal, Syed Lal Badshah, Ayaz Ali Sher, Hammad Ullah, Muhammad Ayaz, Osama F. Mosa, Nada M. Mostafa, Maria Daglia
Summary: Seaweed is known for its beneficial effects on human health, and Dictyota dichotoma extracts contain various bioactive components such as proteins, fats, and carbohydrates. The extracts also contain multiple compounds, including undecane, cetylic acid, hexadecenoic acid, Z-11-, and myristic acid.
Review
Biochemistry & Molecular Biology
Mohammed Ahmed Elawad, Modawy Elnour Modawy Elkhalifa, Alashary Adam Eisa Hamdoon, Liga Hasan Mohammed Salim, Zeeshan Ahmad, Muhammad Ayaz
Summary: Leishmaniasis is a vector-borne infection caused by protozoan parasites from the genus leishmania. Natural products have shown potential as safe and effective drugs against leishmania.
Article
Biotechnology & Applied Microbiology
Hamza Elsayed Ahmad Mohamed, Ali Talha Khalil, Khaoula Hkiri, Muhammad Ayaz, Jamil Anwar Abbasi, Abdul Sadiq, Farhat Ullah, Asif Nawaz, Ikram Ullah, Malik Maaza
Summary: Spherical erbium oxide nanoparticles were synthesized using Hyphaene thebaica fruits via a one-step bioreduction process. The HT-Er2O3 NPS showed potential for antidiabetic treatment based on their physicochemical and morphological characteristics.
Article
Medicine, Research & Experimental
Haider Ali Khan, Mehreen Ghufran, Sulaiman Shams, Alam Jamal, Muhammad Ayaz, Mehran Ullah, Abbas Khan, Mohammad Imran Khan, Zuhier A. Awan
Summary: Therapeutic moieties derived from medicinal plants and plants-based ecofriendly processes for producing selenium nanoparticles have shown great promise in managing type 2 diabetes mellitus. The current study aimed to assess the anti-diabetic potentials of Fagonia cretica mediated biogenic selenium nanoparticles (FcSeNPs) using in-vitro and in-vivo approaches. FcSeNPs demonstrated dose-dependent inhibition against alpha-amylase and alpha-glucosidase and significant antioxidant activity against DPPH and ABTS radicals. Treatment with FcSeNPs resulted in a considerable decline in blood glucose levels in STZ-induced diabetic mice and improved biochemical parameters related to pancreas, liver, kidney, and lipid profile.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Tanzeel Zohra, Faryal Saeed, Aamer Ikram, Tariq Khan, Siyab Alam, Muhammad Adil, Ayesha Gul, Saud Almawash, Muhammad Ayaz
Summary: This review explores the role of nanomedicine-based therapeutic agents against dengue virus and introduces a potential method for better treatment.
Review
Pharmacology & Pharmacy
Ihsan Ullah, Muhammad Ayaz
Summary: The neural mechanisms and receptors involved in chemotherapy-induced nausea and vomiting (CINV) are complex and multifactorial. The acute phase of vomiting is triggered by serotonin release from gastrointestinal cells, while the delayed phase involves Substance P release in the gut. Various receptors, such as 5HT(3), D-2, M-3, GLP(1), H-1, and NK1, are implicated in the vomiting response. Calcium ion signaling also plays a role in the emetic circuitry. This review provides insight into the neurobiology of CINV and recent management approaches.
PHARMACOLOGICAL REPORTS
(2023)
Article
Immunology
Gowhar Ali, Nazar Ul Islam, Muhammad Qaim, Rahim Ullah, Muhammad Saeed Jan, Khadija Shabbiri, Muhammad Shafique, Muhammad Ayaz
Summary: This study evaluated the efficacy of 2-hydroxybenzohydrazide (HBH) as a drug against pyrexia, inflammation, and nociception, as well as its therapeutic effects on oxidative stress and C-reactive proteins. The findings showed that HBH dose-dependently inhibited pain, inflammation, and pyrexia, and had significant anti-nociceptive, anti-inflammatory, and antipyretic activities involving opioidergic mechanism. Computational studies also revealed HBH's affinity for the COX-I/II target receptors.
INFLAMMOPHARMACOLOGY
(2023)
Article
Agronomy
Arwa A. Al-Huqail, Adnan A. Bekhit, Hammad Ullah, Muhammad Ayaz, Nada M. Mostafa
Summary: This study identified compounds in marigold flower extract and evaluated their potential as anti-leishmanial and anti-malarial agents. The results showed that marigold flowers are rich in flavonoids and have antibacterial effects against certain diseases.
Article
Chemistry, Multidisciplinary
Qarib Ullah, Zarshad Ali, Umer Rashid, Gowhar Ali, Nisar Ahmad, Rasool Khan, Sami Ullah, Muhammad Ayaz, H. C. Ananda Murthy
Summary: This study evaluated a novel indazolone derivative for its activity against pain, neuropathy, and inflammation. The results showed that the derivative exhibited significant inhibitory effects on nociception and inflammation, suggesting its potential as a therapeutic agent for the treatment of pyrexia, chemotherapy-induced neuropathic pain, and nociceptive inflammatory pain in the future.
Article
Plant Sciences
Mater H. Mahnashi, Muhammad Ayaz, Yahya S. Alqahtani, Bandar A. Alyami, Muhammad Shahid, Omaish Alqahtani, Saeed M. Kabrah, Alam Zeb, Farhat Ullah, Abdul Sadiq
Summary: This study aimed to analyze the phenolic compounds of Sorbaria tomentosa Lindl. Rehder and evaluate its neuroprotective and anxiolytic potentials. The results showed that S. tomentosa contains abundant phenolic compounds with strong antioxidant and acetylcholinesterase inhibitory activities. Moreover, it exhibited improvements in cognition and exploratory behavior, as well as anxiolytic and memory enhancing effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hamze Elsayed Ahmed Mohamed, Ali Talha Khalil, Khaoula Hkiri, Muhammad Ayaz, Assad Usman, Abdul Sadiq, Farhat Ullah, Ishtiaq Hussain, Malik Maaza
Summary: In this study, holmium oxide nanoparticles were synthesized using Hyphaene thebaica extracts as a bioreductant. The nanoparticles exhibited crystalline structure and quasi-spherical morphology with a size range of 6-12 nm. The nanoparticles showed potential antioxidant, anti-angiogenic, and cytotoxic properties, with the ability to inhibit 3T3 cells. The study suggests that biosynthesis using aqueous extracts can be a suitable and eco-friendly method for nanoparticle synthesis.