Editorial Material
Cell Biology
Lea Montegut, Adrien Joseph, Hui Chena, Mahmoud Abdellatif, Christoph Ruckenstuhlg, Isabelle Martins, Frank Madeo, Guido Kroemer
Summary: DBI/ACBP is a conserved paracrine inhibitor that regulates autophagy and lifespan. Its increased levels in humans are associated with biological age and cardiovascular disease risk factors. Studies have shown that neutralizing DBI/ACBP can alleviate cardiac aging. Therefore, it may serve as a potential target for treating age-associated cardiovascular diseases.
Article
Cell Biology
Dawei Liu, Felix Peyre, Yahir Alberto Loissell-Baltazar, Delphine Courilleau, Sandra Lacas-Gervais, Valerie Nicolas, Eric Jacquet, Svetlana Dokudovskaya, Frederic Taran, Jean-Christophe Cintrat, Catherine Brenner
Summary: This study identified six compounds through high-throughput screening that have the potential to prevent cardiac cell death caused by chemotherapy, suggesting their promising role as cardioprotective drugs.
Article
Pharmacology & Pharmacy
Liqiang Sun, Wenlong Zhang
Summary: The study demonstrates that preconditioning MSCs with ghrelin can enhance cardioprotective effects, especially in elderly subjects, following IR injury. Preconditioned MSCs increase autophagy flux by downregulating Beclin-1 and P62 protein overexpression, and increasing LC3-II expression and the LC3-II/LC3-I ratio. Moreover, combining NMN with ghrelin-preconditioned MSCs synergistically enhances protective effects on infarct size and mitochondrial function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Yan Zhao, Jian-Min Ren, Hui-Ru Liu, Ting-Ting Zhou, Xue-Ying Wang, Song Liu, He-Ping Chen
Summary: The study found that DJ-1 can activate adaptive autophagy through the RACK1/AMPK/mTOR pathway, protecting the myocardium against ischemic injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Yian Peng, Liang Wang, Xiaoyu Zhao, Songqing Lai, Xinlan He, Qigui Fan, Huan He, Ming He
Summary: This study found that Pue pretreatment can protect the myocardium against LPS injury by activating the 14-3-3γ/PKCε pathway. Pue pretreatment alleviates LPS-induced injury by increasing cell viability, reducing cell death and oxidative stress, inhibiting inflammatory responses, and maintaining mitochondrial function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Behnaz Mokhtari, Reza Badalzadeh
Summary: The role of autophagy in myocardial ischemia/reperfusion injury is controversial, as it can both promote cell survival and lead to cell death. Understanding the exact role of autophagy in determining the fate of cardiomyocytes is crucial for future cardioprotective strategies.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Pharmacology & Pharmacy
Meng Sun, Rong Wang, Rui Xia, Zhengyuan Xia, Zhilin Wu, Tingting Wang
Summary: Mechanisms contributing to myocardial ischemia-reperfusion (I/R) injury are complex, but Dexmedetomidine (DEX) shows potential in ameliorating this injury in diabetic states. DEX activates the PI3K/Akt and associated GSK-3 beta pathway, alleviates endoplasmic reticulum stress, and inhibits apoptosis. Additionally, DEX up-regulates autophagy, reduces ROS production, and inhibits inflammation via HMGB1 pathways, leading to the protection against diabetic myocardial I/R injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Milton Packer
Summary: SGLT2 inhibitors reduce the risk of serious heart failure events by inducing a state of hypoxia mimicry through increasing hematocrit. This cardioprotective benefit is linked to a shared underlying molecular mechanism triggered by these drugs.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Alessandra Maria Lodrini, Marie-Jose Goumans
Summary: Despite the advancement in interventional coronary reperfusion strategies, mortality from acute myocardial infarction remains high. MI leads to adverse remodelling in the affected myocardium, with cellular phenotypes like senescence, inflammation, and dedifferentiation playing key roles in the pathophysiology of the infarcted heart. Enhancing electric coupling between cardiomyocytes, eliminating senescent cells, and upregulating cellular processes like autophagy could potentially improve cardiac contractility post-MI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Zhen Qiu, Hao Ming, Shaoqing Lei, Bin Zhou, Bo Zhao, Yanli Yu, Rui Xue, Zhongyuan Xia
Summary: The study demonstrated that HDAC3 contributes to diabetic myocardial injury by modulating the Rev-erb alpha/BMAL1 pathway, exacerbating MI/RI. Additionally, HDAC3 and Rev-erb alpha siRNA can alleviate injury by upregulating BMAL1.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Shigang Qiao, Wen-jie Zhao, Huan-qiu Li, Gui-zhen Ao, Jian-zhong An, Chen Wang, Hui-ling Zhang
Summary: This study showed that DIMO exerts cardioprotection against myocardial I/R injury by reducing RIP1K activation and restoring impaired autophagic flux.
Article
Physiology
Dong-Feng Wan, Shan-Shan Pan, Yi-Shan Tong, Yue Huang
Summary: Exercise preconditioning (EP) has been shown to provide cardioprotection through the modulation of LC3 lipidation-associated proteins. The induction phase and protection phase of EP exhibit different alterations in LC3 lipidation-associated proteins, highlighting the importance of autophagy in maintaining cell homeostasis and survival for cardioprotection against exhaustive exercise-induced myocardial injury.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Behnaz Mokhtari, Reza Badalzadeh
Summary: The debate over the protective or deleterious role of autophagy in cardiac I/R injury continues due to its complex signaling. Further research is needed to clarify the dual role of autophagy and develop new therapeutic strategies for improving outcomes. Preclinical studies targeting autophagy flux have shown promise in mitigating myocardial I/R injury.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Oncology
Kenji Miki, Mikako Yagi, Koji Yoshimoto, Dongchon Kang, Takeshi Uchiumi
Summary: Mitochondria-targeted therapy shows promise in treating glioblastoma by utilizing mitochondrial oxidative phosphorylation under glucose-starved condition. Antimicrobial agents can induce cell death via ferroptosis in glioblastoma cells.
Article
Cardiac & Cardiovascular Systems
Yin Cao, Qinglin Li, Yingbo Yang, Zunji Ke, Shengqi Chen, Mingrui Li, Wenjing Fan, Hui Wu, Jinfeng Yuan, Zhengtao Wang, Xiaojun Wu
Summary: The study showed that stem-leaf saponins from Panax notoginseng can prevent myocardial injury induced by sleep deprivation by attenuating excessive autophagy and apoptosis in myocardial cells through activating the PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Tamas G. Gergely, Daniel Kucsera, Viktoria E. Toth, Tamas Kovacs, Nabil Sayour, Zsofia D. Drobni, Mihaly Ruppert, Balazs Petrovich, Bence Agg, Zsofia Onodi, Nora Fekete, Eva Pallinger, Edit Buzas, Laura Yousif, Wouter C. Meijers, Tamas Radovits, Bela Merkely, Peter Ferdinandy, Zoltan V. Varga
Summary: Anti-PD-1 treatment causes cardiac dysfunction in mice by enhancing thymic inflammatory signaling, and inhibition of IL-17A can prevent ICI-induced cardiac dysfunction.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zsofia Onodi, Sheryl Koch, Jack Rubinstein, Peter Ferdinandy, Zoltan V. Varga
Summary: Pharmacological options for cardiovascular diseases have been effective in slowing disease progression, but long-term prognosis remains poor, necessitating new therapeutic strategies. Drug repurposing offers approved and abandoned drugs new indications, including gout-related inflammation drugs like canakinumab, colchicine, and uricosuric drug probenecid. Probenecid has been found to modulate myocardial contractility, vascular tone, and exert anti-inflammatory effects. This review summarizes experimental and clinical data on repurposing probenecid for ischaemic heart disease and subsequent heart failure and suggests its potential for treating cardiovascular diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Daniel Kucsera, Viktoria E. Toth, Nabil V. Sayour, Tamas Kovacs, Tamas G. Gergely, Mihaly Ruppert, Tamas Radovits, Alexandra Fabian, Attila Kovacs, Bela Merkely, Peter Ferdinandy, Zoltan V. Varga
Summary: This study aimed to investigate the hepatic and cardiac effects of an IL-1 beta targeting monoclonal antibody in an aged mouse model of NASH. The results showed that IL-1 beta inhibition improved cardiac diastolic function, but did not ameliorate features of NASH and may promote hepatic oncogenic transformation.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
David Dora, Imre Voros, Zoltan V. Varga, Peter Takacs, Vanda Teglasi, Judit Moldvay, Zoltan Lohinai
Summary: The expression of BRAF RNA in lung adenocarcinoma is increased and associated with tumor necrosis, immune checkpoint biology, and outcomes. Further research on targeting the overexpressed BRAF pathway in lung adenocarcinoma is recommended.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Biology
Eric Schoger, Federico Bleckwedel, Giulia Germena, Cheila Rocha, Petra Tucholla, Izzatullo Sobitov, Wiebke Moebius, Maren Sitte, Christof Lenz, Mostafa Samak, Rabea Hinkel, Zoltan V. Varga, Zoltan Giricz, Gabriela Salinas, Julia C. Gross, Laura C. Zelarayan
Summary: In a study on the hypertrophy of cardiomyocytes, it was found that aberrant Wnt activation leads to a proteostasis signature in extracellular vesicles and transcriptomic profiling, indicating early patho-physiological states. Aberrant Wnt activation has been observed in failing cardiomyocytes. Further analysis shows enrichment of extracellular vesicles related processes in hearts with Wnt activation, and the identification of differentially enriched proteins including proteasome constituents, chaperones, and cardiac proteins. These findings suggest that the secretion of extracellular vesicles with a proteostasis signature plays a role in the early adaptation of cardiomyocytes and may have diagnostic and prognostic implications.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
David a. Karadi, Anna Rita Galambos, Peter P. Lakatos, Joost Apenberg, Sarah K. Abbood, Mihaly Balogh, Kornel Kiraly, Pal Riba, Nariman Essmat, Edina Szucs, Sandor Benyhe, Zoltan V. Varga, Eva Szoko, Tamas Tabi, Mahmoud Al-Khrasani
Summary: The study investigates the antiallodynic effect of telmisartan and losartan, two AT1 blockers, in combination with morphine for neuropathic pain management. The combination therapy shows promising results in improving pain and delaying morphine tolerance development. Further studies are needed to analyze the effect of each component in the combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zsofia Onodi, Petra Lujza Szabo, Daniel Kucsera, Peter Pokreisz, Christopher Dostal, Karlheinz Hilber, Gavin Y. Oudit, Bruno K. Podesser, Peter Ferdinandy, Zoltan V. Varga, Attila Kiss
Summary: Duchenne muscular dystrophy (DMD) is a muscle wasting disease characterized by difficulty moving and premature death, mainly due to heart failure. Inflammation is thought to play a role in the disease progression, but the specific mechanisms are not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nabil V. Sayour, Viktoria E. Toth, Regina N. Nagy, Imre Voros, Tamas G. Gergely, Zsofia Onodi, Noemi Nagy, Csaba Bodor, Barnabas Varadi, Mihaly Ruppert, Tamas Radovits, Federico Bleckwedel, Laura C. Zelarayan, Pal Pacher, Bence Agg, Aniko Gorbe, Peter Ferdinandy, Zoltan V. Varga
Summary: In this study, we investigated the differential expressions of G-protein-coupled receptors (GPCRs) in a rat model of heart failure (HF) using ddPCR and RNAseq methods. We identified Ptgrf as a potential novel drug target in HF, as antagonizing Ptgrf showed promising results in alleviating cardiomyocyte hypertrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Serena Barachini, Sandra Ghelardoni, Zoltan V. Varga, Radwa A. Mehanna, Maria Magdalena Montt-Guevara, Peter Ferdinandy, Rosalinda Madonna
Summary: With the improvement in cancer prognosis, there has been an increase in survival rate among cancer survivors. However, the use of anti-neoplastic drugs has led to an increase in morbidity among these survivors due to cardiovascular complications. These complications include arrhythmias, myocardial ischemia, heart failure, arterial hypertension, thromboembolic events, and accelerated atherosclerosis. The drugs not only target cancer cells but also affect normal cells within the cardiovascular system, leading to toxicity.
VASCULAR PHARMACOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Nabil V. Sayour, Viktoria E. Toth, Regina N. Nagy, Noemi Nagy, Csaba Bodor, Imre Voros, Tamas G. Gergely, Barnabas Varadi, Bence Agg, Mihaly Ruppert, Tamas Radovits, Aniko Gorbe, Peter Ferdinandy, Zoltan V. Varga
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Viktoria E. Toth, Tamas G. Gergely, Aniko Gorbe, Zsofia Onodi, Agota Apati, Przemyslaw Leszek, Tamas Radovits, Bela Merkely, Peter Ferdinandy, Zoltan V. Varga
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Barnabas Varadi, Zsofia Onodi, Tamas Visnovitz, Bernadett Kiss, Szabolcs Hambalko, Anna Koncz, Bence Agg, Viktoria Eva Toth, Regina Norma Nagy, Tamas Gergely, Dorottya Gergely, Andras Makkos, Csilla Pelyhe, Nora Varga, Dora Ree, Agota Apati, Przemyslaw Leszek, Tamas Kovacs, Bandor Nagy, Peter Ferdinandy, Edit Iren Buzas, Aniko Gorbe, Zoltan Giricz, Zoltan V. Varga
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
David A. . Karadi, Zoltan V. Varga
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Regina N. Nagy, Zsofia Gulyas-Onodi, Peter Ferdinandy, Aniko Gorbe, Zoltan V. Varga
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Agnes Paal, Akos Takacs, Zoltan V. Varga, Istvan Petak, Aniko Gorbe, Peter Ferdinandy, David Dora
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.