Journal
LEUKEMIA & LYMPHOMA
Volume 59, Issue 3, Pages 695-701Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2017.1347930
Keywords
Performance status; leukemia; lymphoma; inter-observer agreement; overall survival; cancer
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Funding
- University of Iowa/Mayo Clinic Lymphoma SPORE [CA P50 CA97274]
- Arnold & Kit Palmer Benefactor Award
- Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery
- NATIONAL CANCER INSTITUTE [P50CA097274, P30CA086862] Funding Source: NIH RePORTER
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This study was conducted to determine the incidence of inter-observer variability in Eastern Cooperative Oncology Group (ECOG) performance status (PS) rating between patients with leukemia and lymphoma and their physicians. ECOG PS was assessed at diagnosis by patients and their physicians and stratified by disease subtype, gender, age, disease stage and education. Association between patient- and physician-rated PS and overall survival (OS) was stratified by subtype and prognostic risk score. Overall, 65% of patients and physicians rated PS the same. Age, disease stage and disease subtype were significant predictors of PS disagreement. PS was a significant predictor of OS irrespective of assessment by patients or physicians across all subtypes except those with Hodgkin lymphoma. These findings suggest the need for physicians to better communicate with patients when determining PS, as PS is a strong predictor of survival and is critical in treatment decisions, including determining fitness for cancer treatment.
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