Journal
LEUKEMIA & LYMPHOMA
Volume 58, Issue 10, Pages 2304-2309Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2017.1300889
Keywords
Zolendronic acid; PPARG; CYP2C8; osteonecrosis
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Specific genetic polymorphisms (SNPs) have been correlated with the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in small series. We screened 140 myeloma patients (36 patients with and 104 without BRONJ) for the presence of previously identified SNPs in PPARG and CYP2C8 genes. All the patients received exclusively zolendronic acid (ZA) therapy and were followed prospectively for BRONJ. SNPs in both genes were associated with a higher risk of development of early BRONJ, occurring within less than 2 years of ZA therapy (59% vs. 16%, p=.022 for PPARG and 29% vs. 7%, p=.07 for CYP2C8) and a shorter time to develop BRONJ (59% versus 12%, p=.011 for PPARG and 29% versus 0% at 2 years, p=.037 for CYP2C8), independently of indices of poor oral hygiene. Thus, although preliminary, our data indicate that the presence of SNPs in PPARG and CYP2C8 genes may be associated with increased risk of early BRONJ.
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