Proteomics profiling identifies induction of caveolin-1 in chronic lymphocytic leukemia cells by bone marrow stromal cells

Direct in vivo evidence for increased proliferation of CLL cells in lymph nodes compared to bone marrow and peripheral blood

(2017) T M Herndon et al.   LEUKEMIA

Absence of caveolin-1 leads to delayed development of chronic lymphocytic leukemia in Eμ-TCL1 mouse model

(2016) Ashima Shukla et al.   EXPERIMENTAL HEMATOLOGY

At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells

(2016) Uri Rozovski et al.   JOURNAL OF IMMUNOLOGY

Caveolin-1 is a Modulator of Fibroblast Activation and a Potential Biomarker for Gastric Cancer

(2015) Xiao-Jun Shen et al.   International Journal of Biological Sciences

RPPA-based protein profiling reveals eIF4G overexpression and 4E-BP1 serine 65 phosphorylation as molecular events that correspond with a pro-survival phenotype in chronic lymphocytic leukemia

(2015) Austin Y. Shull et al.   Oncotarget

Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells

(2014) U. Rozovski et al.   BLOOD

ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells

(2014) Christine M Stellrecht et al.   Journal of Hematology & Oncology

Viability and stress protection of chronic lymphoid leukemia cells involves overactivation of mitochondrial phosphoSTAT3Ser727

(2014) C Capron et al.   Cell Death & Disease

Cav-1 deletion impaired hematopoietic stem cell function

(2014) L Bai et al.   Cell Death & Disease

Regulation of Mcl-1 Expression in Context to Bone Marrow Stromal Microenvironment in Chronic Lymphocytic Leukemia

(2014) Kumudha Balakrishnan et al.   NEOPLASIA

Caveolin-1-LRP6 Signaling Module Stimulates Aerobic Glycolysis in Prostate Cancer

(2013) S. A. Tahir et al.   CANCER RESEARCH

Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression

(2013) Gustavo Ayala et al.   JOURNAL OF PATHOLOGY

Impact of bone marrow stromal cells on Bcl-2 family members in chronic lymphocytic leukemia

(2013) Viralkumar Patel et al.   LEUKEMIA & LYMPHOMA

Caveolin-1 Expression Level in Cancer Associated Fibroblasts Predicts Outcome in Gastric Cancer

(2013) Xianda Zhao et al.   PLoS One

Lymph node-induced immune tolerance in chronic lymphocytic leukaemia: a role for caveolin-1

(2012) Christine E. Gilling et al.   BRITISH JOURNAL OF HAEMATOLOGY

Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival

(2012) Karen N. Wu et al.   CELL CYCLE

Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts

(2012) Samantha A Simpkins et al.   JOURNAL OF PATHOLOGY

Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765

(2011) S. E. M. Herman et al.   BLOOD

STAT-3 Activates NF- B in Chronic Lymphocytic Leukemia Cells

(2011) Z. Liu et al.   MOLECULAR CANCER RESEARCH

Hydrogen peroxide inhibits non-small cell lung cancer cell anoikis through the inhibition of caveolin-1 degradation

(2010) Pimuma Rungtabnapa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia

(2010) Y. Herishanu et al.   BLOOD

Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch

(2010) W. Ding et al.   BLOOD

Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Erα36 and the transformation of MCF10ACE

(2010) Shuang Feng et al.   Science China-Life Sciences

An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

(2009) Agnieszka K. Witkiewicz et al.   AMERICAN JOURNAL OF PATHOLOGY

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

(2009) A. V. Kurtova et al.   BLOOD

Tumor Cell-Secreted Caveolin-1 Has Proangiogenic Activities in Prostate Cancer

(2008) S. A. Tahir et al.   CANCER RESEARCH

Bone marrow fibroblasts induce expression of PI3K/NF-κB pathway genes and a pro-angiogenic phenotype in CLL cells

(2008) J. Edelmann et al.   LEUKEMIA RESEARCH

The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways

(2007) D. de Totero et al.   BLOOD