RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC

Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma

(2015) Lu Jiang et al.   NATURE GENETICS

RUNX3 Facilitates Growth of Ewing Sarcoma Cells

(2014) Krista L. Bledsoe et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

(2014) Arianna Sabò et al.   NATURE

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

(2014) Susanne Walz et al.   NATURE

EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity

(2013) J. Yan et al.   BLOOD

Runx3 Inactivation Is a Crucial Early Event in the Development of Lung Adenocarcinoma

(2013) You-Soub Lee et al.   CANCER CELL

Runx3-mediated Transcriptional Program in Cytotoxic Lymphocytes

(2013) Joseph Lotem et al.   PLoS One

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

(2012) Zuqin Nie et al.   CELL

Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

(2012) Ghee Chong Koo et al.   Cancer Discovery

Dysregulated microRNAs affect pathways and targets of biologic relevance in nasal-type natural killer/T-cell lymphoma

(2011) S.-B. Ng et al.   BLOOD

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Expression of RUNX3 in skin cancers

(2011) J. H. Lee et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

RUNX3 functions as an oncogene in ovarian cancer

(2011) Cecilia Wei Lin Lee et al.   GYNECOLOGIC ONCOLOGY

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of RUNX3 in Bone Morphogenetic Protein Signaling in Colorectal Cancer

(2010) C. W. L. Lee et al.   CANCER RESEARCH

The novel RUNX3/p33 isoform is induced upon monocyte-derived dendritic cell maturation and downregulates IL-8 expression

(2010) Amaya Puig-Kröger et al.   IMMUNOBIOLOGY

RUNX3 Modulates DNA Damage-mediated Phosphorylation of Tumor Suppressor p53 at Ser-15 and Acts as a Co-activator for p53

(2010) Chizu Yamada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic role of RUNX3 in head and neck cancer

(2010) Yasusei Kudo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Activated oncogenic pathways and therapeutic targets in extranodal nasal-type NK/T cell lymphoma revealed by gene expression profiling

(2010) Siok-Bian Ng et al.   JOURNAL OF PATHOLOGY

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type

(2009) Y. Huang et al.   BLOOD

Runt-Related Transcription Factor RUNX3 Is a Target of MDM2-Mediated Ubiquitination

(2009) X.-Z. Chi et al.   CANCER RESEARCH

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

(2009) Fernando Cruz-Guilloty et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies

(2009) J Iqbal et al.   LEUKEMIA

STAT3 transcription factor is constitutively activated and is oncogenic in nasal-type NK/T-cell lymphoma

(2009) P Coppo et al.   LEUKEMIA

RUNX3 Has an Oncogenic Role in Head and Neck Cancer

(2009) Takaaki Tsunematsu et al.   PLoS One

Epstein-Barr Virus in Lymphoproliferative Processes

(2008) Siok-Bian Ng et al.   ADVANCES IN ANATOMIC PATHOLOGY

RUNX3 protein is overexpressed in human epithelial ovarian cancer

(2008) Nicole S. Nevadunsky et al.   GYNECOLOGIC ONCOLOGY

Enhancer of Zeste Homologue 2 (EZH2) Down-regulates RUNX3 by Increasing Histone H3 Methylation

(2008) Satoshi Fujii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY