Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets

Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort

(2017) Darius Juskevicius et al.   Journal of Hematology & Oncology

Recurrent somatic mutations affecting B-cell receptor signaling pathway genes in follicular lymphoma

(2016) Kilannin Krysiak et al.   BLOOD

Next-Generation Sequencing in Diffuse Large B-Cell Lymphoma Highlights Molecular Divergence and Therapeutic Opportunities: a LYSA Study

(2016) S. Dubois et al.   CLINICAL CANCER RESEARCH

Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma

(2016) Y Xia et al.   LEUKEMIA

Distinct genetic evolution patterns of relapsing diffuse large B-cell lymphoma revealed by genome-wide copy number aberration and targeted sequencing analysis

(2016) D Juskevicius et al.   LEUKEMIA

The landscape of new drugs in lymphoma

(2016) Anas Younes et al.   Nature Reviews Clinical Oncology

Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma

(2016) Lixin Rui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is histone acetylation the most important physiological function for CBP and p300?

(2016) David C. Bedford et al.   Aging-US

Seek and Destroy: Relating Cancer Drivers to Therapies

(2015) Emmanuel Martinez-Ledesma et al.   CANCER CELL

In Silico Prescription of Anticancer Drugs to Cohorts of 28 Tumor Types Reveals Targeting Opportunities

(2015) Carlota Rubio-Perez et al.   CANCER CELL

Non-coding recurrent mutations in chronic lymphocytic leukaemia

(2015) Xose S. Puente et al.   NATURE

Whole-exome analysis reveals novel somatic genomic alterations associated with outcome in immunochemotherapy-treated diffuse large B-cell lymphoma

(2015) A J Novak et al.   Blood Cancer Journal

Database of Genomic Biomarkers for Cancer Drugs and Clinical Targetability in Solid Tumors

(2015) Rodrigo Dienstmann et al.   Cancer Discovery

SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients

(2015) Birgit Schif et al.   Oncotarget

Recurrent targets of aberrant somatic hypermutation in lymphoma

(2015) Alireza Hadj Khodabakhshi et al.   Oncotarget

An RCOR1 loss-associated gene expression signature identifies a prognostically significant DLBCL subgroup

(2014) F. C. Chan et al.   BLOOD

Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue

(2014) D. W. Scott et al.   BLOOD

Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification

(2014) Bruce D. Cheson et al.   JOURNAL OF CLINICAL ONCOLOGY

Recurrent mutations ofNOTCHgenes in follicular lymphoma identify a distinctive subset of tumours

(2014) Kennosuke Karube et al.   JOURNAL OF PATHOLOGY

Precision therapy for lymphoma—current state and future directions

(2014) Andrew M. Intlekofer et al.   Nature Reviews Clinical Oncology

Analysis of FOXO1 mutations in diffuse large B-cell lymphoma

(2013) D. L. Trinh et al.   BLOOD

Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing

(2013) R. D. Morin et al.   BLOOD

Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma

(2013) Jessica Okosun et al.   NATURE GENETICS

Genetic heterogeneity of diffuse large B-cell lymphoma

(2013) Jenny Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma

(2013) M. Pfeifer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma

(2013) S. Bea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study

(2012) Z. Y. Xu-Monette et al.   BLOOD

Integrative Analysis Reveals an Outcome-Associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B Cell Lymphoma

(2012) Stefano Monti et al.   CANCER CELL

The coding genome of splenic marginal zone lymphoma: activation ofNOTCH2and other pathways regulating marginal zone development

(2012) Davide Rossi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole-genome sequencing identifies recurrent somaticNOTCH2mutations in splenic marginal zone lymphoma

(2012) Mark J. Kiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphorylation of Nicastrin by SGK1 Leads to Its Degradation through Lysosomal and Proteasomal Pathways

(2012) Jung-Soon Mo et al.   PLoS One

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

(2012) J. G. Lohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma

(2011) R. Kridel et al.   BLOOD

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Analysis of the coding genome of diffuse large B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE GENETICS

ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes

(2011) Mehmet Yabas et al.   NATURE IMMUNOLOGY

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow

(2011) Owen M Siggs et al.   NATURE IMMUNOLOGY

Predicting the functional impact of protein mutations: application to cancer genomics

(2011) Boris Reva et al.   NUCLEIC ACIDS RESEARCH

Diffuse large B-cell lymphomas with CDKN2A deletion have a distinct gene expression signature and a poor prognosis under R-CHOP treatment: a GELA study

(2010) F. Jardin et al.   BLOOD

Genomic lesions associated with a different clinical outcome in diffuse large B-Cell lymphoma treated with R-CHOP-21

(2010) Marta Scandurra et al.   BRITISH JOURNAL OF HAEMATOLOGY

Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase

(2010) J.-S. Mo et al.   JOURNAL OF CELL SCIENCE

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities

(2009) A. Mottok et al.   BLOOD

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

(2008) G. Lenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor- B pathways in subtypes of diffuse large B-cell lymphoma

(2007) L. T. Lam et al.   BLOOD