ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition

Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation

(2016) Amin Huang et al.   CANCER LETTERS

Secondary mutations as mediators of resistance to targeted therapy in leukemia

(2015) N. Daver et al.   BLOOD

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

(2015) Rupert Courtnay et al.   MOLECULAR BIOLOGY REPORTS

Targeting FLT3 to treat leukemia

(2014) Heiko Konig et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway

(2013) P-P Liu et al.   CELL DEATH AND DIFFERENTIATION

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

(2012) Luis E. Raez et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

New agents for acute myeloid leukemia: is it time for targeted therapies?

(2012) Felicetto Ferrara   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside

(2012) Y. H. Ko et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

(2012) Catherine C. Smith et al.   NATURE

K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

(2011) Yumin Hu et al.   CELL RESEARCH

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

(2011) D. Gaglio et al.   Molecular Systems Biology

FLT3 as a therapeutic target in AML: still challenging after all these years

(2010) T. Kindler et al.   BLOOD

A Multicenter Phase II Study of Erlotinib and Sorafenib in Chemotherapy-Naive Patients with Advanced Non-Small Cell Lung Cancer

(2010) J. S. W. Lind et al.   CLINICAL CANCER RESEARCH

Signal transduction to the permeability transition pore

(2010) Andrea Rasola et al.   FEBS LETTERS

Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies

(2010) Mark Stein et al.   PROSTATE

Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate

(2009) Zhao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanisms of resistance to FLT3 inhibitors

(2009) S. Haihua Chu et al.   DRUG RESISTANCE UPDATES

FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML

(2009) Ellen Weisberg et al.   DRUG RESISTANCE UPDATES

Mutant FLT3: A Direct Target of Sorafenib in Acute Myelogenous Leukemia

(2008) Weiguo Zhang et al.   JNCI-Journal of the National Cancer Institute