Journal
LETTERS IN DRUG DESIGN & DISCOVERY
Volume 15, Issue 1, Pages 46-64Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570180814666170823163540
Keywords
Fluoroquinolone; 1,2,4-triazole; 1,3,4-oxadiazole; piperazine; antibacterial activity; antioxidant activity; microwave
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Funding
- Scientific and Technological Research Council of Turkey (TUBITAK) [113Z181]
- Karadeniz Technical University, BAP, Turkey [8623]
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Background: The synthesis of new hybrid molecules consisting of several heterocyclic pharmacophores namely fluoroquinolone, 1,2,4-triazole, 1,3,4-oxadiazole and piperazine was carried out by conventional and successfully optimized microwave mediated techniques. Methods: The structures of new compounds were confirmed using spectroscopic techniques. These compounds were screened for their antibacterial activity against E. coli, P. aeruginosa, Y. pseudotuberculosis, S. aureus, E. faecalis, B. cereus and M. smegmatis. Results and Conclusion: Fourteen of these hybrids exhibited excellent antibacterial activities on the test microorganisms when compared with ampicillin with the mic values varying between 0.03-0.25 mu g/mL.
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