Article
Biology
Qifang Niu, Yang Yang, Delong Li, Wenwen Guo, Chong Wang, Haoyue Xu, Zhien Feng, Zhengxue Han
Summary: This study found that exosomes derived from bone marrow mesenchymal stem cells (BMSCs-exosomes) can effectively reduce necrotic lesions, alleviate oxidative stress and inflammation, and promote new blood vessel formation in a rat model of free abdomen flap transplantation, thus reducing ischemia-reperfusion injury and improving the survival of skin flaps.
Article
Biochemistry & Molecular Biology
Hui Hu, Xiaowei Hu, Lin Li, Yan Fang, Yan Yang, Jingjing Gu, Jiadong Xu, Lisheng Chu
Summary: Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) can promote angiogenesis and improve neurological functions in ischemic stroke mice via upregulation of miR-21-5p. In vitro experiments show that BMSC-Exos also enhance the functions of human umbilical vein endothelial cells (HUVECs).
Review
Medicine, General & Internal
Yuko Ishida, Mizuho Nosaka, Toshikazu Kondo
Summary: Appropriate technology and target cells and molecules are crucial factors for determining wound vitality or wound age in forensic practice. In this study, bone marrow-derived cells were investigated as promising markers and their potential usefulness in estimating wound age was examined. The evaluation of the appearance combination of these cells and other markers may provide a more objective and accurate estimation of wound age.
FRONTIERS IN MEDICINE
(2022)
Article
Cell & Tissue Engineering
Reshef Tal, Jacqueline Kisa, Nafeesa Abuwala, Harvey J. Kliman, Shafiq Shaikh, Alice Y. Chen, Fang Lyu, Hugh S. Taylor
Summary: The study reveals that bone marrow-derived cells contribute to postpartum uterine tissue regeneration, mainly as leukocytes and nonhematopoietic cells, aiding in rapid turnover of uterine tissue and playing a significant role in postpartum uterus remodeling.
Article
Cell Biology
Molly Enrick, Anurag Jamaiyar, Vahagn Ohanyan, Cody Juguilon, Christopher Kolz, Xin Shi, Danielle Janota, Weiguo Wan, Devan Richardson, Kelly Stevanov, Tatevik Hakobyan, Lindsay Shockling, Arianna Diaz, Sharon Usip, Feng Dong, Ping Zhang, William M. Chilian, Liya Yin
Summary: Using a bone marrow transplantation scheme, this study found that bone marrow stem cells (BMSCs) play an important role in coronary collateral growth (CCG) and suggested that regulating the function of BMSCs to promote CCG might be a potential therapeutic approach for ischemic heart diseases (IHD).
Article
Biochemistry & Molecular Biology
Raluca Tutuianu, Ana-Maria Rosca, Daniela Madalina Iacomi, Maya Simionescu, Irina Titorencu
Summary: This study found that MSC-derived exosomes enhance the biological properties of key cell types involved in wound healing, including macrophages, endothelial cells, keratinocytes, and dermal fibroblasts, thus accelerating the process of wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Ziyi Li, Yafei Wang, Shilun Li, Yukun Li
Summary: Bone regeneration is a complex process involving the coordination of osteogenesis and osteoclastogenesis, with the balance between osteogenesis and adipogenesis of BMSCs playing a critical role. Recent studies have shown that exosomes from M2 macrophages facilitate osteogenesis and reduce adipogenesis through the miR-690/IRS-1/TAZ axis, potentially serving as a therapeutic tool for bone loss diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Surgery
Xin Huang, Daiming Liu, Shuchen Gu, Lee L. Q. Pu, Xiangwen Xu, Yimin Khoong, Zi Wang, Yixuan Zhao, Yashan Gao, Tao Zan
Summary: The study found that both vascular supercharge and flap prefabrication significantly increased flap survival areas, but had different effects on vasculature and hemodynamics. While flap prefabrication could greatly increase arterial infusion, it was more susceptible to venous effusion issues. Active neovascularization was confirmed by an increased number of microvessels in the choke zone of the prefabricated flap.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Biotechnology & Applied Microbiology
Chao Deng, Kangkang Dong, Yongjun Liu, Ken Chen, Chuwei Min, Zheming Cao, Panfeng Wu, Gaojie Luo, Gechang Cheng, Liming Qing, Juyu Tang
Summary: Flap necrosis, a common complication of reconstructive surgery, is associated with ischaemia-reperfusion injury. Exosomes derived from hypoxia-preconditioned bone marrow mesenchymal stem cells (BMSCs) were found to promote flap survival, decrease inflammatory cytokines levels, reduce oxidative stress injury and apoptosis in ischaemia-reperfusion injured flap, and protect vascular endothelial cells from ischaemia-reperfusion injury. Furthermore, high-throughput sequencing and bioinformatics analysis revealed that hypoxia-preconditioned exosomes carried abundant miR-421-3p, which targeted and regulated mTOR, promoting autophagy and enhancing the survival of ischaemia-reperfusion injured flaps. Overall, hypoxic preconditioning of BMSC-derived exosomes shows promise in optimizing the therapeutic effects in flap ischaemia-reperfusion injury.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Sher Bahadur Poudel, Han-Sol So, Hyun-Jaung Sim, Joon-Seok Cho, Eui-Sic Cho, Young-Mi Jeon, Sung-Ho Kook, Jeong-Chae Lee
Summary: Deletion of osteoblastic Wls affects hematopoiesis, BM microenvironment, and BMSCs and HSCs maintenance, with age-dependent impacts. The deterioration in BM microenvironment contributes to age-related HSC senescence and impaired hematopoiesis, indicating potential roles of osteoblastic Wls in maintaining BM HSCs.
Article
Cell & Tissue Engineering
Jiahui Jin, Qingjian Ou, Zhe Wang, Haibin Tian, Jing-Ying Xu, Furong Gao, Shuqin Hu, Jie Chen, Juan Wang, Jieping Zhang, Lixia Lu, Caixia Jin, Guo-Tong Xu, Jingjun Zhao
Summary: BMSC-derived EVs, carrying miRNAs, have shown similar efficacy to BMSCs in treating skin dysfunction in SSc, by regulating the WNT and TGF beta signaling pathways.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Chemistry, Medicinal
Duaa Abuarqoub, Sofia Adwan, Rand Zaza, Suha Wehaibi, Nazneen Aslam, Hanan Jafar, Nidal Qinnah, Abdalla Awidi
Summary: Diabetes Mellitus Type 1 is an autoimmune disease that destroys insulin-producing cells, leading to hyperglycemia. This study examined the differentiation potential of dental stem cells (SCAP) and bone-marrow-derived stem cells (BM-MSCs) into functional islet cell aggregates (ICAs). The results showed that both types of stem cells successfully differentiated into beta-cell-like cells.
Article
Medicine, General & Internal
Tao Yang, Wei Li, Anquan Peng, Jia Liu, Qin Wang
Summary: In this study, it was found that hypoxic BMSCs-derived exosomes (hypBMSC-Exo) could alleviate cisplatin-induced ototoxicity and had better therapeutic effects compared to BMSC-Exo. This may be achieved by up-regulating the expression of SOD1 and SOD2 to protect auditory function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hyun-Ji Park, Jessica R. Hoffman, Milton E. Brown, Sruti Bheri, Olga Brazhkina, Young Hoon Son, Michael E. Davis
Summary: Small extracellular vesicles (sEVs) play a critical role in cardiac cell therapy by delivering molecular cargo and mediating cellular signaling. Knocking down miR-192-5p and miR-432-5p in cardiac c-kit+ cell-derived sEVs enhances their therapeutic capabilities and improves cardiac function, reducing fibrosis and necrotic inflammatory responses. This study suggests that targeting deleterious miRNAs in sEVs could be a promising therapeutic strategy for chronic myocardial infarction.
Article
Biochemistry & Molecular Biology
Maria Yoshida, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Keisuke Morimoto, Yoshiki Tanaka, Kensuke Sasaki, Satoshi Maeda, Takao Masaki
Summary: Both adipose-derived and bone marrow-derived mesenchymal stem cells (ADSCs and BMSCs) can suppress renal fibrosis, with ADSCs showing a stronger effect under serum-containing culture conditions. However, ADSC infusion in mice may lead to a higher death rate from pulmonary embolism. Therefore, the selection of ADSCs or BMSCs for clinical applications should consider the target disease and culture method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
Jeong Hwan Moon, Min Young Lee, Young-Jun Chung, Chung-Ku Rhee, Sang Joon Lee
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2018)
Article
Oncology
Phil-Sang Chung, Peijie He, Jang-In Shin, Hee-Jun Hwang, Sang Joon Lee, Jin-Chul Ahn
CANCER BIOLOGY & THERAPY
(2009)
Article
Chemistry, Multidisciplinary
Jang-In Shin, Jin-Chul Ahn, Sang-Joon Lee, Ock Jin Park, Phil-Sang Chung
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2009)
Article
Oncology
Sun Gon Kim, Ji Won Hong, Sung Hyun Boo, Myung Gu Kim, Kang Dae Lee, Jin Chul Ahn, Hee Jun Hwang, Jang-In Shin, Sang Joon Lee, Jang Keun Oh, Phil Sang Chung
Article
Otorhinolaryngology
Min H. Yoo, Yun-Hee Rhee, JaeYun Jung, Sang-Joon Lee, Jung-Hwan Moon, Ji-Hun Mo, Phil-Sang Chung
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Article
Oncology
Ho-Ryun Won, Geon Ho Lee, Jin Hwan Kim, Sang Hyuk Lee, Soon Young Kwon, Seung-Kuk Baek, Chang Hwan Ryu, Sang Joon Lee, Il-Seok Park, Sung-Chan Shin, Dong Wook Lee, Phil-Sang Chung, Bon Seok Koo
Summary: The study found that N-acetylcysteine inhalation therapy can improve the quality of life of head and neck cancer patients receiving radiation therapy, with reductions in pain and improvements in dry mouth symptoms observed in the experimental group.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Jin-Kyoung Oh, Hwa Young Choi, Minji Han, Yuh-Seog Jung, Sang Joon Lee, Moran Ki
Summary: This study estimated the incidence of juvenile-onset recurrent respiratory papillomatosis (RRP) in Korea before the implementation of the national HPV vaccination program. The incidence was estimated at 0.30/100,000 person-years, with the median age at diagnosis being 4.0 years. A younger age at diagnosis was associated with more severe disease, as indicated by more frequent surgical procedures and shorter time intervals between operations. Monitoring of the RRP burden should continue using National Health Insurance Service claims data.
EPIDEMIOLOGY AND HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Sang Joon Lee, Hee-Jun Hwang, Jang-In Shin, Jin-Chul Ahn, Phil-Sang Chung
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2015)
Article
Oncology
Peijie He, Jin-Chul Ahn, Jang-In Shin, Hee-Jun Hwang, Jung-Wook Kang, Sang-Joon Lee, Phil-Sang Chung
