Article
Pharmacology & Pharmacy
Si Gou, Sergio del Rio-Sancho, Hans-Joachim Laubach, Yogeshvar N. Kalia
Summary: This study investigated the use of Erbium:YAG fractional laser ablation and different topical dosage forms to improve the delivery of PTX for skin fibrosis treatment. The results showed that fractional laser ablation significantly increased PTX delivery, with the hydrogel formulation being the optimal choice. By reducing the amount of hydrogel applied, PTX delivery efficiency was further improved.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chris J. Smith, Eric K. Parkinson, Jingjuin Yang, Jonathan Pratten, Edel A. O'Toole, Matthew P. Caley, Kristin M. Braun
Summary: This study explores the differential healing efficiencies and gene expression patterns of gingival and skin keratinocytes. Gingival keratinocytes demonstrated superior wound healing capabilities compared to skin, likely due to distinct migration patterns and gene expression differences. The development of organotypic models will further contribute to the analysis of oral wound response and potential therapeutic interventions in vitro.
JOURNAL OF DENTISTRY
(2022)
Review
Biochemistry & Molecular Biology
Anna-Lisa Pignet, Marlies Schellnegger, Andrzej Hecker, Michael Kohlhauser, Petra Kotzbeck, Lars-Peter Kamolz
Summary: Resveratrol, a well-known polyphenol, has potential benefits in various medical conditions like cancer and neurodegenerative diseases. It is also seen as a promising treatment option for accelerating wound healing. However, the molecular mechanisms of resveratrol action are still not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Samuel Knoedler, Sonja Broichhausen, Ruiji Guo, Ruoxuan Dai, Leonard Knoedler, Martin Kauke-Navarro, Fortunay Diatta, Bohdan Pomahac, Hans-Guenther Machens, Dongsheng Jiang, Yuval Rinkevich
Summary: Injuries to the skin initiate a series of synchronized healing processes. Fibroblasts play various roles in endogenous wound repair, including activating innate immune cells, depositing scar tissue, and transporting fascial connective tissue to the wounds. Understanding the diversity and versatility of fibroblasts is crucial for deciphering wound pathologies and developing new treatment approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Sebastian Huth, Laura Huth, Yvonne Marquardt, Maria Cheremkhina, Ruth Heise, Jens Malte Baron
Summary: The study investigated the role of MMP-3 and its regulation by calcium pantothenate in wound healing after ablative fractional laser treatment. Results showed that aftercare treatment with calcium pantothenate accelerated wound closure in MMP-3 expressing models faster than in MMP-3 knockdown models. This study provides evidence for the first time that calcium pantothenate promotes wound healing at least partly via MMP-3.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Engineering, Biomedical
Aysenur Botsali, Burcu Beksac, Irfan Gahramanov, Ercan Caliskan
Summary: Cryotherapy is commonly used in dermatology practice, and this study tested the hypothesis that ablative laser application before cryotherapy can increase the depth of freezing, leading to improved treatment outcomes. The experimental results showed that erbium:YAG laser before cryotherapy can augment the penetration of cryotherapy, potentially enhancing treatment efficacy.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Andres Montero, Cristina Quilez, Leticia Valencia, Paula Giron, Jose Luis Jorcano, Diego Velasco
Summary: This study demonstrates that increasing fibrin concentration can significantly improve mechanical properties and matrix stability, thereby promoting the development of in vitro skin cultures. These new systems will provide better in vitro skin models for testing drugs, cosmetics, and chemicals, and can even be used for personalized skin diagnosis and determining the most effective treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Camille Togo, Ana Paula Zidorio, Vivian Goncalves, Patricia Botelho, Kenia de Carvalho, Eliane Dutra
Summary: This systematic review summarizes the current evidence on the effect of oral or enteral probiotic therapy on wound healing in humans. The results indicate that probiotic therapy may have a positive impact on wound improvement, but strong evidence is still lacking. Further controlled clinical research is needed to explore the effects of specific probiotic strains, wound types, and target populations.
Review
Immunology
Arnolda Jakovija, Tatyana Chtanova
Summary: The skin, as the body's largest organ, serves as a barrier to pathogens and the first line of immune defense. In the event of skin injury, a series of events contribute to wound repair, including inflammation, tissue formation, and tissue remodeling. Immune cells in the skin work alongside non-immune cells to clear pathogens, debris, and guide tissue regeneration. Disruption to the wound repair process can lead to chronic inflammation and non-healing wounds, which can promote skin cancer development by hijacking the wound healing response.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Materials Science, Multidisciplinary
Joseph D. Tanfani, Jasmin D. Monpara, Sriramakamal Jonnalagadda
Summary: 3D printing is widely used by independent researchers in various fields, with 3D bioprinting being a specific form that utilizes bioinks to create complex, bioactive structures such as artificial skin for wound regeneration. Despite the wide range of available materials and cell types, an ideal bioink for printing artificial skin has yet to be found. This review will discuss the different types of 3D printing, commonly used bioinks, challenges in 3D bioprinting of skin, and future directions for the field.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Pharmacology & Pharmacy
Fabiola V. Borbolla-Jimenez, Sheila I. Pena-Corona, Sonia J. Farah, Maria Teresa Jimenez-Valdes, Emiliano Pineda-Perez, Alejandra Romero-Montero, Maria Luisa Del Prado-Audelo, Sergio Alberto Bernal-Chavez, Jonathan J. Magana, Gerardo Leyva-Gomez
Summary: Wound healing is a complex process involving four phases: hemostasis, inflammation, proliferation, and remodeling. Polymeric films have been widely used as wound dressings due to their biocompatibility, low immunogenicity, ease of application, and gas exchange capabilities. Among various methods for designing polymeric films, solvent casting is a reliable and cost-effective technique. This review focuses on polymeric dressings obtained using solvent casting, discussing the manufacturing factors necessary for effective wound dressing performance.
Review
Biochemistry & Molecular Biology
Thayaalini Subramaniam, Mh Busra Fauzi, Yogeswaran Lokanathan, Jia Xian Law
Summary: Skin injury healing involves complex processes with various cells, extracellular matrix, and mediators. Cell differentiation, migration, and proliferation are crucial for tissue integrity restoration. Although calcium shows promise in wound healing, challenges need to be addressed before clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Polymer Science
N. Disha Moholkar, S. Priyadarshani Sadalage, Diana Peixoto, Ana Claudia Paiva-Santos, D. Kiran Pawar
Summary: Researchers worldwide have shown immense interest in the field of wound healing for decades, aiming to develop effective techniques to accelerate healing process and prevent scar formation. Biopolymeric nanosystems have emerged as alternatives for conventional wound dressings, potentially providing an improved wound healing environment.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Fengze Miao, Ying Li, Zongguang Tai, Yong Zhang, Yue Gao, Menghong Hu, Quangang Zhu
Summary: Chronic wound infections have become a significant issue, and the development of functional wound dressings has made progress. Antimicrobial peptides are attracting attention as an emerging therapeutic option for wound healing.
MACROMOLECULAR BIOSCIENCE
(2021)
Review
Biotechnology & Applied Microbiology
Jinli Zhang, Changling Liu, Xiaojian Li, Zhihe Liu, Zhi Zhang
Summary: Hydrogels play a significant role in wound nursing by promoting wound healing and tissue remodeling through reducing inflammation, facilitating vascularization, and supporting cell growth.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Laura Huth, Sebastian Huth, Yvonne Marquardt, Philipp Winterhalder, Timm Steiner, Frank Hoelzle, Reinhard Gansel, Jens Malte Baron, Laurenz Schmitt
LASERS IN MEDICAL SCIENCE
(2021)
Article
Dermatology
Sebastian Huth, Yvonne Marquardt, Laura Huth, Laurenz Schmitt, Kirsten Prescher, Philipp Winterhalder, Timm Steiner, Frank Hoelzle, Michael Eble, Jens Malte Baron
Summary: The study found that aftercare treatment with dexpanthenol-containing ointment or liquid can completely restore the epidermal part of skin models after radiation, exhibiting anti-oxidative and anti-inflammatory effects, and positively influencing epidermal differentiation and structures.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Engineering, Biomedical
Sebastian Huth, Laura Huth, Yvonne Marquardt, Maria Cheremkhina, Ruth Heise, Jens Malte Baron
Summary: The study investigated the role of MMP-3 and its regulation by calcium pantothenate in wound healing after ablative fractional laser treatment. Results showed that aftercare treatment with calcium pantothenate accelerated wound closure in MMP-3 expressing models faster than in MMP-3 knockdown models. This study provides evidence for the first time that calcium pantothenate promotes wound healing at least partly via MMP-3.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Allergy
Conny Hoeflich, Galina Balakirski, Zuzanna Hajdu, Jens Malte Baron, Katharina Fietkau, Hans F. Merk, Ulrich Strassen, Henning Bier, Wolfgang Dott, Hans-Guido Muecke, Wolfgang Straff, Gerda Wurpts, Amir S. Yazdi, Adam Chaker, Stefani T. M. Roeseler
Summary: The study showed varying sensitization rates to both common and non-frequent pollen allergens in adult patients from two German federal states. Sensitization to non-frequent pollen allergens needs to be considered for patients with seasonal symptoms, and availability of test allergens for these less common allergies is important for patient management. Data on sensitization correlated partly with each other and with symptom periods, showing a seasonal pattern similar to pollen data.
CLINICAL AND TRANSLATIONAL ALLERGY
(2021)
Article
Materials Science, Multidisciplinary
Rahul Rimal, Yvonne Marquardt, Thomas Nevolianis, Suzana Djeljadini, Andrea Bonnin Marquez, Sebastian Huth, Dmitry N. Chigrin, Matthias Wessling, Jens M. Baron, Martin Moeller, Smriti Singh
Summary: Utilizing a dynamic flow culture system improved the stability of scaffold-free vHSEs, enhancing skin barrier properties and promoting thicker tissue fabrication and wound closure. Balancing the expression of MMPs and their inhibitors in dynamic flow culture restored tissue homeostasis by modulating angiogenesis.
APPLIED MATERIALS TODAY
(2021)
Article
Immunology
Ramona A. A. Eichkorn, Morna F. F. Schmidt, Elias Walter, Michael Hertl, Jens Malte Baron, Jens Waschke, Amir S. S. Yazdi
Summary: This study reveals the molecular mechanisms underlying auto-antibody-induced acantholysis in pemphigus vulgaris and identifies UVA as a cofactor for acantholysis. It demonstrates that UVA induces IL-1 secretion in keratinocytes and enhances the loss of epidermal adhesion mediated by anti-Dsg3 antibodies. These findings suggest that UVA plays a caspase-dependent exogenous role in blister formation in pemphigus vulgaris.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Uwe Paasch, Miriam Zidane, Jens Malte Baron, Thorsten Bund, Hans-Joachim Cappius, Michael Drosner, Konstantin Feise, Tanja Fischer, Gerd Gauglitz, Peter Arne Gerber, Sonja Grunewald, Katharina Herberger, Anja Jung, Syrus Karsai, Gerd Kautz, Carsten Philipp, Daniela Schaedel, Anna-Theresa Seitz, Alexander Nast
Summary: This guideline aims to provide specific treatment recommendations for various skin lesions, ensuring safe and effective laser therapy. It emphasizes the importance of understanding the differences in treatment methods for different types of skin conditions to avoid unnecessary risks.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Article
Dermatology
Helena Isabell Riedemann, Morna F. Schmidt, Jens Malte Baron
Summary: A scar is the result of a deep tissue defect during the wound healing process. Disorders can occur at all stages, leading to impaired wound healing or the formation of atrophic and hypertrophic scars or keloids. This article focuses on treating pathologic scars, which may cause functional limitations, complaints, and stigmatization. Medical, physical, surgical, and laser therapeutic approaches are pursued, based on an understanding of pathophysiological mechanisms and a comprehensive therapeutic approach.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Dermatology
Katharina Webollek, Yvonne Marquardt, Sylvia Wagner-Schiffler, Jens Malte Baron, Sebastian Huth
Summary: The purpose of this in vitro study was to investigate the molecular effects of dexpanthenol-containing ointment (DCO) after micro-needling. The results showed that DCO accelerated wound healing and did not impair the immunostimulatory properties of micro-needling. These findings can optimize the aftercare routine and reduce downtime for patients after microneedling procedures.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Allergy
Karsten Weller, Ana Maria Gimenez-Arnau, Jens Baron, Randolf Brehler, Marta Ferrer, Adriane Groffik, Sonja Grundmann, Thilo Jakob, Moises Labrador-Horrillo, Sabine Mueller, Petra Staubach, Gerda Wurpts, Martin Metz, Marcus Maurer
Summary: This study compared on-demand (OD) treatment versus daily maintenance treatment with non-sedating H1-antihistamines for chronic spontaneous urticaria. It also assessed the efficacy of rupatadine updosing and investigated potential long-term disease-modifying effects. The results showed that daily rupatadine treatment significantly improved disease activity and quality of life during treatment, but there was no significant difference after discontinuation of rupatadine.
Article
Dermatology
Helena Isabell Riedemann, Morna F. Schmidt, Jens Malte Baron
Summary: A scar is formed as part of the wound healing process, involving inflammation and the proliferation of connective tissue cells. Pathological scars can result in impaired wound healing or the formation of atrophic and hypertrophic scars or keloids. This article focuses on the treatment of pathological scars using medical, physical, surgical, and laser therapeutic approaches, based on an understanding of the underlying mechanisms and interdisciplinary therapeutic approach.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Multidisciplinary Sciences
Sebastian Huth, Laura Huth, Ruth Heise, Yvonne Marquardt, Linda Lopopolo, Marta Piecychna, Peter Boor, Guenter Fingerle-Rowson, Aphrodite Kapurniotu, Amir S. Yazdi, Richard Bucala, Juergen Bernhagen, Jens Malte Baron
Summary: The study found that MIF and D-DT play important roles in the development and progression of UVB-induced non-melanoma skin cancer (NMSC), but have no major effects on chemically-induced skin tumors. These findings suggest that MIF and D-DT are potential therapeutic targets for the prevention of photocarcinogenesis but not chemical carcinogenesis.
SCIENTIFIC REPORTS
(2023)
Article
Allergy
Conny Hoeflich, Galina Balakirski, Zuzanna Hajdu, Jens Malte Baron, Katharina Fietkau, Hans F. Merk, Ulrich Strassen, Henning Bier, Wolfgang Dott, Hans-Guido Muecke, Wolfgang Straff, Gerda Wurpts, Amir S. Yazdi, Adam Chaker, Stefani T. M. Roeseler
Meeting Abstract
Dermatology
Helena Isabell Riedemann, Yvonne Marquardt, Manuela Jansen, Jens Malte Baron, Sebastian Huth
LASERS IN SURGERY AND MEDICINE
(2023)
Meeting Abstract
Cell & Tissue Engineering
Rahul Rimal, Yvonne Marquardt, Suzana Djeljaidni, Thomas Neovalis, Dmitry Chigrin, Matthias Wessling, Jens Malte Baron, Martin Moeller, Smriti Singh
TISSUE ENGINEERING PART A
(2022)