Review
Cell Biology
Kai-Wen Zhang, Yuan Jia, Yue-Yue Li, Dan-Yang Guo, Xiao-Xiao Li, Kai Hu, Xiao-Xi Qian, Zhong-Hua Chen, Jun-Jie Wu, Zheng-Dong Yuan, Feng-Lai Yuan
Summary: Wound healing is a complex process that can lead to the formation of scars in adults. Leptin and leptin receptors have been found to affect multiple stages of wound healing, but their role in scarless wound healing is paradoxical.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biophysics
Biswajoy Ghosh, Mousumi Mandal, Pabitra Mitra, Jyotirmoy Chatterjee
Summary: Scars are a predominant outcome of adult mammalian wound healing and may lead to partial loss of function, but studies have found that scars have stress-adaptive features that can cushion underlying tissues from external mechanical impacts.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Dermatology
Nagwa Ali Fahmy Diab, Al-shimaa M. Ibrahim, Aya Mohamed Abdallah
Summary: This study evaluated the efficacy of fluid platelet-rich fibrin (PRF) compared to platelet-rich plasma (PRP) in the treatment of atrophic acne scars. The results showed that fluid PRF had a higher therapeutic response than PRP, and the combination with needling further enhanced the effectiveness of both PRF and PRP. Fluid PRF is a highly effective, safe, and simple alternative to PRP for treating acne scars.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Cell Biology
Bibhas Roy, Tina Pekec, Luezhen Yuan, G. V. Shivashankar
Summary: Cell-based therapies are crucial for tissue regeneration and wound healing during aging process. This study demonstrates the potential of implanting partially reprogrammed aged human dermal fibroblasts into in vitro aged skin models for tissue regeneration and wound healing. The implanted cells showed enhanced expression of extracellular matrix proteins and upregulated tissue regeneration and wound healing pathways.
Review
Biotechnology & Applied Microbiology
Xiao Luo, Shu Zhu, Jia Li, Ning Zeng, Haiping Wang, Yiping Wu, Le Wang, Zeming Liu
Summary: Skin wound healing is a complex process, and abnormalities can lead to scar formation. Epigenetic modifications, particularly RNA methylation, play a crucial role in regulating gene expression and cell fate determination. This review aims to discuss the current understanding of the regulatory pathways of RNA methylation in skin wound healing and their therapeutic implications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Zhonglan Pan, Yanqiu Tang, Hui Hua, Zuoqiong Hou, Bingrong Zhou
Summary: This study evaluated the efficacy and safety of a new modality combining ultra-pulse CO2 laser and fractional CO2 laser (MMP) in the treatment of acne atrophic scars. The results showed that MMP can effectively reduce the severity of atrophic scars with limited adverse reactions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Chris J. Smith, Eric K. Parkinson, Jingjuin Yang, Jonathan Pratten, Edel A. O'Toole, Matthew P. Caley, Kristin M. Braun
Summary: This study explores the differential healing efficiencies and gene expression patterns of gingival and skin keratinocytes. Gingival keratinocytes demonstrated superior wound healing capabilities compared to skin, likely due to distinct migration patterns and gene expression differences. The development of organotypic models will further contribute to the analysis of oral wound response and potential therapeutic interventions in vitro.
JOURNAL OF DENTISTRY
(2022)
Review
Critical Care Medicine
Annika S. Walter, Elias Volkmer, Gerd Gauglitz, Wolfgang Boecker, Maximilian M. Saller
Summary: This systematic review summarizes the current knowledge on molecular pathways activated during burn wound healing and identifies key molecules and new research targets.
Review
Cell & Tissue Engineering
Shengxi Zhou, Mengbo Xie, Jingjing Su, Bingjie Cai, Jingan Li, Kun Zhang
Summary: Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical and psychological effects on patients. In recent years, the research of scar-free wound repair has been greatly expanded. This paper reviews the types of wounds, the mechanism of scar formation in the healing process, and the current research progress on scar prevention and strategies for scar-free wound repair.
JOURNAL OF TISSUE ENGINEERING
(2023)
Article
Dermatology
Saranchimeg Enkhtuvshin, Erdenezaya Odkhuu, Khongorzul Batchuluun, Battogtokh Chimeddorj, Enkhtur Yadamsuren, Naranbat Lkhagvasuren
Summary: This study aimed to identify risk factors for post-burn scarring in children aged 0-18 years. A total of 182 participants were followed for 6 months after being diagnosed with upper and lower extremity burns. The degree and location of the burn were found to significantly affect scar development.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Camila Francisco Moreira, Puebla Cassini-Vieira, Maria Cecilia Campos Canesso, Mariane Felipetto, Hedden Ranfley, Mauro Martins Teixeira, Jacques Robert Nicoli, Flaviano Santos Martins, Luciola Silva Barcelos
Summary: The study showed that oral treatment with Lactobacillus rhamnosus accelerates skin wound closure, reduces scar formation, alleviates inflammation and fibrogenesis, and improves angiogenesis in wounded skin.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Cell & Tissue Engineering
Magdalena Plotczyk, Francisco Jimenez, Summik Limbu, Colin J. J. Boyle, Jesse Ovia, Benjamin D. D. Almquist, Claire A. A. Higgins
Summary: In this study, hair follicles were transplanted into human scars and it was found that they can promote tissue regeneration and actively remodel fibrotic tissue, providing new insights for developing regenerative approaches to remodel mature scars.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Ophthalmology
Devon Cogswell, Mei Sun, Erin Greenberg, Curtis E. Margo, Edgar M. Espana
Summary: This study developed a stromal wound healing model and a scar classification system that correlates photographic evaluation with changes in extracellular matrix. Different stromal injury techniques in adult mice were tested to create different severity of scars, which were classified and evaluated by masked observers. The severity of scars was positively correlated with changes in extracellular matrix composition, disorganization, and cell infiltration.
Review
Medicine, General & Internal
Karolina Chilicka, Monika Rusztowicz, Renata Szygula, Danuta Nowicka
Summary: Acne vulgaris is a common chronic skin disease that can lead to the formation of atrophic scars if not treated properly. There are three types of atrophic scars and multiple effective methods to improve them, such as lasers, radiofrequency, and chemical peels.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dermatology
Dong Hyo Kim, Ji Hoon Yang, Soo Ick Cho, Ji Young Yoon, Ji Won Kim, Sungjun Choi, Dae Hun Suh
Summary: The clinical efficacy of epidermal growth factor ointment (EGFO) on acne and acne scars was evaluated in this study. The results indicated that EGFO significantly improved acne lesions and scars. Treatment with EGFO altered the expression of various factors related to acne and scarring.
Article
Engineering, Biomedical
Sebastian Huth, Laura Huth, Yvonne Marquardt, Maria Cheremkhina, Ruth Heise, Jens Malte Baron
Summary: The study investigated the role of MMP-3 and its regulation by calcium pantothenate in wound healing after ablative fractional laser treatment. Results showed that aftercare treatment with calcium pantothenate accelerated wound closure in MMP-3 expressing models faster than in MMP-3 knockdown models. This study provides evidence for the first time that calcium pantothenate promotes wound healing at least partly via MMP-3.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Biology
David Kluwig, Sebastian Huth, Ali T. Abdallah, Carolina M. Pfaff, Katharina Fietkau, Laura Huth, Yvonne Marquardt, Jens M. Baron, Bernhard Luescher
Summary: IL-17A and IL-36 gamma drive psoriatic inflammation through a synergistic interaction, as demonstrated by significantly increased skin pathology changes when these two cytokines are co-injected.
Article
Allergy
Conny Hoeflich, Galina Balakirski, Zuzanna Hajdu, Jens Malte Baron, Katharina Fietkau, Hans F. Merk, Ulrich Strassen, Henning Bier, Wolfgang Dott, Hans-Guido Muecke, Wolfgang Straff, Gerda Wurpts, Amir S. Yazdi, Adam Chaker, Stefani T. M. Roeseler
Summary: The study showed varying sensitization rates to both common and non-frequent pollen allergens in adult patients from two German federal states. Sensitization to non-frequent pollen allergens needs to be considered for patients with seasonal symptoms, and availability of test allergens for these less common allergies is important for patient management. Data on sensitization correlated partly with each other and with symptom periods, showing a seasonal pattern similar to pollen data.
CLINICAL AND TRANSLATIONAL ALLERGY
(2021)
Article
Materials Science, Multidisciplinary
Rahul Rimal, Yvonne Marquardt, Thomas Nevolianis, Suzana Djeljadini, Andrea Bonnin Marquez, Sebastian Huth, Dmitry N. Chigrin, Matthias Wessling, Jens M. Baron, Martin Moeller, Smriti Singh
Summary: Utilizing a dynamic flow culture system improved the stability of scaffold-free vHSEs, enhancing skin barrier properties and promoting thicker tissue fabrication and wound closure. Balancing the expression of MMPs and their inhibitors in dynamic flow culture restored tissue homeostasis by modulating angiogenesis.
APPLIED MATERIALS TODAY
(2021)
Article
Immunology
Ramona A. A. Eichkorn, Morna F. F. Schmidt, Elias Walter, Michael Hertl, Jens Malte Baron, Jens Waschke, Amir S. S. Yazdi
Summary: This study reveals the molecular mechanisms underlying auto-antibody-induced acantholysis in pemphigus vulgaris and identifies UVA as a cofactor for acantholysis. It demonstrates that UVA induces IL-1 secretion in keratinocytes and enhances the loss of epidermal adhesion mediated by anti-Dsg3 antibodies. These findings suggest that UVA plays a caspase-dependent exogenous role in blister formation in pemphigus vulgaris.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Uwe Paasch, Miriam Zidane, Jens Malte Baron, Thorsten Bund, Hans-Joachim Cappius, Michael Drosner, Konstantin Feise, Tanja Fischer, Gerd Gauglitz, Peter Arne Gerber, Sonja Grunewald, Katharina Herberger, Anja Jung, Syrus Karsai, Gerd Kautz, Carsten Philipp, Daniela Schaedel, Anna-Theresa Seitz, Alexander Nast
Summary: This guideline aims to provide specific treatment recommendations for various skin lesions, ensuring safe and effective laser therapy. It emphasizes the importance of understanding the differences in treatment methods for different types of skin conditions to avoid unnecessary risks.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Article
Dermatology
Helena Isabell Riedemann, Morna F. Schmidt, Jens Malte Baron
Summary: A scar is the result of a deep tissue defect during the wound healing process. Disorders can occur at all stages, leading to impaired wound healing or the formation of atrophic and hypertrophic scars or keloids. This article focuses on treating pathologic scars, which may cause functional limitations, complaints, and stigmatization. Medical, physical, surgical, and laser therapeutic approaches are pursued, based on an understanding of pathophysiological mechanisms and a comprehensive therapeutic approach.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Dermatology
Katharina Webollek, Yvonne Marquardt, Sylvia Wagner-Schiffler, Jens Malte Baron, Sebastian Huth
Summary: The purpose of this in vitro study was to investigate the molecular effects of dexpanthenol-containing ointment (DCO) after micro-needling. The results showed that DCO accelerated wound healing and did not impair the immunostimulatory properties of micro-needling. These findings can optimize the aftercare routine and reduce downtime for patients after microneedling procedures.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Allergy
Karsten Weller, Ana Maria Gimenez-Arnau, Jens Baron, Randolf Brehler, Marta Ferrer, Adriane Groffik, Sonja Grundmann, Thilo Jakob, Moises Labrador-Horrillo, Sabine Mueller, Petra Staubach, Gerda Wurpts, Martin Metz, Marcus Maurer
Summary: This study compared on-demand (OD) treatment versus daily maintenance treatment with non-sedating H1-antihistamines for chronic spontaneous urticaria. It also assessed the efficacy of rupatadine updosing and investigated potential long-term disease-modifying effects. The results showed that daily rupatadine treatment significantly improved disease activity and quality of life during treatment, but there was no significant difference after discontinuation of rupatadine.
Article
Dermatology
Helena Isabell Riedemann, Morna F. Schmidt, Jens Malte Baron
Summary: A scar is formed as part of the wound healing process, involving inflammation and the proliferation of connective tissue cells. Pathological scars can result in impaired wound healing or the formation of atrophic and hypertrophic scars or keloids. This article focuses on the treatment of pathological scars using medical, physical, surgical, and laser therapeutic approaches, based on an understanding of the underlying mechanisms and interdisciplinary therapeutic approach.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Multidisciplinary Sciences
Sebastian Huth, Laura Huth, Ruth Heise, Yvonne Marquardt, Linda Lopopolo, Marta Piecychna, Peter Boor, Guenter Fingerle-Rowson, Aphrodite Kapurniotu, Amir S. Yazdi, Richard Bucala, Juergen Bernhagen, Jens Malte Baron
Summary: The study found that MIF and D-DT play important roles in the development and progression of UVB-induced non-melanoma skin cancer (NMSC), but have no major effects on chemically-induced skin tumors. These findings suggest that MIF and D-DT are potential therapeutic targets for the prevention of photocarcinogenesis but not chemical carcinogenesis.
SCIENTIFIC REPORTS
(2023)
Article
Allergy
Conny Hoeflich, Galina Balakirski, Zuzanna Hajdu, Jens Malte Baron, Katharina Fietkau, Hans F. Merk, Ulrich Strassen, Henning Bier, Wolfgang Dott, Hans-Guido Muecke, Wolfgang Straff, Gerda Wurpts, Amir S. Yazdi, Adam Chaker, Stefani T. M. Roeseler
Meeting Abstract
Dermatology
Helena Isabell Riedemann, Yvonne Marquardt, Manuela Jansen, Jens Malte Baron, Sebastian Huth
LASERS IN SURGERY AND MEDICINE
(2023)
Meeting Abstract
Cell & Tissue Engineering
Rahul Rimal, Yvonne Marquardt, Suzana Djeljaidni, Thomas Neovalis, Dmitry Chigrin, Matthias Wessling, Jens Malte Baron, Martin Moeller, Smriti Singh
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Dermatology
Y. Marquardt, H. Heise, S. Soemantri, K. Hoffmann, L. Huth, R. Heise, S. Huth, J. M. Baron
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)