Review
Biotechnology & Applied Microbiology
Ning Li, Yeping Qin, Dan Dai, Pengyu Wang, Mingfei Shi, Junwei Gao, Jinsheng Yang, Wei Xiao, Ping Song, Ruodan Xu
Summary: Psoriasis is a chronic immune-mediated skin disorder, and the optimal treatment is still unsatisfactory. The use of nanomaterials as topical drug carriers may offer potential therapeutic effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jiangmei Xu, Hao Chen, Zhaoyou Chu, Zhu Li, Benjin Chen, Jianan Sun, Wei Lai, Yan Ma, Yulong He, Haisheng Qian, Fei Wang, Yunsheng Xu
Summary: In this study, a nanocomposite-based hydrogel was developed for the combined multiple target therapy of psoriasis by loading methotrexate (MTX) into ZnO/Ag. The results showed that the hydrogel exhibited a self-therapeutic effect and could reduce the production of innate cytokines and the secretion of adaptive cytokines in keratinocytes. In a psoriasis mice model, the hydrogel demonstrated superior transdermal delivery and enhanced therapeutic efficacy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Dan Wu, Xin Shou, Yunru Yu, Xiaocheng Wang, Guopu Chen, Yuanjin Zhao, Lingyun Sun
Summary: A novel photo-thermally dissolvable hyaluronic acid microneedle patch with biologics encapsulation has been developed for the treatment of psoriasis. The microneedles possess suitable mechanical strength and biocompatibility, allowing for minimal immune response upon skin puncture. The rapid melting and release of encapsulated IL-17 mAbs under near-infrared light irradiation provide an effective anti-inflammatory effect around psoriasis lesions. This multifunctional microneedle patch effectively reduces psoriasis-like skin inflammation in an animal model and offers a safer and more effective strategy for psoriasis treatment and other chronic inflammatory autoimmune diseases.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Hua Wang, Yangxue Fu, Pei Liu, Fei Qu, Shuo Du, Yan Li, Hongyao Du, Lianbin Zhang, Juan Tao, Jintao Zhu
Summary: A mechanically robust supramolecular dissolving microneedle (DMN) patch loaded with triamcinolone acetonide (TA) has been developed for efficient treatment of psoriasis. This innovative approach shows promising applications in transdermal drug delivery and expands the range of drugs in DMNs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Pharmacology & Pharmacy
Haleh Mahmoudinoodezh, Srinivasa Reddy Telukutla, Sukhvir Kaur Bhangu, Ava Bachari, Francesca Cavalieri, Nitin Mantri
Summary: Recent studies have shown increased interest in the scientific community regarding the use of Cannabis sativa plant and its extracts for medicinal purposes. Due to their characteristics, cannabinoids are prone to degradation in solution. Thus, various delivery methods, including topical and transdermal, have been developed to enhance their bioavailability and stability. These methods have the potential to eliminate the psychotropic effects of cannabinoids.
Review
Chemistry, Multidisciplinary
Akeemat O. Tijani, Divya Thakur, Dhruv Mishra, Dorcas Frempong, Umeh I. Chukwunyere, Ashana Puri
Summary: There is increasing legal acceptance of cannabis and cannabis-derived products for medicinal purposes in some countries, leading to renewed interest in research work related to cannabinoids. Clinical studies have demonstrated the therapeutic significance of cannabinoids, and efforts are being made to develop acceptable prescription products. However, drawbacks of conventional delivery forms of cannabinoids can be mitigated through transcutaneous drug delivery, which shows promise in developing effective delivery systems for cannabinoids.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Optics
Heesuk Jang, Hajun Song, Hae Seog Koh, Taehyun Yoon, Yong Joon Kwon
Summary: This study investigates the shock wave phenomenon generated by laser-induced breakdown in water using 1064 nm Nd:YAG and 2940 nm Er:YAG lasers. The directivity of the shock wave in water is observed to be different for the two laser wavelengths. The mid-infrared Er:YAG laser induces a shock wave that spreads widely perpendicular to the water surface, making it a potential source for various underwater applications.
OPTICS AND LASER TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Inna S. Afonina, Elien Van Nuffel, Rudi Beyaert
Summary: Psoriasis is a chronic inflammatory skin disease characterized by excessive proliferation and aberrant differentiation of keratinocytes, leading to skin redness. The pathogenesis of psoriasis is still not completely understood, but genetic predisposition plays a significant role in its development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Physical
Zihan Zhao, Huaiji Wang, Lingling Yao, Xilin Zhang, Qian Yu, Jun Gu, Yuling Shi
Summary: This study developed a hyaluronic acid-based system, named blocking patch (BP), for efficient local delivery of FK506 to treat psoriasis. BP showed satisfactory transdermal release ability and demonstrated a good anti-inflammatory capacity and inhibition of immune cell activation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Pharmacology & Pharmacy
S. L. Jyothi, K. L. Krishna, V. K. Ameena Shirin, Renu Sankar, K. Pramod, H. Gangadharappa
Summary: Psoriasis is an autoimmune disorder with genetic and environmental factors as its causes. Various drug targets and targeted therapies, including nano-carriers, have been identified for psoriasis treatment. In addition to traditional treatments, novel drug delivery systems show promising efficacy for psoriasis therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gopika Gopan, Jobin Jose, Kartik Bhairu Khot, Akshay Bandiwadekar
Summary: Obesity is a clinical condition with detrimental impacts on human health, and traditional treatment methods have severe side effects and recurrence. Recent studies have shown that utilizing cellulose, chitosan, and hyaluronic acid can enhance the release and efficacy of obesity medications, and transdermal drug delivery through microneedles offers a promising solution to overcome therapy limitations in managing obesity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Optics
Hamza Qayyum, Aatif Ali Wahaj, Ayesha Noor, Abdel-Haleem Abdel-Aty, Nuha Al-Harbi, Abdul Qayyum, Zia Ur Rehman
Summary: Air breakdown induced by a 1064 nm nanosecond pulsed laser beam is studied, and the laser energy partitioning is analyzed as a function of incident laser energy. The study shows that the energy deposited in the breakdown plasma rapidly increases with incident laser energy, while the energy carried away by the shock wave decreases linearly. At lower laser energies, the shock wave carries most of the laser energy, while at higher laser energies, the energy used in plasma heating or released as radiation becomes more important. These findings have significant implications for various applications such as laser-induced breakdown spectroscopy, laser ignition, and laser propulsion.
Article
Chemistry, Analytical
Yue Fan, Yang Gu, Zhenlin Hu, Feng Chen, Junfei Nie, Yuanchao Liu, Wen Cheng, Lianbo Guo
Summary: The self-absorption effect in Laser-Induced Breakdown Spectroscopy (LIBS) is a bottleneck that causes spectral distortion and poor quantitative accuracy, limiting its engineering application. Microwave-assisted LIBS (MA-LIBS) has been proven to weaken the self-absorption effect, but improvements are needed in microwave excitation stability and radiator design. This study proposed a new single-probe microwave radiator to achieve efficient microwave power injection for the elimination of the self-reversal effect. The results showed that MA-LIBS with single-probe microwave excitation demonstrated excellent potential in eliminating the self-reversal phenomenon and provided technical support for the application of LIBS.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Engineering, Biomedical
Ashraf Badawi, Tarek Sobeih, Vesel Jasmina
Summary: The study evaluated the safety and efficacy of non-ablative long-pulse 2940 nm Er:YAG laser for periorbital static wrinkles and skin laxity. Treatment involved three sessions over a 3-month period, resulting in significant improvement in periorbital wrinkles classification and lasting efficacy up to 1 year.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Qi Tian, Peng Quan, Liang Fang, Hui Xu, Chao Liu
Summary: The study developed a classification system based on the skin permeation/retention behaviors of drugs, correlating them with physicochemical parameters. Molecular mechanisms of drug skin penetration/retention behaviors were clarified through the selection of four representative model drugs. The study demonstrated the importance of lipiddisrupting effect, enhanced partitioning, and molecular characteristics in determining drug skin absorption.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)