Article
Microbiology
Jeffersson Krishan Trigo-Gutierrez, Italo Rodrigo Calori, Geovana de Oliveira Barbara, Ana Claudia Pavarina, Renato Sonchini Goncalves, Wilker Caetano, Antonio Claudio Tedesco, Ewerton Garcia de Oliveira Mima
Summary: A photo-responsive polymer was designed for the light-triggered release of curcumin, providing an effective antimicrobial response. Compared to non-responsive Pluronics P123 and F127, the polymer formed nanoscale photo-responsive micelles with lower critical micelle concentration and higher curcumin entrapment efficiency. The polymer also offered better protection for curcumin compared to P123 micelles, and showed a higher release rate with UV light irradiation.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biophysics
Vidhyashree Rajasekar, Priti Darne, Asmita Prabhune, Richard Y. T. Kao, Adline Princy Solomon, Gordon Ramage, Lakshman Samaranayake, Prasanna Neelakantan
Summary: The study found that the curcumin-sophorolipid nanocomplex effectively inhibited fungal adhesion, biofilm development, maturation, and filamentation. This was accompanied by downregulation of key genes involved in biofilm formation and hyphal regulation, indicating the potential of this nanocomplex as a promising anti-fungal agent against Candida albicans.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
Diego Dantas Lopes dos Santos, Joao Felipe Besegato, Priscila Borges Gobbo de Melo, Joao Augusto Oshiro Junior, Marlus Chorilli, Dongmei Deng, Vanderlei Salvador Bagnato, Alessandra Nara de Souza Rastelli
Summary: The study demonstrates that curcumin-encapsulated Pluronic(R) F-127 in antimicrobial photodynamic therapy can effectively reduce the viability of dual-species biofilm of Streptococcus mutans and Candida albicans, suggesting a potential strategy for biofilm control in oral health.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Biophysics
Amanda Cristina Zangirolami, Fernanda Carbinatto, Jose Dirceu Vollet Filho, Vanderlei Salvador Bagnato, Kate Cristina Blanco
Summary: The study demonstrates that curcuminoids and Photogem formulations combined with light illumination can effectively inhibit the formation and infection of bacterial biofilms. Curcuminoid formulations show better inhibition of Staphylococcus aureus biofilms, while Photogem formulations show better inhibition of Escherichia coli biofilms.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Kasama Kanpittaya, Aroon Teerakapong, Noppawan Phumala Morales, Doosadee Hormdee, Aroonsri Priprem, Wilawan Weera-archakul, Teerasak Damrongrungruang
Summary: This study investigates the role of photosensitizers in photodynamic therapy and their potential therapeutic effects on oral diseases. The results show that a photosensitizer containing curcumin and erythrosine exhibited the highest inhibitory effect on Candida albicans, with no toxicity on human gingival fibroblast cells.
Article
Chemistry, Analytical
Fu-Ming Tzu, Jung-Shun Chen, Shih-Hsien Hsu
Summary: This study investigates the use of LED light sources in thin-film transistors, with results showing that white and blue LED light sources perform well in optical inspection, especially with the blue LED demonstrating superior performance.
Article
Food Science & Technology
Amritha Prasad, Michael Ganzle, M. S. Roopesh
Summary: Decontaminating low water activity foods, such as pet foods, is a challenging task. The study investigated the antibacterial efficacy of treatment using 455 nm LED pulses on dry powdered Salmonella and pet foods equilibrated to 0.75 aw, showing that Salmonella sensitivity varied between powder and pet food. LED treatment was less effective against a 5-strain cocktail of Salmonella in low aw pet foods, with significant reduction in weight and water activity, but also observed lipid oxidation in treated pet foods. The study concluded that dose, treatment time, and sample type influenced the Salmonella inactivation efficacy of 455 nm LED treatment in low aw conditions.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Cesar Augusto Abreu-Pereira, Marlise Inez Klein, Carmelia Isabel Vitorino Lobo, Ana Luiza Gorayb Pereira, Claudia Carolina Jordao, Ana Claudia Pavarina
Summary: This study evaluated the effectiveness of DNase I combined with antimicrobial photodynamic therapy against biofilms formed by a fluconazole-resistant Candida albicans strain. The results showed that DNase treatment combined with aPDT could significantly reduce cell viability and the components of the biofilm.
Article
Biotechnology & Applied Microbiology
Tabata Viana de Sousa, Claudia Carolina Jordao, Cesar Augusto Abreu-Pereira, Ana Luiza Gorayb Pereira, Paula Aboud Barbugli, Marlise Inez Klein, Ana Claudia Pavarina
Summary: The effectiveness of hydrogen peroxide (H2O2) combined with antimicrobial photodynamic therapy (aPDT) on biofilms formed by fluconazole-susceptible or -resistant Candida albicans strains was evaluated. The results showed significant reductions in cell viability, biomass, extracellular matrix components, and proteins in the biofilms treated with H2O2 and aPDT. Microscopy images confirmed the disarticulation of the matrix and dispersed fungal cells after the treatments, indicating the disruption of the extracellular matrix organization by H2O2 and the potentiated effect of aPDT.
Article
Biochemistry & Molecular Biology
Shane Fitzgerald, Ciara Furlong, Linda Holland, Aoife Morrin
Summary: This study analyzed the volatilomes of Candida parapsiliosis, revealing distinct differences between different Candida species and strains. The study also investigated the impact of biofilm formation on the volatilomes. The findings highlight the species-specificity of Candida volatilomes and demonstrate the potential of volatilomics for non-invasive detection of fungal pathogens.
Article
Biochemistry & Molecular Biology
Diego Dantas Lopes dos Santos, Joao Felipe Besegato, Priscila Borges Gobbo deMelo, Joao Augusto Oshiro Junior, Marlus Chorilli, Dongmei Deng, Vanderlei Salvador Bagnato, Alessandra Nara de Souza Rastelli
Summary: The study shows that aPDT with Cur-loaded Pluronic (R) F-127 micelles has antibacterial/antifungal effects against Streptococcus mutans and Candida albicans biofilms, achieving a reduction of around 3 log(10). Confocal images confirmed these results, indicating that Cur-loaded Pluronic (R) F-127 micelles have good photochemical properties and could improve the effectiveness of aPDT for dental caries treatment.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Amritha Prasad, Michael Ganzle, M. S. Roopesh
Summary: Light pulses with wavelengths of 365, 395 and 455 nm have antibacterial effects against Salmonella Typhimurium in low-a(w) conditions, with 365 nm showing better efficacy. Significant generation of intracellular reactive oxygen species (ROS) and membrane lipid oxidation were observed in S. Typhimurium cells after treatments with the light pulses. Overall, the inactivation efficacy of the light pulses against S. Typhimurium at low-a(w) conditions is primarily attributed to the generation of ROS.
APPLIED SCIENCES-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Marco Annunziata, Giovanna Donnarumma, Agostino Guida, Livia Nastri, Gerardo Persico, Alessandra Fusco, Ignacio Sanz-Sanchez, Luigi Guida
Summary: The objective of this randomized clinical trial was to evaluate the efficacy of repeated ICG-aPDT as an adjunct to full-mouth subgingival debridement in treating periodontitis. The study found that the combination of repeated ICG-aPDT and full-mouth subgingival debridement did not provide significant benefits compared to debridement alone, except for selective clinical and microbiological improvements.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Multidisciplinary Sciences
Robert Zarnowski, Hiram Sanchez, Anna Jaromin, Urszula J. Zarnowska, Jeniel E. Nett, Aaron P. Mitchell, David Andes
Summary: Extracellular vesicles play an important role in mediating community interactions among cells. In this study, researchers investigated the composition and function of biofilm-associated vesicles in different Candida species. They found similarities in vesicle size and release over the biofilm lifespan, and identified a group of proteins enriched in these vesicles that are important for biofilm processes. By delivering wild-type vesicle cargo, they were able to restore mutant phenotypes and observed functional complementation in cross-species biofilm interactions. These findings highlight the significance of vesicles in shaping protective biofilm communities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemical Research Methods
Barbara Donadon Reina, Carolina Santezi, Samuel Santana Malheiros, Giovana Calixto, Camila Rodero, Francesca Damiani Victorelli, Marlus Chorilli, Livia Nordi Dovigo
Summary: This study demonstrates the antimicrobial efficacy of a curcumin-loaded liquid crystal precursor for photodynamic inactivation of dental biofilms. The results show a significant reduction in viable colonies when using the curcumin-loaded liquid crystal precursor compared to the control group. Hierarchical linear regression analysis suggests that individual characteristics may affect the efficacy of photodynamic inactivation.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Soil Science
Amanda M. Tadini, Ladislau Martin-Neto, Aleksandar Goranov, Debora M. B. P. Milori, Alberto C. C. Bernardi, Patricia P. A. Oliveira, Jose R. M. Pezzopane, Luiz A. Colnago, Patrick G. Hatcher
Summary: This study evaluated carbon accumulation in soils from integrated agricultural systems, showing that with increasing depth of soil horizons, carbon becomes enriched. Integrated agricultural systems enhance carbon enrichment in soil organic matter and humic acids, promoting long-term carbon storage.
EUROPEAN JOURNAL OF SOIL SCIENCE
(2022)
Article
Engineering, Biomedical
Francine Cristina da Silva, Luciano Pereira Rosa, Iasmym Mendes de Jesus, Gabriel Pinto de Oliveira Santos, Natalia Mayumi Inada, Kate Cristina Blanco, Thalita Santos Dantas Araujo, Vanderlei Salvador Bagnato
Summary: The immune changes from HIV/AIDS infection often lead to systemic and local infections, affecting the oral microbiota. Antimicrobial photodynamic therapy (aPDT) emerges as a promising alternative for controlling oral infections in AIDS patients.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Colin M. Haley, Afsheen Lakhani, Neeraj H. Panchal, Carmem Pfeifer, Ana Paula D. Ribiero, Ethelyn Thomason
JOURNAL OF DENTAL EDUCATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Cesar Augusto Abreu-Pereira, Marlise Inez Klein, Carmelia Isabel Vitorino Lobo, Ana Luiza Gorayb Pereira, Claudia Carolina Jordao, Ana Claudia Pavarina
Summary: This study evaluated the effectiveness of DNase I combined with antimicrobial photodynamic therapy against biofilms formed by a fluconazole-resistant Candida albicans strain. The results showed that DNase treatment combined with aPDT could significantly reduce cell viability and the components of the biofilm.
Article
Physics, Multidisciplinary
Sebastiao Pratavieira, Michelle Barreto Requena, Mirian Denise Stringasci, Erika T. Ponce Ayala, Vanderlei Salvador Bagnato
Summary: Multidisciplinary collaboration is crucial for the development of disease diagnosis and treatment techniques. This paper reviews the research conducted at the Sao Carlos Institute of Physics in Brazil, focusing on the diagnosis and treatment of non-melanoma skin lesions. The advancements in photodynamic therapy (PDT) and the successful clinical trials conducted with over 2000 patients are discussed. The technique has been implemented not only in Brazil but also in nine Latin American countries.
BRAZILIAN JOURNAL OF PHYSICS
(2022)
Article
Biophysics
Amanda Cristina Zangirolami, Fernanda Carbinatto, Jose Dirceu Vollet Filho, Vanderlei Salvador Bagnato, Kate Cristina Blanco
Summary: The study demonstrates that curcuminoids and Photogem formulations combined with light illumination can effectively inhibit the formation and infection of bacterial biofilms. Curcuminoid formulations show better inhibition of Staphylococcus aureus biofilms, while Photogem formulations show better inhibition of Escherichia coli biofilms.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Multidisciplinary Sciences
Lucas Madeira, Vanderlei S. Bagnato
Summary: This paper reviews the recent advances in observing non-thermal fixed points (NTFPs) in experiments involving Bose gases. It provides a brief introduction to the theory behind NTFP universality classes and focuses on experimental observations of NTFPs. The benefits of NTFP universality classes are presented by analogy with renormalization group theory in equilibrium critical phenomena.
Article
Pharmacology & Pharmacy
Bruno Vincenzo Fiod Riccio, Andre Luiz Carneiro Soares do Nascimento, Andreia Bagliotti Meneguin, Camila Fernanda Rodero, Kaio Pini Santos, Rafael Miguel Sabio, Sarah Raquel de Annunzio, Carla Raquel Fontana, Hernane da Silva Barud, Priscileila Colerato Ferrari, Marlus Chorilli
Summary: Trans-resveratrol, although effective in promoting dermatological effects, has low solubility and bioavailability due to its high crystallinity. Solid dispersions were developed to address this issue, however, their powdery form makes cutaneous controlled drug delivery unfeasible. In this study, polyvinylpyrrolidone (PVP) films were utilized to develop a controlled delivery system for treating inflammation and bacterial infections associated with atopic dermatitis. The results showed that the developed system was capable of sustained release, good retention in the skin, and exhibited low cytotoxicity. Moreover, it effectively reduced inflammation and inhibited the growth of Staphylococcus aureus.
Article
Mathematics, Applied
R. L. Romano, L. P. Damaceno, D. V. Magalhaes, P. Parmananda, H. Varela
Summary: This study investigates the catalytic electro-oxidation of methanol and formic acid on polycrystalline platinum and explores the effects of coupling different oscillators on the dynamics of the system. The results suggest that the identity of the master oscillator and the coupling constant play an important role in the coupled system.
Review
Food Science & Technology
Natalia L. Barboza, Josias Martins dos Anjos Cruz, Renilto Frota Correa, Carlos Victor Lamara, Alessandra Ramos Lima, Natalia Mayumi Inada, Edgar Aparecido Sanches, Jaqueline de Araujo Bezerra, Pedro H. Campelo
Summary: Buriti, one of the main fruits in the Amazon region, has significant nutraceutical properties and potential for technological and economic development. Its different parts contain various bioactive compounds with antioxidant, antimicrobial, prebiotic, anti-diabetes, and anti-cancer properties. However, there is a lack of in vivo evaluation of the bioactive compounds in buriti, highlighting the need for further research.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemical Research Methods
Barbara Donadon Reina, Carolina Santezi, Samuel Santana Malheiros, Giovana Calixto, Camila Rodero, Francesca Damiani Victorelli, Marlus Chorilli, Livia Nordi Dovigo
Summary: This study demonstrates the antimicrobial efficacy of a curcumin-loaded liquid crystal precursor for photodynamic inactivation of dental biofilms. The results show a significant reduction in viable colonies when using the curcumin-loaded liquid crystal precursor compared to the control group. Hierarchical linear regression analysis suggests that individual characteristics may affect the efficacy of photodynamic inactivation.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Raquel Vitorio Pereira, Lucas Fernando Tabata, Esther Teofilo Rosemberg, Ana Paula Dias Ribeiro, Deborah Lousan do Nascimento Poubel, Fernanda Cristina Pimentel Garcia
Summary: This study aimed to evaluate the influence of different bonding materials, including pre-heated composite resin, on the fracture resistance of teeth subjected to the reattachment technique compared with a direct composite resin restoration. The results showed that the tooth reattachment technique using pre-heated composite resin showed fracture resistance values similar to those of the sound tooth group, and no difference was found between the fragment reattachment and direct composite resin techniques.
DENTAL TRAUMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Gustavo M. Almeida, Vitor Hugo M. Carvalho, Erika B. P. Silva, Marco Antonio F. Cancado, Leonardo S. Barroso, Erica L. Queiroz, Tien Li An, Ana Paula D. Ribeiro, Jacy R. Carvalho-Junior, Andre F. Leite
Summary: This study aims to explore whether the use of intracanal dressing during endodontic treatment promotes periradicular repair in teeth with apical periodontitis. Three different clinical approaches will be used and patients' postoperative pain levels and long-term follow-up evaluations will be recorded. The results may lead to changes in the clinical approaches of endodontic therapy for teeth with apical periodontitis and reveal the potential of complementary approaches for enhanced root canal system decontamination during preparation.
Editorial Material
Dentistry, Oral Surgery & Medicine
Margeaux Johnson, Ana P. Ribeiro, Tiffany M. Drew, Patricia N. R. Pereira
JOURNAL OF DENTAL EDUCATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Luisa Schertel Cassiano, Ana Paula Ribeiro, Marco Anselmo Peres, Rodrigo Lopez, Alexander Fjaeldstad, Leonardo Marchini, Gustavo G. Nascimento
Summary: This study investigated the association between self-reported periodontitis and the senses of taste and smell among employees of one Danish and two American universities. Data were collected through a digital survey, including 1239 individuals from Aarhus University - Denmark, the University of Iowa, and the University of Florida - USA. Self-reported periodontitis was the exposure, and the perceived senses of taste and smell were measured using a visual analog scale (VAS). Self-perceived halitosis was the mediator. Confounders were adjusted. The total effect was decomposed into direct and indirect effects using a counterfactual approach.