Review
Clinical Neurology
Xiang Huang, Junyu Lin, Huifang Shang, Jing Yang
Summary: In this study, a meta-analysis was conducted to investigate gray matter changes in patients with idiopathic dystonia. The results showed consistent widespread gray matter abnormalities in various brain regions. These abnormalities were shared among different subtypes of idiopathic dystonia and were not limited to the corticostriatal circuits.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Sally C. Chester, Tatsuyoshi Ogawa, Maki Terao, Ryusuke Nakai, Nobuhito Abe, Stephane A. De Brito
Summary: This study investigated the neuroanatomical correlates of psychopathic traits in a Japanese sample using structural magnetic resonance imaging data. The results showed associations between psychopathic traits and gray matter volume as well as gyrification in specific brain regions. The associations varied based on sex and different levels of psychopathy factors.
Review
Neurosciences
Mengzhe Zhang, Xinyu Gao, Zhengui Yang, Mengmeng Wen, Huiyu Huang, Ruiping Zheng, Weijian Wang, Yarui Wei, Jingliang Cheng, Shaoqiang Han, Yong Zhang
Summary: This meta-analysis found a concordance in brain structural changes in prefrontal and insula areas across different types of addiction, potentially related to the higher impulsivity observed in addiction diagnoses. This concordance highlights the importance of shared neural substrates in addiction.
PSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Stuart B. Murray, Christina J. Duval, Ane A. Balkchyan, Ryan P. Cabeen, Jason M. Nagata, Arthur W. Toga, Steven J. Siegel, Kay Jann
Summary: Early-onset binge eating disorder (BED) may be characterized by diffuse morphological abnormalities in gray matter density, suggesting alterations in cortical architecture which may reflect decreased synaptic pruning and arborization, or decreased myelinated fibers and therefore inter-regional afferents.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Clinical
Stuart B. Murray, Joel P. Diaz-Fong, Christina J. Duval, Ane A. Balkchyan, Jason M. Nagata, Darrin J. Lee, Kyle T. Ganson, Arthur W. Toga, Steven J. Siegel, Kay Jann
Summary: This study found regional sex differences in terms of gray matter morphometry in early-onset binge eating disorder (BED), with girls showing higher gray matter density.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Yahui Liu, Jiajia Zhang, Meng Zhang, Xianrui Li, Kun Li, Bi Wang, Yongfeng Yang, Ruize Song, Yajing Si, Tianjun Ni, Xueke Wang, Yibo Geng, Qiaohua Chang, Haisan Zhang, Zhijun Zhang, Hongxing Zhang
Summary: This study found that patients with major depressive disorders have abnormalities in the frontal-limbic structures of the brain, specifically decreased gray matter volume in the right middle frontal and precentral gyri. Childhood trauma may be a contributing factor to these structural abnormalities and increased susceptibility to depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Substance Abuse
Deokjong Lee, Woojin Kim, Jung Eun Lee, Jung Han Lee, Yun Tae Kim, Seung Koo Lee, Sung Soo Oh, Ki Soo Park, Sang Baek Koh, Changsoo Kim, Young-Chul Jung
Summary: The study found that heavy alcohol use among firefighters is associated with lower gray matter volume in core brain regions such as the thalamus and insula. As alcohol consumption increases, the volume of gray matter in the right thalamus decreases. These findings suggest a need for concern regarding heavy alcohol use and its impact on cognitive and behavioral control among firefighters.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Clinical Neurology
Reuben Heyman-Kantor, Mina Rizk, M. Elizabeth Sublette, Harry Rubin-Falcone, Yashar Yousefzadeh Fard, Ainsley K. Burke, Maria A. Oquendo, Gregory M. Sullivan, Matthew S. Milak, Francesca Zanderigo, J. John Mann, Jeffrey M. Miller
Summary: The study found that BI scores were inversely correlated with GMV in unmedicated subjects with MDD and BD, but these correlations appeared to be driven by categorical diagnosis.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Lin Song, Xiaodong Han, Yuanjing Li, Xiaolei Han, Mingqing Zhao, Chunyan Li, Pin Wang, Jiafeng Wang, Yi Dong, Lin Cong, Xiaojuan Han, Tingting Hou, Keke Liu, Yongxiang Wang, Chengxuan Qiu, Yifeng Du
Summary: The KIBRA rs17070145 C-allele is associated with a reduced likelihood of olfactory impairment among older adults, partly mediated through left thalamic gray matter volume.
Article
Neuroimaging
Mandy Pirlich, Cathleen Hoefer, Christopher M. Weise, Anika Stockert, Angelika Thoene-Otto, Alexander Garthe, Stefan Schob, Joseph Classen, Karl-Titus Hoffmann, Dorothee Saur
Summary: After TGA, patients may show increased hippocampal GMV, but only subtle neurocognitive deficits are detected, without signs of hippocampal microstructural damage.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Jiayan Liu, Yahui Lei, Yuyao Diao, Yamei Lu, Xingbo Teng, Qingting Chen, Lian Liu, Jingxiang Zhong
Summary: This study investigates the morphological alterations in gray matter volume (GMV) in form-deprivation myopia (FDM) rats using voxel-based morphometry (VBM) method. The results show that compared to the normal controls, the FDM group exhibits significantly decreased GMVs in the left primary visual cortex, left secondary visual cortex, right subiculum, right cornu ammonis, right entorhinal cortex, and bilateral molecular layer of the cerebellum, while significantly increased GMVs were found in the right dentate gyrus, parasubiculum, and olfactory bulb.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Psychiatry
Carolin Spindler, Louisa Mallien, Sebastian Trautmann, Nina Alexander, Markus Muehlhan
Summary: White matter (WM) alterations are significant in patients with alcohol use disorder (AUD), and these changes may contribute to motor, cognitive, affective, and perceptual impairments. However, further research is needed to understand the variations of WM alterations over the course of the disorder and their reversibility with prolonged abstinence.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biology
Iman Beheshti
Summary: This study investigated the anatomical brain changes in individuals with cocaine use disorder (CUD) and how these changes contribute to accelerated brain aging. The findings revealed widespread gray matter atrophy in CUD patients, particularly in the temporal lobe, frontal lobe, insula, and limbic lobe regions. CUD patients also exhibited a higher brain-predicted age difference compared to healthy controls. Regression analysis showed negative changes in gray matter volume associated with brain-PAD in the CUD group.
Article
Neurosciences
Xia Zhe, Xiaoling Zhang, Li Chen, Li Zhang, Min Tang, Dongsheng Zhang, Longchao Li, Xiaoyan Lei, Chenwang Jin
Summary: This study found that patients with vestibular migraine show structural alterations in areas associated with pain and vestibular processing, as well as changes in resting-state functional connectivity in these regions. Reduced gray matter volume in the left parietoinsular vestibular cortex was negatively correlated with Dizziness Handicap Inventory score in patients, and increased functional connectivity was observed between the left primary somatosensory cortex/inferior parietal lobule and the left PIVC in patients with vestibular migraine.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Hiraku Watanabe, Sho Kojima, Kazuaki Nagasaka, Ken Ohno, Noriko Sakurai, Naoki Kodama, Naofumi Otsuru, Hideaki Onishi
Summary: This study found that although there is small variability in gray matter volumes in the short term, it is influenced by within-subject factors such as gender and BDNF genotype.
Article
Neuroimaging
Pengfei Han, Ilona Croy, Claudia Raue, Moustafa Bensafi, Maria Larsson, Annachiara Cavazzana, Thomas Hummel
BRAIN IMAGING AND BEHAVIOR
(2020)
Article
Behavioral Sciences
Cedric Manesse, Arnaud Fournel, Moustafa Bensafi, Camille Ferdenzi
Article
Chemistry, Analytical
A. Fournel, M. Mantel, M. Pinger, C. Manesse, R. Dubreuil, C. Herrier, T. Rousselle, T. Livache, M. Bensafi
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Pediatrics
Valentin A. Schriever, Liesa Zscheile, Janine Gellrich, Thomas Hummel
Summary: Age significantly influences children's olfactory performance, with the U-Sniff test being a reliable method for evaluating olfactory function in children aged 3-6 years. By the age of 4 years, it is possible to distinguish between normal olfactory function and anosmia using the U-Sniff test with high sensitivity and specificity.
PEDIATRIC RESEARCH
(2021)
Article
Otorhinolaryngology
Janine Gellrich, Liesa Zscheile, Claudia Zickmueller, Valentin A. Schriever
Summary: This study found that untrained individuals can successfully administer the "U-Sniff" odor identification test for children with appropriate guidance. There were no significant differences in test results between the untrained group and the group tested by trained examiners.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2021)
Article
Food Science & Technology
C. Manesse, C. Ferdenzi, M. Mantel, M. Sabri, M. Bessy, A. Fournel, F. Faure, D. Bellil, B. M. Landis, M. Hugentobler, A. Giboreau, C. Rouby, M. Bensafi
Summary: The study revealed a high prevalence of olfactory dysfunctions in the general population, with impacts on eating behavior across different age groups, although most participants were unaware of their olfactory disorders.
FOOD QUALITY AND PREFERENCE
(2021)
Article
Otorhinolaryngology
A. Oleszkiewicz, V. A. Schriever, C. Valder, E. Agosin, A. Altundag, H. Avni, H. Cao Van, C. Cornejo, G. Fishman, M. Guarneros, N. Gupta, R. Kamel, A. Knaapila, I Konstantinidis, B. N. Landis, M. Larsson, J. N. Lundstrom, A. Macchi, F. Marino-Sanchez, E. Mori, J. Mullol, V Parma, E. J. Propst, M. A. Sandell, A. Sorokowska, J. Vodicka, T. Hummel, J. Gellrich
Summary: This study found that the hedonic perception of odors in children aged between 5 and 8 years was consistent across 18 countries, mainly driven by the qualities of an odor and the overall ability of children to label odorants. The limitations of the study lie in the limited set of odors used, and further research is needed to replicate and explore other aspects such as the developmental aspects of hedonic perception of odors and cross-cultural differences in chemosensory perception of children.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2022)
Letter
Allergy
Valentin A. Schriever, Janine Gellrich, Thomas Hummel
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Letter
Pediatrics
Janine Gellrich, Sandy Schlage, Veronika Messer, Valentin A. Schriever
WORLD JOURNAL OF PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Muyesaier Tuluhong, Pengfei Han
Summary: This study investigated the association between chronic stress, food reward, and perception of food and non-food odors. The results showed that chronic stress was associated with emotional eating and reward-related eating, and was negatively correlated with liking for low-calorie sweet foods.
FRONTIERS IN NUTRITION
(2023)
Article
Neurosciences
Michal Pieniak, Katharina Seidel, Anna Oleszkiewicz, Janine Gellrich, Christian Karpinski, Guido Fitze, Valentin A. Schriever
Summary: ObjectiveMild traumatic brain injury (mTBI) can affect smell and cognitive functioning. Olfactory training (OT), which involves repeated exposure to odors, has been proposed as a treatment for olfactory dysfunctions and has shown cognitive benefits in older adults. This study aimed to investigate the effects of OT on olfactory and cognitive functions in pediatric mTBI patients.
Article
Medicine, Research & Experimental
Elisabeth C. Lohrer, Thomas Hummel, Valentin A. Schriever, Janine Gellrich
Review
Behavioral Sciences
Matthias Deller, Janine Gellrich, Elisabeth C. Lohrer, Valentin A. Schriever
Summary: This systematic review aimed to provide information on genes that have been reported to be mutated in patients with congenital olfactory disorders (COD). The results revealed that the majority of these genes are implicated in syndromic COD, while a few are associated with both syndromic and isolated COD, and the least are related to isolated COD. Structural abnormalities in the central nervous system are the most common.
Article
Food Science & Technology
Elisabeth C. Lohrer, Annika Dworschak, Ilona Croy, Janine Gellrich, Maha Sabha, Luca Parisato, Valentin A. Schriever
Summary: This study focuses on the importance of olfaction in children and adolescents and develops a questionnaire to assess their personal significance of olfaction. The results show that olfactory information is more important to adolescents compared to children, and girls score higher than boys in terms of the importance of olfaction.
CHEMOSENSORY PERCEPTION
(2022)
Article
Psychology, Experimental
Agnieszka Sabiniewicz, Elena Schaefer, Guducu Cagdas, Cedric Manesse, Moustafa Bensafi, Nadejda Krasteva, Gabriele Nelles, Thomas Hummel
Summary: The study found that congruent odors can influence the perception of pleasantness in still scenes in a virtual environment, with participants using more descriptors in congruent scenarios. However, this modulation effect does not seem to affect memorization.