Article
Clinical Neurology
Fen Zhao, Ying Ren, Guifu Geng, Tong Zhang, Wandong Hu, Huan Zhang, Ruifeng Jin, Jianguo Shi, Zaifen Gao, Hongwei Zhang, Yong Liu
Summary: This study aimed to assess the clinical effectiveness and tolerability of perampanel (PER) as initial monotherapy in pediatric patients with newly diagnosed focal epilepsy. A retrospective analysis was conducted on 62 children, and the results showed that PER had favorable effectiveness with effective rates of 88.7% (3 months), 79.1% (6 months), and 80.4% (12 months). Adverse events occurred in 35.5% of patients but were mild and tolerable. The study provides potential evidence for using PER as initial monotherapy in children with focal epilepsy.
FRONTIERS IN NEUROLOGY
(2023)
Article
Behavioral Sciences
Rui Zhou, Rui Qu, Min Liu, Dan-Ping Huang, Jin-Yi Zhou, Yan Chen, Xu-Qin Chen
Summary: This study aimed to investigate the efficacy, tolerability, and effect on behavior and emotion of PER and LCM as monotherapy in pediatric patients with newly diagnosed focal epilepsy. The results showed that PER and LCM had similar effectiveness and tolerability as monotherapy, and did not have a significant impact on behavior and emotion. Rating: 8/10.
EPILEPSY & BEHAVIOR
(2023)
Review
Medicine, General & Internal
Francesco Brigo, Stanley C. Igwe, Nicola Luigi Bragazzi, Simona Lattanzi
Summary: This review aimed to evaluate the efficacy and tolerability of oral clonazepam as monotherapy for newly diagnosed epilepsy. The study found limited and very low-certainty evidence from randomized controlled trials on the use of clonazepam in monotherapy for epilepsy, indicating insufficient support for its use.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Medicine, General & Internal
Anthony Marson, Girvan Burnside, Richard Appleton, Dave Smith, John Paul Leach, Graeme Sills, Catrin Tudur-Smith, Catrin Plumpton, Dyfrig A. Hughes, Paula Williamson, Gus A. Baker, Silviya Balabanova, Claire Taylor, Richard Brown, Dan Hindley, Stephen Howell, Melissa Maguire, Rajiv Mohanraj, Philip E. Smith
Summary: In patients with newly diagnosed focal epilepsy, levetiracetam and zonisamide were found to be not suitable as first-line treatments, with lamotrigine remaining the preferred option.
Article
Clinical Neurology
Kiyohito Terada, Yuichi Kubota, Svetlana Dimova, Sami Elmoufti, Florin Floricel, Daya Chellun, Terence J. O'Brien
Summary: This study evaluated the efficacy and tolerability of lacosamide and controlled-release carbamazepine in adults with newly diagnosed temporal lobe epilepsy. The results showed that lacosamide was as effective as carbamazepine and had fewer adverse events in patients.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Review
Behavioral Sciences
Sanjeev Kharel, Rajeev Ojha, Surendra Khanal
Summary: This study compared the efficacy and safety of Levetiracetam and Oxcarbazepine as monotherapy for newly diagnosed focal epilepsy. The results showed comparable seizure freedom and withdrawal rates due to adverse events between the two drugs.
BRAIN AND BEHAVIOR
(2022)
Article
Clinical Neurology
Hire Hersi, Jukka Peltola, Jani Raitanen, Jukka T. Saarinen
Summary: This study evaluates the impact of various clinical features on the dosage of anti-seizure medication in new-onset epilepsy patients aged 16 years and above. The findings indicate that there are dosage differences in oxcarbazepine among different age groups; men require higher doses of valproic acid compared to women; carbamazepine dosage is influenced by certain seizure types. These results provide insights for individualizing initial target dosages based on clinical characteristics.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Hiroki Hoshino, Yoshihiro Miyasato, Takayuki Handa, Yutaro Tomi, Hideaki Kanemura
Summary: The aim of this study was to determine the efficacy of lacosamide (LCM) on interictal epileptiform discharges (IEDs) and evaluate the relationships between IEDs and seizure outcome in pediatric patients with focal epilepsy. The study results showed that the effects of LCM on the number of IEDs may be unrelated to seizure outcome. LCM may be ineffective at improving seizure outcomes in patients with multiple regional or diffuse IEDs.
PEDIATRIC NEUROLOGY
(2023)
Review
Pharmacology & Pharmacy
Chunsong Yang, Yuxuan Peng, Lingli Zhang, Li Zhao
Summary: Lacosamide is generally safe and well tolerated in patients with epilepsy, with common adverse events including sedation, dizziness, and fatigue. More attention should be paid to the prevention and management of these adverse events, and further large-scale and high-quality studies are needed to update safety data.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Ting Zhao, Hong-jian Li, Hui-lan Zhang, Jing Yu, Jie Feng, Ting-ting Wang, Yan Sun, Lu-hai Yu
Summary: This retrospective study aimed to assess the efficacy and tolerability of lacosamide (LCM) as monotherapy for epilepsy treatment in pediatric patients. The results showed that LCM monotherapy was effective and well-tolerated.
PEDIATRIC NEUROLOGY
(2023)
Article
Clinical Neurology
Hire Hersi, Jukka T. Saarinen, Jani Raitanen, Jukka Peltola
Summary: This study found that after failing the first ASM, about 60% of patients responded positively to subsequent ASM regimens, supporting the feasibility and applicability of the ILAE concept of defining DRE as failure of two ASMs.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Jia-Qin Yi, Sheng Huang, Miao-Juan Wu, Jie-Hui Ma, Li-Juan Huang, Song Liang, Dan Sun
Summary: The study compared the efficacy and safety of perampanel and oxcarbazepine as monotherapy in children with newly diagnosed focal epilepsy. Both drugs showed comparable effectiveness in achieving seizure freedom rates at six months, with no serious adverse events reported in either group.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Haoyue Zhu, Xuejun Deng, Li Feng, Yajun Lian, Xiong Han, Zhenli Guo, Yulan Gou, Yuanmin Du, Longshan Xie, Dongai Yao, Yonghong Liu, Qiang Wu, Song Lan, Kaisheng Liu, Peiyan Zhan, Xiahong Wang, Jingxia Dang, Yunqi Hou, Keqiang Chen, Yulan Zhu, Yuliang Shi, Yunli Yu, Bo Xiao, Suiqiang Zhu, Hongmei Meng
Summary: This study compared the efficacy and effects of oxcarbazepine and levetiracetam as monotherapies for patients with newly diagnosed focal epilepsy in China. The results showed that oxcarbazepine monotherapy may be more effective than levetiracetam monotherapy, and both drugs improved the quality of life and anxiety state of the patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Behavioral Sciences
Orhan Talha Ozgun, Melek Kandemir Yilmaz, Murat Mert Atmaca, Selda Keskin Guler, Eser Bulus, Arda Duman, Ozlem Celebi, Candan Gurses
Summary: This study evaluates the effectiveness and tolerability of Lacosamide when used in the immediate switch from sodium channel blockers in patients with focal-onset and generalized-onset epilepsies. The results show that Lacosamide has good clinical response and is able to significantly reduce seizure frequency in patients with both focal-onset and generalized-onset seizures.
EPILEPSY & BEHAVIOR
(2023)
Article
Medicine, General & Internal
Aitana Juan-Giner, Derick Kimathi, Kyra H. Grantz, Mainga Hamaluba, Patrick Kazooba, Patricia Njuguna, Gamou Fall, Moussa Dia, Ndeye S. Bob, Thomas P. Monath, Alan D. Barrett, Joachim Hombach, Edgar M. Mulogo, Immaculate Ampeire, Henry K. Karanja, Dan Nyehangane, Juliet Mwanga-Amumpaire, Derek A. T. Cummings, Philip Bejon, George M. Warimwe, Rebecca F. Grais
Summary: This study assessed the immunogenicity and safety of fractional doses of four yellow fever vaccines compared to standard doses. The results showed that fractional doses from all vaccines were non-inferior to the standard dose, with no major safety concerns. This supports the use of fractional dosage in the general adult population for outbreak response in situations of vaccine shortage.
Article
Clinical Neurology
Elinor Ben-Menachem, Boudewijn Gunning, Carmen Maria Arenas Cabrera, Kevan VanLandingham, Julie Crockett, David Critchley, Louise Wray, Bola Tayo, Gilmour Morrison, Manuel Toledo
Correction
Behavioral Sciences
Laura Abraira, Nicola Giannini, Estevo Santamarina, Sonia Cazorla, Alejandro Bustamante, Manuel Quintana, Manuel Toledo, Laia Grau-Lopez, Marta Jimenez, Jordi Ciurans, Juan Luis Becerra, Monica Millan, Pere Cardona, Mikel Terceno, Josep Zaragoza, David Canovas, Teresa Gasull, Xavier Ustrell, Marta Rubiera, Mar Castellanos, Antoni Davalos, Joan Montaner, Jose Alvarez-Sabin
EPILEPSY & BEHAVIOR
(2020)
Review
Clinical Neurology
Manuel Toledo, Barbara Mostacci, Magdalena Bosak, Joanna Jedrzejzak, Rhys H. Thomas, Javier Salas-Puig, Arnaud Biraben, Bettina Schmitz
Summary: Valproate, a broad-spectrum antiepileptic drug, is particularly effective in certain types of epilepsy syndromes. The European Medicines Agency introduced new restrictions on its use in females of childbearing potential, leading to controversy and debate. Limited information on the teratogenic potential of alternative treatments presents challenges in the clinical management of pregnant women and women of childbearing age.
JOURNAL OF NEUROLOGY
(2021)
Article
Behavioral Sciences
A. Llaurado, E. Santamarina, E. Fonseca, M. Olive, M. Requena, M. Sueiras, L. Guzman, A. Ballve, D. Campos, I. Seijo, L. Abraira, M. Quintana, M. Toledo
EPILEPSY & BEHAVIOR
(2020)
Article
Clinical Neurology
Manuel Quintana, Javier Sanchez-Lopez, Gonzalo Mazuela, Estevo Santamarina, Laura Abraira, Elena Fonseca, Ivan Seijo, Jose Alvarez-Sabin, Manuel Toledo
Summary: The study showed a high incidence of adult epilepsy in a university hospital in Spain, with a mortality rate almost four times higher than expected in the general population. Age, generalized seizures, and tumor-related epilepsy were independently associated with a higher risk of death.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Elena Fonseca, Manuel Quintana, Sofia Lallana, Juan Luis Restrepo, Laura Abraira, Estevo Santamarina, Ivan Seijo-Raposo, Manuel Toledo
ACTA NEUROLOGICA SCANDINAVICA
(2020)
Article
Clinical Neurology
Laura Abraira, Estevo Santamarina, Sonia Cazorla, Alejandro Bustamante, Manuel Quintana, Manuel Toledo, Elena Fonseca, Laia Grau-Lopez, Marta Jimenez, Jordi Ciurans, Juan Luis Becerra, Monica Millan, Maria Hernandez-Perez, Pere Cardona, Mikel Terceno, Josep Zaragoza, David Canovas, Teresa Gasull, Xavier Ustrell, Marta Rubiera, Mar Castellanos, Joan Montaner, Jose Alvarez-Sabin
Article
Behavioral Sciences
Estefania Conde-Blanco, Maria Centeno, Ester Tio, Desiree Muriana, Juan Jose Garcia-Penas, Pedro Serrano, Antonio Gil Nagel, Jose Serratosa, Angeles Perez Jimenez, Manuel Toledo, Antonio Donaire, Isabel Manzanares, Olga Betran, Mar Carreno
EPILEPSY & BEHAVIOR
(2020)
Article
Behavioral Sciences
Andreu Vilaseca-Jolonch, Laura Abraira, Manuel Quintana, Maria Sueiras, Vanessa Thonon, Manuel Toledo, Javier Salas-Puig, Elena Fonseca, Esteban Cordero, Francisco Martinez-Ricarte, Estevo Santamarina
EPILEPSY & BEHAVIOR
(2020)
Article
Clinical Neurology
Alejandro Ballve, Javier Salas-Puig, Manuel Quintana, Daniel Campos, Arnau Llaurado, Miquel Raspall, Elena Fonseca, Laura Abraira, Estevo Santamarina, Manuel Toledo
Summary: This study aimed to evaluate the efficacy of levetiracetam (LEV) as a first-line treatment for Idiopathic Generalized Epilepsy (IGE) in women, showing that LEV could be an effective drug for IGE in women of childbearing potential, with adverse effects being the main limitation. Further comparative studies are needed to establish its indication.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Sofia Lallana, Elena Fonseca, Juan Luis Restrepo, Manuel Quintana, Ivan Seijo-Raposo, Laura Abraira, Estevo Santamarina, Jose Alvarez-Sabin, Manuel Toledo
Summary: The study found that the COVID-19 pandemic had a significant medium-term impact on epilepsy patients, affecting their psychological well-being and seizure control. Depression rates increased significantly, with depression, drug-resistant epilepsy, and a reduction in income being identified as independent risk factors for increased seizure frequency. Perception of telemedicine worsened, indicating the need for readjustment.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Llaurado Arnau, Manuel Quintana, Alejandro Ballve, Daniel Campos, Elena Fonseca, Laura Abraira, Manuel Toledo, Estevo Santamarina
Summary: The study showed that factors like etiology and symptomatology of SE influence the response to BZD treatment. Prompt administration was associated with faster resolution in patients with prominent motor symptoms, chronic structural lesions, or history of epilepsy.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
A. Llaurado, M. Quintana, E. Fonseca, L. Abraira, M. Toledo, M. Requena, M. Olive, A. Ballve, D. Campos, M. Sueiras, E. Santamarina
Summary: This study aimed to determine whether the administration of antiepileptic drugs (AED) alters the likelihood of detecting epileptiform abnormalities in electroencephalographies (EEG) performed early after a first epileptic seizure. The results showed that previous administration of AEDs did not significantly affect the likelihood of detecting epileptiform abnormalities.
Review
Chemistry, Medicinal
Amanda Cano, Elena Fonseca, Miren Ettcheto, Elena Sanchez-Lopez, Itziar de Rojas, Silvia Alonso-Lana, Xavier Morato, Eliana B. Souto, Manuel Toledo, Merce Boada, Marta Marquie, Agustin Ruiz
Summary: Epilepsy is a chronic disease of the central nervous system characterized by an electrical imbalance in neurons. The molecular processes that trigger epileptic seizures and promote neurotoxic effects are currently focused on the glutamate pathway and influx of calcium ions into neurons. Common molecular links between epilepsy and other neurodegenerative diseases have led to investigation of antiseizure drugs for therapeutic potential in these pathologies.
Article
Clinical Neurology
Javier Salas-Puig, David Sopelana, Manuel Quintana, Ivan Seijo-Raposo, Laura Abraira, Elena Fonseca, Estevo Santamarina, Manuel Toledo
Summary: The study revealed that the quality of life in patients with idiopathic generalized epilepsy is affected by poorly controlled seizures, psychiatric comorbidities, and unemployment, with women being more affected than men.
REVISTA DE NEUROLOGIA
(2021)