Journal
LABORATORY INVESTIGATION
Volume 98, Issue 1, Pages 27-40Publisher
SPRINGERNATURE
DOI: 10.1038/labinvest.2017.127
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Funding
- Institute of Life Sciences, Bhubaneswar
- Department of Biotechnology (DBT), Government of India [BT/PR13502/MED/30/1555/2015]
- DBT, Government of India
- Department of Science and Technology, Government of India
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Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic cancer desmoplasia is the pancreatic stellate cell. Various in vitro and in vivo methods have emerged for the isolation, characterization, and use of pancreatic stellate cells in models of cancer-associated fibrosis. In addition to cell culture models, genetically engineered animal models have been established that spontaneously develop pancreatic cancer with desmoplasia. These animal models are currently being used for the study of pancreatic cancer pathogenesis and for evaluating therapeutics against pancreatic cancer. Here, we review various in vitro and in vivo models that are being used or have the potential to be used to study desmoplasia in pancreatic cancer.
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