Article
Engineering, Chemical
Haotian Cha, Hoseyn A. Amiri, Sima Moshafi, Ali Karimi, Ali Nikkhah, Xiangxun Chen, Hang T. Ta, Nam-Trung Nguyen, Jun Zhang
Summary: Inertial microfluidics is a technique that uses the finite inertia of fluid at high flow speed to manipulate and separate microparticles. Embedding periodic micro-obstacles into curvilinear channels has been found to be an effective strategy to improve inertial focusing and separation. This study systematically investigated the influence of micro-obstacles on inertial focusing and developed a high-resolution microfluidic device for particle and cell separation. The results showed that concave obstacles were more effective in tuning particle inertial focusing and separation compared to convex obstacles, and the square concave obstacle channel offered the highest separation resolution. The developed microfluidic device showed high-efficiency separation of polystyrene beads and U87MG cancer cells from blood.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Chemistry, Analytical
Jun-Jie Bai, Xuan Zhang, Xing Wei, Yu Wang, Cheng Du, Ze-Jun Wang, Ming-Li Chen, Jian-Hua Wang
Summary: Exosomes are crucial biomarkers for intercellular communication and disease diagnosis and treatment. This study presents a microfluidic chip called DEIC for isolating high-purity exosomes from small-volume biological samples. The chip utilizes elastoinertial separation to remove protein contaminants and achieves a 70.6% recovery and a 91.4% removal rate for proteins. The technique enables individual-vesicle-level biomarker analysis and shows potential for integration with downstream exosome analyses.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Uihwan Kim, Byeolnim Oh, Jiyeon Ahn, Sangwook Lee, Younghak Cho
Summary: In this study, an integrated microfluidic device was proposed for non-contact, label-free separation of particles and cells using a combination of inertial microfluidics and acoustophoresis. The device demonstrated excellent separation performance and high recovery ratio, making it a potential alternative to current cell separation methods.
Review
Nanoscience & Nanotechnology
Hao Tang, Jiaqi Niu, Han Jin, Shujing Lin, Daxiang Cui
Summary: Passive and label-free microfluidic devices, with their simple design and reliance on geometric structure, have become popular in medical and bioresearch applications. This review discusses the importance of geometric design principles in passive and label-free microfluidics and summarizes the most creative innovations in microfluidic schemes such as deterministic lateral displacement, inertial microfluidics, and viscoelastic microfluidics. The aim of this review is to provide researchers with a guideline for incorporating geometric innovations into passive and label-free microfluidics.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Engineering, Biomedical
Seyed Ali Tabatabaei, Mohammad Zabetian Targhi
Summary: The study focuses on the application of microparticle and biological cell separation techniques on microfluidic chips, with an experimental analysis of the effectiveness of a novel inertial microfluidic system in separating biological particles. Results showed an acceptable efficiency of 86% for both monodisperse and polydisperse particles, demonstrating potential for integration into a broader point-of-care diagnostic system for blood samples.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2021)
Article
Engineering, Chemical
Afshin Shiriny, Morteza Bayareh
Summary: A novel microscale device for continuous flow separation of two types of circulating tumor cells from blood cells was proposed in this study. The separation efficiency reached 100% over a range of Reynolds numbers from 90 to 110, achieved through inertial forces.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Biochemical Research Methods
Jinghong Su, Xiaodong Chen, Yongzheng Zhu, Guoqing Hu
Summary: This study presents a fast numerical algorithm and machine learning techniques for analysis and design of inertial microfluidic devices, generating a database of inertial lift forces in straight microchannels and developing a machine learning assisted model to predict particle trajectories quickly and accurately.
Article
Chemistry, Analytical
Mohamed Adel, Ahmed Allam, Ashraf E. Sayour, Hani F. Ragai, Shinjiro Umezu, Ahmed M. R. Fath El-Bab
Summary: In this study, the application of grayscale in microfluidic channel design was used to overcome the complexity of the fabrication process. Direct engraving with a CO2 laser on PMMA material was also utilized to reduce the cost and fabrication time of the microfluidic chip. Experimental tests demonstrated that the fabricated chip had high separation efficiency in sorting white blood cells.
Article
Multidisciplinary Sciences
Hossein Zargartalebi, S. Hossein Hejazi, Amir Sanati-Nezhad
Summary: The authors introduce a passive protocol to suppress the coffee-ring effect and form uniform films at micro- and nanoscales by combining superhydrophilic substrate with a neutral-wetting low-roughness mold. This method has broad applications in fabricating ordered coatings, producing nanofilters, and creating functionalized nanosensors.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Haotian Cha, Hedieh Fallahi, Yuchen Dai, Sharda Yadav, Samith Hettiarachchi, Antony McNamee, Hongjie An, Nan Xiang, Nam-Trung Nguyen, Jun Zhang
Summary: Inertial microfluidics relies on fluid dynamics at high flow speeds, with channel geometry being the critical design parameter. Four basic channel geometries have been proposed and studied extensively. This work explores embedding periodic concave and convex obstacle microstructures in sinusoidal channels, investigating their impact on particle inertial focusing and separation. The results suggest that embedding microstructures brings flexibility to device design and enables high-performance separation.
Article
Engineering, Chemical
Tong Zhang, Jianping Li, Aosong Wei, Junjun Huang, Shihao Li, Jun Huan, Faquan Wang, Hualin Wang
Summary: This study proposed a method for ultra-clean separation of micro-particle contaminants using mini-hydrocyclones with overflow microchannels. By controlling the width of the overflow microchannels, the adverse effects of short-flow can be significantly reduced, leading to efficient separation. Experimental results showed that this method can greatly decrease the concentration and quantity of micro-particle contaminants in lubricating oil, achieving the cleanliness requirements of international standards and demonstrating excellent technical-economic performance.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Xin Shi, Wei Tan, Yuwen Lu, Wenfeng Cao, Guorui Zhu
Summary: The newly proposed CCEA microdevice features small size, centrosymmetric structure, and efficient particle/cell focusing capability. Experimental results demonstrate stable fluid distribution, indicating potential applications in basic medical research and clinical diagnosis.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Biochemical Research Methods
Hedieh Fallahi, Sharda Yadav, Hoang-Phuong Phan, Hang Ta, Jun Zhang, Nam-Trung Nguyen
Summary: Inertial microfluidics is a cost-effective technique for rare-cell isolation and detection, and a stretchable inertial microfluidic device allows for tuning of the separation threshold to achieve high separation resolution for cells with small size differences. The device was validated to have a high recovery rate and purity for isolating cancer cells from white blood cells, and further testing using whole blood spiked with cancer cells demonstrated a 98.6% recovery rate with 90% purity, showcasing the potential of stretchable microfluidic chips for precise separation.
Article
Chemistry, Multidisciplinary
Shuming Zeng, Tian Wang, Yuanbin Zhang, Bruce G. Elmegreen, Binquan Luan, Zonglin Gu
Summary: In this study, we demonstrate the unprecedented separation efficiency of CO2/C2H2 using a graphene membrane embedded with crown ether nanopores. Through molecular dynamics simulation and density functional theory, we found that the electrostatic gas-pore interaction allows fast transport of CO2 while completely prohibiting C2H2 transport, resulting in remarkable permeation selectivity. Our findings show the potential application of graphene crown pores for CO2 separation with outstanding performance.
Article
Chemistry, Physical
Xiaoyu Zhang, Shuya Wang, Shengpeng Han, Xiao Ouyang, Ning Ma, Hao Wei, Xinyue Zhang
Summary: This study successfully fabricated uniform micro-honeycomb arrays on a large scale in just seconds at ambient humidity by using a commercial linear homopolymer and its nonsolvent. The preparation conditions can be easily controlled, and the morphology of the structures can be tuned accordingly. High fill-factor convex micro-lenses were prepared based on the concave micro-honeycomb arrays as templates, showing properties like multiple image presentation and light diffraction, as well as enhancing fluorescent intensity by over 10%. This method is proposed as a potential low-cost and high-efficiency alternative to breath figure self-assembly for micro-honeycomb arrays under mild conditions.
Review
Materials Science, Multidisciplinary
Minhuan Jin, Jinyi Wang, Kaiqian Weng, Tianxing Sun, Daying Guo, Xueyu Wang, Xi'an Chen, Shun Wang
Summary: Fluorinated solid-state electrolytes (FSSEs) have been widely used in all-solid-state lithium batteries (ASSLBs) due to their good compatibility, wide electrochemical windows, and stable chemical stability. However, challenges such as ionic conductivity, chemical stability, and current limitation hinder the practical application of fluorinated solid electrolytes. This review discusses the development history of FSSEs, analyzes recent advances in improving ion conductivity, chemical stability, and current limit through structural design, interface regulation strategies, etc., and prospects the design requirements for future generations of FSSEs, focusing on simple one-step synthesis methods, room temperature ionic conductivity improvement, and optimization of the electrochemical stability window of FSSEs.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Chemistry, Analytical
Guorui Zhang, Di Kang, Zhonghui Zhang, Yuanchang Li, Jingjing Jiang, Qin Tu, Junzheng Du, Jinyi Wang
Summary: The filter paper-syringe (FPS) delivery method is a new type of cell permeation approach that forces cells to pass through filter paper quickly, enhancing cell membrane permeability and enabling the delivery of exogenous substances. This method is simple, easy-to-operate, and fast, with delivery efficiency comparable to liposomal delivery of siRNA.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Junyu Su, Maosen Yuan, Lu Han, Hongxia Deng, Jiahao Chang, Yuting Zhuang, Jinyi Wang, Yue Zhang
Summary: In this study, a defluoridation approach based on ultrathin two-dimensional metal organic framework nanosheets was proposed. The Ce-DCPBA nanosheets exhibited high-capacity adsorption of fluoride in a wide pH range. The exceptional selectivity and adsorption ability of Ce-DCPBA make it a promising material for the selective and efficient removal of fluoride from complex environmental samples.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Jinyi Wang, Ling Zhou, Daying Guo, Xueyu Wang, Guoyong Fang, Xi'an Chen, Shun Wang
Summary: A flower-shaped NiS2-WS2 heterojunction was prepared to improve the reaction kinetics of sulfur in lithium-sulfur batteries. The heterojunction enhanced mass and charge transfer, and acted as an electron receptor and a donor for bidirectional catalytic activity. The results showed excellent discharge performance and cycle stability.
Article
Chemistry, Applied
Bin Yang, Jinyi Wang, Yuheng Qi, Daying Guo, Xueyu Wang, Guoyong Fang, Xi'an Chen, Shun Wang
Summary: A systematic modification of separators using bismuth oxycarbonate nanoflowers decorated conductive carbon is proposed, which effectively addresses the shuttle effect of polysulfides in lithium-sulfur batteries and improves battery performance and cycling stability.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Article
Chemistry, Analytical
Lingtong Zhou, Yuanchang Li, Jingcheng Xiao, Shu-Wei Chen, Qin Tu, Mao-Sen Yuan, Jinyi Wang
Summary: In recent years, there has been a rapid increase in interest for wearable and stretchable multifunctional sensors. The development of practical and versatile devices has faced challenges in achieving self-healing and adhesion to target objects. This study prepared a hydrogel (LM-SA-PAA) with ultrastretchable, self-healing, self-adhesive, and high-sensitivity sensing capabilities, allowing for conformal contact with the skin during dynamic movements. The hydrogel's excellent self-healing properties arise from its double cross-linked networks, and its adhesion is ensured by the microgel shell formed by alginate. The hydrogel showed strain sensitivity and the ability to detect various human motions and electrocardiographic monitoring, making it a promising option for human-machine interface compatibility and medical monitoring.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Chenjie Zhang, Lin Huang, Jinyi Wang, Tianliang Zhou, Rong-Jun Xie
Summary: In this work, a method is proposed to find hosts that produce broadband NIR Cr3+ emission by screening Ce3+-doped phosphor hosts, allowing Ce3+ and Cr3+ to occupy the same crystallographic site. A NIR phosphor Ba3Sc4O9:Cr3+ is obtained with an emission peak at 835 nm and a FWHM of 188 nm, where Ce3+ or Cr3+ is accommodated at the same Sc3+ site. By following this method, two broadband NIR phosphors Li3Sc2(PO4)3:Cr3+ (lambda(em) = 1000 nm, FWHM = 223 nm) and Na3Sc2(PO4)3:Cr3+ (lambda(em) = 895 nm, FWHM = 184 nm) are discovered.
CHEMISTRY OF MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Chen Chen, Jian Zhou, Jincheng Yu, Jia Ju, Ying Zhang, Jinyi Wang, Bowen Fan
Summary: Tin bronze was cladded on bare steel and nickel-plated steel to fabricate bimetallic materials. The interfacial microstructures and infiltrated cracks were investigated. Infiltrated cracks originated from the interface and propagated into the interior of the steel along the grain boundaries. When tin bronze was cladded on nickel-plated steel, a transition layer with BCC-Fe structure was also generated and the infiltrated cracks were eliminated.
JOURNAL OF MATERIALS SCIENCE
(2023)
Correction
Chemistry, Multidisciplinary
Zuzhe Kang, Jingjing Jiang, Qin Tu, Shuaiting Liu, Yue Zhang, Dong-En Wang, Jinyi Wang, Mao-Sen Yuan
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Engineering, Environmental
Qiuyi Lu, Zhoujie Wang, Jingyi Wang, Lei Xie, Qi Liu, Hongbo Zeng
Summary: Humic acid can form metal-HA complexes with a variety of divalent cations, and the interaction mechanism between them was studied at the nanoscale. The presence of Ca2+ enhances the aggregation and adhesion of HA, while excessive Ca2+ suppresses these behaviors. Cu2+ shows the highest adhesion energy due to its synergistic bonding with both oxygen and amine sites of HA.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Zhoujie Wang, Huadong Tian, Jing Liu, Jingyi Wang, Qingye Lu, Lei Xie
Summary: Adsorption of Cd(II) on serpentine was investigated under typical environment conditions, involving common environmental anions and cations. The adsorption was negligibly affected by anion type, but was specifically modulated by cations. Mono- and divalent cations enhanced the adsorption by weakening electrostatic double layer repulsion, while trivalent cations suppressed the adsorption due to competitive adsorption. Fe3+ and Al3+ prevented Cd(II) adsorption by binding surface active sites, forming more stable inner-sphere complexes. This study provides insights into the influence of interfacial ion specificity on Cd(II) adsorption in terrestrial and aquatic environments.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Analytical
Jingcheng Xiao, Jingjing Jiang, Zexu Zhao, Jiahao Guo, Jinyi Wang
Summary: In this study, a distance-based microfluidic paper-based analytical device (muPAD) modified with carboxyl-containing polystyrene nanoparticles (PS-muPAD) was developed to improve the clarity of the discoloration boundary. The modified device showed improved accuracy in calculating analyte content.
ANALYTICAL METHODS
(2023)
Meeting Abstract
Urology & Nephrology
Eric Davenport, Xiaolei Zhou, Jinyi Wang, Sasikiran Nunna, Dorothee Oberdhan, Ancilla Fernandes, Djalila Mekahli
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Engineering, Chemical
Anrong Yao, Jinghong Qiu, Yafang Wang, Haoyi Hu, Cuimin Huang, Jingyi Wang, Siyao Tian, Lin Yang, Shaojian Lin, Jianwu Lan
Summary: In this study, MIL-88B loaded montmorillonite (MMT) and cellulose nanocrystals (CNC) were incorporated into gelatin aerogel to create a multifunctional and reinforced bio-aerogel, MMCG aerogel, for the removal of organic pollutants. The MMCG aerogel exhibited highly efficient adsorption capacity and showed improved removal performance for all organic contaminants by triggering the Fenton reaction with the addition of H2O2.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Chemistry, Physical
Dianlin Wang, Jiang He, Zili Xiao, Jingyi Wang
Summary: This article discusses the limitations on molar ratios and concentrations in Isothermal titration calorimetry (ITC) caused by the volumes and concentrations of syringe and sample cell. The study explores the neglected aspect of the molar ratios and concentrations of sodium dodecylsulfate (SDS) and imidazolium-based ILs in self-assembly structure transitions. The variations in macroscopic properties and molecular ratios of surfactants responsible for constructing vesicle structures in different alkyl chain lengths systems are investigated using enthalpy changes and cryogenic Transmission Electron Microscopy (cryo-TEM).
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)