M1 macrophage triggered by Mincle leads to a deterioration of acute kidney injury

In the early stage of acute kidney injury, M1 macrophages are proinflammatory and destructive. In this study, Lv et aL reveal that Mincle (macrophage-inducible C-type lectin, Clec4e) is expressed on M1 macrophages in acute kidney injury, and the kidney is protected in a murine model of cisplatin-induced renal injury by inhibiting Mincle expression on macrophages. Mincle expression is regulated by Toll like receptor 4/nuclear factor kappa B signaling, and Mincle maintains the inflammatory phenotype through spleen tyrosine kinase signaling, leading to acute kidney injury. Copyright (C) 2017, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.