Article
Urology & Nephrology
Jingping Wu, Jian Liu, Guanghan Li, Weiliang Sun, Jiang Liu, Wenge Li, Hao Wang, Min Zheng
Summary: This study revealed that there was no correlation between renal resistive index (RRI) and renal microvessel density (RMD) or between RRI and fibrosis in patients with chronic kidney disease (CKD). However, in CKD stages 2 to 5, RRI was negatively correlated with CD34 positive area in the glomerulus, but no correlation was found with CD34 positive area overall, CD34 positive area in the peritubular capillary, or kidney fibrosis. Furthermore, estimated glomerular filtration rate (eGFR) showed a positive correlation with RMD.
Article
Medicine, Research & Experimental
Stephanie Ruiz, Fanny Vardon-Bounes, Marie Virtos, Thierry Seguin, Laure Crognier, Antoine Rouget, Bernard Georges, Jean-Marie Conil, Vincent Minville
Summary: This observational study aimed to evaluate the impact of arterial blood gases on renal arterial resistive index (RI) in the ICU setting. The results showed correlations between RI and PaCO2, age, diastolic arterial pressure, and SaO2. Multivariate analysis confirmed that age > 58 years and PaCO2 were significant factors influencing the RI. These findings suggest that thresholds for PaCO2, age, and diastolic arterial pressure should be considered in interpreting RI.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Urology & Nephrology
Sara Samoni, Gianluca Villa, Silvia De Rosa, Mauro Neri, Lorenzo Tofani, Faeq Husain-Syed, Massimo De Cal, Federico Nalesso, Mario Meola, Claudio Ronco
Summary: The IRRIV test, a safe and inexpensive ultrasound technique, was found to significantly predict the presence and degree of renal functional reserve in healthy subjects. The correlation between IRRIV and renal functional reserve was strong, and the test showed a high concordance in predicting the presence of renal functional reserve.
JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Ying Zhang, Jianing Zhu, Chuyue Zhang, Jing Xiao, Chao Liu, Shuo Wang, Ping Zhao, Yaqiong Zhu, Li Wang, Qiuyang Li, Yukun Luo
Summary: By combining RRI with echocardiographic parameters, the predictive value for S-AKI can be significantly improved in the early stages, especially in early sepsis. This method also detects S-AKI earlier than traditional renal function indicators.
FRONTIERS IN MEDICINE
(2021)
Article
Urology & Nephrology
You Fu, Cong He, Lijing Jia, Chen Ge, Ling Long, Yinxiang Bai, Na Zhang, Quansheng Du, Limin Shen, Heling Zhao
Summary: This study aimed to evaluate the performance of Doppler-based renal resistive index (RI), clinical indicators, and their combinations in predicting short-term kidney prognosis in septic shock patients. The results showed that the renal RI performed poorly in predicting persistent AKI, while the clinical prediction model combining serum creatinine and the nonrenal SOFA score showed better prediction ability.
Article
Transplantation
Satoshi Inotani, Yoshinori Taniguchi, Keisyun Nakamura, Hirofumi Nishikawa, Tatsuki Matsumoto, Taro Horino, Shimpei Fujimoto, Shigetoshi Sano, Motoko Yanagita, Yoshio Terada
Summary: Zeb2 plays a regulatory role in the pathogenesis of acute kidney injury (AKI) and AKI-to-chronic kidney disease (CKD) transition by regulating fibrotic pathways. Inhibition of Zeb2 could be a potential therapeutic strategy for AKI.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Roshan George, Ujjwal Sonika, Bhawna Mahajan, Ashok Sharma, Ashok Dalal, Sanjeev Sachdeva, Ajay Kumar
Summary: This study compared the diagnostic accuracy of urine neutrophil gelatinase-associated lipocalin (UNGAL) and renal resistive index (RRI) in predicting the type of acute kidney injury (AKI) in decompensated cirrhosis (DC) patients. The results showed that UNGAL has an excellent diagnostic accuracy in predicting ATN-AKI.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Critical Care Medicine
Anastasia Saade, Aurelie Bourmaud, David Schnell, Michael Darmon
Summary: This study aimed to evaluate the performance of resistive index and semiquantitative evaluation of renal perfusion according to the operator experience to predict short-term renal prognosis in critically ill patients. The results showed that operator experience did not affect the performance of these measurements in predicting renal recovery patterns.
CRITICAL CARE MEDICINE
(2022)
Article
Hematology
Sara Samoni, Gianluca Villa, Silvia De Rosa, Faeq Husain-Syed, Gabriele Guglielmetti, Lorenzo Tofani, Massimo De Cal, Federico Nalesso, Mario Meola, Claudio Ronco
Summary: The study revealed a significant association between IRRIV and RFR, with the IRRIV test showing 100% sensitivity and negative predictive value in predicting the presence of RFR. RFR predicted subclinical AKI, while the IRRIV test predicted subclinical AKI as well.
BLOOD PURIFICATION
(2022)
Article
Peripheral Vascular Disease
Rosario Cianci, Antonietta Gigante, Domenico Bagordo, Giovanni Pintus, Antonello Giovannetti, Silvia Lai, Sandro Mazzaferro, Edoardo Rosato
Summary: This retrospective observational study found that IgA nephropathy patients have lower RRI values compared to patients with renal scleroderma vasculopathy. Additionally, IgA nephropathy patients showed a higher prevalence of hypertension and were younger in age compared to the renal scleroderma vasculopathy patients.
MICROVASCULAR RESEARCH
(2021)
Article
Peripheral Vascular Disease
Diego Moriconi, Alessandro Mengozzi, Emiliano Duranti, Federica Cappelli, Stefano Taddei, Monica Nannipieri, Rosa Maria Bruno, Agostino Virdis
Summary: This study aimed to explore the relationship between peripheral microcirculation and renal hemodynamics in severely obese patients. The results showed that there was a correlation between renal resistive index (RRI) and microvascular remodeling in obese patients, indicating a tight pathophysiologic connection between renal hemodynamics and microcirculatory disruption.
JOURNAL OF HYPERTENSION
(2023)
Editorial Material
Acoustics
Enrico Giustiniano, Luca Pugliese, Lorenzo Calabro, Fulvio Nisi
Summary: RRI above 0.70 is associated with increased renal blood flow resistance, kidney injury, mortality rate in post-surgery patients, and high levels of serum C-reactive protein in COVID-19 subjects. It can be used as a tool to evaluate the course of critical illness.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Immunology
Reynold I. I. Lopez-Soler, Azadeh Nikouee, Matthew Kim, Saman Khan, Lakshmi Sivaraman, Xiangzhong Ding, Qun Sophia Zang
Summary: This study found that enhancing autophagy can reduce fibrosis caused by renal injury. By observing mice after kidney surgery, it was found that the use of active mutant Beclin-1 can inhibit the fibrosis process, alleviate inflammation and cellular stress response caused by kidney injury. These findings provide new methods for treating fibrosis after kidney transplantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Desiree Tampe, Laura Schridde, Peter Korsten, Philipp Stroebel, Michael Zeisberg, Samy Hakroush, Bjoern Tampe
Summary: Kidney fibrosis presents distinct patterns, including focal and diffuse fibrosis, associated with damage to different renal compartments. Certain renal pathologies may lead to the formation of focal and diffuse fibrosis, impacting renal outcomes.
Article
Nutrition & Dietetics
Priscila G. G. Pereira, Luciana L. L. Alves, Bianca T. T. Ciambarella, Kissila Rabelo, Ana Lucia R. Nascimento, Alan Cesar N. Moraes, Andressa Bernardi, Fernanda V. V. Guimaraes, Gabriela M. M. Carvalho, Jemima F. R. da Silva, Jorge J. J. de Carvalho
Summary: In this study, treatment with capybara oil (CO) was found to improve lipid profile and reduce blood pressure levels in obese mice. It also showed positive effects on renal histopathology, reducing inflammation, oxidative stress, and fibrosis. However, improvement in renal function was not significant.