Article
Clinical Neurology
Jennifer Weuve, Jennifer D'Souza, Todd Beck, Denis A. Evans, Joel D. Kaufman, Kumar B. Rajan, Carlos F. Mendes de Leon, Sara D. Adar
Summary: The study found that an increase in noise level was associated with higher odds of prevalent MCI and AD, as well as worse global cognitive performance, mainly in perceptual speed. However, the association with cognitive decline was not consistent.
ALZHEIMERS & DEMENTIA
(2021)
Article
Dentistry, Oral Surgery & Medicine
Elli Anna Kotsailidi, Catherine Gagnon, Lucy Johnson, Abdul Barmak Basir, Alexandra Tsigarida
Summary: This retrospective study evaluated the association between the use of selective serotonin reuptake inhibitors (SSRIs) and changes in peri-implant marginal bone levels. The results showed a significant correlation between SSRI use and marginal bone loss around dental implants.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Clinical Neurology
Lei Zhang, Xuan Liu, Tong Li, Bing Xu, Binfang Fu
Summary: The study found that fluoxetine may enhance cognitive ability in certain domains for patients with VCIND, and increase serum levels of BDNF and VEGF.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Medicine, General & Internal
Jakob Christensen, Betina B. Trabjerg, Yuelian Sun, Julie Werenberg Dreier
Summary: This study examined the association between maternal antidepressant prescription during pregnancy and standardized test scores among Danish schoolchildren. Results showed that children born to mothers filling antidepressant prescriptions during pregnancy had significantly lower math test scores but no significant difference in language test scores compared to children whose mothers did not fill antidepressant prescriptions. The difference in math scores was small and of uncertain clinical importance, suggesting the need to balance the findings against the benefits of treating maternal depression during pregnancy.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Jill S. S. Chotiyanonta, Kengo Onda, Milap A. A. Nowrangi, Xin Li, Xin Xu, Roy Adams, Constantine G. G. Lyketsos, Peter Zandi, Kenichi Oishi
Summary: This study aimed to investigate the responder rates of cholinesterase inhibitors and selective serotonin reuptake inhibitors in an outpatient setting using electronic medical records. The results showed that the medication effects were similar to previous clinical trials in various types of dementia patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Naiqi Zhang, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: This population-based cohort study suggests that the use of SSRIs is associated with a reduced risk of CRC among individuals with a family history of CRC. The decreased risk of CRC showed a non-linear, dose-dependent pattern. Furthermore, the use of SSRIs was strongly associated with advanced-stage CRC rather than early-stage CRC.
Review
Chemistry, Analytical
Ilona Oledzka, Alina Plenis, Piotr Kowalski, Tomasz Baczek, Anna Roszkowska
Summary: The pharmacotherapy of depression relies on different types of antidepressants, with SSRIs being the most commonly used first-line treatment. There is a growing demand for fast and accurate methods to monitor SSRI levels during depression therapy. Recent efforts have focused on developing instrumental methods that enable lower detection limits, better quantitation, and separation of multiple analytes, resulting in more reliable and selective determination of SSRIs. However, the preparation of biological samples for analysis remains a bottleneck in most analytical procedures. This review discusses recent advancements in methods for preparing various conventional and non-conventional complex biological matrices for precise determination of SSRI levels, as well as the advantages, challenges, and potential applications of these developed methodologies in clinical studies.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Anesthesiology
Li Wang, Joshua Tobe, Emily Au, Cody Tran, Jane Jomy, Yvgeniy Oparin, Rachel J. Couban, James Paul
Summary: The systematic review and meta-analysis found that SSRIs and SNRIs as adjuncts for postoperative pain management significantly reduced postoperative pain, opioid consumption, and improved patient satisfaction without increasing adverse events compared with placebo. SSRIs tend to be less effective than SNRIs, but the effects of SSRIs remain inconclusive due to limited evidence.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Clinical Neurology
Shuzhe Zhou, Qinhong Ma, Yiwei Lou, Xiaozhen Lv, Hongjun Tian, Jing Wei, Kerang Zhang, Gang Zhu, Qiaoling Chen, Tianmei Si, Gang Wang, Xueyi Wang, Nan Zhang, Yu Huang, Qi Liu, Xin Yu
Summary: This study utilized machine learning models to explore baseline variables for predicting the 8-week treatment outcome of patients with MDD receiving SSRIs. Results showed that neurocognitive functions and anxiety symptoms were important predictors, with SVM achieving an accuracy of 74.49% and sensitivity and specificity of 0.899 and 0.422, respectively.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Avital Fischer, Hedy S. Rennert, Gad Rennert
Summary: The study found that the use of SSRIs before and after breast cancer diagnosis is associated with increased mortality in breast cancer patients. Research is needed to further understand the mechanisms behind this association.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Psychiatry
Fredrik Hieronymus, Alexander Lisinski, Elias Eriksson, Soren Dinesen Ostergaard
Summary: This study analyzed patient-level data to assess the relationship between antidepressant side effects and HDRS-17 ratings, finding that some HDRS-17 items are associated with common antidepressant side effects, potentially leading to an underestimation of antidepressant efficacy.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Kinsley Tate, Brenna Kirk, Alisia Tseng, Abigail Ulffers, Karen Litwa
Summary: The developing prenatal brain is sensitive to environmental disturbances, with factors like pharmaceuticals potentially affecting synapse formation and increasing the risk of neurodevelopmental abnormalities. However, there is still a lack of research on how specific environmental factors impact the developing neural circuitry of the human brain. Recent studies show that the selective serotonin reuptake inhibitor fluoxetine can acutely alter synaptic function in developing neural circuits, but the effects are not long-lasting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Julie A. Vignato, S. Banu Gumusoglu, Heather A. Davis, Sabrina M. Scroggins, Wendy S. Hamilton, Debra S. Brandt, Gary L. Pierce, Boyd A. Knosp, Donna A. Santillan, Mark K. Santillan
Summary: Depression and preeclampsia are bi-directionally associated with each other, and SSRIs may attenuate the risk of preeclampsia. This study found that SSRIs use was associated with decreased risk of preeclampsia and reduced copeptin levels in early pregnancy, suggesting a potential therapeutic effect.
REPRODUCTIVE SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Michal Wicinski, Bartlomiej J. Kaluzny, Slawomir Liberski, Daria Marczak, Jakub J. Kaluzny
Summary: Acute angle closure (AAC) is a rare but serious ophthalmological condition, often associated with the use of selective serotonin reuptake inhibitors (SSRIs). AAC in individuals receiving SSRIs is mainly caused by pupillary block mechanism, but may also result from other mechanisms such as uveal effusion.
APPLIED SCIENCES-BASEL
(2021)
Review
Clinical Neurology
Julie E. M. Schulkens, Kay Deckers, Maud Jenniskens, Arjan Blokland, Frans R. J. Verhey, Sjacko Sobczak
Summary: This systematic literature review aims to summarize studies on the effects of SSRI treatment on memory functioning in older adults. Most studies found no association between SSRI use and memory functioning, while some studies even showed improvement in memory performance. Positive effects of SSRIs on memory functioning were particularly found in older adults with mental or neurological disorders such as depression or stroke.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)