Article
Genetics & Heredity
Xiaoyong Chen, Tongling Shan, Dage Sun, Huanjie Zhai, Sujie Dong, Ning Kong, Hao Zheng, Wu Tong, Guangzhi Tong
Summary: Porcine ZCCHC3 plays an inhibitory role in the proliferation of pseudorabies virus (PRV) by regulating cellular innate immune responses. Overexpression of ZCCHC3 inhibits viral titers and protein levels, while knockdown of ZCCHC3 promotes viral growth. ZCCHC3 overexpression upregulates IFN-beta expression to suppress viral replication. PRV infection reduces endogenous expression of ZCCHC3, and PRV-encoded UL13 and UL24 proteins inhibit ZCCHC3 expression, antagonizing its antiviral effect.
Article
Immunology
Yue Yin, Jinglin Ma, Cliff Van Waesberghe, Bert Devriendt, Herman W. W. Favoreel
Summary: This study investigates whether PRV triggers the expression of type I and III interferons and whether these interferons have antiviral activity against PRV in different porcine epithelial cells. The results show that the antiviral response and activity of type I and III interferons depend on the type of epithelial cells used, and it is the first time that type III interferon displays antiviral activity against PRV in respiratory and intestinal epithelial cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
James P. Cwick, Jonathan E. Owen, Irina Kochetkova, Kyle S. Hain, Nick Van Horssen, Matthew P. Taylor
Summary: Most viruses utilize superinfection exclusion (SIE) to conserve resources and control population dynamics. This study provides new insights into how alphaherpesviruses limit sequential infection through the undercharacterized gD-independent SIE, which differs between PRV and HSV-1.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Nele Zoellner, Noemi Coesfeld, Frederik Henry De Vos, Jennifer Denter, Haifeng C. Xu, Elena Zimmer, Birgit Knebel, Hadi Al-Hasani, Sofie Mossner, Philipp A. Lang, Doreen M. Floss, Juergen Scheller
Summary: Researchers found that synthetic type I interferon signaling mainly originates from IFNAR2, rather than IFNAR1, by reformatting the structure of IFNAR1 and IFNAR2.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Qi Wang, Daining Zhang, Wenjing Feng, Yidi Guo, Xiaoning Sun, Maolin Zhang, Zhenhong Guan, Ming Duan
Summary: This study found that the host lncRNA TSPOAP1-AS1 is significantly induced by influenza A virus (IAV) infection and is involved in viral replication through the regulation of the nuclear factor-kappa B signaling pathway. Overexpression of TSPOAP1-AS1 enhances viral replication, while inhibition of TSPOAP1-AS1 restricts viral replication. TSPOAP1-AS1 also negatively regulates the expression of interferon-stimulated genes.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Microbiology
Tonia Zangari, Mila B. Ortigoza, Kristen L. Lokken-Toyli, Jeffrey N. Weiser
Summary: The study found that infection of infants with Streptococcus pneumoniae can trigger inflammatory pathways to facilitate transmission, similar to influenza virus. By activating the type I interferon response, colonization of S. pneumoniae in the upper respiratory tract increases shedding and transmission by stimulating a wide array of genes, including those involved in mucin biosynthesis. This mechanism of S. pneumoniae contagion shared with viral infection highlights the importance of the induction of IFN-I signaling in driving respiratory contagion.
Review
Virology
Duncan W. Wilson
Summary: Alphaherpesviruses infect the mammalian nervous system through mucosal epithelia, establish latency in the peripheral nervous system, and rely on microtubule- and actin-dependent cellular motors for efficient transport of viral particles during assembly and egress.
Article
Immunology
Beibei Wu, Arunachalam Ramaiah, Gustavo Garcia, Spyridon Hasiakos, Vaithilingaraja Arumugaswami, Sonal Srikanth
Summary: This study revealed the different effects of ORAI1 and STIM1 on SARS-CoV-2 infection. Knockout of STIM1 resulted in enhanced resistance to viral infection, while ORAI1 deletion increased susceptibility. ORAI1-mediated Ca2+ signaling played an important role in regulating baseline IFN-I levels, determining host resistance to SARS-CoV-2 infection.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Virology
Mengdong Wang, Yun Liu, Chao Qin, Yue Lang, Aotian Xu, Cuilian Yu, Zhan Zhao, Rui Zhang, Jinbo Yang, Jun Tang
Summary: This study reveals that alphaherpesviruses can use their encoded early protein EP0 to inhibit the upregulation of antiviral proteins induced by IFN by reducing the basal expression levels of IRF9 through transcriptional repression. This finding elucidates a mechanism used by alphaherpesviruses to evade the immune response and suggests that EP0 is an important viral protein in pathogenesis and a potential target for antiviral drug development.
JOURNAL OF VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Shirin Hafezi, Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Hawra Ali Hussain Alsayed, Habiba Alsafar, Fatme Al Anouti, Qutayba Hamid, Rabih Halwani
Summary: Vitamin D has been found to enhance the immune response to SARS-CoV-2 and reduce the risk of death in severe COVID-19 patients. However, further mechanistic studies are needed to fully understand the antiviral effects of vitamin D in COVID-19 infection.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Yalan Lai, Xiaoyan Xia, Anchun Cheng, Mingshu Wang, Xumin Ou, Sai Mao, Di Sun, Shaqiu Zhang, Qiao Yang, Ying Wu, Dekang Zhu, Renyong Jia, Shun Chen, Mafeng Liu, Xin-Xin Zhao, Juan Huang, Qun Gao, Bin Tian, Yunya Liu, Yanling Yu, Ling Zhang, Leichang Pan
Summary: This study revealed that the 3C protein of DHAV-1 inhibits the production of IFN-β by targeting IRF7 protein, inhibits the nuclear translocation of IRF7 protein, and degrades IRF7 protein dependent on caspase 3, thereby promoting the replication of DHAV-1. The findings provide valuable insights into the infection and pathogenicity mechanisms of DHAV-1.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Yang Wang, Shuai Cui, Ting Xin, Xixi Wang, Hainan Yu, Shiyu Chen, Yajun Jiang, Xintao Gao, Yitong Jiang, Xiaoyu Guo, Hong Jia, Hongfei Zhu
Summary: This study discovered that the non-structural protein MGF360-14L of African swine fever virus inhibits interferon production by interfering with the host immune system. The study also revealed that MGF360-14L interacts with and degrades the IRF3 protein, further suppressing immune response.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anastasia S. Nikitina, Anastasia V. Lipatova, Anton O. Goncharov, Anna A. Kliuchnikova, Mikhail A. Pyatnitskiy, Ksenia G. Kuznetsova, Azzam Hamad, Pavel O. Vorobyev, Olga N. Alekseeva, Marah Mahmoud, Yasmin Shakiba, Ksenia S. Anufrieva, Georgy P. Arapidi, Mark V. Ivanov, Irina A. Tarasova, Mikhail V. Gorshkov, Peter M. Chumakov, Sergei A. Moshkovskii
Summary: This study compared the response of different cancer cell lines to type I interferon treatment in oncolytic therapy using vesicular stomatitis virus (VSV). The study identified differential effects and molecular factors by integrating analysis of transcriptome, proteome, and RNA editome. The results showed that inflammatory proteins and overexpression of EGFR and HER2 genes were associated with resistance and sensitivity to VSV, respectively. Furthermore, the protein expression level of HER2 in tumor cells might serve as a predictive biomarker for resistance to oncolytic viral therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Supeng Yin, Mengmeng Yuan, Sirui Zhang, Hongdan Chen, Jing Zhou, Tongyu He, Gang Li, Yanlan Yu, Fan Zhang, Ming Li, Yan Zhao
Summary: This study reveals that SspA-1 from the highly virulent Streptococcus suis 2 strain induces excessive inflammatory response through TLR2 endosomal and type I IFN signaling, uncovering a novel role of type I IFN in S. suis infection.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Takahiro Shoji, Jia Guo, Yingbin Ge, Yankui Li, Gang Li, Toru Ikezoe, Wei Wang, Xiaoya Zheng, Sihai Zhao, Naoki Fujimura, Jianhua Huang, Baohui Xu, Ronald L. Dalman
Summary: This study assessed the influence of type I interferon receptor deficiency on the formation and progression of experimental abdominal aortic aneurysms. The results showed that IFNAR1 deficiency can limit the progression of experimental AAA and suggest an important role for IFNAR1 in AAA pathogenesis.
Article
Cell Biology
Chuang Li, Qiongfang Peng, Xiao Wan, Haili Sun, Jun Tang
JOURNAL OF CELL SCIENCE
(2017)
Article
Multidisciplinary Sciences
Xiaohui Yu, Jinlong Cheng, Zirong He, Chuang Li, Yang Song, Jia Xue, Huiming Yang, Rui Zhang, Guozhong Zhang
SCIENTIFIC REPORTS
(2017)
Article
Biotechnology & Applied Microbiology
Fang Liu, Honglei Wang, Li Du, Zeyu Wei, Qiong Zhang, Wen-hai Feng
JOURNAL OF GENERAL VIROLOGY
(2018)
Article
Biochemistry & Molecular Biology
Qiong Zhang, Ti-Chun Chao, Veena S. Patil, Yue Qin, Shashi Kant Tiwari, Joshua Chiou, Alexander Dobin, Chih-Ming Tsai, Zhonghan Li, Jason Dang, Shagun Gupta, Kevin Urdahl, Victor Nizet, Thomas R. Gingeras, Kyle J. Gaulton, Tariq M. Rana
Article
Chemistry, Organic
Wen-Long Huang, Xu-Dong Wang, Sen Li, Rui Zhang, Yu-Fei Ao, Jun Tang, Qi-Qiang Wang, De-Xian Wang
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Microbiology
Ti-Chun Chao, Qiong Zhang, Zhonghan Li, Shashi Kant Tiwari, Yue Qin, Edwin Yau, Ana Sanchez, Gatikrushna Singh, Kungyen Chang, Marcus Kaul, Maile Ann Young Karris, Tariq M. Rana
Article
Oncology
Wencong Wang, Rui Zhang, Jinxing Wang, Jun Tang, Mingan Wang, Yu Kuang
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2020)
Article
Cell Biology
Shaobo Wang, Qiong Zhang, Shashi Kant Tiwari, Gianluigi Lichinchi, Edwin H. Yau, Hui Hui, Wanyu Li, Frank Furnari, Tariq M. Rana
Article
Immunology
Rui Zhang, Shifan Chen, Ying Zhang, Mengdong Wang, Chao Qin, Cuilian Yu, Yunfan Zhang, Yue Li, Liankai Chen, Xinrui Zhang, Xiufang Yuan, Jun Tang
Summary: The UL42 proteins of alphaherpesviruses can antagonize the IFN-I-induced JAK-STAT signaling pathway, suppressing the association of ISGF3 and ISRE, thereby contributing to immune evasion. This suggests UL42 as a potential antiviral target.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Microbiology
Lei Song, Yongchao Xie, Chuang Li, Lidong Wang, Chunlin He, Yong Zhang, Jingya Yuan, Jingjing Luo, Xi Liu, Yu Xiu, Hang Li, Marina Gritsenko, Ernesto S. Nakayasu, Yue Feng, Zhao-Qing Luo
Summary: The study reveals that SdjA functions as a dual enzyme, inhibiting the activity of SdeB and SdeC by glutamylation and acting as a deglutamylase to reverse SidJ-induced glutamylation on SdeA. This dual function of SdjA highlights the unique regulation of phosphoribosyl ubiquitination by the SidJ effector family.
Article
Biochemistry & Molecular Biology
Rui Zhang, Teng Xue, Anwen Shao, Yue Lang, Chao Qin, Mingliang Zhao, Yu Kuang, Zhengquan Yu, Yunyun Geng, Chenyang Zhao, Jun Tang
Summary: TNF stimulation generates pro-survival signals by activating NF-kappa B and restricting death signaling. Bclaf1 has been identified as a novel component of TNF anti-apoptotic program, promoting CFLAR transcription downstream of NF-kappa B activation. The depletion of Bclaf1 sensitizes cells to TNF-induced apoptosis and exacerbates small intestine injury in mice.
Article
Cell Biology
Rui Zhang, Di Cui, Teng Xue, Yue Lang, Yunfan Zhang, Lianjie Li, Haili Sun, Yu Kuang, Gebin Li, Jun Tang
JOURNAL OF MOLECULAR CELL BIOLOGY
(2020)