Article
Biotechnology & Applied Microbiology
Xubing Long, Ziwei Yang, Yang Li, Qinqin Sun, Xiaojuan Li, Ersheng Kuang
Summary: The study reveals that BRLF1 regulates cellular and viral gene expression and transcription during EBV primary infection, impacting pathways such as DNA replication and metabolism. BRLF1 binds to transcription factors and spliceosome components, influencing RNA polymerase II-dependent transcription and pre-mRNA splicing.
Article
Microbiology
Quincy Rosemarie, Elijah Kirschstein, Bill Sugden
Summary: We have discovered how Epstein-Barr virus (EBV) induces the reorganization of cellular chromatin, with viral DNA replication occurring in the chromatin-free regions. Five families of DNA viruses induce similar reorganization, and they infect a variety of hosts. The viral genes and processes required for EBV's chromatin reorganization have been identified, and a two-step model for the process has been proposed. The importance of chromatin reorganization in viral life cycles is emphasized. Overall, a 9 out of 10 score is given for the importance of this research.
Article
Immunology
Noam Kadouri, Tal Givony, Shir Nevo, Joschka Hey, Shifra Ben Dor, Golda Damari, Bareket Dassa, Jan Dobes, Dieter Weichenhan, Marion Bahr, Michelle Paulsen, Rebecca Haffner-Krausz, Marcus A. Mall, Christoph Plass, Yael Goldfarb, Jakub Abramson
Summary: This study reveals the importance of FOXN1 in the development of thymic epithelial cells and hair follicle cells, and identifies key regulatory regions and transcription factors involved in its expression.
SCIENCE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xubing Long, Jing Yang, Xiaolin Zhang, Ziwei Yang, Yang Li, Fan Wang, Xiaojuan Li, Ersheng Kuang
Summary: The study reveals that Epstein-Barr virus lytic replication inhibits inflammasome activation through the immediate-early protein BRLF1, leading to altered immune responses in T cells and NK cells.
Article
Multidisciplinary Sciences
Yoshimi Enose-Akahata, Limin Wang, Fahad Almsned, Kory R. Johnson, Yair Mina, Joan Ohayon, Xin Wei Wang, Steven Jacobson
Summary: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), and the cause of MS remains unknown. This study investigated the antibody responses against various viruses in the cerebrospinal fluid (CSF) and serum of MS patients, and found significant differences compared to healthy volunteers, as well as a pattern of antibody responses against multiple viruses, including Epstein-Barr virus. These findings indicate that virus-specific antibody signatures might reflect the disease-associated inflammatory milieu in the CSF of patients with neuroinflammatory diseases.
Review
Biochemistry & Molecular Biology
Leila Sawada, Antonio Carlos Rosario Vallinoto, Igor Brasil-Costa
Summary: EBV is an oncovirus associated with various types of cancer, with the reason for cancer development in only some infected individuals still unknown. EBV-associated cancers are more aggressive and resistant to treatment compared to EBV-negative cancers, making monoclonal antibodies targeting immune checkpoints a potential therapy.
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Biophysics
Han-Yun Hsieh, Ray Chang, Yung-Yu Huang, Po-Han Juan, Hidetoshi Tahara, Kuan-Yi Lee, Di Ngoc Kha Vo, Ming-Han Tsai, Pei-Kuen Wei, Horn-Jiunn Sheen, Yu-Jui Fan
Summary: This study successfully detected the DNA sequence of LMP1 using a combination of microfluidic PCR and gold nanoslit-based SPR sensor, achieving rapid and accurate analytical procedures, as well as enhancing the detection efficiency of DNA extracted from EBV-positive cells.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Cell Biology
Zhiwen Fan, Ming Kong, Xiulian Miao, Yan Guo, Haozhen Ren, Jinglin Wang, Shuai Wang, Ning Tang, Longcheng Shang, Zhengyi Zhu, Hanyi Liu, Wei Zhu, Xiaolei Shi
Summary: The research identified a novel epigenetic pathway in which an E2F5-TFDP1-BRG1 complex regulates MYCN transcription to promote liver regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Virology
Sukhum Silpa-Archa, Wararee Sriyuttagrai, C. Stephen Foster
Summary: There are still many research challenges and unanswered questions in relation to Epstein-Barr virus-associated uveitis, including the presence of viral DNA in asymptomatic patients, its pathogenicity in uveitis eyes, and the effectiveness of antiviral therapy. A retrospective review was conducted on data collected from a Thai hospital's Ophthalmology Department, revealing that patients with EBV infection may also be co-infected with other pathogens. Most cases showed clinical improvement with systemic acyclovir and ganciclovir treatment, and the majority of patients achieved a cure for the EBV infection.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Article
Hematology
Hannes Vietzen, Philippe L. Furlano, Jan J. Cornelissen, Georg A. Boehmig, Peter Jaksch, Elisabeth Puchhammer-Stoeckl
Summary: This study found that nonclassic human leukocyte antigen E (HLA-E)-restricted immune responses have a significant impact on the development of Epstein-Barr virus (EBV) diseases in the individual host. The highly expressed HLA-E*0103/0103 genotype is protective against infectious mononucleosis (IM) by inducing potent EBV BZLF1-specific HLA-E-restricted CD8(+) T-cell responses. Variations in the inhibitory NKG2A/LMP-1/HLA-E axis are associated with the risk of symptomatic EBV reactivations in both immunocompetent individuals and immunocompromised transplant recipients.
Article
Multidisciplinary Sciences
Munetoshi Hinata, Tetsuo Ushiku
Summary: A histology-based deep learning model was constructed to efficiently screen EBV and MSI/dMMR subtypes in gastric cancers, showing high accuracy in detecting the subgroup and highlighting intraepithelial lymphocytosis as a discriminative characteristic shared by EBV and MSI/dMMR tumors. This model offers a potential economical and less time-consuming alternative for stratifying patients who respond to ICIs.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Francesco Baccianti, Charlene Masson, Susanne Delecluse, Zhe Li, Remy Poirey, Henri-Jacques Delecluse
Summary: EBV efficiently infects and transforms B lymphocytes by activating viral gene expression and manipulating cellular pathways to limit the immune response, according to this study. The viral particle components sequentially activate proinflammatory B lymphocyte signaling pathways, leading to viral gene expression and cytokine release. However, infection also triggers the expression of ZFP36L1, a stress protein that limits the cytokine response. This study highlights the complex interactions between EBV and host cells during infection and transformation.
Article
Biochemical Research Methods
Hansaim Lim, Chung-Jung Tsai, Ozlem Keskin, Ruth Nussinov, Attila Gursoy
Summary: HMI-PRED 2.0 is a publicly available web service that predicts host-microbe protein-protein interaction using interface mimicry. It aims to be user-friendly without requiring extensive computational experience.
Article
Medicine, General & Internal
Yin Xu, Ayako Hiyoshi, Kelsi A. Smith, Fredrik Piehl, Tomas Olsson, Katja Fall, Scott Montgomery
Summary: The study suggests that having infectious mononucleosis in childhood and especially adolescence is a risk factor associated with a diagnosis of multiple sclerosis, independent of shared familial factors.
Article
Pharmacology & Pharmacy
Chung-Chun Wu, Chih-Yeu Fang, Hui-Yu Hsu, Yen-Ju Chen, Sheng-Ping Chou, Sheng-Yen Huang, Yu-Jhen Cheng, Su-Fang Lin, Yao Chang, Ching-Hwa Tsai, Jen-Yang Chen
ANTIVIRAL RESEARCH
(2016)
Article
Virology
Chung-Pei Lee, Guan-Ting Liu, Hsiu-Ni Kung, Po-Ting Liu, Yen-Tzu Liao, Lu-Ping Chow, Ling-Shih Chang, Yu-Hsin Chang, Chou-Wei Chang, Wen-Chi Shu, Annie Angers, Antonella Farina, Su-Fang Lin, Ching-Hwa Tsai, Fadila Bouamr, Mei-Ru Chen
JOURNAL OF VIROLOGY
(2016)
Article
Oncology
Chung-Chun Wu, Chih-Yeu Fang, Hui-Yu Hsu, Hsin-Ying Chuang, Yu-Jhen Cheng, Yen-Ju Chen, Sheng-Ping Chou, Sheng-Yen Huang, Su-Fang Lin, Yao Chang, Ching-Hwa Tsai, Jen-Yang Chen
Article
Virology
Yen-Ju Chen, Yu-Lian Chen, Yao Chang, Chung-Chun Wu, Ying-Chieh Ko, Sai Wah Tsao, Jen-Yang Chen, Su-Fang Lin
JOURNAL OF VIROLOGY
(2017)
Article
Oncology
Sheng-Yen Huang, Chung-Chun Wu, Yu-Jhen Cheng, Sheng-Ping Chou, Yun-Jin Jiang, Kuo-Chang Chu, Ching-Hwa Tsai, Su-Fang Lin, Jen-Yang Chen
Article
Virology
Shih-Hsin Chiu, Meng-Chuan Wu, Chung-Chun Wu, Yu-Ching Chen, Su-Fang Lin, John T. -A. Hsu, Chung-Shi Yang, Ching-Hwa Tsai, Kenzo Takada, Mei-Ru Chen, Jen-Yang Chen
JOURNAL OF VIROLOGY
(2014)
Article
Biochemistry & Molecular Biology
Chung-Chun Wu, Hsin-Ying Chuang, Chao-Yi Lin, Yen-Ju Chen, Wan-Hua Tsai, Chih-Yeu Fang, Sheng-Yen Huang, Fu-Yang Chuang, Su-Fang Lin, Yao Chang, Jen-Yang Chen
MOLECULAR CARCINOGENESIS
(2013)
Article
Multidisciplinary Sciences
Richard Park, Ayman El-Guindy, Lee Heston, Su-Fang Lin, Kuan-Ping Yu, Mate Nagy, Sumit Borah, Henri-Jacques Delecluse, Joan Steitz, George Miller
Meeting Abstract
Oncology
Su-Fang Lin, Ying-Chieh Ko, Fu-Hui Wang, Sheng-Yao Su, Yu-Lian Chen, Ting-Yu Lai, Yi-Hong Liu, Chung-Yen Lin, Shu-Ching Hsu
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Oncology
Sung-Tau Chou, Hsuan-Yu Peng, Kuan-Chi Mo, Yuan-Ming Hsu, Guan-Hsun Wu, Jenn-Ren Hsiao, Su-Fang Lin, Horng-Dar Wang, Shine-Gwo Shiah
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Chung-Chun Wu, Mei-Shu Chen, Yu-Jhen Cheng, Ying-Chieh Ko, Su-Fang Lin, Ing-Ming Chiu, Jen-Yang Chen
Article
Oncology
Yu-Lian Chen, Wan-Hua Tsai, Ying-Chieh Ko, Ting-Yu Lai, Ann-Joy Cheng, Shine-Gwo Shiah, Jenn-Ren Hsiao, Jang-Yang Chang, Su-Fang Lin
Article
Oncology
Ying-Chieh Ko, Ting-Yu Lai, Shu-Ching Hsu, Fu-Hui Wang, Sheng-Yao Su, Yu-Lian Chen, Min-Lung Tsai, Chung-Chun Wu, Jenn-Ren Hsiao, Jang-Yang Chang, Yi-Mi Wu, Dan R. Robinson, Chung-Yen Lin, Su-Fang Lin
Article
Medicine, Research & Experimental
Ya-Chu Tang, Jenn-Ren Hsiao, Shih-Sheng Jiang, Jang-Yang Chang, Pei-Yi Chu, Ko-Jiunn Liu, Hsun-Lang Fang, Li-Mei Lin, Huang-Hui Chen, Yen-Wen Huang, Yu-Tsen Chen, Fang-Yu Tsai, Su-Fang Lin, Yung-Jen Chuang, Ching-Chuan Kuo
Summary: NRF2, up-regulated in HNSCC, correlates positively with malignant features. Carcinogens trigger c-MYC-directed NRF2 activation. NRF2 reprograms cancer metabolic pathways, particularly the PPP, with G6PD and TKT driving malignant progression. The NRF2/G6PD/TKT gene set may serve as a prognostic biomarker for patient overall survival.