Journal
JOURNAL OF VIROLOGY
Volume 91, Issue 14, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01083-16
Keywords
Kaposi's sarcoma-associated herpesvirus; LANA speckles; cytoplasmic DNA sensors; cytoplasmic variants; structure; virus persistence
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [SFB900]
- DFG [IRTG 1273]
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Kaposi's sarcoma herpesvirus (KSHV) establishes lifelong latency. The viral latency-associated nuclear antigen (LANA) promotes viral persistence by tethering the viral genome to cellular chromosomes and by participating in latent DNA replication. Recently, the structure of the LANA C-terminal DNA binding domain was solved and new cytoplasmic variants of LANA were discovered. We discuss how these findings contribute to our current view of LANA structure and assembly and of its role during viral persistence.
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