Article
Medicine, General & Internal
Mohamed A. Elsebaey, Tamer A. Elbedewy, Heba Elashry, Waleed Elrefaey, Samah A. Elshweikh, Ahmed A. Elhadidy, Neveen A. Shalaby, Assem Mohamed Elsokkary, Hossam Eldin A. Elashtokhy, Yousry Esam-Eldin Abo-Amer, Ashraf Rafat Abo-Elfetoh, Sharaf Elsayed Ali Hassanien, Amina Fouad, Raghda Samir Abdellatif, Amro Abdelaziz Mohammed Ismail
Summary: This study aimed to assess the incidence of HBV reactivation and HBV-related hepatitis in patients with resolved HBV infection receiving immunosuppressive therapy. The results showed that close monitoring was as effective as antiviral prophylaxis in preventing HBV reactivation in these patients.
Review
Gastroenterology & Hepatology
Ferenci Peter, Reiberger Thomas, Stadlbauer Vanessa, Zoller Heinz
Summary: The introduction of Hepatitis B Immunoglobulins (HBIg) prophylaxis has improved long-term survival for liver transplant patients with chronic hepatitis B virus (HBV) infection. However, it is unclear whether long-term HBIg prophylaxis is necessary for patients co-infected with hepatitis D virus (HDV) and HBV.
LIVER INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
George V. Papatheodoridis, Vasileios Lekakis, Thodoris Voulgaris, Pietro Lampertico, Thomas Berg, Henry L. Y. Chan, Jia-Horng Kao, Norah Terrault, Anna S. Lok, K. Rajender Reddy
Summary: This study conducted a systematic review and meta-analysis on the risk of HBV reactivation associated with different classes of immunosuppressive and immunomodulatory therapies. The findings indicate varying levels of HBV reactivation risk among different drugs. The study provides recommendations for NA prophylaxis and monitoring based on the risk level of the drugs.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Samuel Anthony Lachlan Hall, Sara Vogrin, Olivia Wawryk, Gareth S. Burns, Kumar Visvanathan, Vijaya Sundararajan, Alexander Thompson
Summary: A meta-analysis was conducted on clinical outcomes after nucleot(s)ide analogue (NA) discontinuation for HBeAg-negative CHB patients, revealing that virological relapse is common but clinical relapse occurs in only one-third of patients at 12 months post-NA discontinuation. Discontinuation of NA therapy can lead to HBsAg clearance, with higher rates observed with longer follow-up periods.
Article
Surgery
Hsin-Ju Tsai, Ming-Ju Wu, Cheng-Hsu Chen, Sheng-Shun Yang, Yi-Hsiang Huang, Yan-Zin Chang, Horng-Rong Chang, Teng-Yu Lee
Summary: This hospital-based retrospective cohort study found that the prophylaxis strategy for HBV reactivation in kidney transplant recipients with resolved HBV infection remains unclear. The absence of anti-HBs antibody and the use of high-dose steroids were identified as independent risk factors for HBV reactivation. Therefore, the strategy of HBV antiviral prophylaxis may be defined according to the risk stratification.
TRANSPLANT INTERNATIONAL
(2023)
Review
Virology
Wei Huang, Lingyao Du, Hong Tang
Summary: Hepatitis B virus can hide in the liver in the form of covalently closed circular DNA and reactivate when there are changes in immunity. The risk of reactivation is influenced by virological, medication, and host factors. Promoting clinical screening for HBV is crucial for early detection and prevention of high-risk patients.
Review
Medicine, General & Internal
Jin-Feng Liu, Tian-Yan Chen, Ying-Ren Zhao
Summary: The implementation of hepatitis B vaccine has significantly reduced the prevalence of HBV, with antiviral prophylaxis during pregnancy proving to be effective in preventing vertical transmission. However, there are still gaps in perfect strategies versus real-world application, including the need for comprehensive long-term safety profiles of antiviral prophylaxis and the necessity of timely birth dose vaccine and HBIG coverage. Feasible and cost-effective preventive strategies need to be determined across regions to meet the demands for prophylaxis and prevalence targets.
CHINESE MEDICAL JOURNAL
(2021)
Article
Immunology
Suhail A. Shaikh, Jeffrey Kahn, Andraea Aksentijevic, Pnada Kawewat-Ho, Alexandra Bixby, TrisAnn Rendulic, Jeong M. Park
Summary: The prevalence of HBV reactivation in HBsAg-negative anti-HBc-positive kidney transplant recipients is low regardless of antiviral prophylaxis. Furthermore, there were no significant graft-related outcomes among those that did experience reactivation.
TRANSPLANT INFECTIOUS DISEASE
(2022)
Article
Gastroenterology & Hepatology
Xiaoguang Wang, Xiaodan Yang, Fei Chen, Shaohan Wu, Zhengwei Song, Jianguo Fei
Summary: The study found that some patients with primary hepatocellular carcinoma may experience HBV reactivation after TACE therapy, with positive HBV test and immunosuppression being the main risk factors. HBV reactivation may lead to poor prognosis and lower survival rates, highlighting the importance of timely antiviral therapy and immune enhancers.
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Oncology
Xing Cao, Yafei Wang, Panyun Li, Wei Huang, Xiaojuan Lu, Hongda Lu
Summary: HBV-R is a common and dangerous complication during the treatment of NHL patients, potentially leading to increased morbidity and mortality. Immunosuppressive therapies increase the risk of HBV-R, highlighting the importance of enhanced screening and monitoring measures.
FRONTIERS IN ONCOLOGY
(2021)
Article
Microbiology
Chunyan Yuan, Jing Peng, Renxiang Xia, Jian He, Tianji Qiu, Yunqing Yao
Summary: This study reports a middle-aged female patient with occult hepatitis B virus infection (OBI) who experienced HBV reactivation during intermittent entecavir antiviral therapy. Genetic analysis revealed mutations in the S gene region and a drug resistance mutation. The case highlights the importance of genotype, mutation, and drug resistance gene testing in the diagnosis and treatment of OBI.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Chen Pan, Mingnan Cao, Cilin Yan, Xiaojuan Ou, Xia Zhang, Wanyi Xu, Ye Xu, Xiangli Cui
Summary: Recently, clinical reports have shown an association between hepatitis B virus reactivation (HBVr) and Janus kinase (JAK) inhibitors. This study aimed to investigate the association between HBVr and different JAK inhibitors by utilizing the FAERS pharmacovigilance database. The results indicated a potential association between JAK inhibitors and HBVr, with baricitinib showing the strongest signal among the four JAK inhibitors.
EXPERT OPINION ON DRUG SAFETY
(2023)
Article
Gastroenterology & Hepatology
Hye-Lin Kim, Gi-Ae Kim, Jae-A Park, Hye-Rim Kang, Eui-Kyung Lee, Young-Suk Lim
Summary: This study found that starting antiviral therapy in the immune-tolerant phase is more cost-effective compared with delaying treatment until the active hepatitis phase in CHB patients, especially with increasing hepatocellular carcinoma risk, decreasing drug costs, and consideration of productivity loss.
Article
Immunology
Ying Lu, Yarong Song, Xiangjun Zhai, Fengcai Zhu, Jianxun Liu, Zhanjun Chang, Yi Li, Yiwei Xiao, Lili Li, Minmin Liu, Jia Liu, Zhongping Duan, Huaibin Zou, Hui Zhuang, Jie Wang, Jie Li
Summary: This study demonstrated that maternal HBeAg can serve as a surrogate marker for monitoring HBV DNA and evaluating the necessity of antiviral prophylaxis in preventing perinatal HBV transmission.
EMERGING MICROBES & INFECTIONS
(2021)
Review
Urology & Nephrology
Craig E. Gordon, Gaelen P. Adam, Michel Jadoul, Paul Martin, Ethan M. Balk
Summary: This study systematically reviewed the efficacy of kidney transplantation from HCV-infected donors to uninfected recipients, followed by DAA treatment.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Shuxian Wang, Zhang Qian, Xie Ge, Chuwei Li, Mengqi Xue, Kuan Liang, Rujun Ma, Lei Ouyang, Lu Zheng, Jun Jing, Siyuan Cao, Yu Zhang, Yang Yang, Yabing Chen, Jinzhao Ma, Bing Yao
Summary: Sertoli cells play a crucial role in spermatogenesis by forming the blood-testis barrier (BTB) and creating a unique microenvironment. This study reveals that a high-fat diet impairs BTB integrity and decreases sperm quality. The long noncoding RNA (lncRNA) Tug1 is found to be involved in the disruption of BTB by regulating Ccl2 and tight junction (TJ)-related proteins. Mechanistically, Tug1 directly binds to EZH2 and regulates H3K27me3 occupancy in the Ccl2 promoter region.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Siyuan Cao, Zhang Qian, Ronghua Wu, Shanshan Sun, Jun Jing, Guangyun Zhang, Weiqing Chen, Yifeng Ge, Jinzhao Ma, Shuxian Wang, Lei Ouyang, Tongmin Xue, Dandan Wang, Shanmeizi Zhao, Kuan Liang, Xie Ge, Ying Lin, Li Chen, Bing Yao
Summary: Adding mouse cumulus-oocyte complexes (COCs) to human tubal fluid (HTF) medium can enhance the fertilization rate and the number of sperm combined with the zona pellucida during sperm capacitation.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Emily A. Telford, Andrew J. Sanders, Sioned Owen, Fiona Ruge, Gregory M. Harrison, Wen G. Jiang, Tracey A. Martin
Summary: This study found that expression of HAVcR-1 is decreased in patients with prostate cancer, and the levels of HAVcR-1 ectodomain in serum are associated with the severity of the disease. In cell experiments, overexpression of HAVcR-1 led to changes in cell behavior and was associated with dysregulation of junctional complexes.
Article
Biochemistry & Molecular Biology
Yi Ming Yang, Lin Ye, Fiona Ruge, Ziqian Fang, Ke Ji, Andrew J. J. Sanders, Shuqin Jia, Chunyi Hao, Q. Ping Dou, Jiafu Ji, Wen G. G. Jiang
Summary: This study investigated the potential roles of ALCAM in peritoneal transcoelomic metastasis in gastrointestinal cancers. It was found that high levels of ALCAM expression were associated with shorter peritoneal metastasis-free survival. Additionally, ALCAM played a role in the adhesion between tumor cells and peritoneal mesothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Chengcheng Hao, Jane Lane, Wen G. Jiang
Summary: Cancer is a major cause of death worldwide, and drug resistance is a significant obstacle in cancer treatment. Osteopontin (OPN) is a protein that is overexpressed in various types of tumors and is involved in multiple cellular processes related to drug resistance. Understanding the role of OPN in cancer drug resistance may have implications for improving cancer therapy by reducing drug resistance in sensitive tumors.
Article
Biochemistry & Molecular Biology
Sarah Koushyar, Pinar Uysal-Onganer, Wen Guo Jiang, Dafydd Alwyn Dart
Summary: Prohibitin (PHB) is a tumor suppressor gene that has multiple molecular activities. Overexpression of PHB leads to cell cycle arrest in the G1/S phase and represses the androgen receptor (AR) in prostate cancer cells. PHB interacts and represses members of the E2F family, which may also be linked to AR, making the AR:PHB:E2F interaction axis highly complex. Knockdown of PHB using siRNA increased the growth and metastatic potential of LNCaP mouse xenografts. On the other hand, ectopic overexpression of PHB affected the expression of several hundred genes in LNCaP cells, including downregulated expression of WNT family members and cell adhesion pathways. Online data analysis showed decreased PHB expression in clinical cases of metastatic prostate cancer, and its expression was correlated with higher WNT expression in metastasis. Overexpression of PHB reduced cell migration, motility, invasion, and attachment in prostate cancer cells. Mechanistically, AR was found to be involved in the regulation of the WNT genes, and these WNTs were also regulated by the cell cycle. Therefore, the repressive effects of PHB on AR, E2F, and WNT expression suggest its importance in inhibiting prostate cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bethan A. Frugtniet, Fiona Ruge, Andrew J. Sanders, Sioned Owen, Keith G. Harding, Wen G. Jiang, Tracey A. Martin
Summary: This study found that nWASP expression was significantly increased in non-healing chronic wounds and its inhibition improved cellular behavior and wound healing. TrkB and PLC gamma 1 signaling pathways were identified as important regulators of nWASP. Therefore, nWASP is considered a new therapeutic target for non-healing wounds.
Article
Oncology
Yuqi Li, Rongrong Li, Xu Luo, Fang Xu, Meizi Yang, Lanhui Zheng, Qihao Wu, Wenguo Jiang, Yana Li
Summary: This study investigated the effect of vascular endothelial growth factor B (VEGFB) on regulating insulin secretion in type 2 diabetes mellitus (T2DM) and its underlying mechanism. The results showed that knockout of VEGFB exacerbated the decrease in insulin secretion in T2DM mice, while overexpression of VEGFB improved glucose tolerance and insulin sensitivity. VEGFB activated the Ca2+/CaMK2 pathway via VEGFR1-PLC gamma and IP3R pathway to regulate insulin secretion in T2DM.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Chemistry, Medicinal
Zhenhong Xia, Xiaoran Liu, Yuqi Li, Zhiqi Li, Feixue Ni, Geng Tian, Wenguo Jiang
Summary: The results of this study suggest that isobavachalcone acts through the PI3K/AKT signaling pathway in the liver to control the development of type 2 diabetes mellitus and regulate glucose and lipid metabolism.
NATURAL PRODUCT COMMUNICATIONS
(2023)
Correction
Physics, Multidisciplinary
Baishan Hu, Weiguang Jiang, Takayuki Miyagi, Zhonghao Sun, Andreas Ekstroem, Christian Forssen, Gaute Hagen, Jason D. Holt, Thomas Papenbrock, S. Ragnar Stroberg, Ian Vernon
Article
Materials Science, Ceramics
Zexu Sun, Haozhang Hou, Bo Sun, Wenguo Jiang, Shengkai Gong, Yi Ru
Summary: This study investigates the influence of different heat treatment atmospheres on the microstructural and mechanical behaviors of SiC-ZrC fibers. Experimental results show that the fibers' mechanical performance declines under vacuum and argon environments. Under vacuum conditions, the amorphous phase decomposes and crystallinity increases, but no clustering of ZrC phase is observed. In contrast, under argon conditions, the amorphous phase decomposes and clustering of ZrC particles occurs, resulting in inferior mechanical properties of the fibers.
CERAMICS INTERNATIONAL
(2023)
Article
Physics, Nuclear
C. J. Yang, W. G. Jiang, S. Burrello, M. Grasso
Summary: This study proposes a novel method for handling interactions between nuclear matter and finite nuclei, through iterations of interactions and enlargements of the model space under EDF theories, combining principles of effective field theory and ab initio approaches.
Article
Biochemistry & Molecular Biology
Laijian Sui, Andrew Sanders, Wen G. Jiang, Lin Ye
Summary: This study identified key biomarkers, such as GDF11, CD151, PAFAH1B2, YTHDF2, as well as DPP9, FAS, ZNF519, RPP14, FAU, that play important roles in breast cancer bone metastasis, providing potential targets for therapeutic intervention.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Correction
Gastroenterology & Hepatology
Xuefei Dong, Yuxin Cui, Tracey A. Martin, Jiafu Ji, Chunyi Hao, Wen G. Jiang
Correction
Gastroenterology & Hepatology
Xuefei Dong, Yuxin Cui, Fiona Ruge, Tracey A. Martin, Rachel Hargest, Wen G. Jiang
