Article
Agriculture, Dairy & Animal Science
Aaron Forga, Kabel Robbins, Andrew Smith, Makenly Coles, Guillermo Tellez-Isaias, Christine N. Vuong, Billy Hargis, Danielle Graham
Summary: Clostridial cellulitis or dermatitis affects commercial turkey flocks and has been controlled with antibiotics, but alternatives are needed. Bacterin-toxoid vaccination programs have been effective in preventing clostridial diseases. Further research is proposed to understand the relationship between culture phase and antigenic components produced by CS.
Article
Veterinary Sciences
Hakan Kalender, Hasan Ongor, Necati Timurkaan, Burcu Karagulle, Burak Karabulut, Canan Akdeniz Incili, Hatip Enfal Basar, Elif Ekinci, Aydin Cevik, Eray Atil, Burhan Cetinkaya
Summary: This study investigated the frequency and presence of virulence genes of Clostridium perfringens, Paeniclostridium sordellii, and Clostridium septicum in lambs and goat kids with hemorrhagic abomasitis in eastern Turkey. C. perfringens type A was the most frequently detected species, and the toxin gene cpb2 was found in some samples. Vaccination of pregnant animals with toxoid vaccines was suggested for the protection of newborn animals against Clostridial infections.
BMC VETERINARY RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Xieying Ding, Xin Zhong, Yunqiao Yang, Geyin Zhang, Hongbin Si
Summary: This study confirmed the combined inhibitory effect of citric acid (CA) and magnolol (MA) on C. perfringens. The optimal ratio of CA to MA was found to be 50:3, with a dosage of 265 μg/mL inhibiting the growth of C. perfringens and causing damage to its cell structure. The combination of CA and MA exhibited therapeutic effects on C. perfringens challenge in chickens by inhibiting inflammation and enhancing antioxidant capability. Rating: 8/10.
Article
Biotechnology & Applied Microbiology
Mohammad Ali Shamshirgaran, Mehdi Golchin, Elham Mohammadi
Summary: In this study, a recombinant Lactobacillus casei strain expressing the NetB protein of Clostridium perfringens was used as a probiotic-based vector vaccine to immunize broiler chickens against necrotic enteritis. The vaccinated birds showed significant protection against the disease and developed strong antibody responses. This study suggests that a probiotic-based vector vaccine could be a promising candidate for controlling necrotic enteritis in broiler chickens.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Veterinary Sciences
Hyun-Gwan Lee, Yoo-Bhin Kim, Sang-Hyeok Lee, Jun-Ok Moon, Jong-Pyo Chae, Yu-Jin Kim, Kyung-Woo Lee
Summary: The study aimed to evaluate the antibacterial effects of bacteriophages (BPs) in broiler chickens challenged with Clostridium perfringens. The results showed that dietary encapsulated or powdered BPs reversed the C. perfringens-induced increase in crypt depth and reduced C. perfringens counts in the cecum. Chickens fed with encapsulated BPs also had higher serum IgA levels.
VETERINARY SCIENCES
(2022)
Article
Physiology
Xiao Xu, Shunli Yang, Joshua Seun Olajide, Zigang Qu, Zhenxing Gong, Jing Wang, Yanbing Zhang, Heng Wang, Ling Xiong, Kun Zhang, Enmin Zhou, Jianping Cai
Summary: The study showed that dietary supplementation of C. butyricum in broilers with necrotic enteritis (NE) improved chicken growth performance, intestinal integrity and barrier function, and immunological status. The supplementation enhanced weight gain, protected intestinal morphology, and reduced susceptibility to C. perfringens infection. No statistically significant difference was observed between adding C. butyricum on day 1 or day 14.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Ali Daneshmand, Hassan Kermanshahi, Javid Mohammed, Mohammad Hadi Sekhavati, Ali Javadmanesh, Monireh Ahmadian, Marzieh Alizadeh, Jamshid Razmyar, Raveendra R. Kulkarni
Summary: This study evaluated the effects of C. perfringens on the intestines, microbial colonization, and immune responses in broiler chickens. The results showed that C. perfringens can cause intestinal damage, changes in microbial populations, and trigger host immune responses. Furthermore, using coccidia and a wheat-based diet predisposition may facilitate better research on C. perfringens.
Article
Agriculture, Dairy & Animal Science
Shifeng Wang, Charles L. Hofacre, Soo-Young Wanda, Jingyu Zhou, Richard A. Callum, Bob Nordgren, Roy Curtiss
Summary: We have improved a vaccine for C. perfringens by integrating a triple-sugar regulation system and a DsifA mutation, which resulted in increased protection and a safer profile.
Article
Agriculture, Dairy & Animal Science
Fangshen Guo, Fangyuan Wang, Haiyan Ma, Zhouzheng Ren, Xiaojun Yang, Xin Yang
Summary: The study reveals that dietary deoxynivalenol and Clostridium perfringens challenge have harmful effects on the jejunal health of broiler chickens, affecting mucosal expression and intestinal microbiota composition.
Article
Immunology
Jin Liu, Shuangqi Wu, Honghao Zhao, Chun Ye, Shulin Fu, Yu Liu, Ting Liu, Yinsheng Qiu
Summary: Baicalin-aluminum complex, synthesized from baicalin, inhibits the virulence-associated traits and virulence genes expression of Clostridium perfringens. It has potential as a candidate against C. perfringens infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Palmy R. Jesudhasan, Sohini S. Bhatia, Kirthiram K. Sivakumar, Chandni Praveen, Kenneth J. Genovese, Haiqi L. He, Robert Droleskey, Jack L. McReynolds, James A. Byrd, Christina L. Swaggerty, Michael H. Kogut, David J. Nisbet, Suresh D. Pillai
Summary: Clostridium perfringens (Cp) is a bacterium causing necrotic enteritis in chickens, leading to significant economic losses in the poultry industry worldwide. Contaminated chicken meat can lead to foodborne illnesses in humans. Electron beam irradiation (eBeam) inactivates Cp effectively for use as a vaccine, reducing colonization in broiler chickens.
Article
Microbiology
Jiyun Li, Yuqing Zhou, Dawei Yang, Shan Zhang, Zhiliang Sun, Yang Wang, Shaolin Wang, Congming Wu
Summary: The prevalence and antimicrobial susceptibility of Clostridium perfringens in chickens and pigs in Beijing and Shanxi, China were investigated. The study found a high resistance of C. perfringens isolates to gentamicin and sulfonamides, while showing low resistance to other antibiotics. Whole genome sequencing revealed diverse antimicrobial resistance and toxin genes within C. perfringens populations, with close relatedness among isolates from the same farms and regions based on phylogenomic reconstruction.
VETERINARY MICROBIOLOGY
(2021)
Article
Microbiology
Zhifeng Sun, Mingmin Lu, Hyun Lillehoj, Youngsub Lee, Doyun Goo, Baohong Yuan, Xianghe Yan, CCharles Li
Summary: This study found that the collagen adhesion capability of Clostridium perfringens, the etiological agent for necrotic enteritis in broiler chickens, is correlated with its pathogenicity, especially for C. perfringens strains carrying crucial virulence factors such as netB, cnaA, and tpeL. These results suggest that the presence of the cnaA gene may be associated with the virulence of C. perfringens.
Article
Agriculture, Dairy & Animal Science
Kosar Gharib-Naseri, Sarbast Kheravii, Chake Keerqin, Robert A. Swick, Mingan Choct, Shu-Biao Wu
Summary: The primary cause of necrotic enteritis in chickens is the NetB-positive Clostridium perfringens bacterium. This study evaluated the impact of two pathogenic C. perfringens strains on gut health and gene expression in broilers, finding that the challenge is detrimental to performance and different strains can modulate the severity of the disease through gene expression.
Article
Fisheries
Wanwei He, Mohammad Kamely, Jeremy Wakaruk, Emanuele C. Goes, Douglas R. Korver, Daniel R. Barreda
Summary: The study found that B-glucan can reduce the negative impacts of necrotic enteritis in poultry by influencing the context in which C. perfringens is first encountered.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Carlos Daniel Gornatti Churria, Panayiotis Loukopoulos, Javier Origlia, Nancy Arias, Miguel Herrero Loyola, Miguel Piscopo
JOURNAL OF EXOTIC PET MEDICINE
(2017)
Article
Veterinary Sciences
German B. Vigo, Javier Origlia, Daniel Gornatti, Miguel Piscopo, Angela Salve, Maria I. Caffer, Mariana Pichel, Norma Binsztein, Gerardo A. Leotta
Article
Veterinary Sciences
Carlos Daniel Gornatti Churria, Eugenia Spinsanti, Javier Origlia, Hugo Marcantoni, Miguel Piscopo, Miguel Herrero Loyola, Miguel Petruccelli
JOURNAL OF ZOO AND WILDLIFE MEDICINE
(2011)
Article
Microbiology
Carlos D. Gornatti Churria, German B. Vigo, Javier Origlia, Josefina Campos, Maria Caffer, Miguel Piscopo, Miguel Herrero Loyola, Miguel Petruccelli, Mariana Pichel
REVISTA ARGENTINA DE MICROBIOLOGIA
(2014)
Article
Veterinary Sciences
Carlos Daniel Gornatti-Churria, Panayiotis Loukopoulos, Matthew Prescott, Miguel A. Petruccelli, Mariana A. Machuca
Review
Veterinary Sciences
Carlos Daniel Gornatti-Churria, Panayiotis Loukopoulos, Simone T. Stoute, H. L. Shivaprasad, Francisco A. Uzal
Summary: Naturally occurring pigeon herpesvirus infection in domestic pigeons in California was characterized. Histopathology was the main method used for diagnosis, with virus isolation, transmission electron microscopy, and PCR used in some cases. Most infections were concurrent with other diseases.
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2023)
Article
Veterinary Sciences
C. D. Gornatti Churria, P. Loukopoulos
JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY
(2017)
Article
Veterinary Sciences
Carlos Daniel Gornatti Churria, Nancy Arias, Javier Origiia, Cecilia Netri, Hugo Marcantoni, Migue Piscopo, Miguel Herrero Loyola, Miguel Petruccelli
JOURNAL OF ZOO AND AQUARIUM RESEARCH
(2014)