Article
Surgery
Ulrich Rother, Marc Gruber, Christian-Alexander Behrendt, Josefine Guenther, Werner Lang, Alexander Meyer
Summary: Prosthetic bypass graft occlusions were associated with significantly higher rates of acute symptoms compared to vein grafts. Additionally, a shift to a more distal landing zone was observed after the failure of a prosthetic bypass graft during the redo bypass operation.
FRONTIERS IN SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Ameeduzzafar Zafar, Syed Sarim Imam, Nabil K. Alruwaili, Omar Awad Alsaidan, Mohammed H. Elkomy, Mohammed M. Ghoneim, Sultan Alshehri, Ahmed Mahmoud Abdelhaleem Ali, Khalid Saad Alharbi, Mohd Yasir, Kaveripakkam M. Noorulla, Sami I. Alzarea, Abdullah S. Alanazi
Summary: The study developed a piperine self-nanoemulsifying drug delivery system (PE-SNEDDS) through optimization of the formulation and transformation into a solid form (S-PE-SNEDDS). The results showed that S-PE-SNEDDS may be a better approach for oral delivery to improve absorption and therapeutic activity.
Article
Medicine, General & Internal
Gladiol Zenunaj, Pierfilippo Acciarri, Giulia Baldazzi, Alessio Mario Cosacco, Vincenzo Gasbarro, Luca Traina
Summary: This study aimed to evaluate the use of endovascular procedures as a first-line treatment strategy for complex native femoro-popliteal lesions in patients with peripheral arterial disease (PAD). The results showed that endovascular procedures had better outcomes in terms of technical success, primary patency, revascularisation rates, adverse events, and limb loss compared to prosthetic bypass surgery. The cost of endovascular procedures was also lower.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Ugur Avcibasi, Taner Turkyarar, Aysegul Karadag, Buket Bakan, Nefise Ulku Karabay Yavasoglu, Kevser Kusat, Sinan Akgol, Derya Gulcemal, Volkan Tekin, Fazilet Zumrut Biber Muftuler, Gokcen Topal, Yasemin Parlak, Fikriye Gul Gumuser
Summary: The study aimed to synthesize a novel Tc-99m-labeled graft polymer and evaluate its properties in vitro and in vivo. The labeled compound showed high radiochemical yield and non-toxic characteristics in cytotoxicity and hemolysis tests. Biodistribution studies in healthy rats demonstrated high accumulation of the polymer in the pancreas, thyroid, and prostate.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Muhammad Sarfraz, Ume Ruqia Tulain, Alia Erum, Nadia Shamshad Malik, Arshad Mahmood, Mansur Abdullah Sumaira, Sidra Aslam, Mansur Abdullah Sandhu, Muhammad Tayyab
Summary: The study assessed the potential of quince seed mucilage as an excipient in a graft copolymer for oral-controlled drug delivery systems. The graft copolymer was synthesized using a free radical polymerization method and various concentrations of monomers. The drug-loaded hydrogel showed sustained release patterns and improved pharmacokinetic parameters compared to a commercially available product.
Article
Nanoscience & Nanotechnology
Li Lin, Qingyong Chen, Yue Dai, Yufeng Xia
Summary: The purpose of this study was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to improve the oral absorption of madecassic acid (MCA). The results showed that MCA-loaded SNEDDS had higher permeability coefficient and maximum plasma concentration (Cmax) and area under the plasma concentration-time curve (AUC) compared to pure MCA. Therefore, SNEDDS could be a feasible and effective strategy for improving the dissolution rate and bioavailability of poorly soluble ingredients.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Medicine, General & Internal
Lucia Blasco, Inmaculada Lopez-Hernandez, Miguel Rodriguez-Fernandez, Javier Perez-Florido, Carlos S. Casimiro-Soriguer, Sarah Djebara, Maya Merabishvili, Jean-Paul Pirnay, Jesus Rodriguez-Bano, Maria Tomas, Luis Eduardo Lopez Cortes
Summary: This article describes a case study of a patient with a multidrug-resistant prosthetic vascular graft infection caused by Pseudomonas aeruginosa, which was successfully treated with a combination of phages (PT07, 14/01, and PNM) and ceftazidime-avibactam (CZA). After phage therapy, a new infection with a wild-type strain of P. aeruginosa occurred, but this strain was susceptible to β-lactams and quinolones. Microbiology and whole genome sequencing techniques were used to analyze the clinical strains. The clinical isolates before and after phage therapy showed a clonal relationship with important genomic changes that may have contributed to resistance to this therapy. Phenotypic studies revealed a decrease in the Minimum Inhibitory Concentration (MIC) to β-lactams and quinolones, as well as an increase in biofilm production and phage-resistant mutants in the clinical isolate of P. aeruginosa after phage therapy.
FRONTIERS IN MEDICINE
(2023)
Article
Surgery
Thomas Cousin, Wafa Aloui, Julian Van der Giessen, Frederic Mouret, Steven Kum, Yves Alimi
Summary: This article presents a new technique of lateral arterial implantation, which does not require clamping and suturing of the artery. The C2D device is implanted through a simple arterial puncture and allows lateral implantation of a PTFE vascular graft. The in vitro and in vivo testing showed promising results in terms of short implantation time and minimal fluid loss, with perfect application of the stent in the arterial wall. The experiments on living pigs also demonstrated successful implantations and good outcomes.
ANNALS OF VASCULAR SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Niesyto, Wiktoria Lyzniak, Magdalena Skonieczna, Dorota Neugebauer
Summary: In this study, the cytotoxicity of polymer carriers and drug conjugates on bronchial epithelial cells and cancer cells was evaluated, showing that the polymer systems have a supportive effect on normal cells and a cytostatic effect on cancer cells, which can be regulated by the polymer structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Zhe Wang, Bo Dai, Xiaohan Tang, Zhihui Che, Fei Hu, Chengying Shen, Wei Wu, Baode Shen, Hailong Yuan
Summary: This study aimed to develop a new drug nanocrystals self-stabilized Pickering emulsion for improving the oral bioavailability of quercetin. Quercetin nanocrystals were fabricated by high pressure homogenization and then used as solid particle stabilizers to prepare the optimized emulsion. The results showed that the optimized emulsion had good stability, dissolution behavior, and significantly increased the oral bioavailability of quercetin.
Article
Pharmacology & Pharmacy
Rensong Sun, Linlin Fang, Xia Lv, Jiani Fang, Yuting Wang, Dapeng Chen, Liang Wang, Jun Chen, Yan Qi, Zeyao Tang, Jianbin Zhang, Yan Tian
Summary: The study developed novel liver-targeting chitosan nanoparticles to selectively overcome HCC via ASGPR, demonstrating strong anti-cancer efficacy and good biocompatibility. These galactosylated chitosan nanoparticles have great potential for clinical applications in treating hepatocellular carcinoma.
Article
Infectious Diseases
Altea Gallerani, Milo Gatti, Andrea Bedini, Stefania Casolari, Gabriella Orlando, Cinzia Puzzolante, Erica Franceschini, Marianna Menozzi, Antonella Santoro, Nicole Barp, Sara Volpi, Alessandra Soffritti, Federico Pea, Cristina Mussini, Marianna Meschiari
Summary: This retrospective case series reports on the use of dalbavancin in the treatment of cardiovascular prosthetic infections. The results show that dalbavancin is effective and well-tolerated in this setting. Monitoring drug concentrations can individualize dosing and dosing intervals, further improving clinical outcomes.
Article
Chemistry, Physical
Kuie-Bin Chang, Parag Parashar, Li -Chien Shen, An-Rong Chen, Yan-Tsz Huang, Arnab Pal, Kee-Chin Lim, Po-Han Wei, Fu-Cheng Kao, Jin-Jia Hu, Zong-Hong Lin
Summary: This study proposes a self-powered triboelectric nanogenerator (TENG) based flexible tactile sensor array system for real-time monitoring of pressure distribution inside a prosthetic socket. The sensor is made of biocompatible PDMS polymer and PCL nanofiber membranes as triboelectric materials, providing high stability and low cost. Integration of the sensor array within a prosthetic device enables real-time monitoring of pressure distribution during gait simulation.
Article
Chemistry, Physical
Heba S. Elsewedy, Bandar E. Aldhubiab, Mahmoud A. Mahdy, Hanan M. Elnahas
Summary: The study successfully developed BRU-PEG-NE, which showed potential anticancer effects through evaluation of its physicochemical properties, encapsulation efficiency, and protein adsorption. BRU PEG NE was found to effectively inhibit the growth and proliferation of cancer cells, suggesting its potential as a cancer therapy mean.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Pharmacology & Pharmacy
Miray Ilhan, Muge Kilicarslan, Mehmet Eray Alcigir, Nilsun Bagis, Okan Ekim, Kaan Orhan
Summary: Common techniques for healing alveolar bone destruction have limitations, but sustained release of growth factors through a scaffold-based delivery system shows promise in dentistry. Combining antimicrobials with growth factors can guide host response and promote ideal regeneration. This study prepared and evaluated bone morphogenetic protein 7 (BMP-7) and clindamycin phosphate (CDP) loaded polymeric nanoparticles for accelerated hard tissue regeneration, and found that loading the nanoparticles into a film was more effective than loading them into a graft.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Optics
Samit Kumar Gupta
OPTICS COMMUNICATIONS
(2018)
Article
Physics, Applied
Hao Ge, Xu Ni, Yuan Tian, Samit Kumar Gupta, Ming-Hui Lu, Xin Lin, Wei-Dong Huang, C. T. Chan, Yan-Feng Chen
PHYSICAL REVIEW APPLIED
(2018)
Article
Physics, Applied
Zhen Wang, Si-Yuan Yu, Fu-Kang Liu, Yuan Tian, Samit Kumar Gupta, Ming-Hui Lu, Yan-Feng Chen
APPLIED PHYSICS EXPRESS
(2018)
Article
Physics, Applied
Xingping Zhou, Samit Kumar Gupta, Zhong Huang, Zhendong Yan, Peng Zhan, Zhuo Chen, Minghui Lu, Zhenlin Wang
APPLIED PHYSICS LETTERS
(2018)
Article
Optics
Xue-Yi Zhu, Samit Kumar Gupta, Xiao-Chen Sun, Cheng He, Gui-Xin Li, Jian-Hua Jiang, Xiao-Ping Liu, Ming-Hui Lu, Yan-Feng Chen
Article
Physics, Applied
Liping Wang, Hongfei Wang, Samit Kumar Gupta, Peng Wang, Tianying Lin, Xiaoping Liu, Haibin Lv
JAPANESE JOURNAL OF APPLIED PHYSICS
(2019)
Review
Chemistry, Multidisciplinary
Samit Kumar Gupta, Yi Zou, Xue-Yi Zhu, Ming-Hui Lu, Li-Jian Zhang, Xiao-Ping Liu, Yan-Feng Chen
ADVANCED MATERIALS
(2020)
Article
Physics, Applied
Xingping Zhou, Samit Kumar Gupta, Xueyi Zhu, Guangxu Su, Peng Zhan, Yongmin Liu, Zhuo Chen, Minghui Lu, Zhenlin Wang
PHYSICAL REVIEW APPLIED
(2020)
Article
Physics, Multidisciplinary
Xueyi Zhu, Huaiqiang Wang, Samit Kumar Gupta, Haijun Zhang, Biye Xie, Minghui Lu, Yanfeng Chen
PHYSICAL REVIEW RESEARCH
(2020)
Review
Engineering, Electrical & Electronic
Hongfei Wang, Samit Kumar Gupta, Biye Xie, Minghui Lu
FRONTIERS OF OPTOELECTRONICS
(2020)
Article
Materials Science, Multidisciplinary
Hongfei Wang, Biye Xie, Samit Kumar Gupta, Xueyi Zhu, Li Liu, Xiaoping Liu, Minghui Lu, Yanfeng Chen
Article
Optics
Xingping Zhou, Samit Kumar Gupta, Guangxu Su, Peng Zhan, Minghui Lu, Zhenlin Wang
Article
Materials Science, Multidisciplinary
Hong-Fei Wang, Samit Kumar Gupta, Xue-Yi Zhu, Ming-Hui Lu, Xiao-Ping Liu, Yan-Feng Chen
Article
Optics
Samit Kumar Gupta, Amarendra K. Sarma
JOURNAL OF OPTICS-INDIA
(2018)
Article
Materials Science, Multidisciplinary
Kun Jiang, Minghui Lu, Samit Kumar Gupta, Yanfeng Chen
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2017)