Article
Hematology
Haiyun Pei, Huilin Li, Lei Xu, Bowen Zhang, Heng Zhang, Yali Jia, Liqing Liang, Xiaoyan Xie, Zeng Fan, Zhou Yang, Xiaoling Wang, Feiling Song, Lijuan He, Wen Yue, Xuetao Pei
Summary: The major challenge in using human induced pluripotent stem cells (hiPSCs) is their efficient and controlled differentiation into specific cell types. This study focused on understanding the characteristics of hiPSCs derived from human umbilical arterial endothelial cells (HuA-iPSCs) and their differentiation potential. It was found that HuA-iPSCs retained a transcriptional memory and DNA methylation signature similar to their parental cells, and they showed the highest efficiency in differentiating into hematopoietic cells compared to other hiPSCs.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Food Science & Technology
Ho-Jeong Bang, Mok-Ryeon Ahn
Summary: This study found that pinobanksin exhibits antiangiogenic effect by inducing endothelial cell apoptosis, and it can be developed as an antiangiogenic agent. The mechanism involves inactivation of the Raf/MEK/ERK pathway and activation of apoptotic signaling such as caspase cascades.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Kejia Kan, Yifei Mu, Marielle Bouschbacher, Carsten Sticht, Natalia Kuch, Martin Sigl, Nuh Rahbari, Norbert Gretz, Prama Pallavi, Michael Keese
Summary: The study revealed a novel biphasic response of human umbilical vein endothelial cells to blue light illumination. Low fluence blue light promoted cell activities, while high fluence illumination had the opposite effect by upregulating pro-apoptotic signaling pathways. These findings provide insights into photobiomodulation by blue light and potential treatment strategies for angiogenesis-dependent diseases.
Article
Environmental Sciences
Jiajing Cui, Pingwei Wang, Shuqi Yan, Yujun Liang, Dongge Liu, Shuping Ren
Summary: The study aims to explore the role of ferroptosis in endothelial cell dysfunction and its underlying mechanisms.
Article
Polymer Science
Wei-Yun Lai, Tzu-Hsin Lee, Jian-Xun Chen, Hooi-Yee Ng, Tsui-Hsien Huang, Ming-You Shie
Summary: The study successfully fabricated cell blocks containing human dental pulp stem cells and human umbilical vascular endothelial cells, with silicon ion-infused fish gelatin methacrylate (FGelMa) enhancing the expression of dentin regeneration-related markers. This novel combination of materials may serve as a platform for future clinical applications and dentin regeneration.
Article
Toxicology
Xudong Liu, Yuchao Zhang, Liangyu Liu, Sijie Zhu
Summary: The study showed that ethanol could induce systemic effects and alter signaling pathways in HUVECs.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Chin-Feng Hsuan, Thung-Lip Lee, Wei-Kung Tseng, Chau-Chung Wu, Chi-Chang Chang, Tsui-Ling Ko, Ya-Ling Chen, Jer-Yiing Houng
Summary: The study demonstrated that extracts from Glossogyne tenuifolia (GT) can significantly increase nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs), with the root methanol extract showing the most potent effect. The root methanol extract increased NO production by increasing eNOS expression and activating eNOS phosphorylation at serine(1177).
Article
Genetics & Heredity
Regina L. Binz, Rupak Pathak
Summary: This study investigated the cytogenetic integrity of primary human umbilical vein endothelial cells (HUVECs) and found that approximately 50% of the cells have a deletion of the Xq terminal region. Additionally, a similar Xq deletion was identified in the daughter cell line generated by fusing HUVECs with A549 cells.
Article
Biochemistry & Molecular Biology
Zeqing Zhao, Yaxi Sun, Qingchen Qiao, Li Zhang, Xianju Xie, Michael D. Weir, Abraham Schneider, Hockin H. K. Xu, Ning Zhang, Ke Zhang, Yuxing Bai
Summary: The study successfully prevascularized the CPC scaffold by co-culturing hPDLSCs and hUVECs, showing excellent osteogenic and angiogenic capabilities. The co-culture group outperformed monoculture group, presenting promising applications in dental, craniofacial, and orthopedic fields.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Ling Zhou, Juanjuan Wang, Jiannan Liang, Hui Hou, Jiao Li, Juan Li, Yue Cao, Junqin Li, Kaiming Zhang
Summary: Psoriatic dermal mesenchymal stem cells (p-DMSCs) can upregulate VEGF expression, and stimulate migration and angiogenesis of HUVECs, indicating a potential pathogenic role of p-DMSCs in psoriasis.
MICROVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Pablo C. Caracciolo, Patricia Diaz-Rodriguez, Ines Ardao, David Moreira, Florencia Montini-Ballarin, Gustavo A. Abraham, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: The study developed bioresorbable small-diameter vascular grafts functionalized with heparin to promote endothelial cell growth and inhibit smooth muscle cells over-proliferation. The tensile properties of the heparin-functionalized vascular grafts resembled those of saphenous veins, indicating potential clinical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Environmental Sciences
Zixuan Liu, Xiaomin Xia, Xuying Lv, Erqun Song, Yang Song
Summary: Iron-bearing nanoparticles (IBNPs) are abundant in particulate matter (PM) and considered hazardous to human health with unclear toxic mode-of-action. Studies show that IBNPs promote ferroptosis, affecting intracellular iron levels, disrupting cell signaling, causing mitochondrial dysregulation, and activating related genes. This highlights the importance of recognizing the ferroptotic activity of IBNPs for assessing the health risks associated with PM.
ENVIRONMENTAL POLLUTION
(2021)
Article
Nanoscience & Nanotechnology
Yanyi Liu, Xueyang Zhang, Yuan Su, Fei Hu
Summary: The study examined the effects of bone powder with different concentrations of hydroxyapatite on angiogenesis, indicating that a high concentration of hydroxyapatite is most suitable for cell cultures with higher proliferation abilities.
SCIENCE OF ADVANCED MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Elena Yu. Rybakova, Piotr P. Avdonin, Sergei K. Trufanov, Nikolay V. Goncharov, Pavel V. Avdonin
Summary: This study investigates the regulation of intracellular calcium concentration in human umbilical vein endothelial cells by 5-HT1B and 5-HT2B receptors. The findings suggest that simultaneous activation of both receptors leads to a synergistic increase in calcium concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)