Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response

Humanized Mouse Xenograft Models: Narrowing the Tumor–Microenvironment Gap

(2016) J. Jason Morton et al.   CANCER RESEARCH

Propagating Humanized BLT Mice for the Study of Human Immunology and Immunotherapy

(2016) Drake J. Smith et al.   STEM CELLS AND DEVELOPMENT

Evaluation of Immunostimulatory Potential of Branded and US-Generic Enoxaparins in an In Vitro Human Immune System Model

(2014) Ernesto Luna et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Cytosolic Antiviral RNA Recognition Pathway Activates Caspases 1 and 3

(2014) J. Rintahaka et al.   JOURNAL OF IMMUNOLOGY

Genomic responses in mouse models greatly mimic human inflammatory diseases

(2014) Keizo Takao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predictive markers of safety and immunogenicity of adjuvanted vaccines

(2013) Beatris Mastelic et al.   BIOLOGICALS

Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial

(2013) Michele D Tameris et al.   LANCET

Molecular signatures of antibody responses derived from a systems biology study of five human vaccines

(2013) Shuzhao Li et al.   NATURE IMMUNOLOGY

PW03-031 – Activation-induced cell death of human monocytes

(2013) M Miranda-Garcia et al.   Pediatric Rheumatology

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel, disruptive vaccination technology

(2013) Karl-Josef Kallen et al.   Human Vaccines & Immunotherapeutics

Potential use of inflammation and early immunological event biomarkers in assessing vaccine safety

(2012) Béatris Mastelic et al.   BIOLOGICALS

Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages

(2012) D. Shane O'Mahony et al.   International Journal of Medical Sciences

Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect

(2012) Mariola Fotin-Mleczek et al.   JOURNAL OF GENE MEDICINE

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

(2012) Benjamin Petsch et al.   NATURE BIOTECHNOLOGY

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

(2012) K. Schroder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developing mRNA-vaccine technologies

(2012) Thomas Schlake et al.   RNA Biology

Use of human MonoMac6 cells for development of in vitro assay predictive of adjuvant safety in vivo

(2012) Marina Zaitseva et al.   VACCINE

Systems Biology in Immunology: A Computational Modeling Perspective

(2011) Ronald N. Germain et al.   Annual Review of Immunology

Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway

(2011) Christina Lorenz et al.   RNA Biology

Vaccines and the Future of Human Immunology

(2010) Ronald N. Germain   IMMUNITY

Systems Vaccinology

(2010) Bali Pulendran et al.   IMMUNITY

Programmed cell death of dendritic cells in immune regulation

(2010) Min Chen et al.   IMMUNOLOGICAL REVIEWS

Assessing the immunopotency of Toll-like receptor agonists in anin vitrotissue-engineered immunological model

(2010) Yifan Ma et al.   IMMUNOLOGY

TLR1/2, TLR7, and TLR9 Signals Directly Activate Human Peripheral Blood Naive and Memory B Cell Subsets to Produce Cytokines, Chemokines, and Hematopoietic Growth Factors

(2010) Sudhanshu Agrawal et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity

(2010) Mariola Fotin-Mleczek et al.   JOURNAL OF IMMUNOTHERAPY

Molecular Pathways in the Induction of Interleukin-27-Driven Regulatory Type 1 Cells

(2010) Caroline Pot et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Human B Cell Responses to TLR Ligands Are Differentially Modulated by Myeloid and Plasmacytoid Dendritic Cells

(2009) I. Douagi et al.   JOURNAL OF IMMUNOLOGY

Structural Mechanism of RNA Recognition by the RIG-I-like Receptors

(2008) Mitsutoshi Yoneyama et al.   IMMUNITY

A Prescription for Human Immunology

(2008) Mark M. Davis   IMMUNITY

Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses

(2008) Denis Gaucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel approach for the generation of human dendritic cells from blood monocytes in the absence of exogenous factors

(2008) Brian C. Schanen et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY