Article
Chemistry, Multidisciplinary
Chenyuan Gao, Wenli Dai, Xinyu Wang, Liwen Zhang, Yue Wang, Yiqian Huang, Zuoying Yuan, Xin Zhang, Yingjie Yu, Xiaoping Yang, Qing Cai
Summary: Osteochondral regeneration is challenging due to limited self-healing ability and the complexity of its structure. This study designs a double-layered scaffold with an incorporated Mg2+ gradient and hypoxia-mimicking deferoxamine (DFO). The scaffold promotes dual-lineage regeneration of both cartilage and subchondral bone, with the upper hydrogel layer promoting chondrogenic differentiation and the lower cryogel layer promoting stem cell migration, matrix mineralization, and osteogenesis.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Polymer Science
Sairish Malik, Subramanian Sundarrajan, Tanveer Hussain, Ahsan Nazir, Seeram Ramakrishna
Summary: The study investigated highly oriented nanofibrous structures made from various synthetic polymers, with PLGA showing excellent properties compared to others. PLGA grafts displayed good porosity and elongation values, suggesting potential for vascular graft applications when combined with extracellular vesicles (EVs) in the future.
Article
Engineering, Biomedical
Xinyu Wu, Jie Ding, Peifang Xu, Xue Feng, Zhaoyi Wang, Tong Zhou, Chenxi Tu, Wangbei Cao, Jieqi Xie, Liwen Deng, Liyin Shen, Yang Zhu, Zhongru Gou, Changyou Gao
Summary: The novel hybrid scaffold plays a crucial role in cartilage repair and regeneration by scavenging reactive oxygen species. It possesses proper compressive modulus, strong ROS-scavenging capability, and good cell compatibility. In vivo tests demonstrate that the hybrid scaffold significantly modulates inflammation and promotes hyaline cartilage regeneration, leading to superior deposition of glycosaminoglycans and collagen type II compared to traditional PLGA scaffolds.
BIOMEDICAL MATERIALS
(2021)
Review
Engineering, Biomedical
Kang Sun, Chao Tao, Dong-An Wang
Summary: Tissue engineered cartilaginous constructs have made significant advances in the past decades as a treatment for osteoarthritis. Scaffold-free constructs, which involve only cells and cell-derived matrix, have several advantages over scaffold-based constructs in terms of relying on cells to produce matrix, avoiding interference with cell signaling and introducing no exogenous impurities.
BIOMEDICAL MATERIALS
(2022)
Editorial Material
Polymer Science
Xiaofei Dong, Changyou Gao
JOURNAL OF POLYMER SCIENCE
(2022)
Article
Engineering, Biomedical
Wangbei Cao, Shiqiao Peng, Yuejun Yao, Jieqi Xie, Shifen Li, Chenxi Tu, Changyou Gao
Summary: A wound dressing with immunomodulation and electroconductivity properties was prepared and tested for its effectiveness in promoting diabetic wound healing. The dressing successfully accelerated skin regeneration, collagen deposition, revascularization, and re-epithelialization in diabetic wounds. It achieved this by regulating the wound microenvironment, scavenging reactive oxygen species (ROS), and polarizing macrophages to the M2 phenotype.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Xin Shi, Tong Zhou, Shenyu Huang, Yuejun Yao, Peifang Xu, Shaodan Hu, Chenxi Tu, Wei Yin, Changyou Gao, Juan Ye
Summary: Ocular alkali burn is a serious emergency characterized by persistent inflammation and irreversible vision loss. A double network biomaterial, composed of electrospun nanofibres of thioketal-containing polyurethane (PUTK) and a ROS-scavenging hydrogel (RH), was prepared and transplanted onto a rat corneal alkali burn model. The composite patch showed strong antioxidant activity and accelerated corneal wound healing by inhibiting inflammation, promoting epithelial regeneration, and decreasing scar formation.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Min Jin, Chao Tao, Xu Hu, Bangheng Liu, Cheng Ma, Zhonglian Wu, Hang Yao, Dong-An Wang
Summary: Due to safety concerns and poor underwater adhesion, current bioadhesives are not suitable for in vivo physiological environments and diverse medical uses. In this study, a novel bioadhesive, PcC, is developed based on electrostatic and hydrophobic interactions, using catechin as an adhesion provider. PcC demonstrates superior underwater adhesion on cartilage in mechanical tests and shows potential in various medical applications such as closing surgical incisions and reducing seroma formation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Wenbo Zhang, Luca Bertinetti, Efe Cuma Yavuzsoy, Changyou Gao, Emanuel Schneck, Peter Fratzl
Summary: Physical forces play a crucial role in the development and function of biological tissues. However, the measurement of osmotic pressures in cell and organ culture systems has been challenging. In this study, novel liposomal sensors based on resonance energy transfer (FRET) were developed to accurately measure osmotic pressures in physiological conditions. These sensors were successfully applied in pre-osteoblastic cell culture systems, paving the way for in situ osmotic pressure sensing in biological cultures.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Bangheng Liu, Min Jin, Dong-An Wang
Summary: A porous alginate hydrogel-based 3D culture system is effective in maintaining the phenotype and renewability of hematopoietic stem cells (HSCs). It outperforms traditional suspension or non-porous alginate hydrogel culture in terms of HSC expansion efficiency.
ACTA BIOMATERIALIA
(2023)
Editorial Material
Engineering, Biomedical
Kang Sun, Bangheng Liu, Dong-An Wang
Summary: Traditional joint replacement surgery carries risks of trauma and revision, while medication may cause undesirable side effects. Medical research has focused on minimally invasive tissue-engineered scaffolds for cartilage repair. Challenges include cell seeding, scaffold construction, mechanical properties, and regulating the transplant environment. This issue explores cartilage repair development, cutting-edge discoveries, manufacturing technologies, and current technological queries in regenerative medicine.
BIOMEDICAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Haijun Hu, Xiping Chen, Kefei Zhao, Weiwei Zheng, Changyou Gao
Summary: Traumatic brain injury (TBI) is a major public health problem that often results in severe disability and significant financial burden. The detrimental pathological environment caused by TBI triggers secondary injuries, leading to loss of nerve function and hindrance of nerve regeneration. Advances in adaptive biomaterials now allow for the regulation of the microenvironment to reduce secondary injuries and promote neurogenesis. This review discusses the development of pathology after TBI, introduces adaptive biomaterials based on various pathological characteristics, summarizes the use of biomaterials carrying neurotrophic factors and stem cells for TBI treatment, and suggests current drawbacks and future perspectives.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Cell & Tissue Engineering
Zhen Zhang, Yulei Mu, Huiqun Zhou, Hang Yao, Dong-An Wang
Summary: This review focuses on the advances in cartilage tissue engineering, particularly in preclinical trials and clinical applications, prospects, and challenges. Articular cartilage defects significantly impact the global population's quality of life. Despite various strategies for repair, the therapeutic effects remain suboptimal. However, with the development of cartilage tissue engineering, scientists have made progress in therapeutic cells, biomaterial-based scaffolds, and biological factors, providing new possibilities for better cartilage lesion treatment.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Article
Engineering, Biomedical
Meng Ma, Jun Gu, Dong-An Wang, Siwei Bi, Ruiqi Liu, Xiaosheng Zhang, Jing Yang, Yi Zhang
Summary: In this paper, various 3D printing technologies commonly used in the biomedical field are briefly introduced, with a focus on their application in aging research and aging care. The aging-related health conditions of the nervous system, musculoskeletal system, cardiovascular system, and digestive system are closely examined in relation to the application of 3D printing, including the creation of in vitro models and implants, production of drugs and drug delivery systems, and fabrication of rehabilitation and assistive medical devices. The opportunities, challenges, and prospects of 3D printing in the field of aging are discussed.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Chemistry, Multidisciplinary
Min Jin, Bangheng Liu, Zhen Zhang, Yulei Mu, Liang Ma, Hang Yao, Dong-An Wang
Summary: This study develops a nano-scaled micellar composite composed of catechin-functionalized cationic lipopolymer and serum albumin, which improves the bioavailability of catechins by enhancing intracellular delivery. The nano-micellar complexes exhibit anti-tumor properties and the potential for lung disease treatment. The combination of cationic liposomes with catechins creates a tissue-targeted and biologically active delivery system.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Weiwei Zheng, Shun-Yu Yao, Haijun Hu, Xiping Chen, Zhefeng Qian, Wenxing Liu, Yang Zhu, Zhengwei Mao, Dong-Sheng Guo, Changyou Gao
Summary: In this study, a hypoxia-responsive self-assembled peptide hydrogel was prepared for ischemic stroke treatment. The hydrogel showed the ability to release drugs and effectively improve motor function, reduce infarct volume, and alleviate inflammation.
Article
Chemistry, Multidisciplinary
Tong Zhou, Hao Xiong, Shun-Yu Yao, Shuqin Wang, Shifen Li, Jieting Chang, Zihe Zhai, Dong-Sheng Guo, Cunyi Fan, Changyou Gao
Summary: An injectable hydrogel microsphere system triggered by the hypoxic condition has been developed for the treatment of osteoarthritis with an inflammatory microenvironment. The system exhibits high drug loading capacity and ROS scavenging ability, effectively inhibiting inflammatory responses and protecting cartilage.
Article
Engineering, Biomedical
Ziming Li, Tengfei Zhao, Jie Ding, Haochen Gu, Qiaoxuan Wang, Yifan Wang, Deteng Zhang, Changyou Gao
Summary: In this study, a hydrogel containing thioketal and ROS-scavenging properties was used to encapsulate bone marrow derived mesenchymal stem cells (BMSCs). The hydrogel promoted neurogenesis and axon regeneration by scavenging excessive ROS and creating a regenerative microenvironment. It effectively reduced endogenous ROS production, attenuated ROS-mediated oxidative damage, and downregulated inflammatory cytokines, resulting in decreased cell apoptosis and scar formation, as well as improved motor functional recovery in spinal cord injury (SCI) rats. This strategy could have potential applications in other central nervous system diseases with similar pathological conditions.
BIOACTIVE MATERIALS
(2023)