Review
Immunology
Niloofar Deravi, Mohadeseh Poudineh, Marzieh Pirzadeh, Hanie Yavarpour-Bali, Hoda Mehrabi, Gisou Erabi, Amene Saghazadeh, Nima Rezaei
Summary: Endothelial cells play a critical role in innate immune and inflammatory responses, and Toll-like receptors (TLRs) are key in activating innate mechanisms in ECs. Endothelial dysfunction may lead to tissue damage in various diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Critical Care Medicine
Sahil Gupta, James N. Tsoporis, Song-Hui Jia, Claudia C. dos Santos, Thomas G. Parker, John C. Marshall
Summary: This article discusses how host cells recognize danger signals using pattern recognition receptors, focusing on Toll-like receptors (TLRs) as the most studied class of PRRs. It reviews the expression, regulation, and function of different TLRs, emphasizing TLR-4, and how TLR adaptor protein binding directs intracellular signaling to activate or terminate an innate immune response. The recent progress in research on the involvement of S100 proteins as ligands for TLR-4 in inflammatory disease is also highlighted.
Review
Medicine, General & Internal
Wei Li, Li Wan, Shaojun Duan, Jingjing Xu
Summary: This study explores the current status and trends in TLR agonists research through bibliometric analysis. The research shows that the majority of TLR agonists research is conducted in the United States, and there have been changes in research hotspots and trends. This study provides researchers with an overview of TLR agonists research.
Article
Cell Biology
Jun-Lin Lu, Qi-Dong Xia, Yi Sun, Yang Xun, Heng-Long Hu, Chen-Qian Liu, Jian-Xuan Sun, Jin-Zhou Xu, Jia Hu, Shao-Gang Wang
Summary: The study found that TLR4 expression is decreased in tumor tissues compared to surrounding tissues or normal tissue, and is positively correlated to the overall survival rate and cancer-specific survival rate of bladder cancer patients. Low TLR4 expression is associated with malignant performance in tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Sobstyl, Paulina Niedzwiedzka-Rystwej, Rafal Hrynkiewicz, Dominika Bebnowska, Izabela Korona-Glowniak, Marcin Pasiarski, Barbara Sosnowska-Pasiarska, Jolanta Smok-Kalwat, Stanislaw Gozdz, Anna Sobstyl, Wojciech Polkowski, Jacek Rolinski, Ewelina Grywalska
Summary: The study demonstrated the significance of TLR2 as a biomarker in advanced stage ovarian cancer by showing significantly higher expression levels in women with more advanced OC. This research sheds light on the prognostic potential of TLR2 in developing new diagnostic approaches and increasing survival in confirmed ovarian cancer patients.
Review
Biochemistry & Molecular Biology
Saahithh Redddi Patlola, Gary Donohoe, Declan P. McKernan
Summary: Toll-like receptors (TLRs) are pattern recognition receptors that protect the brain from self and foreign antigens/pathogens and can elicit a harmful or beneficial immune response. TLR activation has been associated with neurodegenerative diseases and cytokine imbalance in schizophrenia. This review explores the current literature on TLRs, their potential role in schizophrenia pathogenesis, factors affecting TLR activity and their impact on cognitive performance in schizophrenia.
Review
Immunology
Arash Heidari, Niloufar Yazdanpanah, Nima Rezaei
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and aggregation of alpha-synuclein. Recent studies suggest that neuroinflammation may contribute to the loss of dopaminergic neurons in PD.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Sjanna B. Besteman, Emily Phung, Henriette H. M. Raeven, Gimano D. Amatngalim, Matevz Rumpret, Juliet Crabtree, Rutger M. Schepp, Lisa W. Rodenburg, Susanna G. Siemonsma, Nile Verleur, Rianne van Slooten, Karen Duran, Gijs van Haaften, Jeffrey M. Beekman, Lauren A. Chang, Linde Meyaard, Tjomme van der Bruggen, Guy A. M. Berbers, Nicole Derksen, Stefan Nierkens, Kaitlyn M. Morabito, Tracy J. Ruckwardt, Evelyn A. Kurt-Jones, Douglas Golenbock, Barney S. Graham, Louis J. Bont
Summary: This study identified an association between autosomal recessive CD14 deficiency and recurrent RSV bronchiolitis. The lack of CD14 function resulted in defective immune responses to RSV pre- and post-F protein.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Kensuke Miyake, Takuma Shibata, Ryutaro Fukui, Ryota Sato, Shin-Ichiroh Saitoh, Yusuke Murakami
Summary: Toll-like receptors (TLRs) respond to pathogen constituents by recognizing and degrading nucleic acids with the help of nucleases. However, these nucleases also negatively regulate TLR responses by degrading ligands. Dysregulation of nucleic acid metabolism in endosomal compartments drives TLR-dependent pathologies in human diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Arturo Orlacchio, Pellegrino Mazzone
Summary: Pancreatic cancer is a lethal form of cancer characterized by its aggressiveness and metastatic potential. Toll-like receptors play a pivotal role in inflammation and immune response, and can be potential targets for cancer therapy. Studies have shown that TLRs play an important role in the progression of pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Raja Aadil Hussain Bhat, Ritesh Shantilal Tandel, Pragyan Dash, Mir Ishfaq Nazir, Dar Jaffer Yousuf, Irfan Ahmad Bhat, Parvaiz Ahmad Ganie, Pankaj Gargotra, C. Siva
Summary: In this study, the full-length TLR4 gene was cloned and characterized in Tor putitora, and its phylogenetic relationship, localization, and binding affinity with ligands were investigated. The results suggest that TpTLR4 plays an important role in sensing pathogen-associated molecular patterns, particularly of viral origin.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Piumi B. Wickramasinghe, Shuwen Qian, Lyndsey E. Langley, Chen Liu, Lin Jia
Summary: Accumulating evidence suggests that alcohol overconsumption is associated with insulin resistance, and this study investigated the role of hepatocyte toll-like receptor 4 (TLR4) in alcohol-induced insulin resistance. The findings indicate that hepatocyte TLR4 is both required and sufficient for the development of insulin resistance caused by alcohol overconsumption.
Review
Biochemistry & Molecular Biology
Jae-Min Lee, Seung Geun Yeo, Su Young Jung, Junyang Jung, Sung Soo Kim, Myung Chul Yoo, Hwa Sung Rim, Hye Kyu Min, Sang Hoon Kim, Dong Choon Park
Summary: Facial nerve palsy greatly affects the quality of life, leading to increased rates of depression and limitations in social activities. Improving the prognosis of patients with this condition is crucial as it can devastate their emotional and social lives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Shuangshuang Gao, Teng Xu, Ruifeng Qiao, Jianchao Lu, Yang Xu, Shu Hu, Youchuan Wei, Zhitao Qi
Summary: In this study, two non-mammalian TLRs, troTLR21 and troTLR22, were identified and characterized in golden pompano. These TLRs were found to be highly expressed in immune-related tissues and up-regulated following pathogen stimulation, suggesting their important roles in the immune response against pathogen invasion in this marine teleost species.
AQUACULTURE REPORTS
(2021)
Review
Biotechnology & Applied Microbiology
Danieli F. Buccini, Beatriz C. Roriz, Julia M. Rodrigues, Octavio L. Franco
Summary: Antimicrobial peptides are important molecules in the organism's defense system. They can modulate the immune system and recognize molecules present in pathogens. Overstimulation of TLR4 can lead to uncontrolled inflammatory responses, which can be counteracted by antimicrobial peptides.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kristina Sundquist, Jan Sundquist, Karolina Palmer, Ashfaque A. Memon
Summary: This study found that low baseline mtDNA-CN levels are associated with an increased incidence of cardiovascular disease and may play a mediating role in the association between type 2 diabetes and cardiovascular disease.
Article
Gastroenterology & Hepatology
Xiao Wang, Ashfaque A. Memon, Karolina Palmer, Anna Hedelius, Jan Sundquist, Kristina Sundquist
Summary: This study found that serum ZRP levels were associated with prevalent IBD, but not with incident IBD.
BMC GASTROENTEROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Fabrizio Ricci, Behzad Banihashemi, Mirnabi Pirouzifard, Jan Sundquist, Kristina Sundquist, Richard Sutton, Artur Fedorowski, Bengt Zoller
Summary: This study found a high familial incidence of dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), which is associated with genetic resemblance. The strongest aggregation was observed in relatives of affected females with HCM, while the association was attenuated for DCM.
Article
Medicine, General & Internal
Yanni Li, Kristina Sundquist, Naiqi Zhang, Xiao Wang, Jan Sundquist, Ashfaque A. Memon
Summary: This study used genetic instruments to investigate the causal relationship between mitochondrial dysfunction and multiple cancers. It identified potential candidate genes for cancer prevention and treatment.
Editorial Material
Oncology
Bengt Zoller, Eric Manderstedt, Christina Lind-Hallden, Christer Hallden
LEUKEMIA RESEARCH REPORTS
(2023)
Article
Endocrinology & Metabolism
Filip Jansaker, Ola Ekstrom, Ashfaque A. Memon, Ola Hansson, Sven-Erik Johansson, Kristina Sundquist
Summary: This longitudinal study examines the possible causal effect between type 2 diabetes and ischemic heart disease using data from Swedish Statistics on Income and Living Conditions and nationwide healthcare registers. The results show a significantly higher risk of ischemic heart disease in participants with type 2 diabetes compared to those without. Although causality cannot be determined, the findings provide insights into a potential causal relationship between type 2 diabetes and ischemic heart disease.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Annie Brink, Johan Elf, Peter J. J. Svensson, Gunnar Engstrom, Olle Melander, Bengt Zoller
Summary: This study aimed to investigate whether there are sex-specific differences in risk factors for noncancer-related DVT and PE in middle-aged and older individuals. The results showed that anthropometric obesity measures were more strongly associated with DVT and PE in women than in men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Sakshi Vats, Kristina Sundquist, Yanni Li, Xiao Wang, Mun-Gwan Hong, Jan Sundquist, Moncef Zarrouk, Anders Gottsater, Ashfaque A. Memon
Summary: This study for the first time investigated the mitochondrial genome in AAA and identified important genetic alterations and haplogroups associated with AAA and clinical risk factors. These findings have the potential to fill in gaps in the missing genetic information on AAA.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Artur Fedorowski, Per Rosengren, Mirnabi Pirouzifard, Jan Sundquist, Kristina Sundquist, Richard Sutton, Bengt Zoller
Summary: This nationwide study aimed to determine the occurrence of complete atrioventricular block (CAVB) in different degrees of relatives (full siblings, half-siblings, and cousins). The results showed that the risk of CAVB is highest in young siblings, and the degree of familial relationship is associated with the risk of disease, indicating the presence of genetic components in the cause of CAVB.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Article
Hematology
Xiao Wang, Ashfaque A. Memon, Anna Hedelius, Anton Grundberg, Johan L. Elf, Peter J. Svensson, Jan Sundquist, Kristina Sundquist
Summary: Mitochondrial dysfunction is a known factor in the development of deep vein thrombosis (DVT). This study aimed to investigate the potential role of 7S RNA, a long noncoding RNA that plays a role in mitochondrial function, in DVT. The findings showed a significant decrease in plasma expression of 7S RNA in DVT patients, suggesting it may serve as a biomarker for DVT.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
Sakshi Vats, Kristina Sundquist, Jan Sundquist, Naiqi Zhang, Xiao Wang, Stefan Acosta, Anders Gottsater, Ashfaque A. Memon
Summary: The study investigates the impact of genetic variations in genes related to oxidative stress, intake of antioxidant vitamins, and potential interactions on abdominal aortic aneurysm (AAA) and its rupture. Results show that a variant in NOX3 is associated with increased risk of AAA and rupture. Higher intake of antioxidant vitamins, riboflavin, and folate are associated with reduced incidence of AAA. The relationship between riboflavin and vitamin B12 intake and AAA risk is modified by sex.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Letter
Endocrinology & Metabolism
Bengt Zoller, Eric Manderstedt, Christina Lind-Hallden, Christer Hallden
JOURNAL OF DIABETES
(2023)
Letter
Cardiac & Cardiovascular Systems
Bengt Zoller, Eric Manderstedt, Christina Lind-Hallden, Christer Hallden
Letter
Cardiac & Cardiovascular Systems
Bengt Zoller, Eric Manderstedt, Christina Lind-Hallden, Christer Hallden
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Letter
Peripheral Vascular Disease
Bengt Zoller, Eric Manderstedt, Christina Lind-Hallden, Christer Hallden
JOURNAL OF HUMAN HYPERTENSION
(2023)
