Review
Surgery
Alexandre Tran, Shannon M. Fernando, Rebecca S. Gates, Jacob R. Gillen, Molly E. Droege, Marc Carrier, Kenji Inaba, Elliott R. Haut, Bryan Cotton, Amanda Teichman, Paul T. Engels, Rakesh V. Patel, Jacinthe Lampron, Bram Rochwerg
Summary: This study compared anti-Xa-guided dosing with fixed dosing of low molecular weight heparin (LMWH) for VTE prevention in adult trauma patients. The findings suggest that anti-Xa-guided dosing may reduce the risk of deep vein thrombosis, pulmonary embolism, and any VTE, although the certainty of evidence is low. The impact on mortality and bleeding events remains uncertain. Overall rating: 8 out of 10.
Article
Cardiac & Cardiovascular Systems
Megan Kunka Fritz, Scott E. Kincaid, Charles G. Sargent, Amanda H. Green, George A. Davis
Summary: Hospital-acquired venous thromboembolism (VTE) remains a concern for general medical patients, but determining the most appropriate venous thromboembolism risk assessment model is still uncertain. Providers tend to assess patients as moderate or high VTE risk, despite institutional guidelines recommending lower risk categories, leading to potentially unnecessary use of pharmacologic prophylaxis. Further research, such as a prospective study utilizing the Padua Prediction Score, is warranted to determine the best method for predicting VTE risk in general medicine patients.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Hematology
Jerome J. Federspiel, Lauren E. Wein, Ryan Duggal, Evan R. Myers, Kimberly A. Boggess, Andra H. James
Summary: The adoption of different guidelines has notable implications for clinical practice and the rate of VTE following cesarean delivery may vary accordingly.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, General & Internal
Verinder S. Sidhu, Thu-Lan Kelly, Nicole Pratt, Stephen E. Graves, Rachelle Buchbinder, Sam Adie, Kara Cashman, Ilana Ackerman, Durga Bastiras, Roger Brighton, Alexander W. R. Burns, Beng Hock Chong, Ornella Clavisi, Maggie Cripps, Mark Dekkers, Richard de Steiger, Michael Dixon, Andrew Ellis, Elizabeth C. Griffith, David Hale, Amber Hansen, Anthony Harris, Raphael Hau, Mark Horsley, Dugal James, Omar Khorshid, Leonard Kuo, Peter Lewis, David Lieu, Michelle Lorimer, Samuel MacDessi, Peter McCombe, Catherine McDougall, Jonathan Mulford, Justine Maree Naylor, Richard S. Page, John Radovanovic, Michael Solomon, Rami Sorial, Peter Summersell, Phong Tran, William L. Walter, Steve Webb, Chris Wilson, David Wysocki, Ian A. Harris
Summary: Aspirin had a significantly higher rate of symptomatic VTE compared to enoxaparin in patients undergoing hip or knee arthroplasty, although there were no significant differences in other secondary outcomes.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Hematology
Antonella Tufano, Benjamin Brenner
Summary: Current guidelines do not provide specific recommendations on thromboprophylaxis for hospitalized patients with thrombocytopenia and/or platelet dysfunction. However, antithrombotic prophylaxis should be considered in most cases, except for those with absolute contraindications to anticoagulant drugs. Patients with liver cirrhosis, COVID-19, and antiphospholipid antibodies are particularly at risk and may benefit from thromboprophylaxis. Thrombocytopenia, as long as it is not severe, should not interfere with VTE prevention decisions.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Review
Medicine, General & Internal
Mudassir Wani, Abdullah Al-Mitwalli, Subhabrata Mukherjee, Ghulam Nabi, Bhaskar K. Somani, Jayasimha Abbaraju, Sanjeev Madaan
Summary: The aim of this study was to investigate the occurrence and risk factors of venous thromboembolism (VTE) in post-radical prostatectomy patients. It was found that the overall incidence of VTE in post-RP patients is 1%, and minimally invasive procedures and RP without pelvic lymph node dissection are associated with a lower risk of developing VTE. Additional pharmacological prophylaxis may not be necessary in all cases and should be considered in high-risk patients only.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Sang-A Kim, Ju Hyun Lee, Ji Yun Lee, Hun-Gyu Hwang, Yang-Ki Kim, Ho-Young Yhim, Junshik Hong, Jeong-Ok Lee, Soo-Mee Bang
Summary: This study found that DOACs have become the most prescribed anticoagulant in Korea after five years, but bleeding complications occurred more frequently in CT patients, especially in those treated with DOACs.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Surgery
Mbaga Walusimbi, Avafia Y. Dossa, Kiran Faryar, Ronald J. Markert, Mary C. McCarthy
Summary: This study aimed to identify the risk factors, mortality, and morbidity associated with upper extremity deep venous thrombosis (UEDVT) in trauma patients and the impact of pharmacological prophylaxis. The results showed that UEDVT is associated with higher mortality and the presence of upper extremity fractures, peripherally inserted central catheter (PICC) lines, and traumatic brain injury (TBI) were identified as independent risk factors for UEDVT. Additionally, pharmacological prophylaxis reduced the risk of UEDVT.
WORLD JOURNAL OF SURGERY
(2022)
Article
Hematology
E. Schapkaitz, E. Libhaber, A. Gerber, H. Rhemtula, J. Zamparini, B. F. Jacobson, H. R. Buller
Summary: This study aimed to assess the thrombosis and bleeding risks associated with anticoagulation therapy in pregnant women. The results showed that the rates of thrombosis and bleeding in both intermediate-risk and high-risk pregnancies were consistent with similar studies.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Article
Surgery
David S. Liu
Summary: This study aimed to investigate the variability in perioperative chemoprophylaxis and assess the impact of timing on bleeding and symptomatic venous thromboembolism in elective major ventral hernia surgery. The findings showed that early initiation of chemoprophylaxis significantly increased the risk of bleeding without providing substantial additional protection against venous thromboembolism. The incidence of symptomatic venous thromboembolism after the surgery was low.
Review
Hematology
Lotte Hejberg Pedersen, Gitte Bonde Villadsen, Maja Hellfritzsch, Anne-Mette Hvas
Summary: Venous thromboembolism (VTE) in children is a rare but serious event. Current guidance on pharmacological thromboprophylaxis in children is mostly based on adult studies and expert opinions. This systematic review found that only children with multiple risk factors for VTE are likely to benefit from pharmacological thromboprophylaxis.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Surgery
Navpreet K. Dhillon, Galinos Barmparas, Ting Lung Lin, Nikhil T. Linaval, Audrey R. Yang, Harveen K. Sekhon, Russell Mason, Daniel R. Margulies, Bruce L. Gewertz, Eric J. Ley
Summary: Systematic changes in enoxaparin dosing after trauma led to a significant reduction in VTE rate. The wider application of this strategy should be considered.
WORLD JOURNAL OF SURGERY
(2021)
Article
Oncology
Maureen D. Moore, Christopher Agrusa, Timothy M. Ullmann, Toni Beninato, Rasa Zarnegar, Thomas J. Fahey, Brendan M. Finnerty
Summary: This study aimed to determine the incidence and risk factors of venous thromboembolism (VTE) after adrenalectomy for adrenal cortical carcinoma (ACC). The results showed that the occurrence of postoperative VTE was highest in ACC patients, with age, presence of adrenal cancer, and Khorana score being identified as risk factors. ACC patients with increased age and/or Khorana score >= 2 should be considered for extended prophylaxis.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Surgery
Alexandre Tran, Shannon M. Fernando, Marc Carrier, Deborah M. Siegal, Kenji Inaba, Kelly Vogt, Paul T. Engels, Shane W. English, Salmaan Kanji, Kwadwo Kyeremanteng, Jacinthe Lampron, Dennis Kim, Bram Rochwerg
Summary: This study summarizes the efficacy and safety of low molecular weight heparin (LMWH) versus unfractionated heparin (UFH) for the prevention of venous thromboembolism (VTE) in trauma patients. The results showed that LMWH is more effective than UFH in reducing the risk of deep vein thrombosis and VTE, and may also reduce the risk of pulmonary embolism and mortality. However, the impact on adverse events and heparin induced thrombocytopenia is uncertain.
Review
Medicine, General & Internal
Qingqing Wei, Jing Sun, Yusuo Bai, Chang Meng, Guobin Miao, Peng Liu, Haijun Wang
Summary: Low molecular weight heparin (LMWH) is commonly used for perioperative venous thrombosis prevention, but aspirin is also recommended. This meta-analysis compared the safety and efficacy of aspirin and LMWH for VTE prophylaxis after orthopedic surgery. The results showed that the risk of DVT was similar between the two groups when aspirin was combined with mechanical devices. There were no significant differences in all cause death, PE, wound infection, and wound complication between the aspirin and LMWH groups. Based on the findings, we suggest using aspirin combined with mechanical devices for VTE prophylaxis in patients after orthopedic surgery.
Article
Pharmacology & Pharmacy
Xavier Delavenne, Yesim Dargaud, Edouard Ollier, Claude Negrier
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Letter
Hematology
Zizhen Xu, Yesim Dargaud, Valerie Chamouard, Sandra Le Quellec, Anne Lienhart, Sandrine Meunier, Lucia Rugeri
Article
Obstetrics & Gynecology
Pierre Descargues, Catherine Battie, Cyril Huissoud, Nathalie Hoen, Yesim Dargaud, Muriel Doret, Pascal Gaucherand
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2019)
Article
Hematology
Lucia Rugeri, Stephanie Desage, Linda Khouatra, Catherine Battie, Muriel Doret-Dion, Christine Trzeciak, Yesim Dargaud
BLOOD COAGULATION & FIBRINOLYSIS
(2020)
Article
Hematology
Xavier Delavenne, Edouard Ollier, Anne Lienhart, Yesim Dargaud
Article
Hematology
Maissa Janbain, Nathalie Enjolras, Jean-Claude Bordet, Radu Bolbos, Marie Brevet, Cindy Leissinger, Yesim Dargaud
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Hematology
Christophe Nougier, Remi Benoit, Marie Simon, Helene Desmurs-Clavel, Guillaume Marcotte, Laurent Argaud, Jean Stephane David, Aurelie Bonnet, Claude Negrier, Yesim Dargaud
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Review
Hematology
Xavier Delavenne, Yesim Dargaud
THROMBOSIS RESEARCH
(2020)
Letter
Hematology
Christophe Nougier, Remi Benoit, Yesim Dargaud
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Hematology
Lorine Giffard-Quillon, Helene Desmurs-Clavel, Claire Grange, Yohann Jourdy, Yesim Dargaud
THROMBOSIS JOURNAL
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Vicky Mai, Kim Boun Tan, Sabine Mainbourg, Arnaud Frigerri, Laurent Bertoletti, Marion Douplat, Yesim Dargaud, Claire Grange, Steeve Provencher, Jean-Christophe Lega
Article
Hematology
Yesim Dargaud
Meeting Abstract
Hematology
Nicolas Drillaud, Anne Lienhart, Antoine Babuty, Yesim Dargaud, Valerie Chamouard, Marc Trossaert, Marc Fouassier, Lucia Rugeri, Marianne Sigaud, Carole Lefranc, Catherine Ternisien, Sandrine Meunier
Meeting Abstract
Hematology
C. Escuriola-Ettinghausen, R. F. Sidonio, J. Oldenburg, B. Pezeshkpoor, J. Mueller, B. A. Konkle, S. L. Meeks, Y. Dargaud, A. Pavlova, G. Young, J. Snedeker
Meeting Abstract
Hematology
S. Desage, X. Vanhoye, S. Meunier, L. Rugeri, A. Lienhart, C. Nougier, Y. Dargaud