Article
Biochemistry & Molecular Biology
Woo Kyung Ryu, Sekyung Oh, Jun Hyeok Lim, Seung Jae Lee, Hyun-Tae Shin, Jeong-Seon Ryu
Summary: Recent research suggests that changes in ctDNA levels are correlated with TB changes, and the detection of ctDNA can be used to predict new metastases, rapid tumor growth, and poor survival in NSCLC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Wei Zhao, Wei Zhou, Li Rong, Mao Sun, Xing Lin, Lulu Wang, Shiqiang Wang, Ying Wang, Zhouguang Hui
Summary: This review summarizes the incidence, characteristics, strategies, treatment influence, and prognosis of brain metastases in EGFR-mutated NSCLC, and highlights the heterogeneity between primary tumors and brain metastases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yuki Katayama, Tadaaki Yamada, Shinsaku Tokuda, Naoko Okura, Naoya Nishioka, Kenji Morimoto, Keiko Tanimura, Yoshie Morimoto, Masahiro Iwasaku, Mano Horinaka, Toshiyuki Sakai, Kenji Kita, Seiji Yano, Koichi Takayama
Summary: EGFR-T790M mutation is a major mechanism of acquired resistance to EGFR-TKIs in lung cancer. The biological characteristics of T790M tumors differ based on treatment regimens with each generation of EGFR-TKI. The maintenance of EGFR dependency after acquiring resistance may depend on the type of EGFR-TKI.
Article
Immunology
How-Wen Ko, Shian-Sen Shie, Chih-Wei Wang, Chi-Tsun Chiu, Chih-Liang Wang, Tsung-Ying Yang, Shou-Chu Chou, Chien-Ying Liu, Chih-Hsi Scott Kuo, Yu-Ching Lin, Li-Fu Li, Cheng-Ta Yang, Chin-Chou Wang
Summary: This study identifies a comprehensive spectrum of uncommon EGFR mutations and demonstrates a positive relationship between smoking status and the frequency of uncommon EGFR mutations, particularly complex uncommon EGFR mutations. The results suggest that smoking contributes to the development of complex EGFR mutations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Yuli Wang, Jing Li, Jian Huang, Chaoqun Wu, Li Li, Ping Gong
Summary: This study investigated cfDNA mutations in NSCLC patients and healthy subjects of Uygur and Han ethnicity, revealing distinct distributions of cancer subtypes, smoking proportion, cfDNA level, and mutation patterns between the two ethnicities. These results may have implications for diagnosis and individualized therapy of NSCLC patients from different ethnic backgrounds in the future.
Article
Oncology
Xiao-Bo Wu, Shu-Ling Hou, Qiao-Hua Zhang, Ning Jia, Min Hou, Wen Shui
Summary: This study investigated the features of ctDNA mutated genes in lymphoma subtypes and found significant correlation between genetic alterations in ctDNA and clinical indices. The genetic heterogeneity across lymphoma subtypes was observed, indicating potential implications for therapeutic targets and risk-adaptive therapies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Julie Ko, Monte M. Winslow, Julien Sage
Summary: Metastasis is a major cause of morbidity and mortality in cancer patients, especially with small cell lung cancer (SCLC) known for its remarkable metastatic proclivity. Recent advances in research, such as using circulating tumor cells and genetically engineered mouse models, are helping to overcome limitations in studying SCLC metastasis. New insights into cellular mechanisms associated with increased metastatic ability offer promise for future therapeutic options.
EMBO MOLECULAR MEDICINE
(2021)
Article
Oncology
Cloud P. Paweletz, Grace A. Heavey, Yanan Kuang, Emily Durlacher, Thian Kheoh, Richard C. Chao, Alexander I. Spira, Konstantinos Leventakos, Melissa L. Johnson, Sai-Hong Ignatius Ou, Gregory J. Riely, Kenna Anderes, Wenjing Yang, James G. Christensen, Pasi A. Janne
Summary: This study reports on early ctDNA changes of KRAS G12C in lung cancer patients and suggests that ctDNA changes can be used as a potential measure for early prediction of clinical response.
CLINICAL CANCER RESEARCH
(2023)
Review
Oncology
Lihui Liu, Chao Wang, Sini Li, Hua Bai, Jie Wang
Summary: The tumor immune microenvironment (TIME) in EGFR-mutated NSCLC differs from non-mutated NSCLC, leading to poor response to ICIs. TIME in EGFR-mutated NSCLC changes during EGFR-TKI treatment. In EGFR-TKI-resistant tumors, there is an increase in immunosuppressive cells, decrease in immune-activated cells, and secretion of negative immune regulatory factors, resulting in immune escape and eventual resistance to EGFR-TKIs.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Immunology
Jianzhen Lin, Songhui Zhao, Dongxu Wang, Yang Song, Yue Che, Xu Yang, Jinzhu Mao, Fucun Xie, Junyu Long, Yi Bai, Xiaobo Yang, Lei Zhang, Jin Bian, Xin Lu, Xinting Sang, Jie Pan, Kai Wang, Haitao Zhao
Summary: The study revealed widespread intertumoral heterogeneity in multifocal HCC, with TP53 and TERT being the most common truncal drivers and TSC2 being the most frequently mutated branchy driver. Patients with higher levels of intertumoral heterogeneity had shorter recurrence-free survival after surgical resection. Genomic profiling of cfDNA could effectively capture tumor-derived driver mutations in patients with resected multifocal HCC, serving as a non-invasive strategy to decipher genomic alterations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shih-Hong Li, Min-Hsien Wu, Hung-Ming Wang, Ping-Chih Hsu, Yueh-Fu Fang, Chih-Liang Wang, Hui-Chun Chu, Hung-Chih Lin, Li-Yu Lee, Ching-Yang Wu, Cheng-Ta Yang, Jen-Shi Chen, Jason Chia-Hsun Hsieh
Summary: This study developed a hybrid platform using a negative and positive selection strategy to capture circulating tumor cells (CTCs) and detect EGFR mutations in patients with metastatic lung adenocarcinoma. The results showed that CTCs could serve as a reliable source of lung cancer tumor DNA for detecting EGFR mutations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Cheol-Kyu Park, Sung-Yong Lee, Jae Cheol Lee, Chang-Min Choi, Shin Yup Lee, Tae-Won Jang, In-Jae Oh, Young-Chul Kim
Summary: This study aimed to evaluate the efficacy of afatinib in lung cancer patients with EGFR mutations detected in their ctDNA, regardless of tumor EGFR mutation status. The results showed that afatinib had a favorable objective response rate and progression-free survival in this population. Using ctDNA assays can be beneficial for determining the efficacy of afatinib treatment in a real-world setting.
Article
Surgery
Shuonan Xu, Jianfei Zhu, Daixing Zhong, Wenchen Wang, Yinsheng Wen, Lanjun Zhang, Tao Jiang
Summary: This study aimed to analyze the heterogeneity in EGFR gene mutation and its impact on clinical outcomes in primary tumor and corresponding brain metastasis in NSCLC. The results showed that patients with inconsistent EGFR mutations had better outcomes compared to those with consistent mutations. Therefore, the heterogeneity of EGFR mutation status may have significant implications for the treatment and prognosis of NSCLC.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Oncology
Ying Jin, Yamei Chen, Huarong Tang, Xiao Hu, Shawna M. Hubert, Qian Li, Dan Su, Haimiao Xu, Yun Fan, Xinmin Yu, Qixun Chen, Jinshi Liu, Wei Hong, Yujin Xu, Huan Deng, Dapeng Zhu, Pansong Li, Yuhua Gong, Xuefeng Xia, Carl M. Gay, Jianjun Zhang, Ming Chen
Summary: This study investigates treatment resistance mechanisms in small cell lung cancer (SCLC) by comparing the genotype and phenotype in tumor samples of treatment-resistant and treatment-sensitive SCLC. The results suggest that activation of the PI3K/AKT pathway may be a potential mechanism underlying therapeutic resistance of SCLC, and provides a possible approach to reverse resistance to chemo/radiotherapy.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Pimpin Incharoen, Artit Jinawath, Lalida Arsa, Kaettipong Kamprerasart, Narumol Trachu, Nanamon Monnamo, Khantong Khiewngam, Dittapol Muntham, Phichai Chansriwong, Ekaphop Sirachainan, Thanyanan Reungwetwattana
Summary: This study explores the clinical correlates of ctDNA and tissue/plasma-based gene mutation status in different stages of NSCLC. The results show that ctDNA levels are variable and not significantly associated with clinical/surgical parameters in early-stage patients, but the clinical value of ctDNA testing is higher in advanced-stage and recurrent NSCLC. Therefore, using ctDNA testing in advanced-stage and recurrent NSCLC is feasible.
Article
Environmental Sciences
Zheng Li, Zhenghui Fu, Shuhang Wang, Yang Zhang, Jinbo Zhang, Yanxiao Liu, Huaicheng Guo, Pingjian Yang
Summary: This study conducted an ecological and human health risk assessment of metals and heavy metals in Qinghai Lake, the largest inland saltwater lake in China. The concentration, distribution, and source of these metals were investigated. It was found that the metals in the sediments of Qinghai Lake mainly came from five rivers entering the lake, with copper and zinc showing the highest enrichment capacity. The results of the risk assessment indicated low ecological risks and no threat to human health from the heavy metals in the lake's sediments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Wenwen Wang, Junyi Chen, Shuhang Wang, Wei Li
Summary: This study compares the properties and sources of SOM and SPOM in Hulun Lake, a typical lake in the cold and arid region of China. The results show that the content of SOM and SPOM is higher in the northern and western regions of the lake, and that SOM and SPOM mainly originate from terrestrial sources, closely related to climate change.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Oncology
Ning Jiang, Yue Yu, Dawei Wu, Shuhang Wang, Yuan Fang, Huilei Miao, Peiwen Ma, Huiyao Huang, Min Zhang, Yu Zhang, Yu Tang, Ning Li
Summary: This review provides a current understanding of the role of HLAs in cancer immunology. It summarizes how HLA alterations contribute to immune escape and resistance to immunotherapy, and potential methods to overcome HLA defects. The review also discusses the potential association between HLA and immune-related adverse events (irAEs). Downregulation, loss of heterogeneity, and entire loss of HLAs are responsible for immune escape. Overcoming HLA defects can be effective in cancer therapy. Non-classical HLA-I molecules, such as HLA-E and HLA-G, are reliable predictors of prognosis, while classical HLA-I expression is a potential predictor of favorable immunotherapy response. Certain HLA types may be associated with enhanced affinity to self-antigen-mimicked tumor antigens, which may positively correlate with irAEs triggered by checkpoint inhibitors.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Xin-Sen Chen, Jing-Rui Cui, Xiang-Long Meng, Shu-Hang Wang, Wei Wei, Yu-Lei Gao, Song-Tao Shou, Yan-Cun Liu, Yan-Fen Chai
Summary: There is an abnormal activation of the renin angiotensin aldosterone system (RAAS) in patients with Sepsis-Induced Cardiomyopathy (SIC). This study measured the protein concentrations of angiotensin II (Ang II) and angiotensin-(1-7) (Ang-(1-7)) in peripheral plasma collected from SIC patients and healthy controls, and explored the relationship between SIC, Ang II, and Ang-(1-7) levels. It was found that SIC patients had elevated Ang II and Ang II/Ang-(1-7) levels, while the healthy controls had higher Ang-(1-7) levels. Additionally, exogenous Ang-(1-7) showed protective effects against SIC by inhibiting inflammatory and oxidative stress pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yong Li, Aiping Zhou, Shuoyan Liu, Ming He, Keneng Chen, Ziqiang Tian, Yin Li, Jianjun Qin, Zhen Wang, Haiquan Chen, Hui Tian, Yue Yu, Wang Qu, Liyan Xue, Shun He, Shuhang Wang, Fenglong Bie, Guangyu Bai, Bolun Zhou, Zhaoyang Yang, Huiyao Huang, Yan Fang, Benjamin Li, Xiangrong Dai, Shugeng Gao, Jie He
Summary: A Phase II study evaluated the safety and efficacy of neoadjuvant socazolimab combined with nab-paclitaxel and cisplatin for locally advanced ESCC. The results showed promising major pathological response and complete pathological response rates, as well as significant T downstaging, without increasing surgical complication rates.
Letter
Oncology
Guo Zhao, Yale Jiang, Peiwen Ma, Shuhang Wang, Guangjun Nie, Ning Li
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Environmental Sciences
Abdul Qadeer, Zeeshan Ajmal, Hanxia Liu, Dai Ran, Tadiyose Girma Bekele, Kelly L. Kirsten, Sisi Liu, Mengyang Liu, Huang Zhifeng, Dong Jing, Shuhang Wang, Jiang Xia, Xingru Zhao
Summary: This study investigates the influence of physicochemical factors and habitats on the trophic transfer of antibiotics in freshwater food webs. The results show significant differences in the transfer of antibiotics in the pelagic and benthic food webs, with higher transfer in the pelagic food web. The study highlights the importance of aqueous solubility as a key factor influencing the trophic transfer of antibiotics.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Chemistry, Multidisciplinary
Shijie Duan, Shuhang Wang, Lei Qiao, Xinbo Yu, Nan Wang, Liting Chen, Xinyuan Zhang, Xu Zhao, Hongyu Liu, Tianye Wang, Ying Wu, Ning Li, Funan Liu
Summary: With advancements in cancer biology and molecular virology, oncolytic virus-driven therapies have emerged as a promising alternative to traditional cancer treatments. However, current clinical trials have shown limited efficacy when using a single oncolytic virus. Integrated approaches combining immunotherapy, chemotherapy, or radiotherapy with oncolytic virus therapy have shown considerable effectiveness. Challenges in oncolytic virus therapy include restricted delivery and poor targeting. Further optimization of delivery methods is needed before oncolytic viruses can become a viable tumor treatment option.
Review
Pharmacology & Pharmacy
Yuan Fang, Shuhang Wang, Songzhe Han, Yizhou Zhao, Cunjing Yu, Huaqing Liu, Ning Li
Summary: Anticancer-targeted therapies have been used in clinical settings for decades, but targeting non-catalytic cancer-related proteins remains a challenge. Targeted protein degradation (TPD) has expanded the druggable proteome for cancer treatment. The past 10 years have seen explosive growth in the field of TPD with the introduction of new TPD drugs into clinical trials, but there are still challenges to overcome for successful clinical translation.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Huiyao Huang, Yu Tang, Dawei Wu, Xinyu Meng, Shuhang Wang, Jun Wang, Yue Yu, Yuan Fang, Hong Fang, Qi Zhu, Ning Li, Binghe Xu, Yan Sun, Jie He
Summary: The proportion of upper age restrictions in cancer clinical trials in mainland China is relatively high, especially for trials initiated by domestic enterprises and early-phase trials. It is crucial to take action and promote treatment equity for older patients while ensuring adequate evidence from clinical trials.
Review
Oncology
Shuhang Wang, Peiwen Ma, Ning Jiang, Yale Jiang, Yue Yu, Yuan Fang, Huilei Miao, Huiyao Huang, Qiyu Tang, Dandan Cui, Hong Fang, Huishan Zhang, Qi Fan, Yuning Wang, Gang Liu, Zicheng Yu, Qi Lei, Ning Li
Summary: Advances in novel drugs, therapies, and genetic techniques have greatly improved the prognosis of cancer patients. However, rare tumors pose challenges to precision medicine and novel therapies due to their low incidence and regional disparities, leading to difficulties in informative diagnosis, lack of recommended treatment strategies, and insufficient biomarkers for prognosis/efficacy.
FRONTIERS OF MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Shuhang Wang, Haoran Yang, Feifei Che, Wei Huang, Dianhai Yang
Summary: This study investigated rural domestic sewage treatment facilities in two urban areas in Jiaxing and found high concentrations of total phosphorus and ammonia nitrogen in the plain river network. A new synthetic filler (FA-SFe) was selected to enhance nitrogen and phosphorus reduction in constructed wetlands, highlighting the importance of fillers. Experiments showed the high adsorption capacity of FA-SFe, with removal rates of ammonia nitrogen and total phosphorus reaching 71.3% and 62.7% respectively in actual wastewater treatment.
FRONTIERS IN CHEMISTRY
(2023)
Article
Medicine, General & Internal
Qian Zhang, Xiuli Tao, Shijun Zhao, Ning Li, Shuhang Wang, Ning Wu
Summary: This study aims to investigate the predictive ability of clinical and chest CT features in predicting the severity of symptomatic immune checkpoint inhibitor-related pneumonitis (CIP). The results showed that the diagnostic performance of chest CT scores was better than clinical symptom scores, and the combination of the three scores demonstrated the best diagnostic value. Therefore, the clinical and chest CT features have important application value in assessing the disease severity of symptomatic CIP, and the routine use of chest CT is recommended in comprehensive clinical evaluation.
Article
Health Care Sciences & Services
Huiyao Huang, Yu Tang, Yue Yu, Anqi Yu, Dawei Wu, Hong Fang, Shuhang Wang, Chao Sun, Xin Wang, Qi Fan, Yuan Fang, Qiyu Tang, Ning Jiang, Jingting Du, Huilei Miao, Ying Bai, Peiwen Ma, Shujun Xing, Dandan Cui, Shuangman Miao, Yale Jiang, Jingxiao Zhu, Qi Zhu, Ye Leng, Lan Wei Guo, Shanmei Liao, Yaguang Shao, Yinyin Song, Zeyuan Liu, Minghuang Hong, Suxia Luo, Binghe Xu, Gongtao Lan, Ning Lia
Summary: Overall survival (OS) is a standard clinical endpoint for new drug applications, but its source and reliability in clinical trials have seldom been questioned. This study addresses the issue of data integrity and reliability when collecting OS information without sufficient supporting material, particularly in the context of the COVID-19 pandemic. Through discussions with Chinese experts, potential sources for obtaining death dates were analyzed and comprehensive strategies for improving data integrity and reliability were proposed.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Environmental Sciences
Zhihao Wu, Xia Jiang, Junyi Chen, Shuhang Wang, Cheng Yao
Summary: This research used DGT assemblies with different binding layers to study the mobility of N and P in sediments in Western Lake Taihu. The results provide important insights into the biogeochemical processes and nutrient release in lakes, which are crucial for effective nutrient management.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
