Article
Thermodynamics
Widson M. Santos, Fernanda P. Nobrega, Jessica C. Andrade, Lucas F. Almeida, Marta M. Conceicao, Ana Claudia D. Medeiros, Francinalva D. Medeiros
Summary: This study aimed to assess the compatibility of dexamethasone with solid pharmaceutical excipients. The results showed slight anticipations of decomposition and interactions with certain excipients, indicating caution should be taken when using heat-based manufacturing processes with these excipients in solid dosage forms.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Thermodynamics
Cosmina Bengescu, Adriana Ledeti, Tudor Olariu, Denisa Circioban, Cornelia Muntean, Gabriela Vlase, Titus Vlase, Carmen Tomoroga, Anca Octavia Dragomirescu, Daniela Dascalu, Lenuta-Maria Suta, Ionut Ledeti, Marius Murariu
Summary: This study investigated ten samples containing promestriene (PRMS), including pure active pharmaceutical ingredient (API) and nine binary mixtures with commonly used excipients. The necessity of this study lies in the lack of reported physicochemical screening of PRMS in the literature. Additionally, the discontinuation of promestriene containing formulations in the Romanian pharmaceutical market since 2015, which caused health problems to a large number of patients, further supports the importance of this study. The results revealed that PRMS is compatible with all selected excipients, as confirmed by spectroscopy, X-ray diffraction patterns, and thermal analysis.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Pharmacology & Pharmacy
Andrea Fuerst, Iram Shahzadi, Zeynep Burcu Akkus-Dagdeviren, Gergely Kali, Andrea Hupfauf, Ronald Gust, Andreas Bernkop-Schnuerch
Summary: This study synthesized entirely S-protected thiolated hydrox-yethylcellulose (HEC) with low and high viscosity, as well as thiolated poly-L-lysine (poly-L-Lys) for dual-acting hydrogels. The thiomers showed lower cytotoxicity and significantly increased dynamic viscosity.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Swayamprakash Patel, Mehul Patel, Mangesh Kulkarni, Mruduka S. Patel
Summary: The compatibility of drugs with excipients is crucial for the stability of pharmaceutical formulations. Traditional analytical tools and machine learning can be used to identify drug-excipient interactions and develop predictive tools for incompatibility. In this study, a machine learning model (DE-Interact) was trained using PubChem Fingerprint as compounds' descriptors and achieved high accuracy in predicting incompatibilities.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Rodrigo Henrique Saatkamp, Bruna Mattos Dos Santos, Mariele Paludetto Sanches, Julia Conte, Gabriela Schneider Rauber, Thiago Caon, Alexandre Luis Parize
Summary: This study investigated the physical-chemistry properties of BNZ/MGs mixtures under different processing conditions (maceration, ball milling, and melting) to guide the development of new solid formulations. The results showed that GML was more effective in improving the solubility of BNZ due to its malleable structure, less hydrophobic nature, and greater interaction with BNZ. Regardless of the processing method, the drug remained crystalline, and the presence of spherulites was observed.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Materials Science, Multidisciplinary
Elena-Emilia Tudoroiu, Madalina Georgiana Albu Kaya, Irina Titorencu, Cristina Elena Dinu-Pirvu, Maria Minodora Marin, Ana-Maria Rosca, Lacramioara Popa, Valentina Anuta, Aurora Antoniac, Ciprian Chelaru, Durmu Alpaslan Kaya, Razvan Mihai Prisada, Mihaela Violeta Ghica
Summary: This research aimed to design and characterize new hydrogels and spongious matrices for wound dressings. The compatibility of biopolymers was evaluated through rheological and spectroscopic analyses, and the stability of the matrices was studied in terms of morphology, thermal properties, and biodegradation. The results showed that the dressings had proper swelling ability, stability, and biocompatibility.
MATERIALS & DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Pravat Ranjan Guru, Rajat Kumar Kar, Amit Kumar Nayak, Snehamayee Mohapatra
Summary: Biopolysaccharides extracted from plants have gained significant attention as pharmaceutical excipients in various dosage forms due to their wide availability, sustainable production, easy extraction methods, aqueous solubility, swelling capability, non-toxicity, and biodegradability. This comprehensive review highlights the extensive use of plant-derived biopolysaccharides as effective pharmaceutical excipients in the formulation of different dosage forms such as gels, pastes, films, emulsions, suspensions, capsules, tablets, nanoparticles, microparticles, beads, buccal formulations, transdermal formulations, ocular formulations, nasal formulations, etc.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Rocio Gonzalez, Ma Angeles Pena, Norma Sofia Torres, Guillermo Torrado
Summary: This work proposes a methodology for the design and development of amorphous rosuvastatin calcium tablets, aiming to improve its bioavailability. By carefully selecting excipients and utilizing their properties, cost-effective tablets with optimal pharmacotechnical characteristics were successfully developed.
Article
Medicine, Research & Experimental
Navpreet Kaur, Raj Suryanarayanan
Summary: The study found that different tablet excipients have an impact on the physical form and chemical stability of levothyroxine sodium pentahydrate, including hygroscopic and acidic excipients. HPLC analysis revealed that certain excipients caused pronounced chemical decomposition of LSP, while others did not affect its stability under specific storage conditions. Excipient properties such as hygroscopicity and microenvironmental acidity were identified as critical determinants of the physical and chemical stability of LSP in a drug product.
MOLECULAR PHARMACEUTICS
(2021)
Article
Instruments & Instrumentation
Guilherme L. Alves, Fernanda V. Teixeira, Priscila Bianca Rodrigues da Rocha, Anna Paula Krawczyk-Santos, Ligia Marquez Andrade, Marcilio Cunha-Filho, Ricardo N. Marreto, Stephania F. Taveira
Summary: The transdermal administration of raloxifene hydrochloride (RLX)-loaded nanostructured lipid carriers (NLCs) has been proposed to overcome its low oral bioavailability. Preformulation studies, in vitro release studies, and skin permeation studies revealed that NLC7 and NLC8 are the most promising formulations for controlling RLX release and potential use in transdermal drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Engineering, Chemical
Julia Marushka, Jana Brokesova, Chiazor Ugo Ogadah, Arash Kazemi, Jurjen Duintjer Tebbens, Zdenka Sklubalova
Summary: This study investigated the milling properties of 24 pharmaceutical excipients and identified ten excipients with acceptable milling performance. The effect of milling speed and time on particle size was evaluated using a circumscripted central composite design (CCD), and optimal milling conditions were established.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Polymer Science
Alireza Eivazi, Bruno Medronho, Bjorn Lindman, Magnus Norgren
Summary: In this study, cellulose-based core-shell particles were developed using the Layer-by-Layer (LbL) technique by alternating two cellulose derivatives onto a cationic vesicular template. The size of the particles could be tuned by controlling the number of layers deposited, with pH having a significant effect on the process. This work demonstrates the electrostatic driving force for LbL deposition and the potential advantages of using biobased containers for pharmaceutical and biomedical applications.
Article
Green & Sustainable Science & Technology
Danping Wang, Wean Sin Cheow, Nur Amalina, Muhammad Faiezin, Kunn Hadinoto
Summary: The study conducted a life cycle assessment of API tablet production with two different excipient formulations. The results showed that excipient selection plays a significant role in the environmental impacts of API tablet production.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Pharmacology & Pharmacy
Jue Wang, Ying Jiang, Yang Yang, Kai Xu, Xiaofeng Wang, Rui Yang, Xinyue Xiao, Huimin Sun
Summary: This study evaluated the early immune risk associated with impurities in trehalose, a pharmaceutical excipient, using multiple models. The results showed that nanoparticle impurities in trehalose can elicit an immune response in vitro, which may be related to the impurities and not the excipient itself. Assessing the immune risk of impurities in trehalose is important for the safety of high-risk administration routes.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Review
Chemistry, Medicinal
Anne-Cecile. Bayne, Zdravka Misic, Rehe T. Stemmler, Marc Wittner, Margarita Frerichs, Julia K. Bird, Ahmed Besheer
Summary: N-nitrosamines are potential carcinogens, and there has been a regulatory framework established for risk assessment, testing, and mitigation of these contaminants in drug products. One approach to prevent the formation of N-nitrosamines during drug manufacturing and storage is to incorporate nitrite scavengers into the formulation. Various molecules, including antioxidant vitamins, amino acids, and other antioxidants used in food or drugs, have been tested for their potential to mitigate N-nitrosamine formation in drug products. This review article provides a comprehensive overview of key considerations for incorporating nitrite scavengers in oral drug formulations.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Thermodynamics
Manuela Crisan, Mihaela Petric, Gabriela Vlase, Titus Vlase, Anatolii V. Siminel, Paulina N. Bourosh, Lilia Croitor
Summary: Two new multicomponent crystal forms based on the 4-nitrobenzoic acid-diethanolamine system were synthesized and analyzed, revealing structural and thermal differences. The study also discussed the kinetic properties and photoluminescence performance of these compounds.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Thermodynamics
Dan Vlase, Titus Vlase, Madalin Bunoiu, Paula Sfirloaga, Alexandra-Gabriela Ursut, Gabriela Vlase
Summary: This study analyzed pottery sherds and clay samples from an archaeological rescue dig in the Transilvania Highway. The analysis aimed to determine the composition similarities between pottery sherds and soil samples, as well as the local origin of raw materials and pottery technology.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Thermodynamics
Gabriela Vlase, Dan Vlase, Iosif Vasile Ferencz, Paula Sfirloaga, Dorel Micle, Florin Manea, Titus Vlase
Summary: Thermal analysis and infrared spectroscopy were used to study mortar samples from different historical periods in south-western Transylvania, Romania. These techniques provide valuable information about the characteristics and construction techniques of the mortar samples, which is of great importance for the preservation of Romanian heritage.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Thermodynamics
Lilia Croitor, Gabriela Vlase, Titus Vlase, Paulina N. Bourosh, Yurii M. Chumakov, Manuela Crisan
Summary: The crystal structures and thermal characteristics of two polymorphs of methylethanolammonium 2-chloro-4-nitrobenzoate were analyzed using experimental and computational methods. The study focused on the synthesis of the polymorphs, structural characterization, intermolecular interactions, thermodynamic stability, and thermal decomposition kinetics. The results revealed distinct crystal packing arrangements and different numbers of independent molecules pairs in the asymmetric crystal unit. The alpha polymorph had a more stable lattice than the beta polymorph at high temperatures. The thermodynamic stability was determined by measuring melting points and heats of fusion. The alpha polymorph also exhibited higher activation energies compared to the beta polymorph in the thermal decomposition processes.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Materials Science, Ceramics
Dan Vlase, Gabriela Vlase, Gabriela Ursut, Paula Sfirloaga, Florin Manea, Mihaela Budiul, Andrei Rotaru, Titus Vlase, Ion Creanga
Summary: This study aims to analyze pottery samples from the Foeni Tell - Orthodox Cemetery archaeological site in Romania. Results indicate that Foeni pottery was locally produced using a high plasticity clay and various minerals, with firing temperatures ranging from 550-600 degrees Celsius.
CERAMICS INTERNATIONAL
(2023)
Article
Thermodynamics
Cosmina Bengescu, Adriana Ledeti, Tudor Olariu, Denisa Circioban, Cornelia Muntean, Gabriela Vlase, Titus Vlase, Carmen Tomoroga, Anca Octavia Dragomirescu, Daniela Dascalu, Lenuta-Maria Suta, Ionut Ledeti, Marius Murariu
Summary: This study investigated ten samples containing promestriene (PRMS), including pure active pharmaceutical ingredient (API) and nine binary mixtures with commonly used excipients. The necessity of this study lies in the lack of reported physicochemical screening of PRMS in the literature. Additionally, the discontinuation of promestriene containing formulations in the Romanian pharmaceutical market since 2015, which caused health problems to a large number of patients, further supports the importance of this study. The results revealed that PRMS is compatible with all selected excipients, as confirmed by spectroscopy, X-ray diffraction patterns, and thermal analysis.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Thermodynamics
Mihaela Maria Budiul, Cristina Adela Marioane, Ionela-Amalia Bradu, Gabriela Vlase, Titus Vlase
Summary: A study was conducted to develop and characterize medicated jellies containing topiramate, using sodium alginate, gelatin, and pectin as gelling agents. The thermal behavior and potential interactions between topiramate, moist binary mixtures, and oral medicated jellies were analyzed using FTIR-UATR spectroscopy, UV-Vis spectroscopy, and thermogravimetry.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Chemistry, Multidisciplinary
Vasile Lozovan, Victor Ch. Kravtsov, Yurii M. Chumakov, Natalia V. Costriucova, Nikita Siminel, Oleg Petuhov, Titus Vlase, Gabriela Vlase, Alic Barba, Marina S. Fonari
Summary: Four new neutral metal-organic frameworks (MOFs) and three coordination complexes were synthesized using an azine-functionalized polymer synthesis strategy. These compounds exhibited diverse structures and optical properties, as well as demonstrated efficient capture of CO2 molecules.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Thermodynamics
Madalina Mateescu, Gabriela Vlase, Mihaela Maria Budiul, Bianca Denisa Cernusca, Titus Vlase
Summary: The objectives of this study were to formulate and evaluate medicated oral jellies containing Ambroxol HCl, the most commonly used mucolytic agent for chronic bronchitis, as well as medicated oral jellies containing Ibuprofen, a recognized nonsteroidal anti-inflammatory drug. The medicated jellies included different gelling agents such as gelatin, sodium alginate, and pectin. Compatibility studies were conducted to assess the interaction between Ibuprofen or Ambroxol and each component of the medicated jellies. Analysis was performed using FTIR-UATR and thermogravimetry.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Engineering, Chemical
Bianca Baul, Adriana Ledeti, Denisa Circioban, Amalia Ridichie, Titus Vlase, Gabriela Vlase, Francisc Peter, Ionut Ledeti
Summary: The stability of APIs and pharmaceutical formulations is crucial in pharmaceutical research and technology. Various factors such as light, air exposure, temperature, humidity, formulation composition, and packaging materials can affect the quality and stability of APIs and finished pharmaceutical products. This study analyzed the degradation kinetics of the antihypertensive drug moxonidine in different solid mixtures using FTIR spectroscopy and thermoanalytical methods. The results showed that excipients have a stabilizing effect on moxonidine, but the decomposition mechanism is complex.
Article
Thermodynamics
Dorinel Okolisan, Titus Vlase, Gabriela Vlase, Ionela-Amalia Bradu, Claudiu Avram
Summary: A new type of polysaccharide film containing amide-type anesthetics was synthesized in this study. The stability of these films suggests their potential use as carriers for local anesthesia.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Polymer Science
Ionela-Amalia Bradu, Titus Vlase, Madalin Bunoiu, Madalina Gradinaru, Alexandru Pahomi, Dorothea Bajas, Mihaela Maria Budiul, Gabriela Vlase
Summary: This study presents the synthesis of membranes based on anionic polysaccharides and cationic polysaccharides for transdermal delivery of methotrexate. The membranes suitable for the release of the active ingredient were validated through characterization.
Article
Plant Sciences
Adina-Elena Segneanu, Gabriela Vlase, Titus Vlase, Crina Andreea Sicoe, Maria Viorica Ciocalteu, Dumitru Daniel Herea, Ovidiu-Florin Ghirlea, Ioan Grozescu, Valentin Nanescu
Summary: The current nanomedicinal approach combines medicinal plants and nanotechnology to create new scaffolds with enhanced bioavailability, biodistribution, and controlled release. This study presents an innovative method for encapsulating herb in nanosized chitosan matrices, and investigates the properties and therapeutic effects of these nanocarriers. The results suggest that this new antioxidant vehicle has potential as a promising candidate in tumor therapeutic strategy.
Article
Engineering, Biomedical
Florin Borcan, Titus Vlase, Gabriela Vlase, Roxana Popescu, Codruta M. Soica
Summary: The study aims to develop and characterize polyurethane particles for the delivery of nucleosides. The samples show suitable size, stable properties, good penetration and release performance. Further clinical trials are required to test the synthesized products.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
