Article
Oncology
Nishant Chovatiya, Kawaljit Kaur, Sara Huerta-Yepez, Po-Chun Chen, Adam Neal, Gabriella DiBernardo, Serhat Gumrukcu, Sanaz Memarzadeh, Anahid Jewett
Summary: We studied the sensitivity of different ovarian tumor cell lines to NK cell-mediated cytotoxicity and found that the levels of tumor differentiation and aggressiveness were correlated with the sensitivity to NK cell killing. Poorly differentiated ovarian tumors were unable to upregulate MHC-class I under activating conditions, which may be a specific feature of ovarian tumors. NK cells showed targeted killing of these tumors and could be utilized in immunotherapeutic strategies.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Geriatrics & Gerontology
Rachel O. Coats, Amanda H. Waterman, Fiona Ryder, Amy L. Atkinson, Richard J. Allen
Summary: The study found that demonstration significantly improved serial recall performance for both young and older adults, while self-enactment only enhanced performance in young adults, and to a lesser extent compared to demonstration.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Rachel R. Deer, Erin Hosein, Alejandra Mera, Kristen Howe, Shawn Goodlett, Nicole Robertson, Elena Volpi
Summary: The study found that community-dwelling older adults did not meet their nutritional needs during recovery after acute hospitalization, particularly in terms of protein intake. This highlights the need for better nutritional evaluation and support of geriatric patients recovering from hospitalization.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Immunology
Robert G. Feldman, Raffaele Antonelli-Incalzi, Katie Steenackers, Dong-Gun Lee, Alberto Papi, Michael G. Ison, Laurence Fissette, Marie-Pierre David, Celine Marechal, Marie Van der Wielen, Lusine Kostanyan, Veronica Hulstrom
Summary: The study shows that older adults with chronic cardiorespiratory or endocrine/metabolic conditions are more prone to respiratory illnesses caused by RSV. A new vaccine has demonstrated significant efficacy against RSV-related diseases in these high-risk populations. The study evaluated the vaccine efficacy and immunogenicity in participants with coexisting medical conditions.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Anthropology
Adam R. Roth, Siyun Peng, Max E. Coleman, Evan Finley, Brea L. Perry
Summary: This study explores how cognitive impairment affects older adults' perceptions of their personal networks, finding that individuals are more likely to omit weaker ties and maintain stronger ones in their self-reported networks. Despite moderate levels of agreement between participants and study partners, there is minimal evidence of perceptual differences across diagnostic groups.
Review
Cell Biology
Abdelhady Osman, Nellie Kamkar, Mark Speechley, Shehzad Ali, Manuel Montero-Odasso
Summary: The purpose of this review was to systematically evaluate the association between FRIDs and gait performance in community-dwelling older adults without neurological movement disorders. The study found that drugs with sedative properties are associated with reduced gait speed in older adults, while statin use has no association with gait speed. There is insufficient evidence on the association between FRIDs and other gait performance measures.
AGEING RESEARCH REVIEWS
(2022)
Review
Medicine, General & Internal
Ecler Jaqua, Wessam Labib, Katalin Danji
Summary: In geriatric practices, the life expectancy of people living with HIV has increased due to effective antiretroviral therapy, making their medical needs similar to the general population. Geriatricians focus on the non-AIDS disorders associated with HIV. Falls, motor function impairment, memory loss, cardiovascular diseases, bone abnormalities, and drug interactions are some of the common challenges faced by older adults living with HIV. Providing comprehensive medical care and psychosocial support through interdisciplinary teams is crucial for improving their quality of life.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Psychology, Mathematical
Jennifer H. Coane, Sharda Umanath
Summary: General knowledge questions are used to measure cognitive processes such as metacognition, knowledge acquisition, and retrieval processes. Older adults typically outperform younger adults in tasks assessing retrieval of information from the knowledge base. Comparisons with young adult data confirm previous findings of greater knowledge in older adults.
BEHAVIOR RESEARCH METHODS
(2021)
Article
Health Care Sciences & Services
Soojin Park, Jin Young Nam
Summary: This study examines the relationship between cognitive function and out-of-pocket medical cost in older individuals with multiple chronic conditions. The findings suggest that older adults with multiple chronic conditions have significantly higher out-of-pocket medical cost, especially those with deteriorating conditions. Furthermore, cognitive decline is associated with higher out-of-pocket medical cost, particularly for prescription drugs. This study highlights the importance of improving the management of multiple chronic conditions to enhance the health and long-term financial stability of older adults.
Review
Public, Environmental & Occupational Health
Yan Zhang, Chao Chen, Lingfeng Huang, Gang Liu, Tingyu Lian, Mingjuan Yin, Zhiguang Zhao, Jian Xu, Ruoling Chen, Yingbin Fu, Dongmei Liang, Jinmei Zeng, Jindong Ni
Summary: The study comprehensively analyzed and compared the associations among multimorbid conditions by age and sex in a large number of middle-aged and older Chinese adults. The results highlighted the prevalence of multimorbidity and the specific associations between certain conditions within different age and sex groups. This provides evidence for further research on disease clusters and personalized treatment strategies.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Endocrinology & Metabolism
Summary: The American Diabetes Association's Standards of Medical Care in Diabetes provides clinical practice recommendations, components of care, treatment goals, and tools for evaluating quality of care. The ADA Professional Practice Committee is responsible for regularly updating the standards, and readers can provide feedback at a designated website.
Article
Endocrinology & Metabolism
Summary: The American Diabetes Association provides standards of medical care for diabetes, which includes clinical practice recommendations and guidelines for diabetes care. These guidelines are regularly updated by a committee of multidisciplinary experts.
Article
Oncology
Fangcheng Yuan, Ruth M. Pfeiffer, Sachelly Julian-Serrano, Simran Arjani, Michael J. Barrett, Jill Koshiol, Rachael Z. Stolzenberg-Solomon
Summary: There is an association between autoimmune conditions and pancreatic cancer risk, with certain autoimmune conditions being associated with an increased risk of pancreatic cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Behavioral Sciences
Lu Wang, Yundan Pan, Chunyan Ye, Lizhe Guo, Sumei Luo, Sisi Dai, Na Chen, E. Wang
Summary: Orexin receptor antagonists can be widely used in adults and the elderly, with both short-term and long-term use being effective for primary insomnia. H1 antagonists are more effective in adults than in the elderly. Although benzodiazepines have a more obvious effect on sleep maintenance, it is best to reduce their use due to their side effects, especially for the elderly. As a food supplement, melatonin has little effect on adults, but it still has a certain effect on the elderly.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Health Care Sciences & Services
Siddharth Jain, Paul R. Rosenbaum, Joseph G. Reiter, Omar Ramadan, Alexander S. Hill, Sean Hashemi, Rebecca T. Brown, Rachel R. Kelz, Lee A. Fleisher, Jeffrey H. Silber
Summary: The conventional definition of multimorbidity, which identifies patients with >= 2 comorbidities, labels almost all older patients as multimorbid, making it less useful. This study developed new medical condition-specific definitions, called Qualifying Comorbidity Sets (QCSs), for acute myocardial infarction (AMI), heart failure (HF), and pneumonia patients, which resulted in fewer patients being labeled as multimorbid but with a higher risk of death compared to the conventional definition.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)