Article
Multidisciplinary Sciences
Su-su Bao, Peng-fei Tang, Nan-yong Gao, Zhong-xiang Xiao, Jian-chang Qian, Long Zheng, Guo-xin Hu, Huan-hai Xu
Summary: This study evaluated the effects of apatinib on the pharmacokinetics of tramadol and its main metabolite O-desmethyltramadol, as well as its inhibitory effects on liver microsomes and CYP2D6.1. The findings suggest that apatinib can enhance the analgesic effect of tramadol and O-desmethyltramadol and has a strong inhibitory effect on their metabolism.
Article
Biochemical Research Methods
O. Yoo, E. K. Y. Tang, M. N. Nguyen, S. Salman, A. J. Hua, B. S. von Ungern Sternberg, L. Y. Lim
Summary: A validated HPLC-UV method was developed for quantifying tramadol and its main metabolite in human plasma in the presence of potentially interfering drugs, and successfully used in analyzing blood samples from 137 pediatric participants in a tramadol pharmacokinetic trial.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Piotr J. Rudzki, Katarzyna Jarus-Dziedzic, Monika Filist, Edyta Gilant, Katarzyna Bus-Kwasnik, Andrzej Les, Malgorzata Sasinowska-Motyl, Lukasz Nagraba, Magdalena Bujalska-Zadrozny
Summary: This study demonstrated that magnesium ions (Mg2+) do not alter the pharmacokinetics of tramadol and the combination is safe for use in the clinical practice for pain management.
PHARMACOLOGICAL REPORTS
(2021)
Article
Pharmacology & Pharmacy
Washim Khan, Yan-Hong Wang, Narayan D. D. Chaurasiya, N. P. Dhammika Nanayakkara, H. M. Bandara Herath, Kerri A. A. Harrison, Gray Dale, Donald A. A. Stanford, Eric P. P. Dahl, James D. D. McChesney, Waseem Gul, Mahmoud A. A. ElSohly, David Jollow, Babu L. L. Tekwani, Larry A. A. Walker
Summary: Primaquine (PQ) is an effective antimalarial drug used to treat dormant Plasmodium vivax hypnozoites and P. falciparum mature gametocytes. This study compared the tolerability and metabolism of PQ enantiomers in human volunteers and found no significant differences in safety and tolerability in G6PDn subjects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Andressa Nunes Mouta, Isabelle de Oliveira Lima, Maria Glaucia Carlos de Oliveira, Leticia Pereira Alves, Lua Barbalho de Macedo, Gabriel Araujo-Silva, Jose Perez-Urizar, Valeria Veras de Paula
Summary: This study aimed to determine the pharmacokinetics of tramadol and its metabolite M1 in donkeys, finding that plasma levels of tramadol and M1 were higher than clinically meaningful levels in humans after intravenous administration of 2 and 4 mg/kg. However, the AUC did not increase proportionally with dose. Higher dose led to adverse effects, recommending 2 mg/kg intravenous tramadol for donkeys. Further clinical studies are needed to understand the pharmacodynamic response to tramadol in Northeast Brazilian donkeys.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Chemistry, Medicinal
Wanjun Bai, Haojing Song, Yiting Hu, Xueyuan Zhang, Xiaoru Wang, Caihui Guo, Bo Qiu, Zhanjun Dong
Summary: This study compared the pharmacokinetics and safety of generic and original vortioxetine hydrobromide tablets under fasting and fed conditions. The results showed that the pharmacokinetic parameters of the test drug were similar to those of the reference drug, indicating bioequivalence. Both formulations were safe and well-tolerated in healthy Chinese subjects.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Chemistry, Medicinal
Joanna Czerwinska, Mark C. Parkin, Agostino Cilibrizzi, Claire George, Andrew T. Kicman, Paul I. Dargan, Vincenzo Abbate
Summary: This study successfully resolved the enantiomers of mephedrone and determined their absolute configuration. The research found that while both enantiomers showed similar kinetics, R-(+)-mephedrone had higher peak concentration, longer half-life, lower clearance, and greater area under the curve compared to S-(-)-mephedrone in blood samples. The study suggests that enantiomers of mephedrone may exhibit enantioselective pharmacokinetics.
Article
Chemistry, Medicinal
Jin Wang, Huan Zhang, Rui Wang, Yun Cai
Summary: In this study, the pharmacokinetics, bioequivalence and safety profiles of 90 mg ticagrelor tablets and their active metabolite were evaluated in healthy Chinese subjects under fasting and fed conditions. The results showed no significant differences in PK parameters and bioequivalence between the test and reference drugs, with no severe adverse events observed.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Chemistry, Medicinal
Qiuying Li, Lihui Jia, Wenli Hu, Shu Dong, Chaohong Cai
Summary: The study evaluated the bioequivalence and safety of two formulations of 25 mg tenofovir alafenamide tablets in Chinese healthy male and female subjects under fed and fasting conditions. The results showed that both formulations met the bioequivalence acceptance criteria and were well tolerated by the subjects, demonstrating bioequivalence in pharmacokinetic parameters under different feeding conditions.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Infectious Diseases
Thomas D. Dieringer, Joanna M. Schaenman, Matthew R. Davis
Summary: By retrospectively reviewing pharmacy records, we found that administration of crushed posaconazole DR tablets and opened isavuconazole capsules via enteral feeding tube (EFT) can achieve target plasma drug concentrations in the majority of patients, providing an alternative treatment option for patients unable to swallow medications.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Clinical Neurology
Natalia Erenburg, Roa'a Hamed, Chanan Shaul, Dinorah Barasch, Emilio Perucca, Meir Bialer
Summary: The pharmacokinetics of d- and l- norfenfluramine were investigated in rat plasma and brain, revealing rapid absorption and elimination, as well as high brain penetration.
Article
Biochemical Research Methods
Friederike A. Sandbaumhuter, Claudia Gittel, M. Paula Larenza-Menzies, Regula Theurillat, Wolfgang Thormann, Christina Braun
Summary: The enantioselectivity of the pharmacokinetics of methadone was demonstrated in anesthetized Shetland ponies, with lower concentrations of the d-enantiomer compared to the l-enantiomer and faster elimination of d-methadone and d-EDDP. This study highlights the importance of considering enantioselective disposition in racemic methadone administration in equines.
Article
Microbiology
Angela Koryakova, Victoria Shcherbakova, Olga Riabova, Yurii Kazaishvili, Roman Bolgarin, Vadim Makarov
Summary: This study evaluated the pharmacokinetics of Macozinone (MCZ) in different formulations. The results showed that extended-release tablets significantly increased the bioavailability of MCZ compared to dispersible tablets, potentially improving treatment adherence and reducing the development of drug resistance.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pharmacology & Pharmacy
Tao Long, Rodrigo Cristofoletti, Brian Cicali, Veronique Michaud, Pamela Dow, Jacques Turgeon, Stephan Schmidt
Summary: The study demonstrates that CYP2D6 inhibitors have different impacts on tramadol and O-desmethyltramadol, based on their mechanisms of inhibition. Quinidine significantly affects the exposure of tramadol, while metoprolol has minimal impact on it.
JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Ling Yang, Liangliang Zhang, Zhu Luo
Summary: This study aimed to investigate the pharmacokinetics and bioequivalence of pramipexole dihydrochloride extended-release tablets in healthy Chinese subjects. The results showed that the test and reference formulations had similar pharmacokinetic properties in terms of peak concentration, time to reach peak concentration, and area under the curve. Therefore, the extended-release tablets demonstrated bioequivalence and safety in Chinese subjects.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Oncology
Daniele Ouellet, Nastya Kassir, Joannellyn Chiu, Mohamad-Samer Mouksassi, Cathrine Leonowens, Donna Cox, Douglas J. DeMarini, Olivia Gardner, Wendy Crist, Kiran Patel
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2016)
Article
Geriatrics & Gerontology
Sybil Skinner Robertson, Mohamad Samer Mouksassi, France Varin
Article
Public, Environmental & Occupational Health
Lazaro M. Mwandigha, Keith J. Fraser, Amy Racine-Poon, Mohamad-Samer Mouksassi, Azra C. Ghani
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2020)
Review
Pharmacology & Pharmacy
Michael Dodds, Yuan Xiong, Samer Mouksassi, Carl M. Kirkpatrick, Katrina Hui, Eileen Doyle, Kashyap Patel, Eugene Cox, David Wesche, Fran Brown, Craig R. Rayner
Summary: This article discusses the five steps of model-informed drug repurposing (MIDR) and categorizes activities under these steps into three stages. MIDR helps extract more information from emerging data and integrate disparate data into actionable insights.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Anesthesiology
Sarah Maximos, Eric Vaillancourt-Jean, Samer Mouksassi, Alessandro De Cassai, Sophie Ayoub, Monique Ruel, Julie Desroches, Pierre-Oliver Hetu, Alex Moore, Stephan Williams
Summary: The aim of this study was to investigate the maximum concentrations and timing of plasma bupivacaine after ESPB and PIFB. The study found that the C-max of total and free bupivacaine were significantly lower than toxic levels reported in the literature when using a dose of 2 mg/kg.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Article
Pharmacology & Pharmacy
Jean-Francois Marier, Nathan Teuscher, Mohamad-Samer Mouksassi
Summary: This tutorial explains the importance of forest plots in communicating covariate effects effectively, the construction methods, and presentation techniques. It also introduces simulation-based methodologies and graphical tools for evaluating covariate effects, along with providing an R package and application for designing and constructing forest plots.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jaap Mandema, Hugh Montgomery, Louis Dron, Shuai Fu, Estelle Russek-Cohen, Christina Bromley, Samer Mouksassi, Amy Lalonde, Aaron Springford, Larry Tsai, Phil Ambery, Doug Mcnair, Nawab Qizilbash, Stuart Pocock, Nevine Zariffa
Summary: Rapid and robust strategies that include large randomized controlled trials (RCTs) and well-designed observational real-world studies (RWS) are necessary to evaluate the efficacy and effectiveness of pharmacotherapeutic interventions in future pandemics. The results of a study analyzing the data from COVID-19 RCTs and RWS suggest that large RCTs provide more accurate conclusions about the clinical benefits of treatments, while RWS tend to yield more varied results. Therefore, in future pandemics, prioritizing large RCTs, improving the design and data matching of RWS, enhancing reporting standards, and promoting access to patient-level data are crucial for evaluating therapies.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Anesthesiology
Sybil Skinner-Robertson, Mohamad-Samer Mouksassi, France Varin
Article
Urology & Nephrology
Ronald D. Perrone, Mohamad-Samer Mouksassi, Klaus Romero, Frank S. Czerwiec, Arlene B. Chapman, Berenice Y. Gitomer, Vicente E. Torres, Dana C. Miskulin, Steve Broadbent, Jean F. Marier
KIDNEY INTERNATIONAL REPORTS
(2017)
Article
Urology & Nephrology
Ronald D. Perrone, Mohamad-Samer Mouksassi, Klaus Romero, Frank S. Czerwiec, Arlene B. Chapman, Berenice Y. Gitomer, Vicente E. Torres, Dana C. Miskulin, Steve Broadbent, Jean F. Marier
KIDNEY INTERNATIONAL REPORTS
(2017)
Article
Computer Science, Interdisciplinary Applications
Chay Ngee Lim, Shuang Liang, Kevin Feng, Jason Chittenden, Ana Henry, Samer Mouksassi, Angela K. Birnbaum
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2017)
Article
Pharmacology & Pharmacy
T. H. T. Nguyen, M-S Mouksassi, N. Holford, N. Al-Huniti, I. Freedman, A. C. Hooker, J. John, M. O. Karlsson, D. R. Mould, J. J. Perez Ruixo, E. L. Plan, R. Savic, J. G. C. van Hasselt, B. Weber, C. Zhou, E. Comets, F. Mentre
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2017)
Article
Pharmacology & Pharmacy
Nathalie H. Gosselin, Mohamad-Samer Mouksassi, Jian-Feng Lu, Cheng-Pang Hsu
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
(2015)
Article
Pharmacology & Pharmacy
Mohamad-Samer Mouksassi, Jean-Francois Marier, Leon Bax, Yutaka Osawa, Kazuhisa Tsuruta
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
(2015)