Review
Medicine, General & Internal
Shibili Nuhmani, Mohammad Ahsan, Mohd Arshad Bari, Deepak Malhotra, Wafa Hashem Al Muslem, Saad Mohammed Alsaadi, Qassim Ibrahim Muaidi
Summary: This systematic review aimed to analyze the effectiveness of various injection treatments for patellar tendinopathy. Nine randomized control trials were included in the review, showing overall positive outcomes. Although injection treatments showed promising results, the limited number of studies and disparities in study populations and protocols prevent drawing firm conclusions on their efficacy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Wen Bo Sam Zhou, JingWen Meng, Ji Zhang
Summary: Chronic inflammation may be a predisposing and/or precipitating factor in the development of chronic pain, which requires further research to understand their complex interactions.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Chemistry, Medicinal
Fahad S. Alshehri
Summary: Tapentadol is a centrally acting analgesic compound that has dual mechanisms of action as a mu-opioid receptor agonist and noradrenaline re-uptake inhibitor. It provides a significant advantage over classic opioids in pain management, especially for chronic neuropathic pain. Tapentadol has fewer adverse effects compared to tramadol and other opioids, making it a new alternative for acute, chronic, and neuropathic pain treatment.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Cell Biology
Pasquale Mone, Jessica Gambardella, Antonella Pansini, Antonio de Donato, Giuseppe Martinelli, Eugenio Boccalone, Alessandro Matarese, Salvatore Frullone, Gaetano Santulli
Summary: The study demonstrates the detrimental effects of hypertension and hyperglycemia on endothelial cell function and cognitive decline in older adults. Metformin shows beneficial effects on brain microvascular endothelial cells, improving cell death and reactive oxygen species generation induced by high glucose, and mitigating cognitive impairment.
Article
Geriatrics & Gerontology
Sara Molla-Casanova, Elena Munoz-Gomez, Nuria Sempere-Rubio, Marta Ingles, Marta Aguilar-Rodriguez, Alvaro Page, Juan Lopez-Pascual, Pilar Serra-Ano
Summary: The aim of this study is to evaluate the effects of a virtual running treatment combined with specific physical gait exercise on functionality, pain, and muscular tone in pre-frail and frail older persons. The experimental group showed improvement in aerobic capacity, functional lower-limb strength, reaction time, and pain, while the control group remained the same. Further analysis is needed to assess the effectiveness of virtual running therapy on gait, stand-up and sit-down performance, and velocity.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Oncology
Haley K. Perlow, Rahul N. Prasad, Mike Yang, Brett Klamer, Jennifer Matsui, Livia Marrazzo, Beatrice Detti, Marta Scorsetti, Elena Clerici, Andrea Arnett, Sasha Beyer, Mario Ammirati, Arnab Chakravarti, Raju R. Raval, Paul D. Brown, Pierina Navarria, Silvia Scoccianti, John C. Grecula, Joshua D. Palmer
Summary: The study explored the use of accelerated hypofractionated radiation in treating patients with GBM, particularly elderly or frail patients, and found it to be safe and effective, with good overall survival and progression-free survival outcomes. Concurrent chemotherapy was identified as an independent prognostic factor for improved outcomes.
Article
Neurosciences
Martin W. Herklots, Michael Kroon, Gerwin Roks, Annemarie Oldenbeuving, Guus G. Schoonman
Summary: Frailty has a significant impact on outcomes in elderly patients with severe TBI. High frailty is associated with higher mortality and poorer functional recovery. Low frailty is associated with significant improvement in functional outcome after 6 months.
Article
Geriatrics & Gerontology
Ulderico Freo, Maurizio Furnari, Francesco Ambrosio, Paolo Navalesi
Summary: The study indicates that tapentadol extended release maintains efficacy and good tolerability in elderly patients with chronic low back pain, providing significant pain relief, and improving quality of life and sleep.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Hiroya Honda, Ryota Ashizawa, Kazuya Kiriyama, Koki Take, Tatsuya Hirase, Shinichi Arizono, Yoshinobu Yoshimoto
Summary: The study identified chronic pain as a significant factor influencing falls in frail elderly individuals, with sleep disorders playing a partial mediating role in the relationship between chronic pain and falls. Interventions targeting chronic pain and sleep disorders are suggested to focus on preventing falls in this vulnerable population.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Geosciences, Multidisciplinary
Rui Hugman, John Doherty
Summary: The primary tasks of decision-support modelling are to quantify and reduce uncertainties in model predictions. This requires assimilating information from site measurements and expert knowledge. The design process involves a compromise between model complexity and parameter assignment.
FRONTIERS IN EARTH SCIENCE
(2022)
Article
Clinical Neurology
Michihiro Iwaki, Takaomi Kessoku, Taro Kanamori, Kentaro Abe, Nobuhiro Takeno, Ryoko Kawahara, Taisuke Fujimoto, Takashi Igarashi, Yasutomo Kumakura, Naoki Suzuki, Kouhei Kamiya, Naoto Suzuki, Keita Tagami, Tomoya Saeki, Hironori Mawatari, Hiroki Sakurai, Takahiro Higashibata, Takeshi Hirohashi, Atsushi Nakajima, Yasushi Ichikawa, Hiroto Ishiki
Summary: This study aimed to assess the safety profile of Tapentadol in Japanese cancer patients and found that patients prescribed Tapentadol by a palliative care physician, those switching to Tapentadol, and those not using naldemedine were more likely to discontinue treatment due to adverse events.
Article
Clinical Neurology
Matthew Smuck, Kevin Barrette, Agnes Martinez-Ith, Geoffrey Sultana, Patricia Zheng
Summary: This study evaluated the reasons for seeking care in patients with back pain and compared them to physicians' assumptions. The results showed that patients placed high importance on the explanation of the pain cause, improvement in pain level, and improvement in daily tasks ability, while they attributed low importance to surgery and medication. Furthermore, physicians underestimated the importance of an explanation for the pain.
Article
Biochemistry & Molecular Biology
Caihong Wu, Xingwei Zhang, Feifei Yan, Yani Cui, Yuan Song, Shoumeng Yan, Weiwei Cui
Summary: Background: Precocious puberty is a common pediatric endocrine system disease associated with reduced adult height, adverse psychological outcomes, and long-term health consequences. Low levels of vitamin D have been linked to precocious puberty, but its effect remains controversial. Methods: A meta-analysis was conducted to evaluate the differences in vitamin D concentration between precocious puberty subjects and normal subjects, the risk of precocious puberty in subjects with low vitamin D levels, and the effect of vitamin D supplementation on subjects with precocious puberty. Results: The study revealed that precocious puberty subjects had lower serum vitamin D levels compared to the normal population, and lower vitamin D levels were associated with an increased risk of precocious puberty. Additionally, subjects who received vitamin D supplementation alongside intervention had improved hormone levels, bone age, and predicted adult height. Conclusions: Vitamin D may play a potential role in precocious puberty, but further data from large clinical trials are needed to validate these findings.
Article
Psychiatry
Csilla agoston, Robert Urban, Zsolt Horvath, Wim van den Brink, Zsolt Demetrovics
Summary: This study aimed to examine the relationship between ADHD symptoms, caffeine consumption, caffeine use disorder (CUD), and well-being. The results showed no associations between ADHD symptoms and coffee, tea, energy drink, or cola consumption or daily caffeine consumption. However, path analysis revealed a positive association between ADHD symptoms and CUD severity, as well as a negative association between ADHD symptoms and well-being.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Oncology
Haley K. Perlow, Alexander Yaney, Michael Yang, Brett Klamer, Jennifer Matsui, Raju R. Raval, Dukagjin M. Blakaj, Andrea Arnett, Sasha Beyer, James B. Elder, Mario Ammirati, Russell Lonser, Douglas Hardesty, Shirley Ong, Pierre Giglio, Clement Pillainayagam, Justin Goranovich, John Grecula, Arnab Chakravarti, Vinai Gondi, Paul D. Brown, Joshua D. Palmer
Summary: In this study, the survival outcomes of elderly glioblastoma patients receiving different radiation doses were compared. The results showed that elderly patients who received an isoeffective dose of 52.5 Gy in 15 fractions had better overall survival compared to those receiving the standard 40 Gy in 15 fractions. These findings support the potential use of accelerated hypofractionated radiation in future trials.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Editorial Material
Pharmacology & Pharmacy
Wubshet Tesfaye, Gregory Peterson
Summary: This paper provides a summary of free self-report measures for medication adherence which have been validated in various health conditions. Researchers should be aware of potential licensing and fee requirements when selecting tools for their studies. Improved understanding of available self-report questionnaires will help researchers make informed decisions.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Andrew Ridge, Gregory M. Peterson, Alex Kitsos, Bastian M. Seidel, Vinah Anderson, Rosie Nash
Summary: This study aimed to determine the factors associated with potentially preventable hospitalizations (PPH) in an Australian rural population. The study found that being single and having a higher comorbidity burden were the strongest independent risk factors for PPH in a rural population. Demographic and socioeconomic factors were found to be as, if not more, important than medical factors when considering programs to reduce PPH risk in rural communities.
INTERNAL MEDICINE JOURNAL
(2023)
Review
Emergency Medicine
Tesfay Mehari Atey, Gregory M. Peterson, Mohammed Saji Salahudeen, Luke R. Bereznicki, Barbara C. Wimmer
Summary: Pharmacist interventions in emergency departments can improve the quality use of medicines by reducing medication errors and providing more accurate medication histories, leading to improved patient outcomes.
EMERGENCY MEDICINE JOURNAL
(2023)
Article
Environmental Sciences
Thilini Sudeshika, Mark Naunton, Gregory M. Peterson, Louise S. Deeks, Line Guenette, Ravi Sharma, Christopher Freeman, Theo Niyonsenga, Sam Kosari
Summary: With the development of team-based care, pharmacists have been integrated into general practice teams in many countries to enhance medication use and patient safety. However, there is limited evidence on the collaboration and effectiveness of pharmacists in general practice. This study aimed to compare interprofessional collaboration and team effectiveness of general practice pharmacists in Australia, Canada, and the UK and identify associated factors. The results showed high levels of collaboration and similar team effectiveness among general practice pharmacists from these countries. Long-term employment and longer work hours were found to enhance collaboration and effectiveness.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Pharmacology & Pharmacy
Ahmed M. Gharib, Ivan K. Bindoff, Gregory M. Peterson, Mohammed S. Salahudeen
Summary: Computer-based simulations are an innovative and cost-effective approach that can be utilized more in pharmacy practice education. This review identifies 29 unique simulators described in the literature, with only eight currently available. The characteristics of these simulators are examined through eight main criteria, and educators are encouraged to choose the product that best aligns with their teaching goals.
Article
Pharmacology & Pharmacy
Thilini Sudeshika, Louise S. Deeks, Mark Naunton, Gregory M. Peterson, Sam Kosari
Summary: This study aimed to evaluate the potential outcomes of pharmacist-led activities in Australian general practices. The majority of pharmacists' activities were related to medication management services, with 75% of their recommendations fully accepted by general practitioners. About 50% of the clinical activities had the potential for a moderate or major positive impact on patients, and 63% had the potential to decrease healthcare costs. Almost all pharmacist-led clinical activities had a positive impact on the organization.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)
Article
Medicine, General & Internal
Woldesellassie M. Bezabhe, Jan Radford, Mohammed S. Salahudeen, Ivan Bindoff, Tristan Ling, Peter Gee, Barbara C. Wimmer, Gregory M. Peterson
Summary: This study found a decline in psychotropic prescribing in Australian primary care patients with dementia from 2011 to 2020, especially for antipsychotics. However, psychotropic polypharmacy still occurred in almost one in five patients with dementia at the end of the study period.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Sheraz Ali, Colin M. M. Curtain, Gregory M. M. Peterson, Mohammed S. S. Salahudeen
Summary: This study aimed to explore Australian pharmacists' views on reducing the risk of medicines-related harm in older residents in residential aged care facilities. The major causes of medicines-related harm include polypharmacy, inappropriate medicines, anticholinergic activity, sedative load, and lack of reconciliation of medicines. Pharmacists believed that strengthening relationships, educating stakeholders, and funding for pharmacists would facilitate the reduction of medicines-related harm.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2023)
Article
Pharmacology & Pharmacy
Louise S. Deeks, Sam Kosari, Gregory M. Peterson, Thilini Sudeshika, Mark Naunton
Summary: Qualitative interviews with pharmacists who had left employment in general practice within 12 months identified lack of utilization and part-time hours as specific reasons for leaving. Other themes included challenges of the new role, poor role definition, professional relationships, and job satisfaction.
INTERNATIONAL JOURNAL OF PHARMACY PRACTICE
(2023)
Review
Pharmacology & Pharmacy
Ahmed M. Gharib, Gregory M. Peterson, Ivan K. Bindoff, Mohammed S. Salahudeen
Summary: Computer-based simulation (CBS) is an interactive pedagogical training method that has gained increased attention. However, its adoption in pharmacy education lags behind other healthcare disciplines. This systematic review explores potential barriers to integrating CBS in pharmacy practice education and provides suggestions to overcome them.
Article
Medicine, General & Internal
Adane Teshome Kefale, Woldesellassie M. Bezabhe, Gregory M. Peterson
Summary: This study investigated the prescription rate of oral anticoagulants (OACs) in low-risk atrial fibrillation (AF) patients and identified associated factors. It also described incident bleeding events in these patients. The results showed that 25.1% of low-risk AF patients received OACs within 60 days of diagnosis. Older age and the period following the widespread availability of direct-acting OACs were associated with a higher likelihood of OAC prescription. However, using OACs did not increase the rate of bleeding compared to non-users.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemical Research Methods
Mahsa Pouranayatihosseinabad, Maggie Taylor, Jason Hawrelak, Gregory M. Peterson, Felicity Veal, Tristan Ling, Mackenzie Williams, Megan Whatley, Kyan Ahdieh, Corinne Mirkazemi
Summary: This study aims to investigate the association between antibiotic use during pregnancy and the development of depressive symptoms, specifically during the antenatal and postpartum periods. A national cohort study has been designed to examine this relationship, with a sample size of 1500 pregnant individuals. The study will collect data at multiple time points and explore potential risk factors for depression during pregnancy and postpartum.
METHODS AND PROTOCOLS
(2023)
Article
Pharmacology & Pharmacy
Louise S. Deeks, Mark Naunton, Gregory M. Peterson, Thilini Sudeshika, Christopher Freeman, Ravi Sharma, Stacy Leavens, Sam Kosari
Summary: Pharmacists embedded in general practice can improve medicines optimisation and patient safety. Australia has been slower to adopt and fund this model compared to other countries. An evaluation in Canberra showed positive clinical outcomes of pharmacist involvement in medication reviews and audits. The general practice pharmacist role was welcomed by patients, GPs, and other healthcare professionals. However, challenges such as lack of clear job description and funding support exist.
JOURNAL OF PHARMACY PRACTICE AND RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Anum Saqib Zaidi, Gregory M. Peterson, Luke R. E. Bereznicki, Colin M. Curtain, Mohammed S. Salahudeen
Summary: This study investigated the trends and characteristics of hospitalizations associated with medication problems among people with dementia. The results showed an increasing annual incidence of such hospitalizations, with antithrombotics being the most commonly implicated drugs. These hospitalizations were associated with longer hospital stays and higher mortality rates.
THERAPEUTIC ADVANCES IN DRUG SAFETY
(2022)
Article
Education & Educational Research
Sarah Jane Prior, Pieter Jan Van Dam, Phoebe E. J. Griffin, Nicole S. Reeves, Lea Kirkwood, Bronwyn Paton, Amelia Giles, Gregory M. Peterson
Summary: The study found that students highly value social interaction, communication, and knowledge and skills development, with course structure and organizational support significantly influencing student outcomes. Cross-discipline interaction and networking opportunities further enhanced student learning.
HIGHER EDUCATION RESEARCH & DEVELOPMENT
(2022)