Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 372, Issue -, Pages 14-18Publisher
ELSEVIER
DOI: 10.1016/j.jns.2016.11.027
Keywords
Parkinson's disease; Orthostatic hypotension; Body mass index; Sympathetic nervous system; Autonomic dysfunction
Categories
Funding
- Grants-in-Aid for Scientific Research [15K09350] Funding Source: KAKEN
Ask authors/readers for more resources
Introduction: Lower body mass index (BMI) is associated with orthostatic hypotension (OH) in the general population, especially in the elderly; however, no studies have addressed this issue in Parkinson's disease (PD). Methods: We investigated the results of the head-up tilt test and BMI of patients with PD, and evaluated whether BMI is related to orthostatic systolic blood pressure (SBP) change during the head-up tilt test. PD patients were divided into male and female groups, and further divided into middle-aged (age < 65 years) and elderly (age 65 years) subgroups in each sex. Results: OH was observed in 13 of 64 male and 12 of 75 female patients with PD. BMI was lower in patients with OH than in those without, in both men and women. In the elderly group, a significant correlation between BMI and orthostatic SBP change was found (men, r = 0.47, p = 0.006; women, r = 0.43, p = 0.005), and a BMI below mean - 0.5 standard deviation increased OH odds (men: BMI < 20.5; odds ratio, 6.79; 95% CI, 1.06-43.36; women: BMI < 18.5; odds ratio, 5.11; 95% CI, 1.05-24.96). Conclusion: Lower BMI is a predisposing factor of OH in elderly patients with PD. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available