Looking for protein stabilizing drugs with thermal shift assay

Conformational Response to Ligand Binding in Phosphomannomutase2

(2014) Giuseppina Andreotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Chaperone Enhances Blood α-Glucosidase Activity in Pompe Disease Patients Treated With Enzyme Replacement Therapy

(2014) Giancarlo Parenti et al.   MOLECULAR THERAPY

A thermodynamic assay to test pharmacological chaperones for Fabry disease

(2013) Giuseppina Andreotti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Fabry_CEP: a tool to identify Fabry mutations responsive to pharmacological chaperones

(2013) Marco Cammisa et al.   Orphanet Journal of Rare Diseases

Biochemical phenotype of a common disease-causing mutation and a possible therapeutic approach for the phosphomannomutase 2-associated disorder of glycosylation

(2013) Giuseppina Andreotti et al.   Molecular Genetics & Genomic Medicine

2-(3-Oxo-1,3-diphenylpropyl)malonic Acids as Potent Allosteric Ligands of the PIF Pocket of Phosphoinositide-Dependent Kinase-1: Development and Prodrug Concept

(2012) Adriana Wilhelm et al.   JOURNAL OF MEDICINAL CHEMISTRY

Co-administration With the Pharmacological Chaperone AT1001 Increases Recombinant Human α-Galactosidase A Tissue Uptake and Improves Substrate Reduction in Fabry Mice

(2012) Elfrida R Benjamin et al.   MOLECULAR THERAPY

The Molecular Basis of Pharmacological Chaperoning in Human α-Galactosidase

(2011) Abigail I. Guce et al.   CHEMISTRY & BIOLOGY

Effects of pH and Iminosugar Pharmacological Chaperones on Lysosomal Glycosidase Structure and Stability

(2009) Raquel L. Lieberman et al.   BIOCHEMISTRY

Treating lysosomal storage diseases with pharmacological chaperones: from concept to clinics

(2009) Giancarlo Parenti   EMBO Molecular Medicine

The pharmacological chaperone 1-deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha-glucosidase

(2009) John J. Flanagan et al.   HUMAN MUTATION

Molecular interaction of imino sugars with human α-galactosidase: Insight into the mechanism of complex formation and pharmacological chaperone action in Fabry disease

(2009) Kanako Sugawara et al.   MOLECULAR GENETICS AND METABOLISM