Article
Oncology
Fan Meng, Le Lu, Yuan Tan, Qianqian Duan, Hongwei Lu
Summary: Utilizing next-generation sequencing, a rare case of KRAS wild-type pancreatic ductal adenocarcinoma with KANK1-ALK, UPP2-NTRK3 fusion, and pathogenic BRCA mutation was identified. This comprehensive screening for actionable genomic alterations has the potential to greatly enhance therapeutic outcomes for patients with PDAC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Sidsel C. Lindgaard, Zsofia Sztupinszki, Emil Maag, Inna M. Chen, Astrid Z. Johansen, Benny Jensen, Stig E. Bojesen, Dorte L. Nielsen, Carsten P. Hansen, Jane P. Hasselby, Kaspar R. Nielsen, Zoltan Szallasi, Julia S. Johansen
Summary: A study identified two circulating protein indices with the potential to discriminate between individuals with and without PDAC.
CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Beatriz Parejo-Alonso, Alba Royo-Garcia, Pilar Espiau-Romera, Sarah Courtois, Alvaro Curiel-Garcia, Sladjana Zagorac, Isabel Villaoslada, Kenneth P. Olive, Christopher Heeschen, Patricia Sancho
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by metastasis and chemoresistance. Targeting the ALK signaling pathway can decrease tumor formation and chemoresistance in PDAC by inhibiting pancreatic cancer stem cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Liwei Cao, Chen Huang, Daniel Cui Zhou, Yingwei Hu, T. Mamie Lih, Sara R. Savage, Karsten Krug, David J. Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A. Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M. Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D. Jewell, Galen Hostetter, Chelsea J. Newton, Qing Kay Li, Michael H. Roehr, David Fenyo, Pei Wang, Alexey Nesvizhskii, D. R. Mani, Gilbert S. Omenn, Emily S. Boja, Mehdi Mesri, Ana Robles, Henry Rodriguez, Oliver F. Bathe, Daniel W. Chan, Ralph H. Hruban, Li Ding, Bing Zhang, Hui Zhang
Summary: This study conducted comprehensive proteogenomic analysis of PDAC to understand the molecular alterations that drive oncogenesis. Multiple analyses were performed on tissues from patients, providing valuable resources for early detection and identification of therapeutic targets.
Article
Biotechnology & Applied Microbiology
Hongjin Wu, Weiwei Tian, Xiang Tai, Xuanpeng Li, Ziwei Li, Jing Shui, Juehua Yu, Zhihua Wang, Xiaosong Zhu
Summary: This study identified five potential central genes highly expressed in PDAC, including a novel oncogene DDX60L. RNA sequencing analyses revealed that siDDX60L and siMYEOV may impact the tumor microenvironment in PDAC by affecting signaling pathways and chemokine CXCL2 expression.
Article
Biochemistry & Molecular Biology
Mark Kriegsmann, Katharina Kriegsmann, Georg Steinbuss, Christiane Zgorzelski, Anne Kraft, Matthias M. Gaida
Summary: This study used deep learning to automatically identify histopathological images of pancreatic tissue specimens, achieving identification of different anatomical tissue structures and diseases. The convolutional neuronal network and optimized algorithm allowed for automatic localization and quantification of lesions in whole tissue slides. This approach serves as a valuable tool for routine diagnostic review and research in pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Nausika Betriu, Juan Bertran-Mas, Anna Andreeva, Carlos E. Semino
Summary: Syndecans, a subfamily of proteoglycans, play critical roles in various physiological processes and have implications in disease progression. Their interactions with other macromolecules contribute to normal cellular functions and disease pathogenesis.
Article
Oncology
Jiatong Wang, Chi Hin Wong, Yinxin Zhu, Xiaoqiang Yao, Kelvin K. C. Ng, Chengzhi Zhou, Ka Fai To, Yangchao Chen
Summary: The study identifies GRIN2D as a potential therapeutic target for pancreatic ductal adenocarcinoma (PDAC) and demonstrates its oncogenic role in PDAC progression.
BIOMARKER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Chaozhi Yang, Xuebing Wang, Chenjie Qiu, Ziruo Zheng, Kai Lin, Min Tu, Kai Zhang, Kuirong Jiang, Wentao Gao
Summary: In this study, we found that FEZ2 was upregulated in PDAC tissues and correlated with poor prognosis. High expression of FEZ2 could promote PDAC cells proliferation, migration, and 5-FU resistance, and it was also correlated with Wnt signaling activation.
Review
Oncology
Eleonora Lai, Pina Ziranu, Dario Spanu, Marco Dubois, Andrea Pretta, Simona Tolu, Silvia Camera, Nicole Liscia, Stefano Mariani, Mara Persano, Marco Migliari, Clelia Donisi, Laura Demurtas, Valeria Pusceddu, Marco Puzzoni, Mario Scartozzi
Summary: Despite ongoing research, there is still insufficient data on BRCA1/2-mutant PDAC, and more understanding is needed on the specific landscape of PDAC with BRCA mutations.
BRITISH JOURNAL OF CANCER
(2021)
Review
Cell Biology
Tianyi Zhang, Yanxian Ren, Pengfei Yang, Jufang Wang, Heng Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a high deposition of extracellular matrix (ECM) and poor prognosis. ECM proteins derived from tumor cells reduce the effectiveness of conventional cancer treatment and contribute to tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) in the ECM are promising targets for novel anti-tumor interventions.
CELL DEATH & DISEASE
(2022)
Editorial Material
Biology
Jessica Castrillon Lal
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a low survival rate. Understanding the complexity of tumor architecture and identifying targetable cellular phenotypes are major challenges in PDAC. Recent research has found recurrent gene expression patterns in malignant and fibroblast cellular neighborhoods in PDAC tumors that are correlated with treatment outcomes.
COMMUNICATIONS BIOLOGY
(2022)
Review
Oncology
Eric M. Anderson, Shant Thomassian, Jun Gong, Andrew Hendifar, Arsen Osipov
Summary: Pancreatic cancer, with its highly immunosuppressive tumor microenvironment and dense stroma, presents challenges for traditional treatment approaches. Emerging treatment strategies have the potential to significantly improve outcomes for pancreatic cancer patients.
Review
Pharmacology & Pharmacy
Delphine Quatannens, Yannick Verhoeven, Peter Van Dam, Filip Lardon, Hans Prenen, Geert Roeyen, Marc Peeters, Evelien L. J. Smits, Jonas Van Audenaerde
Summary: PDAC is a leading cause of cancer related death, with urgent need for effective therapies. Aberrant activation of the Hh signaling pathway in PDAC prompts it as a possible target for treatment, despite ongoing debate on its clinical benefits.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Roman Bubin, Romans Uljanovs, Ilze Strumfa
Summary: The discovery of cancer stem cells (CSCs) in leukemia has led to active research on stemness in neoplastic tissues. CSCs are a subpopulation of malignant cells with unique properties, including a dedifferentiated state, self-renewal, pluripotency, resistance to therapy, epigenetic alterations, and higher tumorigenicity. CSCs have been confirmed in various malignancies, including pancreatic ductal adenocarcinoma, which has a poor prognosis. This review aims to summarize the current knowledge on the markers and molecular features of CSCs in pancreatic ductal adenocarcinoma and the therapeutic options for their elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
R. J. Hartmaier, S. E. Trabucco, N. Priedigkeit, J. H. Chung, C. A. Parachoniak, P. Vanden Borre, S. Morley, M. Rosenzweig, L. M. Gay, M. E. Goldberg, J. Suh, S. M. Ali, J. Ross, B. Leyland-Jones, B. Young, C. Williams, B. Park, M. Tsai, B. Haley, J. Peguero, R. D. Callahan, I. Sachelarie, J. Cho, J. M. Atkinson, A. Bahreini, A. M. Nagle, S. L. Puhalla, R. J. Watters, Z. Erdogan-Yildirim, L. Cao, S. Oesterreich, A. Mathew, P. C. Lucas, N. E. Davidson, A. M. Brufsky, G. M. Frampton, P. J. Stephens, J. Chmielecki, A. V. Lee
ANNALS OF ONCOLOGY
(2018)
Article
Oncology
Erica L. Gornstein, Sara Sandefur, Jon H. Chung, Laurie M. Gay, Oliver Holmes, Rachel L. Erlich, Salil Soman, L. Katherine Martin, Andrea V. Rose, Philip J. Stephens, Jeffrey S. Ross, Vincent A. Miller, Siraj M. Ali, Sibel Blau
CLINICAL BREAST CANCER
(2018)
Article
Oncology
Alexa B. Schrock, Dean Pavlick, Samuel J. Klempner, Jon H. Chung, Brady Forcier, Allison Welsh, Lauren Young, Bryan Leyland-Jones, Rodolfo Bordoni, RichardD. Carvajal, Joseph Chao, Razelle Kurzrock, Jason K. Sicklick, Jeffrey S. Ross, Philip J. Stephens, Craig Devoe, Fadi Braiteh, Siraj M. Ali, Vincent A. Miller
CLINICAL CANCER RESEARCH
(2018)
Letter
Oncology
Andrea Necchi, Daniele Raggi, Patrizia Giannatempo, Alessandra Alessi, Gianluca Serafini, Maurizio Colecchia, Siraj M. Ali, Jon H. Chung
EUROPEAN JOURNAL OF CANCER
(2018)
Letter
Urology & Nephrology
Sumanta K. Pal, Paulo Bergerot, Nazli Dizman, Cristiane Bergerot, Jacob Adashek, Russell Madison, Jon H. Chung, Siraj M. Ali, Jeremy O. Jones, Ravi Salgia
Article
Urology & Nephrology
Sumanta K. Pal, Siraj M. Ali, Evgeny Yakirevich, Daniel M. Geynisman, Jose A. Karam, Julia A. Elvin, Garrett M. Frampton, Xuan Huang, Douglas I. Lin, Mark Rosenzweig, Doron Lipson, Philip J. Stephens, Jeffrey S. Ross, Vincent A. Miller, Neeraj Agarwal, Brian Shuch, Toni K. Choueiri, Jon H. Chung
Article
Pathology
Travis A. Clark, Jon H. Chung, Mark Kennedy, Jason D. Hughes, Niru Chennagiri, Daniel S. Lieber, Bernard Fendler, Lauren Young, Mandy Zhao, Michael Coyne, Virginia Breese, Geneva Young, Amy Donahue, Dean Pavlick, Alyssa Tsiros, Timothy Brennan, Shan Zhong, Tariq Mughal, Mark Bailey, Jie He, Steven Roels, Garrett M. Frampton, Jill M. Spoerke, Steven Gendreau, Mark Lackner, Erica Schleifman, Eric Peters, Jeffrey S. Ross, Siraj M. Ali, Vincent A. Miller, Jeffrey P. Gregg, Philip J. Stephens, Allison Welsh, Geoff A. Otto, Doron Lipson
JOURNAL OF MOLECULAR DIAGNOSTICS
(2018)
Article
Oncology
Hyunseok Kang, Dean Pettinga, Adrian D. Schubert, Paul W. Ladenson, Douglas W. Ball, Jon H. Chung, Alexa B. Schrock, Russell Madison, Garrett M. Frampton, Phil J. Stephens, Jeffrey S. Ross, Vincent A. Miller, Siraj M. Ali
Article
Multidisciplinary Sciences
Bhavna S. Paratala, Jon H. Chung, Casey B. Williams, Bahar Yilmazel, Whitney Petrosky, Kirstin Williams, Alexa B. Schrock, Laurie M. Gay, Ellen Lee, Sonia C. Dolfi, Kien Pham, Stephanie Lin, Ming Yao, Atul Kulkarni, Frances DiClemente, Chen Liu, Lorna Rodriguez-Rodriguez, Shridar Ganesan, Jeffrey S. Ross, Siraj M. Ali, Brian Leyland-Jones, Kim M. Hirshfield
NATURE COMMUNICATIONS
(2018)
Article
Oncology
Steven E. Powell, Elie G. Dib, Jonathan S. Bleeker, Michael D. Keppen, Miroslaw Mazurczak, Keely M. Hack, Mark M. Gitau, Preston D. Steen, Shelby A. Terstriep, John Reynolds, Megan L. Landsverk, Chun-Hung Chan, Morgan E. Nelson, Paul A. Thompson, Christie Ellison, Lora J. Black, James M. Ford, Jon H. Chung, Rachel Anhorn, Anu G. Gaba
JCO PRECISION ONCOLOGY
(2018)
Article
Oncology
Young Kwang Chae, Keerthi B. Tamragouri, Jon Chung, Xiaoqi Lin, Vincent Miller, Siraj M. Ali, Francis J. Giles
JCO PRECISION ONCOLOGY
(2018)
Article
Oncology
J. H. Chung, D. Pavlick, R. Hartmaier, A. B. Schrock, L. Young, B. Forcier, P. Ye, M. K. Levin, M. Goldberg, H. Burris, L. M. Gay, A. D. Hoffman, P. J. Stephens, G. M. Frampton, D. M. Lipson, D. M. Nguyen, S. Ganesan, B. H. Park, L. T. Vahdat, B. Leyland-Jones, T. I. Mughal, L. Pusztai, J. O'Shaughnessy, V. A. Miller, J. S. Ross, S. M. Ali
ANNALS OF ONCOLOGY
(2017)
Article
Oncology
Sahar Nozad, Christine E. Sheehan, Laurie M. Gay, Julia A. Elvin, Jo-Anne Vergilio, James Suh, Shakti Ramkissoon, Alexa B. Schrock, Kim M. Hirshfield, Nadia Ali, Shridar Ganesan, Siraj M. Ali, Vincent A. Miller, Philip J. Stephens, Jeffrey S. Ross, Jon H. Chung
BREAST CANCER RESEARCH AND TREATMENT
(2017)
Article
Oncology
Munveer S. Bhangoo, Carrie Costantini, Brian T. Clifford, Jon H. Chung, Alexa B. Schrock, Siraj M. Ali, Samuel J. Klempner
JCO PRECISION ONCOLOGY
(2017)