Article
Oncology
Shadi Azam, Mikael Eriksson, Arvid Sjolander, Marike Gabrielson, Roxanna Hellgren, Kamila Czene, Per Hall
Summary: The study revealed that mammographic microcalcification clusters are an independent risk factor for breast cancer, with a higher estimated risk in premenopausal women. For postmenopausal women, microcalcification clusters and mammographic density have a similar influence on breast cancer risk, and there is no interaction between the two factors.
BRITISH JOURNAL OF CANCER
(2021)
Article
Obstetrics & Gynecology
Haim A. Abenhaim, Samy Suissa, Laurent Azoulay, Andrea R. Spence, Nicholas Czuzoj-Shulman, Togas Tulandi
Summary: The use of menopausal hormone therapy (HT) is associated with an increased risk of breast cancer, particularly with formulations containing synthetic progestins. However, the use of bioidentical estrogens or animal-derived estrogens is not associated with breast cancer. When prescribing HT, micronized progesterone may be the safer option.
OBSTETRICS AND GYNECOLOGY
(2022)
Review
Oncology
Sara P. Lester, Aparna S. Kaur, Suneela Vegunta
Summary: This review examines emerging evidence for the association of modifiable factors on mammographic breast density (MBD) and the influence of MBD on breast cancer risk, recommending that patients be counseled on modifiable risk factors to tailor breast cancer prevention strategies.
Article
Radiology, Nuclear Medicine & Medical Imaging
John Heine, Erin Fowler, Christopher G. Scott, Matthew R. Jensen, John Shepherd, Carrie B. Hruska, Stacey J. Winham, Kathleen R. Brandt, Fang F. Wu, Aaron D. Norman, Vernon S. Pankratz, Diana L. Miglioretti, Karla Kerlikowske, Celine M. Vachon
Summary: The study found that variation measures derived from mammograms were significantly associated with breast cancer risk, showing similar associations in an independent population. These measures were strongly correlated with volumetric density measures but not with dense volume measures.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaoliang Wang, Pooja Middha Kapoor, Paul L. Auer, Joe Dennis, Alison M. Dunning, Qin Wang, Michael Lush, Kyriaki Michailidou, Manjeet K. Bolla, Kristan J. Aronson, Rachel A. Murphy, Angela Brooks-Wilson, Derrick G. Lee, Pascal Guenel, Therese Truong, Claire Mulot, Lauren R. Teras, Alpa Patel, Laure Dossus, Rudolf Kaaks, Reiner Hoppe, Thomas Bruening, Ute Hamann, Kamila Czene, Marike Gabrielson, Per Hall, Mikael Eriksson, Audrey Jung, Heiko Becher, Fergus J. Couch, Nicole L. Larson, Janet E. Olson, Kathryn J. Ruddy, Graham G. Giles, Robert J. MacInnis, Melissa C. Southey, Loic Le Marchand, Lynne R. Wilkens, Christopher A. Haiman, Hakan Olsson, Annelie Augustinsson, Ute Krueger, Philippe Wagner, Christopher Scott, Stacey J. Winham, Celine M. Vachon, Charles M. Perou, Andrew F. Olshan, Melissa A. Troester, David J. Hunter, Heather A. Eliassen, Rulla M. Tamimi, Kristen Brantley, Irene L. Andrulis, Jonine Figueroa, Stephen J. Chanock, Thomas U. Ahearn, Gareth D. Evans, William G. Newman, Elke M. VanVeen, Anthony Howell, Alicja Wolk, Niclas Hakansson, Argyrios Ziogas, Michael E. Jones, Nick Orr, Minouk J. Schoemaker, Anthony J. Swerdlow, Cari M. Kitahara, Martha Linet, Ross L. Prentice, Douglas F. Easton, Roger L. Milne, Peter Kraft, Jenny Chang-Claude, Sara Lindstrom
Summary: This study found limited evidence that common genetic variants modify the effect of menopausal hormone therapy (MHT) on breast cancer risk.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Maria Sund, Hans Garmo, Anne Andersson, Sara Margolin, Johan Ahlgren, Antonis Valachis
Summary: This study investigates the impact of estrogen therapy on breast cancer mortality risk in women receiving adjuvant endocrine treatment. The results suggest that concurrent use of estrogen therapy with endocrine treatment, either in the short term or long term, does not significantly increase the risk of breast cancer mortality.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Oncology
Maddison Archer, Pallave Dasari, Andreas Evdokiou, Wendy V. Ingman
Summary: Primary prevention strategies are crucial in combating the rising global burden of breast cancer. Breast density, a significant independent risk factor for breast cancer, presents an exciting potential target for reducing incidence. Further research is needed to understand the biological mechanisms underlying high breast density and potentially develop new prevention strategies, with a focus on immune system factors that may play a role in this process.
Review
Oncology
F. T. H. Bodewes, A. A. van Asselt, M. D. Dorrius, M. J. W. Greuter, G. H. de Bock
Summary: Mammographic breast density is associated with an increased risk of breast cancer, and extremely dense breast tissue increases the risk. The use of digital mammography and BI-RADS lexicon 5th edition provides a novel and lower risk estimate.
Article
Oncology
Huijiao Yan, Wenhui Ren, Mengmeng Jia, Peng Xue, Zhifang Li, Shaokai Zhang, Lichun He, Youlin Qiao
Summary: In Chinese women with average risk for breast cancer, age, BMI, number of births, menopausal status, lactation, and age at menopause were found to be associated with mammographic density.
Article
Oncology
Anna Morra, Audrey Y. Jung, Sabine Behrens, Renske Keeman, Thomas U. Ahearn, Hoda Anton-Culver, Volker Arndt, Annelie Augustinsson, Paivi K. Auvinen, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Hermann Brenner, Ignacio Briceno, Sara Y. Brucker, Nicola J. Camp, Daniele Campa, Federico Canzian, Jose E. Castelao, Stephen J. Chanock, Ji-Yeob Choi, Christine L. Clarke, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Thilo Dork, Alison M. Dunning, Miriam Dwek, Douglas F. Easton, Diana M. Eccles, Kathleen M. Egan, D. Gareth Evans, Peter A. Fasching, Henrik Flyger, Manuela Gago-Dominguez, Susan M. Gapstur, Jose A. Garcia-Saenz, Mia M. Gaudet, Graham G. Giles, Mervi Grip, Pascal Guenel, Christopher A. Haiman, Niclas Hakansson, Per Hall, Ute Hamann, Sileny N. Han, Steven N. Hart, Mikael Hartman, Jane S. Heyworth, Reiner Hoppe, John L. Hopper, David J. Hunter, Hidemi Ito, Agnes Jager, Milena Jakimovska, Anna Jakubowska, Wolfgang Janni, Rudolf Kaaks, Daehee Kang, Pooja Middha Kapoor, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, James Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Michael Lush, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Shivaani Mariapun, Keitaro Matsuo, Dimitrios Mavroudis, Roger L. Milne, Taru A. Muranen, William G. Newman, Dong-Young Noh, Borge G. Nordestgaard, Nadia Obi, Andrew F. Olshan, Hakan Olsson, Tjoung-Won Park-Simon, Christos Petridis, Paul D. P. Pharoah, Dijana Plaseska-Karanfilska, Nadege Presneau, Muhammad U. Rashid, Gad Rennert, Hedy S. Rennert, Valerie Rhenius, Atocha Romero, Emmanouil Saloustros, Elinor J. Sawyer, Andreas Schneeweiss, Lukas Schwentner, Christopher Scott, Mitul Shah, Chen-Yang Shen, Xiao-Ou Shu, Melissa C. Southey, Daniel O. Stram, Rulla M. Tamimi, William Tapper, Rob A. E. M. Tollenaar, Ian Tomlinson, Diana Torres, Melissa A. Troester, Therese Truong, Celine M. Vachon, Qin Wang, Sophia S. Wang, Justin A. Williams, Robert Winqvist, Alicja Wolk, Anna H. Wu, Keun-Young Yoo, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Xiaohong R. Yang, A. Heather Eliassen, Michelle D. Holmes, Montserrat Garcia-Closas, Soo Hwang Teo, Marjanka K. Schmidt, Jenny Chang-Claude
Summary: Modifiable lifestyle factors such as BMI, smoking, physical activity, and age at first pregnancy are strongly associated with 10-year all-cause mortality among breast cancer patients. Associations were similar across different subtypes of breast cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Soyeoun Kim, Thi Xuan Mai Tran, Huiyeon Song, Boyoung Park
Summary: Breast density and microcalcifications are associated with breast cancer risk. The study shows that microcalcification is an independent risk factor for breast cancer, and its risk is elevated when combined with breast density.
BREAST CANCER RESEARCH
(2022)
Article
Oncology
Tuong L. Nguyen, Shuai Li, James G. Dowty, Gillian S. Dite, Zhoufeng Ye, Tu Nguyen-Dumont, Ho N. Trinh, Christopher F. Evans, Maxine Tan, Joohon Sung, Mark A. Jenkins, Graham G. Giles, Melissa C. Southey, John L. Hopper
Summary: This study measured the correlation and contribution of genetic factors to breast cancer risk scores in 593 monozygotic and 326 dizygotic female twin pairs, as well as 1592 sisters. The results showed that genetic factors have a significant impact on risk scores and explain the familial aggregation of breast cancer.
Article
Oncology
Ellie Darcey, Nina McCarthy, Eric K. Moses, Christobel Saunders, Gemma Cadby, Jennifer Stone
Summary: This study systematically assessed mammographic breast density as an endophenotype for breast cancer and confirmed its association with disease risk and heritability in two independent samples.
Article
Oncology
Shuai Li, Tuong L. Nguyen, Tu Nguyen-Dumont, James G. Dowty, Gillian S. Dite, Zhoufeng Ye, Ho N. Trinh, Christopher F. Evans, Maxine Tan, Joohon Sung, Mark A. Jenkins, Graham G. Giles, John L. Hopper, Melissa C. Southey
Summary: Mammogram risk scores based on pixel brightness predict breast cancer risk. Genetic markers associated with breast cancer risk have weak correlation with mammogram risk scores. Discovering genetic determinants of bright regions in mammogram could reveal new genetic causes of breast cancer.
Review
Medicine, General & Internal
Emma C. Atakpa, Mangesh A. Thorat, Jack Cuzick, Adam R. Brentnall
Summary: Endocrine therapy is effective at reducing mammographic density, which could potentially serve as a prognostic biomarker for breast cancer recurrence. Studies suggest that changes in mammographic density following endocrine therapy may have a greater impact on breast cancer prognosis than on predicting response to treatment. Further research is needed to fully understand the role of mammographic density as a biomarker for different classes of endocrine therapy.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Oncology
Rita Peila, Mace Coday, Tracy E. Crane, Nazmus Saquib, Aladdin H. Shadyab, Fred K. Tabung, Xiochen Zhang, Jean Wactawski-Wende, Thomas E. Rohan
Summary: This study found that a healthy lifestyle is associated with a reduced risk of pancreatic cancer in postmenopausal women.
CANCER CAUSES & CONTROL
(2022)
Meeting Abstract
Oncology
Rebecca Nelson, Kathy Pan, Rowan Chlebowski, Thomas E. Rohan, Joanne Mortimer, Jean Wactawski-Wende, Dorothy Lane, Laura Kruper
Meeting Abstract
Cardiac & Cardiovascular Systems
Laura B. Harrington, Eric Johnson, Michael J. LaMonte, Matthew A. Allison, Charles B. Eaton, Jean Wactawski-Wende, Joann E. Manson, I-Min Lee, Majken K. Jensen, Gregory Wellenius, Christopher Kabrhel, Andrea Z. LaCroix, Kenneth J. Mukamal
Article
Public, Environmental & Occupational Health
Jonathan Fix, Macarius M. Donneyong, Stephen R. Rapp, Maryam Sattari, Beverly M. Snively, Jean Wactawski-Wende, Emily W. Gower
Summary: Predictors associated with pneumococcal and seasonal influenza vaccination among older women include race, health insurance, and residential area. The study emphasizes the need to improve access, education, and provider recommendations for vaccination.
PUBLIC HEALTH REPORTS
(2023)
Article
Geriatrics & Gerontology
Bonnie C. Sachs, Sarah A. Gaussoin, Gretchen A. Brenes, Ramon Casanova, Rowan T. Chlebowski, Jiu-Chiuan Chen, Juhua Luo, Stephen R. Rapp, Aladdin H. Shadyab, Sally Shumaker, Jean Wactawski-Wende, Gretchen L. Wells, Kathleen M. Hayden
Summary: The relationship between optimism and cognitive functioning is not fully understood. This study found that less pessimism was associated with a lower risk of mild cognitive impairment (MCI) and dementia, while more optimism did not have a significant relationship with these conditions.
AGING & MENTAL HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Alexi Vasbinder, Richard K. Cheng, Susan R. Heckbert, Hilaire Thompson, Oleg Zaslavksy, Rowan T. Chlebowski, Aladdin H. Shadyab, Lisa Johnson, Jean Wactawski-Wende, Gretchen Wells, Rachel Yung, Lisa Warsinger Martin, Electra D. Paskett, Kerryn Reding
Summary: This study aimed to investigate the associations between biomarkers and long-term radiation-induced cardiovascular disease (RICVD) in breast cancer survivors. The results showed that a higher 8-OH-dG ratio was significantly associated with an elevated long-term risk of RICVD, suggesting that oxidative DNA damage may be a potential pathway for RICVD.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lindsey J. Mattick, Jennifer W. Bea, Kathy M. Hovey, Jean Wactawski-Wende, Jane A. Cauley, Carolyn J. Crandall, Lili Tian, Heather M. Ochs-Balcom
Summary: We investigated the effects of two endogenous hormones on bone health in older women. Higher levels of follicle-stimulating hormone (FSH) were associated with bone disease, particularly in lower levels of estradiol. FSH attenuates the relationship between estradiol and bone density, which may have implications for future clinical interventions on bone loss.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Cell Biology
Sabine Kuznia, Anna Zhu, Taisuke Akutsu, Julie E. Buring, Carlos A. Camargo Jr, Nancy R. Cook, Li-Ju Chen, Ting-Yuan David Cheng, Sari Hantunen, I. -Min Lee, JoAnn E. Manson, Rachel E. Neale, Robert Scragg, Aladdin H. Shadyab, Sha Sha, John Sluyter, Tomi-Pekka Tuomainen, Mitsuyoshi Urashima, Jyrki K. Virtanen, Ari Voutilainen, Jean Wactawski-Wende, Mary Waterhouse, Hermann Brenner, Ben Schoettker
Summary: A systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted to evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients. The main meta-analysis of the 14 RCTs showed a non-significant reduction in cancer mortality by 6%. Subgroup analyses revealed a significant reduction in cancer mortality in trials with daily dosing, while no reduction was seen in trials using a bolus regimen. The IPD meta-analysis confirmed the findings of all trials.
AGEING RESEARCH REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Lukas Lofling, Nathalie C. Stoer, Sara Nafisi, Giske Ursin, Solveig Hofvind, Edoardo Botteri
Summary: This study evaluates the association between aspirin use and breast cancer risk, finding inconsistent results. The use of low-dose aspirin is associated with a reduced risk of ER-positive breast cancer, especially in women aged 65 years and above, as well as overweight women.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Aaron Holman-Vittone, Brian Monahan, Erin S. LeBlanc, Simin Liu, Rami Nassir, Nazmus Saquib, Peter F. Schnatz, Aladdin H. Shadyab, Rachel Sinkey, Jean Wactawski-Wende, Robert A. Wild, Lisa Chasan-Taber, JoAnn E. Manson, Cassandra N. Spracklen
Summary: Preterm birth is associated with increased risk of developing type 2 diabetes at an earlier age, but not with overall risk of incident type 2 diabetes. The association between preterm birth and type 2 diabetes may exist during early years but wane over time.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Sandi L. Navarro, G. A. Nagana Gowda, Lisa F. Bettcher, Robert Pepin, Natalie Nguyen, Mathew Ellenberger, Cheng Zheng, Lesley F. Tinker, Ross L. Prentice, Ying Huang, Tao Yang, Fred K. Tabung, Queenie Chan, Ruey Leng Loo, Simin Liu, Jean Wactawski-Wende, Johanna W. Lampe, Marian L. Neuhouser, Daniel Raftery
Summary: Demographic and clinical factors have an influence on the metabolome. A study on 444 post-menopausal women found correlations between serum and urine metabolites and demographic and clinical parameters.
Article
Medicine, General & Internal
Diddier Prada, Carolyn J. Crandall, Allison Kupsco, Marianthi-Anna Kioumourtzoglou, James D. Stewart, Duanping Liao, Jeff D. Yanosky, Andrea Ramirez, Jean Wactawski-Wende, Yike Shen, Gary Miller, Iuliana Ionita-Laza, Eric A. Whitsel, Andrea A. Baccarelli
Summary: Osteoporosis has a major impact on postmenopausal women, and it is influenced by environmental exposures. This study found that criteria air pollutants, such as PM10, NO, NO2, and SO2, were negatively associated with bone mineral density in postmenopausal women. Nitrogen oxides exposure was identified as the leading contributor to bone loss in this population.
Article
Oncology
Ana Babic, Qiao-Li Wang, Alice A. Lee, Chen Yuan, Nader Rifai, Juhua Luo, Fred K. Tabung, Aladdin H. Shadyab, Jean Wactawski-Wende, Nazmus Saquib, Jihye Kim, Peter Kraft, Howard D. Sesso, Julie E. Buring, Edward L. Giovannucci, JoAnn E. Manson, Meir J. Stampfer, Kimmie Ng, Charles S. Fuchs, Brian M. Wolpin
Summary: The study found that high levels of adiponectin in the prediagnostic period were associated with shorter survival among women with pancreatic cancer. Several polymorphisms in ADIPOR1 and LEPR were associated with patient survival.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Health Care Sciences & Services
Elin Borosund, Anders Meland, Hege R. Eriksen, Christine M. Rygg, Giske Ursin, Lise Solberg Nes
Summary: This study aimed to develop two digital psychosocial stress-management interventions, namely cognitive behavioral therapy-based intervention (CBI) and mindfulness-based intervention (MBI), for survivors of breast cancer. Through extensive collaboration, researchers successfully developed these two interventions for survivors of breast cancer and made improvements through iterative user testing.
JMIR FORMATIVE RESEARCH
(2023)
Article
Oncology
L. Lukas Lofling, Nathalie C. Stoer, Bettina Kulle Andreassen, Giske Ursin, Edoardo Botteri
Summary: This study assessed the prognostic effect of aspirin, statins, and metformin in breast cancer patients, with inconclusive results. It found evidence supporting an association between post-diagnostic use of statins and metformin and survival in patients with breast cancer, with potential differences according to estrogen receptor status.
BREAST CANCER RESEARCH
(2023)