Review
Immunology
Ellen McKenna, Aisling Ui Mhaonaigh, Richard Wubben, Amrita Dwivedi, Tim Hurley, Lynne A. Kelly, Nigel J. Stevenson, Mark A. Little, Eleanor J. Molloy
Summary: This review explores the various names and potential subgroups of neutrophils in diseases. By profiling the surface markers and granule expression at different stages of neutrophil development, it reveals the plasticity and significant differences in surface marker expression profiles among these supposed neutrophil populations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rodrigo Canas-Arranz, Patricia de Leon, Sira Defaus, Elisa Torres, Mar Forner, Maria J. Bustos, David Andreu, Esther Blanco, Francisco Sobrino
Summary: The study demonstrates that tethering B- and T-cell epitopes to a single molecular platform is crucial for successful T-cell help and induction of high nAb levels in mice. Additionally, immunization of mice with a mixture of B2T-3A dendrimers containing B-cell epitopes from FMDV types O and C resulted in similarly high nAb levels against both serotypes, suggesting the development of a multivalent vaccine platform against various serologically distinct FMDVs.
Article
Chemistry, Multidisciplinary
A. Ya-Ting Huang, C. -L. Kao, A. Selvaraj, L. Peng
Summary: Dendrimers have a unique dendritic structure and multivalent cooperativity, making them promising for various applications. However, dendrimer synthesis faces challenges with structural defects and purification. Solid-phase synthesis can overcome these problems by enabling complete reactions and facilitating purification. This review discusses the challenges and current research in solid-phase dendrimer synthesis, as well as efforts to develop more effective methods.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Genetics & Heredity
Marina T. DiStefano, Scott Goehringer, Lawrence Babb, Fowzan S. Alkuraya, Joanna Amberger, Mutaz Amin, Christina Austin-Tse, Marie Balzotti, Jonathan S. Berg, Ewan Birney, Carol Bocchini, Elspeth A. Bruford, Alison J. Coffey, Heather Collins, Fiona Cunningham, Louise C. Daugherty, Yaron Einhorn, Helen Firth, David R. Fitzpatrick, Rebecca E. Foulger, Jennifer Goldstein, Ada Hamosh, Matthew R. Hurles, Sarah E. Leigh, Ivone U. S. Leong, Sateesh Maddirevula, Christa L. Martin, Ellen M. McDonagh, Annie Olry, Arina Puzriakova, Kelly Radtke, Erin M. Ramos, Ana Rath, Erin Rooney Riggs, Angharad M. Roberts, Charlotte Rodwell, Catherine Snow, Zornitza Stark, Jackie Tahiliani, Susan Tweedie, James S. Ware, Phillip Weller, Eleanor Williams, Caroline F. Wright, Thabo Michael Yates, Heidi L. Rehm
Summary: This study addresses the lack of universal standards and terminologies in defining gene-disease relationships. The Gene Curation Coalition (GenCC) was formed to establish harmonized definitions and develop a unified database. The results show that conflicts in gene-disease validity assertions exist, highlighting the importance of standardization and collaboration in genetic testing and variant interpretation.
GENETICS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Annarita Falanga, Valentina Del Genio, Stefania Galdiero
Summary: The alarming rise in antimicrobial resistance and recent viral pandemics have increased the demand for novel approaches, such as antimicrobial peptides, cell-penetrating peptides, antiviral peptides, and dendrimers, to combat bacteria and viruses effectively. Nanoplatforms constructed with peptides and dendrimers show promising potential for advanced nanosystems with diverse applications.
Review
Biochemistry & Molecular Biology
Mark J. Pallen, Andrea Telatin, Aharon Oren
Summary: Latin binomials, popularized by Linnaeus in the 18th century, have provided a stable and clear system of nomenclature in biology. However, with the increasing exploration of the microbial world, there is a need for a large number of new names for Archaea and Bacteria. To address this issue, an automated approach using Latin and Greek roots for creating linguistically correct names has been proposed, demonstrating the potential for creating millions of new names for Bacteria and Archaea.
TRENDS IN MICROBIOLOGY
(2021)
Article
Microbiology
Isabel Park, Troy J. J. Kemp, Ligia A. A. Pinto
Summary: The HPV Serology Laboratory is leading a global partnership initiative to standardize and harmonize serology assay platforms used in assessing immune responses to HPV vaccines. This initiative is important for the approval of new vaccine dosing schedules or formulations. The laboratory has been holding meetings with partnering laboratories to enable data comparisons and expedite the implementation of new vaccines.
Article
Medical Laboratory Technology
Xin Zhou, Zaishuan Liu, Yining Ma, Chongwei Zhang, Yongkang Wu
Summary: The developed mathematical algorithm allows for harmonizing TSH measurements between different instruments, enabling comparability of TSH data across laboratories.
CLINICA CHIMICA ACTA
(2023)
Article
Neurosciences
Delin Sun, Gopalkumar Rakesh, Courtney C. Haswell, Mark Logue, C. Lexi Baird, Erin N. O'Leary, Andrew S. Cotton, Hong Xie, Marijo Tamburrino, Tian Chen, Emily L. Dennis, Neda Jahanshad, Lauren E. Salminen, Sophia Thomopoulos, Faisal Rashid, Christopher R. K. Ching, Saskia B. J. Koch, Jessie L. Frijling, Laura Nawijn, Mirjam van Zuiden, Xi Zhu, Benjamin Suarez-Jimenez, Anika Sierk, Henrik Walter, Antje Manthey, Jennifer S. Stevens, Negar Fani, Sanne J. H. van Rooij, Murray Stein, Jessica Bomyea, Inga K. Koerte, Kyle Choi, Steven J. A. van der Werff, Robert R. J. M. Vermeiren, Julia Herzog, Lauren A. M. Lebois, Justin T. Baker, Elizabeth A. Olson, Thomas Straube, Mayuresh S. Korgaonkar, Elpiniki Andrew, Ye Zhu, Gen Li, Jonathan Ipser, Anna R. Hudson, Matthew Peverill, Kelly Sambrook, Evan Gordon, Lee Baugh, Gina Forster, Raluca M. Simons, Jeffrey S. Simons, Vincent Magnotta, Adi Maron-Katz, Stefan du Plessis, Seth G. Disner, Nicholas Davenport, Daniel W. Grupe, Jack B. Nitschke, Terri A. DeRoon-Cassini, Jacklynn M. Fitzgerald, John H. Krystal, Ifat Levy, Miranda Olff, Dick J. Veltman, Li Wang, Yuval Neria, Michael D. De Bellis, Tanja Jovanovic, Judith K. Daniels, Martha Shenton, Nic J. A. van de Wee, Christian Schmahl, Milissa L. Kaufman, Isabelle M. Rosso, Scott R. Sponheim, David Bernd Hofmann, Richard A. Bryant, Kelene A. Fercho, Dan J. Stein, Sven C. Mueller, Bobak Hosseini, K. Luan Phan, Katie A. McLaughlin, Richard J. Davidson, Christine L. Larson, Geoffrey May, Steven M. Nelson, Chadi G. Abdallah, Hassaan Gomaa, Amit Etkin, Soraya Seedat, Ilan Harpaz-Rotem, Israel Liberzon, Theo G. M. van Erp, Yann Quide, Xin Wang, Paul M. Thompson, Rajendra A. Morey
Summary: This study compared the impact of different data harmonization methods on cortical thickness data analysis results, finding that ComBat-GAM was more sensitive than other methods in detecting differences between cases and controls.
Article
Chemistry, Multidisciplinary
Yuan Yue, Cheng Liu, Jingbo Sun, Kaiqi Ye, Shuting Dai, Jiangbin Zhong, Liuyang Jin, Xiqiao Yang, Chengde Ding, Ran Lu
Summary: By employing the cocrystal strategy, both the photochemical reactivity and photomechanical behaviors of molecular crystals can be controlled and harmonized. In this study, (E)-2-(2,4-difluorostyryl)quinoline (24FQL) and (E)-2-(3,5-difluorostyryl)quinoline (35FQL) were synthesized and their reactivity and movement were investigated in cocrystals. The results showed enhanced reactivity and photomechanical effects in the cocrystals.
CRYSTAL GROWTH & DESIGN
(2023)
Review
Peripheral Vascular Disease
Antonia Vlahou, Dara Hallinan, Rolf Apweiler, Angel Argiles, Joachim Beige, Ariela Benigni, Rainer Bischoff, Peter C. Black, Franziska Boehm, Jocelyn Ceraline, George P. Chrousos, Christian Delles, Pieter Evenepoel, Ivo Fridolin, Griet Glorieux, Alain J. van Gool, Isabel Heidegger, John P. A. Ioannidis, Joachim Jankowski, Vera Jankowski, Carmen Jeronimo, Ashish M. Kamat, Rosalinde Masereeuw, Gert Mayer, Harald Mischak, Alberto Ortiz, Giuseppe Remuzzi, Peter Rossing, Joost P. Schanstra, Bernd J. Schmitz-Draeger, Goce Spasovski, Jan A. Staessen, Dimitrios Stamatialis, Peter Stenvinkel, Christoph Wanner, Stephen B. Williams, Faiez Zannad, Carmine Zoccali, Raymond Vanholder
Summary: This article discusses the impact of GDPR on data and biological sample sharing in biomedical research, highlighting areas for clarification and amendment, as well as emphasizing the importance of public engagement and education.
Article
Plant Sciences
Matteo Conti, Pier Luigi Nimis, Stefano Martellos
Summary: Scientific names can easily be associated with typographical errors in query systems, leading to the use of matching algorithms globally. FlorItaly has integrated a near match algorithm and a tool for aligning names with the national checklists to enhance user experience.
Review
Nutrition & Dietetics
Tatianna Oliva Kowalsky, Ruben Morilla Romero de la Osa, Isabel Cerrillo
Summary: Climate change and global health are closely linked, and adapting health systems and professionals to sustainable diets can bring co-benefits for health and the environment.
Article
Chemistry, Multidisciplinary
Qian Li, Yaxin Zhou, Weidong He, Xiaomeng Ren, Mengzhu Zhang, Yue Jiang, Zhaocai Zhou, Yuxia Luan
Summary: IFN-gamma has both positive and negative effects in tumor immunology, with its double-edge nature posing challenges in postoperative chemotherapy. The platelet-engineered nanoplatform PMF@DR NPs effectively modulates IFN-gamma to enhance immune response and inhibit tumor progression, offering a potential innovative strategy for high-drug-loading biomimic nanoplatforms.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Christopher J. Bowman, Nathalie Becourt-Lhote, Virginie Boulifard, Rudiger Cordts, Solange Corriol-Rohou, Brian Enright, Linda Erkman, Jayne Harris, Andreas Hartmann, Jan Hilpert, Sophie Kervyn, Britta Mattson, LaRonda Morford, Mireille Muller, Marcy Powell, Zhanna Sobol, Rajamuthu Srinivasan, Claudia Stark, Kary E. Thompson, Katie J. Turner, Paul Barrow
Summary: This review presents a consensus by the EFPIA-PDEG on a data-driven approach to harmonize contraception recommendations in clinical trial protocols and product labeling. There is no international agreement on when/if contraception is warranted in pharmaceutical clinical trials or product labeling, leading to different recommendations among regions. Contraception recommendations are generally based on nonclinical data and mechanism, and differ between clinical trials and product labeling.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Physical
Sivaram Nallamolu, Vijaya Ratna Jayanti, Mallikarjun Chitneni, Liew Yun Khoon, Shikha Sood, Yassine Riadi, Prashant Kesharwani
Summary: The study successfully synthesized a highly solubilized and biocompatible formulation of RES, using SMEDDS technology to overcome issues related to poor water solubility and low bioavailability.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Sima Singh, Arshid Numan, Balaji Maddiboyina, Saahil Arora, Yassine Riadi, Shadab Md, Nabil A. Alhakamy, Prashant Kesharwani
Summary: Triple-negative breast cancers are a heterogeneous group of breast carcinomas that do not express estrogen receptor, progesterone receptor, and epidermal growth factor receptor 2. Recent trials using immune checkpoint inhibitors for treatment have shown promising early results. This review provides an overview of immunotherapy-based treatments and discusses future opportunities for their use in TNBC.
DRUG DISCOVERY TODAY
(2021)
Article
Pharmacology & Pharmacy
Soma Patnaik, Bapi Gorain, Santwana Padhi, Hira Choudhury, Gamal A. Gabr, Shadab Md, Dinesh Kumar Mishra, Prashant Kesharwani
Summary: The potential of nanotechnology-based drug delivery systems has attracted the attention of researchers in recent decades, offering solutions to overcome limitations of conventional deliveries. These systems can enhance drug solubility, improve targeting potential, and ultimately maximize bioavailability and pharmacokinetics while also addressing toxicity concerns.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Review
Environmental Sciences
Sima Singh, Arshid Numan, Dinesh Sharma, Rahul Shukla, Amit Alexander, Gaurav Kumar Jain, Farhan Jalees Ahmad, Prashant Kesharwani
Summary: The outbreak of the COVID-19 pandemic in 2019 and 2020 has led to a new era of communicable infectious diseases, with the emergence of Hantavirus infection posing a new public health emergency. Hantavirus, a zoonotic pathogen, causes two major clinical manifestations - HFRS and HCPS. Despite the lack of effective treatments or vaccines, public awareness and precautionary measures can help reduce the spread of the virus.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Sunil Kumar Dubey, Rajesh Pradhan, Siddhanth Hejmady, Gautam Singhvi, Hira Choudhury, Bapi Gorain, Prashant Kesharwani
Summary: Age-related macular degeneration (AMD) is a degenerative eye disease that causes irreversible vision loss in individuals aged 50 and older, with environmental and genetic factors playing important roles. While there are currently no options to cure or treat AMD, recent innovations in nanotherapeutics offer a potential alternative for drug delivery to improve drug bioavailability and bioactivity, providing sustained release.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Nazeer Hasan, Mohammad Imran, Prashant Kesharwani, Kushagra Khanna, Ritu Karwasra, Nitin Sharma, Sonalika Rawat, Deeksha Sharma, Farhan Jalees Ahmad, Gaurav Kumar Jain, Aseem Bhatnagar, Sushama Talegaonkar
Summary: The study developed naloxone-loaded solid-lipid nanoparticles for intranasal administration, addressing the limitations of oral administration and achieving improved therapeutic effects; the optimized formulation showed efficient drug release and uptake by nasal membrane; in vitro and in vivo experiments demonstrated the effectiveness and safety of the nanoscale formulation in treating opioid overdose.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Manisha Choudhari, Siddhanth Hejmady, Ranendra Narayan Saha, Shantanu Damle, Gautam Singhvi, Amit Alexander, Prashant Kesharwani, Sunil Kumar Dubey
Summary: An understanding of the blood-brain barrier (BBB) is crucial for drug targeting to the brain, but challenges remain in treating brain diseases as traditional drugs struggle to cross the BBB.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Instruments & Instrumentation
Akanksha R. Singh, Prasanna Kumar Desu, Ramya Krishna Nakkala, Vanitha Kondi, Sushma Devi, Mohammad Sarwar Alam, Hinna Hamid, Rajani B. Athawale, Prashant Kesharwani
Summary: Nanotechnology has opened up new possibilities in the field of nutraceuticals and food industries, offering enhanced properties and applications for nanomaterials. The small size and unique properties of nanomaterials have led to advancements in bioavailability, solubility, stability, and targeted drug delivery in the development of nano-based nutraceuticals, highlighting the potential benefits and future prospects in improving treatment strategies and quality of life in the health sectors.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Health Care Sciences & Services
Maha Ali Alghamdi, Antonino N. Fallica, Nicola Virzi, Prashant Kesharwani, Valeria Pittala, Khaled Greish
Summary: Personalized medicine and nanomedicine are both new concepts in medical practice. Personalized medicine aims to customize therapeutic management based on a patient's personal attributes, while nanomedicine applies nanotechnology advances in medicine for diagnosis and treatment. The integration of these two fields can provide more effective treatment options tailored to individual patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Chemistry, Analytical
Vanshikha Singh, Afsana Sheikh, Mohammed A. S. Abourehab, Prashant Kesharwani
Summary: Immunotherapy, especially the use of anti-PD-1 monoclonal antibody Dostarlimab, has shown promising results in various cancer treatments, with complete cure observed in colorectal cancer patients. This review emphasizes the mechanism of action of immunotherapy and discusses the ongoing clinical trials and combination therapies involving Dostarlimab to provide insights for future clinicians and researchers.
Article
Chemistry, Analytical
Praveen Gupta, Afsana Sheikh, Mohammed A. S. Abourehab, Prashant Kesharwani
Summary: This study developed a dendrimer-based hydrogel bandage for the treatment of full-thickness wounds. Incorporating hesperidin, a bioflavonoid, into the dendrimer core improved its water solubility and bioavailability. The experimental results showed that the prepared formulation had better wound healing activity compared to the control group.
Review
Medicine, General & Internal
Tannaz Jamialahmadi, Zeljko Reiner, Mona Alidadi, Wael Almahmeed, Prashant Kesharwani, Khalid Al-Rasadi, Ali H. Eid, Manfredi Rizzo, Amirhossein Sahebkar
Summary: This meta-analysis study showed that bariatric surgery significantly reduced IMT, with the reduction remaining robust in sensitivity analysis. The study did not find a relationship between changes in IMT and changes in BMI or duration of follow-up after bariatric surgery, but subgroup analysis indicated a greater reduction in IMT after laparoscopic sleeve gastrectomy (LSG) compared to Roux-en-Y gastric bypass (RYGB).
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Tannaz Jamialahmadi, Mitra Abbasifard, Zeljko Reiner, Prashant Kesharwani, Amirhossein Sahebkar
Summary: This meta-analysis found that bariatric surgery significantly decreases MCP-1 concentration, but there was no association between the changes in BMI and absolute difference in MCP-1 levels before and after the surgery. However, a linear relationship between the changes in MCP-1 and length of follow-up was proven.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Multidisciplinary
Prashant Kesharwani, Mahak Fatima, Vanshikha Singh, Afsana Sheikh, Waleed H. Almalki, Virendra Gajbhiye, Amirhossein Sahebkar
Summary: This study developed a new hydrogel formulation for treating onychomycosis. The sustained release of drugs from the hydrogel showed promising activity, making it an effective method of drug delivery.
Review
Engineering, Biomedical
Amir R. Afshari, Mehdi Sanati, Prashant Kesharwani, Amirhossein Sahebkar
Summary: Standard cancer chemotherapeutics often lose effectiveness and produce adverse effects due to resistance mechanisms. Curcumin, when combined with traditional chemotherapeutics, has been found to enhance cancer treatment effectiveness and reduce resistance. However, limited bioavailability requires co-delivery strategies for Cur and conventional pharmaceuticals in clinical settings.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
