Review
Chemistry, Multidisciplinary
Mithun Rajendra Dethe, A. Prabakaran, Hafiz Ahmed, Mukta Agrawal, Upal Roy, Amit Alexander
Summary: Stimuli-responsive hydrogels have been extensively studied in biomedical applications due to their biodegradability and biocompatibility. The emergence of in situ stimuli-responsive hydrogels is the result of advancements in synthetic chemistry and materials science. The copolymer PCL-PEG, recognized by the FDA, can form thermosensitive injectable hydrogels that exhibit rapid and reversible gelation behavior.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biotechnology & Applied Microbiology
Lei Yu, Yi Liu, Jianxin Wu, Shuang Wang, Jiangming Yu, Weiheng Wang, Xiaojian Ye
Summary: Intervertebral disc degeneration (IDD) is the pathological basis of disc degenerative diseases (DDD), characterized by reduction in the number of cells and degeneration of the extracellular matrix in the nucleus pulposus. An injectable ECM hydrogel combined with stem cell transplantation shows promise, but lacks sufficient biomechanics and stability. A genipin cross-linked decellularized nucleus pulposus hydrogel (GDH) was developed as a delivery system, showing good mechanical properties, biocompatibility, and differentiation induction in vitro. In vivo studies demonstrated that GDH loaded with adipose-derived mesenchymal stem cells (GDHA) improved stem cell survival and intervertebral disc regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Applied
Arman Jafari, Mojtaba Farahani, Mahsa Sedighi, Navid Rabiee, Houman Savoji
Summary: Biomaterials play a crucial role in tissue engineering, regenerative medicine, and drug delivery, with polymeric biomaterials being the most promising candidates. Carrageenan, derived from red seaweed, possesses unique properties and various biological activities, making it highly attractive for tissue engineering and drug delivery research.
CARBOHYDRATE POLYMERS
(2022)
Review
Chemistry, Multidisciplinary
Di Wu, Gaocai Li, Xingyu Zhou, Weifeng Zhang, Huaizhen Liang, Rongjin Luo, Kun Wang, Xiaobo Feng, Yu Song, Cao Yang
Summary: Intervertebral disc degeneration is a major cause of low back pain, and finding effective treatments to postpone its progression and repair degenerated discs is of great importance. Bioactive functional materials have shown promising advancements in tissue repair and remodeling, making them a potential therapeutic approach for intervertebral disc recovery and regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Yiyang Wang, Haoming Wang, Yunyun Zhuo, Yanzhu Hu, Xiaoxiao Li, Yanqin Xu, Biemin Sun, Min Liu, Luetao Zou, Liehua Liu, Lei Luo, Chen Zhao, Pei Li, Qiang Zhou
Summary: The study developed a three-dimensional spheroid culture method for NPC spheroids and found them to have superior self-renewal and ECM synthesis capacities compared to monolayer-cultured NPCs. In vivo, NPC spheroids promoted NP regeneration in a disc degeneration model induced by partial NP excision, potentially through the regulation of N-CDH and ITG beta 1 interaction-mediated ECM homeostasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Materials Science, Characterization & Testing
Xuan Peng, Lingjia Yu, Lin Shi, Huajun Dong, Xiaohui Meng, Bin Zhu
Summary: Intervertebral disc degeneration (IVDD) is characterized by the loss of nucleus pulposus (NP) cells, making replenishing NP cells crucial for IVDD treatment. Advances in polymer materials and decellularization technology offer hope for relieving pain, replacing damaged tissue, reversing disc degeneration, maintaining spinal mechanical properties, and improving conditions. This review discusses the limitations of traditional therapies, as well as the research progress in materials for intervertebral disc (IVD) repair and regeneration, including polymeric hydrogels and decellularized nucleus pulposus extracellular matrix (dNP-ECM) technology. While these technologies are not widely used clinically, they hold promise as alternative approaches to IVDD treatment and have significant research value.
Article
Biochemistry & Molecular Biology
Ming Guan, Can Liu, Qiangqiang Zheng, Guangyu Chu, Hehui Wang, Jiale Jin, Honghao Wu, Jingyao Chen, Qiong Huang, Zexing Deng, Yue Wang
Summary: We found that disc degeneration is closely associated with nucleus pulposus (NP) cell senescence, and exosomes derived from mesenchymal stem cells (MSCs) can alleviate NP cell senescence and promote extracellular matrix (ECM) deposition. We developed an exosomes-laden hydrogel based on quaternized chitosan (QCS) and oxidized starch (OST) which showed injectability, self-healing properties, biocompatibility, and sustained release of exosomes. In a rat model of disc degeneration, the QCS-OST/Exos hydrogel rejuvenated NP cell senescence, promoted ECM remodeling, and partially restored the structures of NP and annulus fibrosis. Our findings suggest that the QCS-OST/Exos hydrogel is an effective therapeutic strategy for treating disc degeneration by alleviating NP cell senescence.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Yu Wang, Ye Wu, Bo Zhang, Cheng Zheng, Cheng Hu, Chuan Guo, Qingquan Kong, Yunbing Wang
Summary: A injectable hydrogel gene delivery system was developed for sustained delivery of antagomir-21 into the nucleus pulposus, leading to anti-inflammatory effects and extracellular matrix regeneration against intervertebral disc degeneration (IDD). The system utilized tannic acid nanoparticles (TA NPs) as a vector to release antagomir-21 and inhibit the MAPK/ERK signaling pathway. In vivo experiments demonstrated the therapeutic potential of this system for IDD repair.
Article
Cell Biology
Panpan Xu, Jingjing Guan, Yu Chen, Hui Xiao, Tianhao Yang, Hengheng Sun, Nan Wu, Changchun Zhang, Yingji Mao
Summary: This study evaluated the encapsulation of nucleus pulposus cells (NPCs) in GelMA hydrogel to improve intervertebral disc degeneration. Adjusting the concentration of GelMA affected the mechanical properties and viability of the encapsulated NPCs. The controllability of GelMA hydrogels makes them promising candidates for NP tissue engineering and repairing endogenous NPCs.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Engineering, Biomedical
Haibin Xu, Miao Sun, Chenggui Wang, Kaishun Xia, Shining Xiao, Ye Wang, Liwei Ying, Chao Yu, Quanming Yang, Yong He, An Liu, Linwei Chen
Summary: Injectable gelatin methacryloyl microspheres (GMs), combined with stem cells and growth factors, demonstrate good mechanical properties and biocompatibility. This integrated system effectively attenuates in vivo degeneration of intervertebral discs in rats, maintaining tissue integrity and accelerating extracellular matrix synthesis, showing promise for the treatment of degenerative disc disease.
Review
Engineering, Environmental
Akbar Mirzaei, Maryam Esmkhani, Mahsa Zallaghi, Zahra Nezafat, Shahrzad Javanshir
Summary: Carrageenan, a renewable polymer derived from red algae, has valuable properties such as water absorption, gel formation, and antibacterial effects. It shows great potential in biomedical and environmental applications.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Biotechnology & Applied Microbiology
Wenzhong Kuang, Chen Liu, Hongguang Xu
Summary: In this study, a decellularized nucleus pulposus matrix/chitosan hydrogel scaffold with crosslinker genipin was successfully prepared for nucleus pulposus tissue engineering. The incorporation of TGF-beta 3 into the scaffold enhanced the gene expression of collagen-I, collagen-II, and aggrecan, indicating the potential of this hybrid hydrogel as a candidate scaffold for nucleus pulposus tissue engineering.
Article
Engineering, Biomedical
Michal Dziadek, Kinga Dziadek, Kamila Checinska, Barbara Zagrajczuk, Monika Golda-Cepa, Monika Brzychczy-Wloch, Elzbieta Menaszek, Aneta Kopec, Katarzyna Cholewa-Kowalska
Summary: Polymeric and bioactive glass-modified composite films loaded with polyphenols extracted from sage have been successfully developed. The polyphenolic compounds significantly altered material properties and exhibited biological activity. PPh can act as plasticizers for PCL and coupling agents in composite materials, improving mechanical performance.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Dingding Xiang, Yangyang Cui, Zhiping Wan, Song Wang, Lu Peng, Zhenhua Liao, Changsheng Chen, Weiqiang Liu
Summary: In this study, PVA/PVP and PVA/Pectin composite hydrogels were prepared and tested, with the PVA/PVP CH showing the best performance, providing significant advantages for future clinical application in replacing nucleus pulposus.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Cell & Tissue Engineering
C. Y. Wang, M. K. Hsieh, Y. J. Hu, A. Bit, P. L. Lai
Summary: A multi-layered cell-loaded sponge model with oxygen and nutrient gradients and lactate accumulation was developed to mimic the in vivo microenvironment of intervertebral disc degeneration (IVDD). This model can be used to explore potential agents for IVDD treatment.
EUROPEAN CELLS & MATERIALS
(2022)
Review
Biochemical Research Methods
Jessica Houang, Gabriel Perrone, Damia Mawad, Philip C. Boughton, Andrew J. Ruys, Antonio Lauto
JOURNAL OF BIOPHOTONICS
(2018)
Article
Chemistry, Physical
Adhi Anindyajati, Philip Boughton, Andrew J. Ruys
Article
Engineering, Biomedical
Babak Sarrafpour, Philip Boughton, Ramin M. Farahani, Stephen C. Cox, Gareth Denyer, Elizabeth Kelly, Hans Zoellner
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2018)
Article
Chemistry, Physical
Adhi Anindyajati, Philip Boughton, Andrew J. Ruys
Article
Neurosciences
Daryl H. C. Fong, Adrian Cohen, Philip Boughton, Paul Raftos, Joseph E. Herrera, Neil G. Simons, David Putrino
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Engineering, Biomedical
Kazi Rizwana Mehzabeen, Philip Boughton, Wen Hao Kan, Andrew J. Ruys, Massimiliano Guazzato
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Article
Surgery
Jeremy Kwarcinski, Philip Boughton, James van Gelder, Omprakash Damodaran, Alessandra Doolan, Andrew Ruys
Summary: The study clinically evaluated 3D print-formed implants using cranioplasty as a proof of concept, with favorable functional results and stability reported by participating surgeons. Three out of ten patients rated their cosmetic results as good or excellent, with zero rate of surgical revision at the time of writing.
ANZ JOURNAL OF SURGERY
(2021)
Correction
Neurosciences
Daryl H. C. Fong, Adrian Cohen, Philip Boughton, Paul Raftos, Joseph E. Herrera, Neil G. Simon, David Putrino
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Immunology
Turaab Khan, Jeremy Kwarcinski, Tony Pang, Ahmer Hameed, Philip Boughton, Greg O'Grady, Wayne J. Hawthorne, Natasha M. Rogers, Germaine Wong, Henry C. Pleass
Summary: A novel ischemic-injury thermal protection jacket was designed to reduce second warm ischemic time, surgical complications, and graft ischemia-reperfusion injury during kidney transplantation. Experimental results showed significantly reduced time and thermal energy transfer with the use of the protective jacket compared to controls.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Engineering, Biomedical
Adhi Anindyajati, Philip Boughton, Andrew J. Ruys
Summary: Electrospinning is a versatile method for fabricating biomaterials, with factors like flow rate, collector distance, and collector rotation speed affecting fiber properties. Optimization through factorial design yielded fibrous membranes suitable for tissue engineering, demonstrating the potential for further development of electrospinning technologies.
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2022)
Review
Polymer Science
Sonia B. Wahed, Colin R. Dunstan, Philip A. Boughton, Andrew J. Ruys, Shaikh N. Faisal, Tania B. Wahed, Bidita Salahuddin, Xinying Cheng, Yang Zhou, Chun H. Wang, Mohammad S. Islam, Shazed Aziz
Summary: The selection of biomaterials for biomedical implants is a significant challenge. UHMWPE and its composites are widely used due to their biocompatibility and high wear resistance. However, issues such as wear debris and oxidative degradation exist in UHMWPE implants, necessitating surface functionalization to enhance their performance.
Article
Engineering, Biomedical
Turaab Khan, Jeremy Kwarcinski, Philip Boughton, Peter Yoon, Ahmer Hameed, Animesh Singla, Tony Pang, Henry Pleass
Summary: This study primarily focused on determining the effect of a novel thermally insulating jacket on the thermal profile of the human kidney and quantifying the reduction in thermal energy experienced using this device. The results showed that the kidneys with the thermally insulating jacket reached the metabolic threshold temperature later and stayed below the threshold for a longer period compared to the control group.
Meeting Abstract
Clinical Neurology
Adrian Cohen, Daryl Fong, David Putrino, Philip Boughton, Joseph Herrera, Neil G. Simon, Paul Raftos, Dylan Mahony
Article
Pharmacology & Pharmacy
Jessica Houang, Gabriel G. Perrone, Christian Pedrinazzi, Leonardo Longo, Damia Mawad, Philip C. Boughton, Andrew J. Ruys, Antonio Lauto
ADVANCED THERAPEUTICS
(2019)
Proceedings Paper
Infectious Diseases
J. Houang, G. G. Perrone, C. Pedrinazzi, L. Longo, D. Mawad, P. C. Boughton, A. J. Ruys, A. Lauto
PHOTONIC DIAGNOSIS AND TREATMENT OF INFECTIONS AND INFLAMMATORY DISEASES II
(2019)
Article
Engineering, Biomedical
Xinyao Zhu, Yifan Liu, Jing Ye, Wei Xu, Xuexia Zhao, Tianyan Liu
Summary: This study reveals the adverse effect of acid on dentin in terms of degradation of its fracture toughness. The peritubular dentin plays a significant role in enhancing the dentin's fracture resistance capability. The findings highlight the importance of structural integrity for dentin.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ziad Guerfi, Oum keltoum Kribaa, Hanane Djouama
Summary: Hydroxyapatite, a biocompatible and bioactive ceramic material, has been widely studied in fields such as orthopedics and plastic surgery. The use of computational tools, especially density functional theory, has become increasingly important in research. In this study, Hydroxyapatite was synthesized using the double decomposition method and quantum mechanical computations were performed using density functional theory. The experimental and computational results confirmed the successful synthesis of Hydroxyapatite and showed good agreement in spectroscopic characterizations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Veronika Geiger, Felicitas Mayinger, Moritz Hoffmann, Marcel Reymus, Bogna Stawarczyk
Summary: The study investigated the mechanical properties of four additively manufactured denture base resins in different measurement environments, and found that the measurement environment impacts the strength and fracture toughness of the materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Junxiao Wang, Amatjan Sawut, Rena Simayi, Huijun Song, Xueying Jiao
Summary: The development of cost-effective and eco-friendly conductive hydrogels with excellent mechanical properties, self-healing capabilities, and non-toxicity is of great significance in the field of biosensors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Mehdi Jahandardoost, Donald Ricci, Abbas S. Milani, Mohsen Jahandardoost, Dana Grecov
Summary: Tubular flow diverters are important for treating cerebral aneurysms. A new design called VR-eCLIPs has been developed to cover the neck of challenging bifurcation aneurysms. A finite element model has been used to simulate the implantation processes of VR-eCLIPs and assess potential plastic deformation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marek Traczynski, Adam Patalas, Katarzyna Roslan, Marcin Suszynski, Rafa l Talar
Summary: This article evaluates the forces acting on intravenous needles during insertion into the skin and selects the most suitable model for future research. The experimental results show that needle size, insertion angle, and insertion speed have an influence on the measured force values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chester Jar, Andrew Archibald, Monica Gibson, Lindsey Westover
Summary: This study evaluates the ASIST technique for assessing the stability of dental implants. The results show that the ASIST technique can reliably measure the interfacial stiffness of dental implants, which is not significantly influenced by different abutment types. This method may provide an improved non-invasive way to measure the stability of dental implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ali Kamali, Kaveh Laksari
Summary: In this paper, a UNet-based neural network model (El-UNet) is developed to infer the spatial distributions of mechanical parameters. The El-UNet shows superior performance in terms of accuracy and computational cost compared to other neural network models. A self-adaptive spatial loss weighting approach is proposed, which achieves the most accurate reconstructions in equal computation times.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chunyan Yu, Yanju Lu, Jinhui Pang, Lu Li
Summary: In this study, a safe and effective hemostatic composite sponge was developed by combining chitosan and hydroxypropylmethylcellulose (HPMC). The sponge exhibited excellent flexibility and rapid hemostatic ability in vitro. In vivo assessments showed that the sponge had the shortest clotting time and minimal blood loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Zhongliang Yu, Lin Yu, Junjie Liu
Summary: The study proposes incorporating functionally graded tablets into nacreous composites to enhance both stiffness and damping properties. Analytical formulae and numerical experiments demonstrate the effectiveness of this design, surpassing existing homogeneous composites in performance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marc Graham, Sandra Klinge
Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Abdur-Rasheed Alao
Summary: This study aimed to find the optimal sandblasting parameters for roughening YTZP surfaces. Through experimental and statistical analysis, the best setting was found to be IA = 45 degrees, AP = 110 μm, ST = 20 s, and P = 400 kPa, which resulted in the maximum surface roughness, phase transformation, and shear bond strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)